DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and SCN5A

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:NP_001092874.1 Gene:SCN5A / 6331 HGNCID:10593 Length:2016 Species:Homo sapiens


Alignment Length:2079 Identity:495/2079 - (23%)
Similarity:844/2079 - (40%) Gaps:622/2079 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   747 ALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFL 811
            ||:.||..:|:|...::|:....|..||:.||..||:.:|.:.|.|.:         :.|||.|.
Human   110 ALYVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPWT---------KYVEYTFT 165

  Fly   812 VIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAFRVLR 876
            .|:|.|.::||||.||.||...:||:.||.|||:::::..:|..:.     ..::.|||.|||||
Human   166 AIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIK-----LGNLSALRTFRVLR 225

  Fly   877 PLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDEIT----- 936
            .|:.:|.:|.|:.::.::::::..|..:.:|.:|.:.::|:|||:||.|.|...|....|     
Human   226 ALKTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGT 290

  Fly   937 -GEYE----------------EN---------IRPCGVGYQ---CPPGYKCYGGWDGPNDGITNF 972
             |..|                ||         :..||....   ||.||:|....:.|:.|.|:|
Human   291 NGSVEADGLVWESLDLYLSDPENYLLKNGTSDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSF 355

  Fly   973 DNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKE 1037
            |:|..|.|.:|:.:|.:.|..:......:.|..:. ::|:.::.||:|:::||||.|::..: :|
Human   356 DSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYM-IFFMLVIFLGSFYLVNLILAVVAMAY-EE 418

  Fly  1038 RNKA------KNRGDFQKLREKQQIEED---LRGYLDWITQAEDIEPDAVGGLIS-DGKGKQPNE 1092
            :|:|      :....||:..|..:.|.:   :|| :|.:::: .:|...:..:.| :.:.|:...
Human   419 QNQATIAETEEKEKRFQEAMEMLKKEHEALTIRG-VDTVSRS-SLEMSPLAPVNSHERRSKRRKR 481

  Fly  1093 MDS-TENLGEE-------------MPEVQMTESRWRKMKK------------------------- 1118
            |.| ||..||:             |..:.:|....|...|                         
Human   482 MSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRGSIFTFRRRDLGSEADFADD 546

  Fly  1119 ----------------------------------------------------------------- 1118
                                                                             
Human   547 ENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKNSTVDCNGVVSLLGAGDPEA 611

  Fly  1119 ----------------------------------------DFDRVNRRMRRACRKAVKSQAF--- 1140
                                                    .|:....|.|.....:|.:.|.   
Human   612 TSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPGARQRALSAVSVLTSALEEL 676

  Fly  1141 -------------------------YWL------------------IIVLVFLNTGVLATEHYGQ 1162
                                     .|:                  |.:.:.|||..:|.|||..
Human   677 EESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLTITMCIVLNTLFMALEHYNM 741

  Fly  1163 LDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPP 1227
            ....:...:..|:.|.|:||.||..|:.:|....||...:|.||..:||.|:.|     .|:...
Human   742 TSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLME-----LGLSRM 801

  Fly  1228 LGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKF- 1291
            ..:||||..|||||||:.|.|.:|:.|:..:.||:.::.:|.|:|.:.:.|||::|||:||..: 
Human   802 SNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYS 866

  Fly  1292 ----NFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILF 1352
                :..|...::.| .| |:.|.|.:|:|:.|| |...|:..:...|     .:|..:.|:::.
Human   867 ELRDSDSGLLPRWHM-MD-FFHAFLIIFRILCGE-WIETMWDCMEVSG-----QSLCLLVFLLVM 923

  Fly  1353 ICGNYILLNVFLAI-----AVDNLADADSLSEV------------------------------EK 1382
            :.||.::||:|||:     :.|||...|...|:                              ::
Human   924 VIGNLVVLNLFLALLLSSFSADNLTAPDEDREMNNLQLALARIQRGLRFVKRTTWDFCCGLLRQR 988

  Fly  1383 EEEPHDESAQKK-------SHSPTPT-----------------------IDGMDDHLSIDIDMEQ 1417
            .::|...:||.:       .:||.|.                       ..|..:.:.:.|.:.:
Human   989 PQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQGTPGDPEPVCVPIAVAE 1053

  Fly  1418 QELDDEDKMDHETLSDEEVREMCEEEEEVDEEGMITARP--RRMSEV------------------ 1462
            .:.||:::.:..:|..||  |..:::|.....|...|.|  |..|:|                  
Human  1054 SDTDDQEEDEENSLGTEE--ESSKQQESQPVSGGPEAPPDSRTWSQVSATASSEAEASASQADWR 1116

  Fly  1463 -----------------------------NTATKILPIP-------------------------- 1472
                                         |||..:..||                          
Human  1117 QQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDCFTEGCVRRCPCCAV 1181

  Fly  1473 -----PGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDDLNKVLNK 1532
                 ||..::      |.|..|:.:..||.|...|:..|:.||..||.|:.........|||.:
Human  1182 DTTQAPGKVWW------RLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLE 1240

  Fly  1533 F-DYFFTAVFTIELILKLISYGFVLH-DGAFCRSAFNLLDLLVVCVSLISLVSSS---NAISVVK 1592
            : |..||.||.:|::||.::|||..: ..|:|     .||.|:|.|||:|||:::   ..:..:|
Human  1241 YADKMFTYVFVLEMLLKWVAYGFKKYFTNAWC-----WLDFLIVDVSLVSLVANTLGFAEMGPIK 1300

  Fly  1593 ILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKCVVV 1657
            .||.||.||||||::|.:|::.||..::.|:.:|.|::|| ||:.::                  
Human  1301 SLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLV-CLIFWL------------------ 1346

  Fly  1658 AIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKC---TDGS-------KMTQDECYGTYLVYDDG 1712
                             :|:::||.||.|||.:|   |:|.       ...:.:|....|.   |
Human  1347 -----------------IFSIMGVNLFAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLT---G 1391

  Fly  1713 DVHKPRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAA 1777
            :::        |:..:.:||:|..|.|.|..|:||:||..::|.::||......|...:...:..
Human  1392 ELY--------WTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEYNLYMYI 1448

  Fly  1778 YYIIYIIIIAFFMVNIFVGFVIVTFQNE----GEQEYKNCDLDKNQRNCIEFALKAKPVRRYIPK 1838
            |::|:||..:||.:|:|:|.:|..|..:    |.|:....:..|...|.:: .|.:|..::.||:
Human  1449 YFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMK-KLGSKKPQKPIPR 1512

  Fly  1839 HGIQYKVWWF--VTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVF 1901
            ...:|:.:.|  ||..:|:.||..||.:|.||:.::..:|......:|..:|::|.|:|..|.:.
Human  1513 PLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIV 1577

  Fly  1902 KLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLIS 1966
            ||||.| ..||.::||:|||::|:.|.:..|.|:|..|                       ...|
Human  1578 KLAALR-HYYFTNSWNIFDFVVVILSIVGTVLSDIIQK-----------------------YFFS 1618

  Fly  1967 INFF---RLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIA 2028
            ...|   ||.|:.|:::|:...:||||||:..:.|..||..:.||:.|:.|||::.||..|..:.
Human  1619 PTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVK 1683

  Fly  2029 LDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCD---MNSDTPGEPCGSSI 2090
            .:.|  |....|||||..::|.||:..|...|..::..........||   .||:.....|||..
Human  1684 WEAG--IDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPTLPNSNGSRGDCGSPA 1746

  Fly  2091 AYPYFISFYVLCSFLI-INLFVAVIMDNFDYLTRD-WSILGPHHLDEFIRLWSEYDPDAKGRIKH 2153
            ....|.:.|::.|||| :|:::|:|::||...|.: ...|.....|.|..:|.::||:|...|::
Human  1747 VGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEY 1811

  Fly  2154 LDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIKTDGNID 2218
            ..:......:|.||...|  |::::   |::|::|:.|...:.....|||..:..|.  ..|.:|
Human  1812 SVLSDFADALSEPLRIAK--PNQIS---LINMDLPMVSGDRIHCMDILFAFTKRVLG--ESGEMD 1869

  Fly  2219 DANSELRATIKQIWKRTNPKLLDQVVPPPGNDDEVTVGKFYATYLIQDYFRRFKKRKEQEGKEGH 2283
                .|:..:::.:...||..:..                                        .
Human  1870 ----ALKIQMEEKFMAANPSKISY----------------------------------------E 1890

  Fly  2284 PDSNTVTLQAGLRTLHEVSPA--LKRAISGNLDELDQEPEPMHRRHHTLFGSVWSSIRRHGNGTF 2346
            |.:.|      ||..||...|  ::||.                |.|.|..|:     :|.:..|
Human  1891 PITTT------LRRKHEEVSAMVIQRAF----------------RRHLLQRSL-----KHASFLF 1928

  Fly  2347 RRSAKATASQSNG-------ALAIGGSASAALGVGGSSLVLGSSDPAGGDYLYDTLNRSVADGV 2403
            |:.|.:..|:.:.       |..:..:.|..||...||.:..:|.|..    ||::.|:.:|.:
Human  1929 RQQAGSGLSEEDAPEREGLIAYVMSENFSRPLGPPSSSSISSTSFPPS----YDSVTRATSDNL 1988

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 93/314 (30%)
Ion_trans 1137..1379 CDD:395416 83/297 (28%)
Ion_trans 1496..1809 CDD:395416 100/331 (30%)
Ion_trans 1851..2126 CDD:395416 89/282 (32%)
GPHH 2135..2188 CDD:407139 13/52 (25%)
Ca_chan_IQ 2199..2271 CDD:400901 9/71 (13%)
SCN5ANP_001092874.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..56
I. /evidence=ECO:0000305 113..420 96/322 (30%)
Ion_trans 151..423 CDD:278921 84/287 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 461..591 13/129 (10%)
Na_trans_cytopl 485..578 CDD:288761 8/92 (9%)
II. /evidence=ECO:0000305 699..969 83/282 (29%)
Ion_trans 734..927 CDD:278921 66/205 (32%)
Na_trans_assoc 953..1200 CDD:284034 32/254 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1005..1141 18/137 (13%)
III. /evidence=ECO:0000305 1187..1501 108/372 (29%)
Ion_trans 1222..1479 CDD:278921 92/308 (30%)
Na_channel_gate 1471..1523 CDD:240441 10/52 (19%)
IV. /evidence=ECO:0000305 1510..1807 102/322 (32%)
Ion_trans 1545..1782 CDD:278921 81/262 (31%)
GPHH 1792..1849 CDD:293510 16/61 (26%)
Interaction with FGF13. /evidence=ECO:0000269|PubMed:22705208 1839..1901 15/113 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1959..2016 10/34 (29%)
Interaction with NEDD4, NEDD4L and WWP2. /evidence=ECO:0000269|PubMed:15548568 1974..1977 1/6 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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