DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ca-alpha1D and Scn7a

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:NP_001375437.1 Gene:Scn7a / 64155 RGDID:61922 Length:1680 Species:Rattus norvegicus


Alignment Length:1758 Identity:424/1758 - (24%)
Similarity:742/1758 - (42%) Gaps:395/1758 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   747 ALFC-LSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVF 810
            ::.| ||..:.||...|:::....|..|||:::..:.|.:.:        ||:....| .||...
  Rat    96 SILCTLSPLSSLRRAVIKVLVHPLFRLLILISVLTDSILMCM--------SNLPEWIL-AVENTL 151

  Fly   811 LVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAI--STALSQLMKDAFDVKALRAFR 873
            |.|:|.|.::|::|.|....:.::|.:.||.|||::.:...|  |:.||.|..    .|.:|..|
  Rat   152 LGIYTFEILVKVIARGIWAGSFSFLGDLWNWLDFSVTLFELITRSSPLSSLPM----FKTIRTLR 212

  Fly   874 VLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKL-HKACR----- 932
            :|:.:.|..|:.|:.|.|...||.::....:|   ||.:.:.::.|:.||.|.| ||..|     
  Rat   213 ILKIIPLNHGLQSIVVTLVQCLKKLLGAIALA---LFFLTVSSLFGMGLFMGNLKHKCVRWPQED 274

  Fly   933 -DEI----TGE-----------YEENIR---PCG----VGYQCPPGYKCYGGWDGPNDGITNFDN 974
             :::    ||.           |.|..|   .||    .|. ||.||.|......|::|.|:|||
  Rat   275 GNDVMYNGTGSQYHILERENFYYMEGARYALLCGNKTDAGL-CPEGYMCVKEGSNPDNGFTSFDN 338

  Fly   975 FGLAMLTVFQCVTLEGWTDVLY-SIQDAMGSDWQWMYFISMVILG---AFFVMNLILGVLSGEFS 1035
            ||.|:|.:|:.:| :.:.::|| .|..|.|.    :|.|..|::.   ||::.:|.||:|:..:.
  Rat   339 FGWALLAMFRLMT-QDYPELLYHQILYASGK----IYMIFFVLISFWFAFYMASLFLGILTMAYE 398

  Fly  1036 KERNKAKNRG---DFQKLREKQQIEEDLRGYLDWITQAEDIEPDAVGGLISDGKGKQPNEMDSTE 1097
            :|:.:|....   |.:..:..::.||:..|.....||.|             .|.:.|..:::|.
  Rat   399 QEKQRASEESRDMDSKCHQTVKEFEEEHEGAEMETTQIE-------------MKKRSPTSINTTL 450

  Fly  1098 NLGE-------EMPEVQMTESR------------------WRKMKKDFDRVNRRMRRACRKAVKS 1137
            ::.|       |.||....|..                  |.|:.:..||:           :..
  Rat   451 DILEDTALGHKEEPETSRKECPLCWYKFTKTCFIWKCSPCWIKLNEFADRI-----------ITH 504

  Fly  1138 QAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLF 1202
            ..|...:::.:.||...||.||:...:.|.:.....|:.|||::|.||:||:.::...|||...:
  Rat   505 PLFDLFLVICIILNICFLALEHFPMSEELMSLLAIGNLVFIGIYTIEMILKIIAMHPYGYFQISW 569

  Fly  1203 NRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIAS 1267
            :.||..:|:..:||.||.:..     .::|...|.|:.: |:.||.....||:..|..::.::..
  Rat   570 HIFDSILVVLGLTEMLLADIE-----EITVFILVPLIFI-KLGKYAPPFKNLMRILGRALVALKD 628

  Fly  1268 LLLLLFLFIVIFALLGMQVFGGKF-----NFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVM 1327
            |:||:.:||...|:.||::||..:     :.|...::.|.:...|..|.:|||:|:.|| |...:
  Rat   629 LVLLVSIFIYFSAVFGMKLFGRSYKDCVCHVDQDCQRQRWHMSDFLHAYVTVFRILCGE-WIETL 692

  Fly  1328 YVGINAYGGVSSYGALACI-YFIILFICGNYILLNVFLAIAVDNLADADSLSEVEKE-------- 1383
            :..:..      .|...|| :::::.:.||.::|.:|:|: |.:.|..|:.:||.||        
  Rat   693 WECMEV------AGEAWCIPFYMMVILIGNLLILYLFVAL-VSSFASYDATTEVSKEAKNLQLAV 750

  Fly  1384 ----------------------EEPHDESA---------------------------QKKSHSPT 1399
                                  .|..|::.                           |......|
  Rat   751 AWIKMVINCVLLKILCKEKTVSTEATDQTCDPSVKENISGHTLSELSNTQTFLRYKDQSSGTEKT 815

  Fly  1400 PTIDGMDDHL------SIDIDMEQQELDDEDKMDHET-------LSDEEVRE------------M 1439
            |..:.....|      |..:.:...|.|.|:..:.||       .|.|::::            :
  Rat   816 PVTESESQSLIASPSVSETVPIASGESDIENLDNKETRSKSANGSSKEKMKQSSSSECSTVDIAI 880

  Fly  1440 CEEEEEVDEEGMITARPRRMSEVNTATKILPIPPGTSFFLFSQTNR-------FRVFCHWLCNHS 1497
            .||||.|.|..............::|.::            |:.:|       .|..|..:..:|
  Rat   881 SEEEEMVYEHEKSKLHKNGYERKSSAGQV------------SRESRNGKIWRNIRKTCCKIVENS 933

  Fly  1498 NF----GNIILCCIMFSSAMLAAENPLRANDDLNKVLNKF----DYFFTAVFTIELILKLISYGF 1554
            .|    |.:.|.|    :..||.|:   ...|..|.:..|    |..|..:|.:|::||.::|||
  Rat   934 WFECFIGLVTLLC----TGTLALED---IYIDQRKTIKIFLEYGDMIFAYIFILEMLLKWVAYGF 991

  Fly  1555 VLHDGAFCRSAFNLLDLLVVCVSLISLVSSS----NAISVVKILRVLRVLRPLRAINRAKGLKHV 1615
                .|:..:.:..||.:||.|..:||:..:    |.::.:|.||.||||.              
  Rat   992 ----KAYFSNNWYKLDFMVVIVLCLSLIGKTREDLNPLASIKFLRALRVLS-------------- 1038

  Fly  1616 VQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIG 1680
                                 ||       :..|.|::.::.......::.||..::..:|:|:|
  Rat  1039 ---------------------QF-------ERMKVVLRALIKTTLPAVSVFLVCLMIWLLFSVMG 1075

  Fly  1681 VQLFKGKFFKCTDGSK---------MTQDECYGTYLVYDDGDVHKPRLREREWSNNRFHFDDVAK 1736
            |.||.|||::|.|.::         |.:.:|..  ||:::         ...|.|.:.:||:|..
  Rat  1076 VFLFAGKFYECIDPTRGERFSVFEVMNKSQCEN--LVFNE---------SMPWENAKLNFDNVGN 1129

  Fly  1737 GMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVT 1801
            |.|:||.|:||.||..::..:|||......|.......:..|:||:::...|..:.:.:|.:|..
  Rat  1130 GFLSLFQVATFNGWISIMNSAIDSVGVYMQPSFEHSLHMYTYFIIFVVFGLFLPLCMLIGVIIRN 1194

  Fly  1802 FQNEG-EQEYKNCDL---DKNQRNCIE---FALKAKPVRRYIPKHGIQYKVWWFVTSSSFEYTIF 1859
            |..:. :|...|..:   .|.|...::   :|...||..|  |::..|..:...||...|...|.
  Rat  1195 FNKQKIKQGGSNIFITVKQKKQYRALKKLLYADSQKPAAR--PRNKFQGFICDVVTHRVFNVIII 1257

  Fly  1860 ILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIV 1924
            :||.....|:.::...|.......:..:|.:||.:|.||.:.||.|||. :||..||||.||::|
  Rat  1258 LLICFQATTIMIQNDEQSPQIETAVFWMNSLFTMLFTLECILKLTAFRC-HYFTSAWNVHDFMVV 1321

  Fly  1925 LGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEG-- 1987
            :.|...::                       ...|.|...:..:..:|..:.|::.:|..|:|  
  Rat  1322 VFSITGLL-----------------------LPLSIGQYFVPPSLVQLLLLSRIIHVLRPGKGPK 1363

  Fly  1988 -IRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIALDGGNAITANNNFQTFQQAVLVL 2051
             ...|:...:.|..||..:||||.|:.||||:.||..|..:..:.|  |...:||:||..::|.|
  Rat  1364 VFHDLMLPLMLSLPALLNIALLIFLVMFIYAIFGMYNFAYVKKEAG--INDVSNFETFGSSMLCL 1426

  Fly  2052 FRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGE----PCGS-SIAYPYFISFYVLCSFLIINLFV 2111
            |:..|...|..::.:........||.:...||.    .||| |:...||:|:.::...:|:|::|
  Rat  1427 FQVTTFSGWDGMLDAIFNSQWSDCDPDKINPGTQVRGDCGSPSVGIFYFVSYILISWLIIVNMYV 1491

  Fly  2112 AVIMDNFDYLT----RDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTL---LRKISPPLGF 2169
            .:||   ::|:    |....|.......|.::|:.:|||   |.:::|...|   ...:.|||..
  Rat  1492 VLIM---EFLSIPSKRKNRTLSEDDFRRFFKVWNRFDPD---RTQYIDSTKLSDFAAALDPPLFM 1550

  Fly  2170 GKLCPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIKTDGNIDDANSELRATIKQIWKR 2234
            .|  |::   .:||:|::|:.:...:.....|.|..:..:.  .|..::...||    |:..:..
  Rat  1551 AK--PNK---GQLVAMDLPMAAGDRIHCLDILLAFTKRVMG--KDERVEKILSE----IESGFML 1604

  Fly  2235 TNP-KLLDQVVPPPGNDDEVTVGKFYATYLIQDYFRRFKKRKEQ-------EGKEGHPDSNTVTL 2291
            .|| |:..:.:.......:..|.   || :||..::.::.|:..       |..:|..|.|:..:
  Rat  1605 ANPFKITYEPITTTLKRKQEAVS---AT-IIQRAYKSYRLRQSDKKIQDIPEIDDGREDPNSKGV 1665

  Fly  2292 QAG 2294
            .:|
  Rat  1666 HSG 1668

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 90/309 (29%)
Ion_trans 1137..1379 CDD:395416 68/247 (28%)
Ion_trans 1496..1809 CDD:395416 82/334 (25%)
Ion_trans 1851..2126 CDD:395416 79/286 (28%)
GPHH 2135..2188 CDD:407139 16/55 (29%)
Ca_chan_IQ 2199..2271 CDD:400901 14/72 (19%)
Scn7aNP_001375437.1 Ion_trans 117..405 CDD:395416 90/309 (29%)
Ion_trans 504..738 CDD:395416 68/247 (28%)
Na_trans_assoc 742..926 CDD:399489 25/195 (13%)
Ion_trans 932..1203 CDD:395416 82/334 (25%)
Na_channel_gate 1194..1245 CDD:240441 11/52 (21%)
Ion_trans 1249..1496 CDD:395416 77/275 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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