DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and SCN8A

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:NP_001317189.1 Gene:SCN8A / 6334 HGNCID:10596 Length:1980 Species:Homo sapiens


Alignment Length:1906 Identity:466/1906 - (24%)
Similarity:807/1906 - (42%) Gaps:553/1906 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   747 ALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFL 811
            ||:.||..|.:|.:.|:|:....|..:|:.||..||:.:....| |....|        |||.|.
Human   111 ALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNP-PDWSKN--------VEYTFT 166

  Fly   812 VIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAFRVLR 876
            .|:|.|.::||:|.||.:....:||:.||.|||:::::..::..:     |..:|.|||.|||||
Human   167 GIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYVTEFV-----DLGNVSALRTFRVLR 226

  Fly   877 PLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKAC---------- 931
            .|:.:|.:|.|:.::.::::::..|..:.:|.:|.:.::|:|||:||.|.|...|          
Human   227 ALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNES 291

  Fly   932 --RDEITG----EYEEN----------IRP--CG----VGYQCPPGYKCYGGWDGPNDGITNFDN 974
              .:...|    ||..|          :.|  ||    .| |||.||:|......||.|.|:||.
Human   292 YLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAG-QCPEGYQCMKAGRNPNYGYTSFDT 355

  Fly   975 FGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERN 1039
            |..|.|.:|:.:|.:.|.::......|.|..:. ::|:.::.:|:|:::||||.|::..: :|:|
Human   356 FSWAFLALFRLMTQDYWENLYQLTLRAAGKTYM-IFFVLVIFVGSFYLVNLILAVVAMAY-EEQN 418

  Fly  1040 KAKNRGDFQKLREKQQIEEDLRGYLDWI-------------TQAEDIEPDAV-------GG---- 1080
            :|       .|.|.:|.|.:.:..|:.:             |.|..:..||:       ||    
Human   419 QA-------TLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEEGGGSPRS 476

  Fly  1081 ------LISDG--------KGKQPNEMDSTENLGEEMPE-VQMTESRWRKMKKDF----DRVNR- 1125
                  |.|..        |.::..|:...|..|:  || |..:||.....:|.|    :|:.| 
Human   477 SSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGD--PEKVFKSESEDGMRRKAFRLPDNRIGRK 539

  Fly  1126 ----------------------------------------------------------------- 1125
                                                                             
Human   540 FSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEGRRDSLFIP 604

  Fly  1126 ---RMRR--------------------ACRKAVKSQAF--------------------------- 1140
               |.||                    :.|::||..:.                           
Human   605 IRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGGPGSHIGGRLLPEATT 669

  Fly  1141 ----------------------------------------------------------------- 1140
                                                                             
Human   670 EVEIKKKGPGSLLVSMDQLASYGRKDRINSIMSVVTNTLVEELEESQRKCPPCWYKFANTFLIWE 734

  Fly  1141 ---YWL------------------IIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCE 1184
               ||:                  |.:.:.|||..:|.||:......::.....|:.|.|:||.|
Human   735 CHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAE 799

  Fly  1185 MLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWR 1249
            |.||:.::....||...:|.||.|:|..|:.|..|.:..     |:||||..|||||||:.|.|.
Human   800 MFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVE-----GLSVLRSFRLLRVFKLAKSWP 859

  Fly  1250 SLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEKYRMNFDC-------- 1306
            :|:.|:..:.||:.::.:|.|:|.:.:.|||::|||:||..:    ||...::|.||        
Human   860 TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY----KECVCKINQDCELPRWHMH 920

  Fly  1307 -FWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYILLNVFLAI---- 1366
             |:.:.|.||:::.|| |...|:..:...|     .|:..|.|:::.:.||.::||:|||:    
Human   921 DFFHSFLIVFRVLCGE-WIETMWDCMEVAG-----QAMCLIVFMMVMVIGNLVVLNLFLALLLSS 979

  Fly  1367 -AVDNLADAD----------SLSEVEK-----------------------EEEPHDESAQKKSH- 1396
             :.||||..|          |:..::|                       |.:|.||..:||:: 
Human   980 FSADNLAATDDDGEMNNLQISVIRIKKGVAWTKLKVHAFMQAHFKQREADEVKPLDELYEKKANC 1044

  Fly  1397 -----------------SPTPTIDGM----------DDHLSI----------------------- 1411
                             :...|..|:          :||:|.                       
Human  1045 IANHTGADIHRNGDFQKNGNGTTSGIGSSVEKYIIDEDHMSFINNPNLTVRVPIAVGESDFENLN 1109

  Fly  1412 --DIDMEQQELDDEDKMDHETLSDE--------EVREMCEE--EEEVDEEGMIT---ARPRRMSE 1461
              |:..|......:||:| :|.|.|        ||.|:..|  ||.:|.:...|   .:..:..:
Human  1110 TEDVSSESDPEGSKDKLD-DTSSSEGSTIDIKPEVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQ 1173

  Fly  1462 VNTATKILPIPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAEN-PLRANDD 1525
            ||....:     |.|:::..:|      |..:..|:.|...|:..|:.||..||.|: .:.....
Human  1174 VNIEEGL-----GKSWWILRKT------CFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKT 1227

  Fly  1526 LNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISLVSSS---NA 1587
            :..:|...|..||.:|.:|::||..:||||    .|..:|:..||.|:|.|||:||::::   :.
Human  1228 IRTILEYADKVFTYIFILEMLLKWTAYGFV----KFFTNAWCWLDFLIVAVSLVSLIANALGYSE 1288

  Fly  1588 ISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVV 1652
            :..:|.||.||.||||||::|.:|::.||..::.|:.:|.|::|| ||:.::             
Human  1289 LGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLV-CLIFWL------------- 1339

  Fly  1653 KCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDDGDVHKP 1717
                                  :|:::||.||.||:..|.:.:         :.:.::..||:..
Human  1340 ----------------------IFSIMGVNLFAGKYHYCFNET---------SEIRFEIEDVNNK 1373

  Fly  1718 RLRER---------EWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRP 1773
            ...|:         .|.|.:.:||:|..|.|.|..|:||:||..::|.::||.|.:..|.:....
Human  1374 TECEKLMEGNNTEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPKYEDNI 1438

  Fly  1774 IVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNE----GEQEYKNCDLDKNQRNCIEFALKAKPVRR 1834
            .:..|::|:||..:||.:|:|:|.:|..|..:    |.|:....:..|...|.:: .|.:|..::
Human  1439 YMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMK-KLGSKKPQK 1502

  Fly  1835 YIPK--HGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFAL 1897
            .||:  :.||..|:.|||..:|:..|.:||.:|.||:.::...|......:|..:|::|...|..
Human  1503 PIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTC 1567

  Fly  1898 EFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGS 1962
            |.|.|:.|.| ..||...||:|||::|:.|.:.:..:             ||:|     |.....
Human  1568 ECVLKMFALR-HYYFTIGWNIFDFVVVILSIVGMFLA-------------DIIE-----KYFVSP 1613

  Fly  1963 NLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKI 2027
            .|..:  .||.|:.|:::|:...:||||||:..:.|..||..:.||:.|:.||:::.||..|..:
Human  1614 TLFRV--IRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYV 1676

  Fly  2028 ALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGE----PCGS 2088
            ..:.|  |....||:||..:::.||:..|...|..:::....:|. .|.::.:.||.    .||:
Human  1677 KHEAG--IDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPP-DCSLDKEHPGSGFKGDCGN 1738

  Fly  2089 -SIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWS-ILGPHHLDEFIRLWSEYDPDAKGRI 2151
             |:...:|:|:.::...:::|:::|:|::||...|.:.: .|.....:.|..:|.::||||...|
Human  1739 PSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQFI 1803

  Fly  2152 KHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIKTDGN 2216
            ::..:......:..||...|  |:.:   .|::|::|:.|...:.....|||..:..|.  ..|.
Human  1804 EYCKLADFADALEHPLRVPK--PNTI---ELIAMDLPMVSGDRIHCLDILFAFTKRVLG--DSGE 1861

  Fly  2217 IDDANSELRATIKQIWKRTNP 2237
            :|    .||..:::.:..:||
Human  1862 LD----ILRQQMEERFVASNP 1878

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 92/306 (30%)
Ion_trans 1137..1379 CDD:395416 87/378 (23%)
Ion_trans 1496..1809 CDD:395416 95/329 (29%)
Ion_trans 1851..2126 CDD:395416 78/279 (28%)
GPHH 2135..2188 CDD:407139 13/52 (25%)
Ca_chan_IQ 2199..2271 CDD:400901 10/39 (26%)
SCN8ANP_001317189.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..62
I. /evidence=ECO:0000305 114..442 104/351 (30%)
Ion_trans 131..421 CDD:395416 93/313 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 446..530 18/85 (21%)
Na_trans_cytopl 504..702 CDD:403218 17/199 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 568..602 0/33 (0%)
II. /evidence=ECO:0000305 735..1007 87/286 (30%)
Ion_trans 752..965 CDD:395416 72/227 (32%)
Na_trans_assoc 991..1192 CDD:399489 34/212 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1107..1148 11/41 (27%)
III. /evidence=ECO:0000305 1180..1495 102/375 (27%)
Ion_trans 1197..1473 CDD:395416 94/324 (29%)
Na_channel_gate 1465..1517 CDD:240441 12/52 (23%)
IV. /evidence=ECO:0000305 1504..1801 93/320 (29%)
Ion_trans 1522..1776 CDD:395416 78/277 (28%)
GPHH 1788..1835 CDD:407139 13/51 (25%)
IQ 1894..1915 CDD:197470
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1922..1980
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.950

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