DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and CACNA1A

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:NP_075461.2 Gene:CACNA1A / 773 HGNCID:1388 Length:2512 Species:Homo sapiens


Alignment Length:2561 Identity:850/2561 - (33%)
Similarity:1155/2561 - (45%) Gaps:819/2561 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   676 ARYDSGEGDLGGGNNIMGIDSMGIANIPETMNGTTIGPSGAGGQKGGAAAGAAGQKRQQRRGKPQ 740
            |||       |||.:       |.|      .|..:|..|..|..|....|..|.:|..::...|
Human    10 ARY-------GGGGS-------GAA------AGVVVGSGGGRGAGGSRQGGQPGAQRMYKQSMAQ 54

  Fly   741 PDRP----------------QRALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYT 789
            ..|.                .|:||..|..|.:|....:|.||.|||::||.||.||||.||:..
Human    55 RARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQ 119

  Fly   790 PYPGSDSNVTNQTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAIST 854
            ..|..|....::.|:..|..|:.||..|..:||:|.||..|.|:|||||||::||.:|:.|.::|
Human   120 HLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILAT 184

  Fly   855 ALSQLMKDAFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIG 919
            ..::     ||::.|||.||||||:||||:|||||||.||:|||:||..|.||:.|.|:|:||||
Human   185 VGTE-----FDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIG 244

  Fly   920 LELFSGKLHKACRDEITGEYE-ENIRPCGV---GYQCPPGYKCYGGWDGPNDGITNFDNFGLAML 980
            ||.:.||.|..|.:|.|.:.: |:..|||.   ...||.|.||...|:|||:|||.|||...|:|
Human   245 LEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGITQFDNILFAVL 309

  Fly   981 TVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERNKAKNRG 1045
            |||||:|:|||||:||:..||.|:.|.|:|||.::|:|:||::||:||||||||:|||.:.:||.
Human   310 TVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRR 374

  Fly  1046 DFQKLREKQQIEEDLRGYLDWITQAEDI---EPDAVGGLISDGKGKQPNE---------MDSTEN 1098
            .|.|||.:||||.:|.||::||::||::   |.:      :||:.:.|.:         ...|:.
Human   375 AFLKLRRQQQIERELNGYMEWISKAEEVILAEDE------TDGEQRHPFDGALRRTTIKKSKTDL 433

  Fly  1099 LGEEMPEVQMTE------------SRWRKMKKD--FDRVNRRMRRACRKAVKSQAFYWLIIVLVF 1149
            |..|..|.|:.:            .:..|::..  |.:..||||...|:.||:|||||.::.||.
Human   434 LNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVA 498

  Fly  1150 LNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSI 1214
            |||..:|..||.|.:||.:|..|....|:|||..||.:|||.||.:.||.|.||.|||.|:||||
Human   499 LNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSI 563

  Fly  1215 TETLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIF 1279
            .|.:..........|:||||.:||||:|||||||.||.|||.|||||::||.|||.|||||||:|
Human   564 FEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVF 628

  Fly  1280 ALLGMQVFGGKFNFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALA 1344
            ||||||:|||:||||  |.....|||.|..|::|||||:||||||.|||.||.:.|||.. |.:.
Human   629 ALLGMQLFGGQFNFD--EGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQG-GMVF 690

  Fly  1345 CIYFIILFICGNYILLNVFLAIAVDNLADADSLSEVEKEEEPHDESA------------------ 1391
            .||||:|.:.|||.||||||||||||||:|..|::||.:|:..:|:|                  
Human   691 SIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKVEADEQEEEEAANQKLALQKAKEVAEVSPL 755

  Fly  1392 -----------QKKSHSPT---------------------------------------------- 1399
                       |:|:..|.                                              
Human   756 SAANMSIAVKEQQKNQKPAKSVWEQRTSEMRKQNLLASREALYNEMDPDERWKAAYTRHLRPDMK 820

  Fly  1400 --------------------------PTID-----------------------------GMD--- 1406
                                      ||:|                             |:|   
Human   821 THLDRPLVVDPQENRNNNTNKSRAAEPTVDQRLGQQRAEDFLRKQARYHDRARDPSGSAGLDARR 885

  Fly  1407 --------------------DHLSIDIDME----------------------------------- 1416
                                ||.:.:..:|                                   
Human   886 PWAGSQEAELSREGPYGRESDHHAREGSLEQPGFWEGEAERGKAGDPHRRHVHRQGGSRESRSGS 950

  Fly  1417 ----------------------------------------------------------------- 1416
                                                                             
Human   951 PRTGADGEHRRHRAHRRPGEEGPEDKAERRARHREGSRPARGGEGEGEGPDGGERRRRHRHGAPA 1015

  Fly  1417 ---------------------------------------QQELDDED------------------ 1424
                                                   ||:|..:|                  
Human  1016 TYEGDARREDKERRHRRRKENQGSGVPVSGPNLSTTRPIQQDLGRQDPPLAEDIDNMKNNKLATA 1080

  Fly  1425 ----------------------------------------------------------------- 1424
                                                                             
Human  1081 ESAAPHGSLGHAGLPQSPAKMGNSTDPGPMLAIPAMATNPQNAASRRTPNNPGNPSNPGPPKTPE 1145

  Fly  1425 --------------------KMDHETL----------------------------SDEEVREMCE 1441
                                |.||.|:                            .:||.:|  |
Human  1146 NSLIVTNPSGTQTNSAKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPDPLPKKEEEKKE--E 1208

  Fly  1442 EEEEVDEEGMITARPRRMSEVNTATKILPIPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCC 1506
            ||::..|:|     |:            |:||.:|.|:.|.||..|..||::.|...|...||..
Human  1209 EEDDRGEDG-----PK------------PMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMV 1256

  Fly  1507 IMFSSAMLAAENPLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDL 1571
            |..||..||||:|::.|...|.||..|||.||.|||.|:::|:|..|.|||.||:.|..:|:||.
Human  1257 IAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDF 1321

  Fly  1572 LVVCVSLISLVSSSNA----ISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLV 1632
            :||..:|::...:.|:    |:.:|.||||||||||:.|.|...||.|..               
Human  1322 IVVSGALVAFAFTGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFD--------------- 1371

  Fly  1633 TCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTDGSKM 1697
                                 |||.::|.:.||::|..|..|:|||:.|||||||||.|||.||.
Human  1372 ---------------------CVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKE 1415

  Fly  1698 TQDECYGTYLVYDDGDVHKPRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNK 1762
            .:.:|.|.||:|:..:|   :.|:|||....||:|:|...:||||||||.||||.:|..|:|:..
Human  1416 FEKDCRGKYLLYEKNEV---KARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATF 1477

  Fly  1763 ENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQEYKNCDLDKNQRNCIEFAL 1827
            ||.||...:|..::.:|::|.::..||.|||||..:|:|||.:|::..:...|:||:|.||:||:
Human  1478 ENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAI 1542

  Fly  1828 KAKPVRRYIP--KHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMI 1890
            .|||:.|::|  |...||::|.||.|..|||||..:|.:||:.|.||||...:.|...|...|::
Human  1543 SAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIV 1607

  Fly  1891 FTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKS 1955
            ||::|:||.|.|:.||...|||.||||:|||:.||||..||:.:|..:.                
Human  1608 FTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNP---------------- 1656

  Fly  1956 TKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVG 2020
                  :|.|:::|.||||..||:|||.:|..||.|||||::||:|||||.|||.:||||||::|
Human  1657 ------NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIG 1715

  Fly  2021 MQVFGKIALDGGN--------AITANNNFQTFQQAVLVLFRSATGEAWQEIMMSC-SAQPDVKCD 2076
            |||||.|.:|..:        .||.:|||:||.||:::||||||||||..||:|| |.:|   ||
Human  1716 MQVFGNIGIDVEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKP---CD 1777

  Fly  2077 MNSDTPGEPCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWS 2141
            .||......||:..||.||:||..|||||::|||||||||||:|||||.||||||||||::|:|:
Human  1778 KNSGILTRECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWA 1842

  Fly  2142 EYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVR 2206
            ||||.|.||:.:||:..:||.:|||||.||.||.|:|.|||:.|::|:..|.||.||:||.|::|
Human  1843 EYDPAAWGRMPYLDMYQMLRHMSPPLGLGKKCPARVAYKRLLRMDLPVADDNTVHFNSTLMALIR 1907

  Fly  2207 TSLSIK-TDGNID--DANSELRATIKQIWKRTNPKLLDQVVPPPGNDDEVTVGKFYATYLIQDYF 2268
            |:|.|| ..|..|  ..::|||..:..||...:.|.||.:|.|..:.| :||||.||..:|.:|:
Human  1908 TALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTD-LTVGKIYAAMMIMEYY 1971

  Fly  2269 RRFKKRKEQEGKEGHPDSNTVTLQAGLRTLHEVSPALKRAISGNLDELDQEPEPMHRRHHTLFGS 2333
            |:.|.:|.|..:|                                   :|:..|:          
Human  1972 RQSKAKKLQAMRE-----------------------------------EQDRTPL---------- 1991

  Fly  2334 VWSSIRRHGNGTFRRSAKATASQSNGALAIGGSASAALGVGGSSLVLGSSDPAGGDYLYDTLNRS 2398
                       .|:|....:.:|..|.             |.::|.....||.|....:::..:.
Human  1992 -----------MFQRMEPPSPTQEGGP-------------GQNALPSTQLDPGGALMAHESGLKE 2032

  Fly  2399 VADGVNNITRNIMQARLAAAGKLQDELQGA----------GSGGELRTFGE---SISMRPLAKNG 2450
            ....|....:.:.|    ..|....| ||.          ....|:|..|.   |.|...|...|
Human  2033 SPSWVTQRAQEMFQ----KTGTWSPE-QGPPTDMPNSQPNSQSVEMREMGRDGYSDSEHYLPMEG 2092

  Fly  2451 GGAATVAGTLPPEANAINYDNRNRGILLHPYNNVYAPNGALPGHERMIQSTPASPYDQRRLPTSS 2515
            .|.|.....||.|      :.|.||          .|.|                   ..|.|.|
Human  2093 QGRAASMPRLPAE------NQRRRG----------RPRG-------------------NNLSTIS 2122

  Fly  2516 DMNGLAESLIGGVLAAEGLGKYCDSEFVGTAAREMRE-ALDMTPEEMNLAAHQ------ILSNEH 2573
            |.:.:..|                :..:|..||.:.: :|:..|.|.|...||      ..::|.
Human  2123 DTSPMKRS----------------ASVLGPKARRLDDYSLERVPPEENQRHHQRRRDRSHRASER 2171

  Fly  2574 SLSLIGSSNGSIFGGSAGGLGGAGSGGVGGLGGSSSIRNAFGGSGSGPSS------------LSP 2626
            ||                   |..:....|||...|:...   ||..||.            ...
Human  2172 SL-------------------GRYTDVDTGLGTDLSMTTQ---SGDLPSKERDQERGRPKDRKHR 2214

  Fly  2627 QHQPYSGTLNSPPIPDNRLRRVATVTTTNNNNKSQVSQNNSNSLNVRAN---------------A 2676
            ||..:....:.||.||                |.:.:|...:....||.               |
Human  2215 QHHHHHHHHHHPPPPD----------------KDRYAQERPDHGRARARDQRWSRSPSEGREHMA 2263

  Fly  2677 NSQMNMSPTGQPVQQQS----PLRGQ 2698
            :.|.:.|.:|.|....|    |.||:
Human  2264 HRQGSSSVSGSPAPSTSGTSTPRRGR 2289

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 147/278 (53%)
Ion_trans 1137..1379 CDD:395416 145/241 (60%)
Ion_trans 1496..1809 CDD:395416 131/316 (41%)
Ion_trans 1851..2126 CDD:395416 145/283 (51%)
GPHH 2135..2188 CDD:407139 29/52 (56%)
Ca_chan_IQ 2199..2271 CDD:400901 30/74 (41%)
CACNA1ANP_075461.2 I 85..363 146/282 (52%)
Ion_trans 115..371 CDD:278921 135/260 (52%)
Binding to the beta subunit. /evidence=ECO:0000250 383..400 9/16 (56%)
II 473..717 147/246 (60%)
Ion_trans 504..725 CDD:278921 135/223 (61%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 822..1224 27/420 (6%)
III 1234..1517 132/321 (41%)
Ion_trans 1264..1523 CDD:278921 125/297 (42%)
Ion_trans 1586..1827 CDD:278921 136/265 (51%)
GPHH 1835..1898 CDD:293510 34/62 (55%)
Ca_chan_IQ 1900..1974 CDD:285917 30/74 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1994..2037 8/55 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2049..2512 66/331 (20%)
polyglutamine repeat 2319..2331
Peptidase_C53 2352..>2424 CDD:283255
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100303
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.850

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