DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and SCN10A

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:XP_005265428.1 Gene:SCN10A / 6336 HGNCID:10582 Length:1959 Species:Homo sapiens


Alignment Length:2053 Identity:500/2053 - (24%)
Similarity:839/2053 - (40%) Gaps:602/2053 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   746 RALFCLSVKNPLRALCIRI-VEWKP--FEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVE 807
            |||:..|..|.:|...|:: |...|  |...|.:||..||:.: ..|..|           ||:|
Human   108 RALWLFSPFNLIRRTAIKVSVHSYPLWFSLFITVTILVNCVCM-TRTDLP-----------EKIE 160

  Fly   808 YVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAF 872
            |||.||:|.|.::||||.||.|:...|||:.||.|||:::.:..:.||:     |...:..||.|
Human   161 YVFTVIYTFEALIKILARGFCLNEFTYLRDPWNWLDFSVITLAYVGTAI-----DLRGISGLRTF 220

  Fly   873 RVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKAC-RDEI- 935
            ||||.|:.||.:|.|:|::.:::.::..|..:.:|.:|.:.::|::||:||.|.|...| :::: 
Human   221 RVLRALKTVSVIPGLKVIVGALIHSVKKLADVTILTIFCLSVFALVGLQLFKGNLKNKCVKNDMA 285

  Fly   936 ---TGEYEENIRP--------------CGVGY---QCPPGYKCYGGWDGPNDGITNFDNFGLAML 980
               |..|..:.:|              ||.|.   .||.||.|....|.|:...|:||:|..|.|
Human   286 VNETTNYSSHRKPDIYINKRGTSDPLLCGNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFL 350

  Fly   981 TVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERNKA---- 1041
            ::|:.:|.:.|..:........|..:. ::|:.::.||:|:::||||.|::..: :|:|:|    
Human   351 SLFRLMTQDSWERLYQQTLRTSGKIYM-IFFVLVIFLGSFYLVNLILAVVTMAY-EEQNQATTDE 413

  Fly  1042 ------KNRGDFQKLREKQQI---------------------------------------EEDLR 1061
                  |.:...:.||::|::                                       .||.:
Human   414 IEAKEKKFQEALEMLRKEQEVLAALGIDTTSLHSHNGSPLTSKNASERRHRIKPRVSEGSTEDNK 478

  Fly  1062 ------------GYLDW---------------------ITQAEDIEPDAV---------GG-LIS 1083
                        .:|..                     |:..|.:..|.|         |. |:.
Human   479 SPRSDPYNQRRMSFLGLASGKRRASHGSVFHFRSPGRDISLPEGVTDDGVFPGDHESHRGSLLLG 543

  Fly  1084 DGKGK----------QPNEMDSTENLGEEMP-----------EVQMTESRWRKMKKDFDRVNR-- 1125
            .|.|:          ||:..||.....|..|           :|...::..:|.....:.::.  
Human   544 GGAGQQGPLPRSPLPQPSNPDSRHGEDEHQPPPTSELAPGAVDVSAFDAGQKKTFLSAEYLDEPF 608

  Fly  1126 RMRRA-----------------------CRKAVKSQAFYW------------------------L 1143
            |.:||                       |..::..:...|                        .
Human   609 RAQRAMSVVSIITSVLEELEESEQKCPPCLTSLSQKYLIWDCCPMWVKLKTILFGLVTDPFAELT 673

  Fly  1144 IIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCF 1208
            |.:.:.:||..:|.||:|.....:...:..|:.|...||.||:.|:.:.....||...:|.|||.
Human   674 ITLCIVVNTIFMAMEHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCI 738

  Fly  1209 VVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLF 1273
            :|..|:.|..:...|     .:||||..|||||||:.|.|.:|:.|:..:.||:.::.:|.::|.
Human   739 IVTVSLLELGVAKKG-----SLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILA 798

  Fly  1274 LFIVIFALLGMQVFGGKFNFDGK------EEKYRMNFDCFWQALLTVFQIMTGE----DWNAVMY 1328
            :.:.:|||:|.|:.|..:..:.|      |:..|.:...|:.:.|.||:|:.||    .| |.|.
Human   799 IIVFVFALVGKQLLGENYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGEWIENMW-ACME 862

  Fly  1329 VGINAYGGVSSYGALACIYFIILFICGNYILLNVFLAIAVDNLADADSLSEVEKEEEPHD----- 1388
            ||         ..::..|.|:.:.:.||.::||:|:|:.:::.: ||:|:..|.:.|.::     
Human   863 VG---------QKSICLILFLTVMVLGNLVVLNLFIALLLNSFS-ADNLTAPEDDGEVNNLQVAL 917

  Fly  1389 ---------------------------------------ESAQKKSHSPTPTIDG---------- 1404
                                                   .|::.::|....|..|          
Human   918 ARIQVFGHRTKQALCSFFSRSCPFPQPKAEPELVVKLPLSSSKAENHIAANTARGSSGGLQAPRG 982

  Fly  1405 -MDDH----------LSIDIDMEQQELDD------EDKM----------------------DH-- 1428
             .|:|          :|:.|...:.:|||      ||..                      ||  
Human   983 PRDEHSDFIANPTVWVSVPIAEGESDLDDLEDDGGEDAQSFQQEVIPKGQQEQLQQVERCGDHLT 1047

  Fly  1429 ------------------ETLSDE-------------------------------EVREMCEEEE 1444
                              ||..||                               ::.|:.::.|
Human  1048 PRSPGTGTSSEDLAPSLGETWKDESVPQVPAEGVDDTSSSEGSTVDCLDPEEILRKIPELADDLE 1112

  Fly  1445 EVDE---EGMITARPRRMSEVNTATKILPIPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCC 1506
            |.|:   ||.|...|  ..:::|...  |...|.         :.|..|:.:..||.|.:.|:..
Human  1113 EPDDCFTEGCIRHCP--CCKLDTTKS--PWDVGW---------QVRKTCYRIVEHSWFESFIIFM 1164

  Fly  1507 IMFSSAMLAAEN-PLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLH-DGAFCRSAFNLL 1569
            |:.||..||.|: .|.....:..:|...|..||.:|..|::||.::|||..: ..|:|     .|
Human  1165 ILLSSGSLAFEDYYLDQKPTVKALLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWC-----WL 1224

  Fly  1570 DLLVVCVSLISL---VSSSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVL 1631
            |.|:|.:|||||   :...:.::.:|.||.||.||||||::|.:|::.||..::.|:.:|.|::|
Human  1225 DFLIVNISLISLTAKILEYSEVAPIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLL 1289

  Fly  1632 VTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKC---TD 1693
            | ||:.::                                   :|:::||.||.|||::|   ||
Human  1290 V-CLIFWL-----------------------------------IFSIMGVNLFAGKFWRCINYTD 1318

  Fly  1694 GS--------KMTQDEC-----YGTYLVYDDGDVHKPRLREREWSNNRFHFDDVAKGMLTLFTVS 1745
            |.        ...:.:|     .|::.                |.|.:.:||:||.|.|.|..|:
Human  1319 GEFSLVPLSIVNNKSDCKIQNSTGSFF----------------WVNVKVNFDNVAMGYLALLQVA 1367

  Fly  1746 TFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNE----G 1806
            ||:||..::|.::||.:.|..|.......:..|::|:||...||.:|:|||.:|..|..:    |
Human  1368 TFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQKKKLG 1432

  Fly  1807 EQEYKNCDLDKNQRNCIEFALKAKPVRRYIPK--HGIQYKVWWFVTSSSFEYTIFILIMINTVTL 1869
            .|:....:..|...|.:: .|.:|..::.||:  :..|..|:..||..:|:.||.:||.:|.:|:
Human  1433 GQDIFMTEEQKKYYNAMK-KLGSKKPQKPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMITM 1496

  Fly  1870 AMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYS 1934
            .::..:|....|::|..:|..|.|||..|.|.|:.|.| :.||.:.|||||||:|:.|...:::|
Human  1497 MVETDDQSEEKTKILGKINQFFVAVFTGECVMKMFALR-QYYFTNGWNVFDFIVVVLSIASLIFS 1560

  Fly  1935 EIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSF 1999
            .|                .||.:......|..:  .||.|:.|:::|:...:||||||:..:.|.
Human  1561 AI----------------LKSLQSYFSPTLFRV--IRLARIGRILRLIRAAKGIRTLLFALMMSL 1607

  Fly  2000 QALPYVALLIVLLFFIYAVVGMQVFGKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIM 2064
            .||..:.||:.|:.|||::.||..|..:..:.|  |....|||||..::|.||:..|...|..::
Human  1608 PALFNIGLLLFLVMFIYSIFGMSSFPHVRWEAG--IDDMFNFQTFANSMLCLFQITTSAGWDGLL 1670

  Fly  2065 MSCSAQPDVKCDMN----SDTPGEPCGSSIAYPYFISFYVLCSFLI-INLFVAVIMDNFDYLTRD 2124
            ..........||.|    :.|.|: |||......|.:.|::.|||| :|:::|||::||:..|.:
Human  1671 SPILNTGPPYCDPNLPNSNGTRGD-CGSPAVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEE 1734

  Fly  2125 -WSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMP 2188
             ...|.....|.|...|.::||:|...|....:......:|.||...|  |:|   ..|:.|::|
Human  1735 STEPLSEDDFDMFYETWEKFDPEATQFITFSALSDFADTLSGPLRIPK--PNR---NILIQMDLP 1794

  Fly  2189 LNSDGTVLFNATLFAVVRTSLSIKTDGNIDDANSELRATIKQIWKRTNPKLLDQVVPPPGNDDEV 2253
            |.....:.....|||..:..|.  ..|.:|    .|:|.:::                       
Human  1795 LVPGDKIHCLDILFAFTKNVLG--ESGELD----SLKANMEE----------------------- 1830

  Fly  2254 TVGKFYATYLIQDYFRRFKK--RKEQEGKEGHPDSNTVTLQAGLRT--LHEV-----SPALKRAI 2309
               ||.||.|.:..:.....  |.:||      |.:...:|...|:  ||..     :|.:.|| 
Human  1831 ---KFMATNLSKSSYEPIATTLRWKQE------DISATVIQKAYRSYVLHRSMALSNTPCVPRA- 1885

  Fly  2310 SGNLDELDQEPEPMHRRHHTLFGSVWSSIRRHGNGTFRRSAKATASQSNGALAIGGSASAALGVG 2374
                                                   ..:|.:....|.:|...:.:..|...
Human  1886 ---------------------------------------EEEAASLPDEGFVAFTANENCVLPDK 1911

  Fly  2375 GSSLVLGSSDPAGGDYLYDTLNRSVADGVNNITRNIMQ 2412
            ..:....|..|:     |:::.|.::|.||..|.:.:|
Human  1912 SETASATSFPPS-----YESVTRGLSDRVNMRTSSSIQ 1944

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 96/308 (31%)
Ion_trans 1137..1379 CDD:395416 76/275 (28%)
Ion_trans 1496..1809 CDD:395416 101/337 (30%)
Ion_trans 1851..2126 CDD:395416 92/280 (33%)
GPHH 2135..2188 CDD:407139 14/52 (27%)
Ca_chan_IQ 2199..2271 CDD:400901 13/71 (18%)
SCN10AXP_005265428.1 Ion_trans 150..410 CDD:278921 88/278 (32%)
Na_trans_cytopl 466..>537 CDD:288761 7/70 (10%)
Ion_trans 685..897 CDD:278921 69/226 (31%)
Na_trans_assoc 907..1150 CDD:284034 33/255 (13%)
Ion_trans 1172..1430 CDD:278921 93/314 (30%)
Na_channel_gate 1422..1474 CDD:240441 11/52 (21%)
Ion_trans 1496..1735 CDD:278921 85/260 (33%)
GPHH 1745..1802 CDD:293510 17/61 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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