DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ca-alpha1D and SCN3A

DIOPT Version :10

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:NP_008853.3 Gene:SCN3A / 6328 HGNCID:10590 Length:2000 Species:Homo sapiens


Alignment Length:1972 Identity:490/1972 - (24%)
Similarity:827/1972 - (41%) Gaps:574/1972 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   747 ALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFL 811
            ||:.|:..||:|.:.|:|:....|..||:.||..||:.:.:..| |....|        |||.|.
Human   107 ALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTLSNP-PDWTKN--------VEYTFT 162

  Fly   812 VIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAFRVLR 876
            .|:|.|.::||||.||.|.:..:||:.||.|||:::|:..::..:     |..:|.|||.|||||
Human   163 GIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFV-----DLGNVSALRTFRVLR 222

  Fly   877 PLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKAC---------- 931
            .|:.:|.:|.|:.::.::::::..|..:.:|.:|.:.::|:|||:||.|.|...|          
Human   223 ALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPSDSAF 287

  Fly   932 ----------------------------RDEI---------TGEYEENIRPCGVGY---QCPPGY 956
                                        :|.|         .|:.:..:  ||.|.   |||.||
Human   288 ETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLL--CGNGSDAGQCPEGY 350

  Fly   957 KCYGGWDGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFF 1021
            .|......||.|.|:||.|..|.|::|:.:|.:.|.::......|.|..:. ::|:.::.||:|:
Human   351 ICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTYM-IFFVLVIFLGSFY 414

  Fly  1022 VMNLILGVLSGEFSKERNKA------KNRGDFQKLRE--KQQIEE------------DLRGY--- 1063
            ::||||.|::..: :|:|:|      :...:||::.|  |:|.||            |..|.   
Human   415 LVNLILAVVAMAY-EEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSGIGGL 478

  Fly  1064 ------------------LDWIT------QAEDIEPDAVG------------------------- 1079
                              .:|..      |.|.:|.:..|                         
Human   479 GELLESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVKRSSFLFSMDG 543

  Fly  1080 -GLISDGK--------------------------------------------------------- 1086
             .|.||.|                                                         
Human   544 NRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEHSTFEDSESRR 608

  Fly  1087 ---------------------------------GKQPNEMDS-------------TENLGEEMPE 1105
                                             ||..:.:|.             |...|:..||
Human   609 DSLFVPHRHGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVGGPSALTSPTGQLPPE 673

  Fly  1106 VQMTESRWRKMKKDFDRVNRRM---------------------------RRACRKAVKSQAFY-- 1141
            ...||:..||.:....:::..|                           |:.|     ...:|  
Human   674 GTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEELEESRQKC-----PPCWYRF 733

  Fly  1142 ------------WL------------------IIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVF 1176
                        ||                  |.:.:.|||..:|.|||...:...:.....|:.
Human   734 ANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLTVGNLV 798

  Fly  1177 FIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRV 1241
            |.|:||.||:||:.::....||...:|.||..:|..|:.|..|:|..     |:||||..|||||
Human   799 FTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVE-----GLSVLRSFRLLRV 858

  Fly  1242 FKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEKYRMNFDC 1306
            ||:.|.|.:|:.|:..:.||:.::.:|.|:|.:.:.|||::|||:||..:    ||...::|.||
Human   859 FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY----KECVCKINDDC 919

  Fly  1307 ---------FWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYILLNV 1362
                     |:.:.|.||:::.|| |...|:..:...|     ..:..|.|:::.:.||.::||:
Human   920 TLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAG-----QTMCLIVFMLVMVIGNLVVLNL 978

  Fly  1363 FLAIAV-----DNLADADSLSE--------------VEKEEEPHDESAQK---------KSHSPT 1399
            |||:.:     ||||..|..:|              ::..:....|..||         :.|...
Human   979 FLALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMRECFQKAFFRKPKVIEIHEGN 1043

  Fly  1400 PTIDGMDDHLSIDI---------------------DMEQQELDDEDKM----------------- 1426
            .....|.::..|:|                     .:|:..:|:.|.|                 
Human  1044 KIDSCMSNNTGIEISKELNYLRDGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVG 1108

  Fly  1427 --DHETLSDEEVREMCEEEEEVDEEGMITARPRRMSEVNTATKILP-------------IPPGTS 1476
              |.|.|:.||.....|.||..::....::     ||.:|...:||             :.|...
Human  1109 ESDFENLNTEEFSSESELEESKEKLNATSS-----SEGSTVDVVLPREGEQAETEPEEDLKPEAC 1168

  Fly  1477 F-------FLFSQTN----------RFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAEN-PLRAN 1523
            |       |.|.|.:          ..|..|:.:..|:.|...|:..|:.||..||.|: .:...
Human  1169 FTEGCIKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQR 1233

  Fly  1524 DDLNKVLNKFDYFFTAVFTIELILKLISYGFVLH-DGAFCRSAFNLLDLLVVCVSLISLVSSS-- 1585
            ..:..:|...|..||.:|.:|::||.::|||..: ..|:|     .||.|:|.|||:|||:::  
Human  1234 KTIKTMLEYADKVFTYIFILEMLLKWVAYGFQTYFTNAWC-----WLDFLIVDVSLVSLVANALG 1293

  Fly  1586 -NAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFK 1649
             :.:..:|.||.||.||||||::|.:|::.||..::.|:.:|.|::|| ||:.::          
Human  1294 YSELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLV-CLIFWL---------- 1347

  Fly  1650 YVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDDGDV 1714
                                     :|:::||.||.|||:.|.:   ||      |..::|..||
Human  1348 -------------------------IFSIMGVNLFAGKFYHCVN---MT------TGNMFDISDV 1378

  Fly  1715 H-----KPRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPI 1774
            :     :...::..|.|.:.:||:|..|.|.|..|:||:||..::|.::||......|::.....
Human  1379 NNLSDCQALGKQARWKNVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRDVKLQPVYEENLY 1443

  Fly  1775 VAAYYIIYIIIIAFFMVNIFVGFVIVTFQNE----GEQEYKNCDLDKNQRNCIEFALK------- 1828
            :..|::|:||..:||.:|:|:|.:|..|..:    |.|:....:..|...|    |:|       
Human  1444 MYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYN----AMKKLGSKKP 1504

  Fly  1829 AKPVRRYIPKHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTA 1893
            .||:.|  |.:..|..|:.|||...|:.:|.|||.:|.||:.::..:|..:.|.:|..:|::|..
Human  1505 QKPIPR--PANKFQGMVFDFVTRQVFDISIMILICLNMVTMMVETDDQGKYMTLVLSRINLVFIV 1567

  Fly  1894 VFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKK 1958
            :|..|||.||.:.| ..||...||:|||::|:.|.:.:..:|:..|                   
Human  1568 LFTGEFVLKLVSLR-HYYFTIGWNIFDFVVVILSIVGMFLAEMIEK------------------- 1612

  Fly  1959 SAGSNLISINFF---RLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVG 2020
                ..:|...|   ||.|:.|:::|:...:||||||:..:.|..||..:.||:.|:.||||:.|
Human  1613 ----YFVSPTLFRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFG 1673

  Fly  2021 MQVFGKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSC--SAQPDVKCDMNSDTPG 2083
            |..|..:..:.|  |....||:||..:::.||:..|...|..::...  ||.||  ||.::..||
Human  1674 MSNFAYVKKEAG--IDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPD--CDPDTIHPG 1734

  Fly  2084 E----PCGS-SIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWS-ILGPHHLDEFIRLWSE 2142
            .    .||: |:...:|:|:.::...:::|:::|||::||...|.:.: .|.....:.|..:|.:
Human  1735 SSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWEK 1799

  Fly  2143 YDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRT 2207
            :||||...|:...:......:.|||...|  |:::   :|::|::|:.|...:.....|||..:.
Human  1800 FDPDATQFIEFSKLSDFAAALDPPLLIAK--PNKV---QLIAMDLPMVSGDRIHCLDILFAFTKR 1859

  Fly  2208 SLSIKTDGNIDDANSELRATIKQIWKRTNPKLLDQVVPPP------GNDDEVT---VGKFYATYL 2263
            .|.  ..|.:|    .||..::..:..:||   .:|...|      ...:||:   :.:.:..||
Human  1860 VLG--ESGEMD----ALRIQMEDRFMASNP---SKVSYEPITTTLKRKQEEVSAAIIQRNFRCYL 1915

  Fly  2264 IQDYFRRFKKRKEQEGKEGHPD 2285
            ::...:.......:|..:|..|
Human  1916 LKQRLKNISSNYNKEAIKGRID 1937

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:459842 96/330 (29%)
Ion_trans 1137..1379 CDD:459842 87/287 (30%)
Ion_trans 1496..1809 CDD:459842 98/326 (30%)
Ion_trans 1851..2126 CDD:459842 87/284 (31%)
GPHH 2135..2188 CDD:465306 14/52 (27%)
Ca_chan_IQ 2198..2273 CDD:462591 16/83 (19%)
SCN3ANP_008853.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..60
I. /evidence=ECO:0000305 110..455 106/362 (29%)
Ion_trans 127..434 CDD:459842 95/324 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 493..528 5/34 (15%)
Na_trans_cytopl 558..710 CDD:463401 12/151 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 587..631 0/43 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 662..681 6/18 (33%)
II. /evidence=ECO:0000305 742..1014 87/286 (30%)
Ion_trans 759..972 CDD:459842 72/227 (32%)
Na_trans_assoc 998..1200 CDD:461936 31/206 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1118..1162 10/48 (21%)
III. /evidence=ECO:0000305 1188..1499 105/364 (29%)
Ion_trans 1205..1477 CDD:459842 97/321 (30%)
Na_channel_gate 1469..1521 CDD:240441 13/57 (23%)
IV. /evidence=ECO:0000305 1508..1806 101/327 (31%)
Ion_trans 1525..1781 CDD:459842 87/283 (31%)
GPHH 1793..1840 CDD:465306 14/51 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1949..2000
Blue background indicates that the domain is not in the aligned region.

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