Sequence 1: | NP_723952.2 | Gene: | Ca-alpha1D / 34950 | FlyBaseID: | FBgn0001991 | Length: | 2705 | Species: | Drosophila melanogaster |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_001092874.1 | Gene: | SCN5A / 6331 | HGNCID: | 10593 | Length: | 2016 | Species: | Homo sapiens |
Alignment Length: | 2079 | Identity: | 495/2079 - (23%) |
---|---|---|---|
Similarity: | 844/2079 - (40%) | Gaps: | 622/2079 - (29%) |
- Green bases have known domain annotations that are detailed below.
Fly 747 ALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFL 811
Fly 812 VIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAFRVLR 876
Fly 877 PLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDEIT----- 936
Fly 937 -GEYE----------------EN---------IRPCGVGYQ---CPPGYKCYGGWDGPNDGITNF 972
Fly 973 DNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKE 1037
Fly 1038 RNKA------KNRGDFQKLREKQQIEED---LRGYLDWITQAEDIEPDAVGGLIS-DGKGKQPNE 1092
Fly 1093 MDS-TENLGEE-------------MPEVQMTESRWRKMKK------------------------- 1118
Fly 1119 ----------------------------------------------------------------- 1118
Fly 1119 ----------------------------------------DFDRVNRRMRRACRKAVKSQAF--- 1140
Fly 1141 -------------------------YWL------------------IIVLVFLNTGVLATEHYGQ 1162
Fly 1163 LDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPP 1227
Fly 1228 LGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKF- 1291
Fly 1292 ----NFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILF 1352
Fly 1353 ICGNYILLNVFLAI-----AVDNLADADSLSEV------------------------------EK 1382
Fly 1383 EEEPHDESAQKK-------SHSPTPT-----------------------IDGMDDHLSIDIDMEQ 1417
Fly 1418 QELDDEDKMDHETLSDEEVREMCEEEEEVDEEGMITARP--RRMSEV------------------ 1462
Fly 1463 -----------------------------NTATKILPIP-------------------------- 1472
Fly 1473 -----PGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDDLNKVLNK 1532
Fly 1533 F-DYFFTAVFTIELILKLISYGFVLH-DGAFCRSAFNLLDLLVVCVSLISLVSSS---NAISVVK 1592
Fly 1593 ILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKCVVV 1657
Fly 1658 AIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKC---TDGS-------KMTQDECYGTYLVYDDG 1712
Fly 1713 DVHKPRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAA 1777
Fly 1778 YYIIYIIIIAFFMVNIFVGFVIVTFQNE----GEQEYKNCDLDKNQRNCIEFALKAKPVRRYIPK 1838
Fly 1839 HGIQYKVWWF--VTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVF 1901
Fly 1902 KLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLIS 1966
Fly 1967 INFF---RLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIA 2028
Fly 2029 LDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCD---MNSDTPGEPCGSSI 2090
Fly 2091 AYPYFISFYVLCSFLI-INLFVAVIMDNFDYLTRD-WSILGPHHLDEFIRLWSEYDPDAKGRIKH 2153
Fly 2154 LDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIKTDGNID 2218
Fly 2219 DANSELRATIKQIWKRTNPKLLDQVVPPPGNDDEVTVGKFYATYLIQDYFRRFKKRKEQEGKEGH 2283
Fly 2284 PDSNTVTLQAGLRTLHEVSPA--LKRAISGNLDELDQEPEPMHRRHHTLFGSVWSSIRRHGNGTF 2346
Fly 2347 RRSAKATASQSNG-------ALAIGGSASAALGVGGSSLVLGSSDPAGGDYLYDTLNRSVADGV 2403 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
Ca-alpha1D | NP_723952.2 | Ion_trans | 767..1042 | CDD:395416 | 93/314 (30%) |
Ion_trans | 1137..1379 | CDD:395416 | 83/297 (28%) | ||
Ion_trans | 1496..1809 | CDD:395416 | 100/331 (30%) | ||
Ion_trans | 1851..2126 | CDD:395416 | 89/282 (32%) | ||
GPHH | 2135..2188 | CDD:407139 | 13/52 (25%) | ||
Ca_chan_IQ | 2199..2271 | CDD:400901 | 9/71 (13%) | ||
SCN5A | NP_001092874.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 28..56 | ||
I. /evidence=ECO:0000305 | 113..420 | 96/322 (30%) | |||
Ion_trans | 151..423 | CDD:278921 | 84/287 (29%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 461..591 | 13/129 (10%) | |||
Na_trans_cytopl | 485..578 | CDD:288761 | 8/92 (9%) | ||
II. /evidence=ECO:0000305 | 699..969 | 83/282 (29%) | |||
Ion_trans | 734..927 | CDD:278921 | 66/205 (32%) | ||
Na_trans_assoc | 953..1200 | CDD:284034 | 32/254 (13%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1005..1141 | 18/137 (13%) | |||
III. /evidence=ECO:0000305 | 1187..1501 | 108/372 (29%) | |||
Ion_trans | 1222..1479 | CDD:278921 | 92/308 (30%) | ||
Na_channel_gate | 1471..1523 | CDD:240441 | 10/52 (19%) | ||
IV. /evidence=ECO:0000305 | 1510..1807 | 102/322 (32%) | |||
Ion_trans | 1545..1782 | CDD:278921 | 81/262 (31%) | ||
GPHH | 1792..1849 | CDD:293510 | 16/61 (26%) | ||
Interaction with FGF13. /evidence=ECO:0000269|PubMed:22705208 | 1839..1901 | 15/113 (13%) | |||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1959..2016 | 10/34 (29%) | |||
Interaction with NEDD4, NEDD4L and WWP2. /evidence=ECO:0000269|PubMed:15548568 | 1974..1977 | 1/6 (17%) | |||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 0 | 0.000 | Not matched by this tool. | |||
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 1 | 1.010 | - | - | D172471at2759 | |
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
2 | 1.920 |