DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and cacna1ab

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:XP_021335317.1 Gene:cacna1ab / 569528 ZFINID:ZDB-GENE-090514-3 Length:2336 Species:Danio rerio


Alignment Length:2377 Identity:848/2377 - (35%)
Similarity:1175/2377 - (49%) Gaps:544/2377 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   676 ARYDSGEGDLGGGNNIMGIDSMGIANIPETMNGTTIGPSGAGGQKGGAAAGAAGQKRQQ--RRGK 738
            |||..|    |||.:..|                  || |.||.:.|...||....:|.  :|.:
Zfish    10 ARYGGG----GGGGSGQG------------------GP-GRGGSRQGGPPGAQRMYKQSMAQRAR 51

  Fly   739 ------PQPDRP-----QRALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYP 792
                  |.|.|.     .|:||..|..|.:|....:|.||.|||::||.||.||||.||:....|
Zfish    52 TMAIYNPIPVRQNCLTVNRSLFLFSEDNIVRKYAKKITEWPPFEWMILTTIIANCIVLALEQHLP 116

  Fly   793 GSDSNVTNQTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALS 857
            ..|....::.||:.|..|:.||..|..:||||.||..|.|:|||||||::||.:|:.|.:|:..|
Zfish   117 VGDKTPLSERLEETEPYFIAIFCFESGIKILALGFAFHKGSYLRNGWNVMDFVVVLTGILSSVGS 181

  Fly   858 QLMKDAFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLEL 922
            :|     |::.|||.||||||:||||:|||||||.||:|||:||..|.:|:...|:::||||||.
Zfish   182 EL-----DLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGVLLFVAILMFAIIGLEF 241

  Fly   923 FSGKLHKACRDEITGE-YEENIRPCGVGYQCPPGYKCYGGWDGPNDGITNFDNFGLAMLTVFQCV 986
            :.||.|..|.:.|||| |:|  ||||.........:|.|.|.|||.|||.|||...|:||||||:
Zfish   242 YMGKFHTTCFNTITGEMYDE--RPCGARTCDANNTQCQGYWLGPNYGITQFDNVLFAVLTVFQCI 304

  Fly   987 TLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERNKAKNRGDFQKLR 1051
            |:|||||:||...||:||.|.|||::.::|:|:||::||:||||||||:|||.:.:||.:|.||:
Zfish   305 TMEGWTDMLYYSNDALGSAWNWMYYVPLIIIGSFFMLNLVLGVLSGEFAKERERVENRSEFLKLK 369

  Fly  1052 EKQQIEEDLRGYLDWITQAEDI---EPDAVGG-----LISDGKGKQPNEMDSTENLGEEM--PEV 1106
            .:||||.:|.|||:||.:||::   |.|...|     .:...|....|..:..:::|:.:  |..
Zfish   370 RQQQIERELNGYLEWICKAEEVILAEDDNDTGSRRRPTLKKNKADLLNPQEGVDHMGDSVGSPFA 434

  Fly  1107 QMTESRWRKMKKD---FDRVNRRMRRACRKAVKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDN 1168
            :.:.|.    |.|   |.:..||:|...||.||:|||||.:|.||.|||..:|..||.|.:.|.:
Zfish   435 RGSMSG----KGDETPFSKKERRLRFLIRKMVKTQAFYWTVISLVALNTLCVAVVHYDQPELLSD 495

  Fly  1169 FQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPP---LGV 1230
            |..|....|:|||..|||:|||.||.:.||.|.||.|||.|::|||.|.:   ..|:.|   .|:
Zfish   496 FLYYAEFIFLGLFMSEMLIKMYGLGTRPYFHSSFNCFDCAVIVGSIFEVV---WAMVKPGTSFGI 557

  Fly  1231 SVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFD- 1294
            ||||.:||||:|||||||.||.|||.|||||::||.|||.|||||||:|||||||:|||:|||: 
Zfish   558 SVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFEL 622

  Fly  1295 GKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYIL 1359
            |...   .|||.|..|::|||||:||||||.|||.||.:.|||.. |.:..::||:|.:.|||.|
Zfish   623 GTPP---TNFDTFPAAIMTVFQILTGEDWNVVMYDGIKSQGGVDK-GMIFSVFFIVLTLFGNYTL 683

  Fly  1360 LNVFLAIAVDNLADADSLSEVEKEEEPHDESAQKKSHSPTPTIDGMDD----HLSIDIDMEQQ-- 1418
            |||||||||||||:|..|::.|:|||  :.:.||.:......:..:..    :|||....:|:  
Zfish   684 LNVFLAIAVDNLANAQELTKDEQEEE--EATTQKMALQKAKEVAEVSPLSAANLSIAAKEQQKNS 746

  Fly  1419 ----------------------------ELDDED--KMDHETLSD-------------------- 1433
                                        |||.||  ||::....|                    
Zfish   747 KGSKSVWEQRTSEIRRQNLMTSREALYNELDAEDHWKMNYRNRPDVKTHLDRPLVVNPQENRNNN 811

  Fly  1434 ---------------EE-----------------------------VREMCEEEEEVDEEG---- 1450
                           ||                             :.|:.|...|.|.||    
Zfish   812 TNKPRPDDPNPQERSEEHPSRSHHHHSHHHHHHHHHTHHSSRQSLHLPELAETGFECDVEGAGEH 876

  Fly  1451 ----------------------------------------------------------------- 1450
                                                                             
Zfish   877 RRPRHHQHRRRDEDGGERGRKHRDHHSRGETAGGDAEDGQEKRQRRHRHANHGDGDGRRERSRLH 941

  Fly  1451 -------MITARP-------------------RRMSEV--------------------------- 1462
                   :.||||                   |..|::                           
Zfish   942 RNKKEGSLSTARPIQPGLPHTESQYSEDLDNLRNSSKMAIHDPDPDLYDPYYDPEQANNLLNLRG 1006

  Fly  1463 -----------------NTATKILP---------------------------------------- 1470
                             :||..:.|                                        
Zfish  1007 PDLHDSSLILTDSSKLEHTAIDMPPIYPSLNAKLQVNKNANTEPAKEGEKKEEEEDDGGDEEGHK 1071

  Fly  1471 -IPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDDLNKVLNKFD 1534
             |||.:|.|:.|.||.||..||::.....|...||..|..||..||||:|:..:.:.||||..||
Zfish  1072 RIPPFSSCFILSTTNPFRRCCHYILTLRYFEMCILSVIAMSSIALAAEDPVSQDSERNKVLRYFD 1136

  Fly  1535 YFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISLVSSS--------NAISVV 1591
            |.||.|||.|:::|::..|.:||:|::.|..:|.||.:||..:|::...:|        ..||::
Zfish  1137 YVFTGVFTFEMLIKMVVLGLILHEGSYFRDLWNFLDFVVVSGALVAFAFTSFSGGSGKGKDISII 1201

  Fly  1592 KILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKCVV 1656
            |.||||||||||:.|.|...||.|..                                    |||
Zfish  1202 KSLRVLRVLRPLKTIKRLPKLKAVFD------------------------------------CVV 1230

  Fly  1657 VAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYD-DGDVHKPRLR 1720
            .::|.:.||::|..|..|:|||:.||||||:||.|||.||....:|.|.||||: |.:|   :.:
Zfish  1231 NSLKNVLNILIVYMLFMFIFAVVAVQLFKGRFFYCTDESKEFARDCRGEYLVYERDNEV---KSQ 1292

  Fly  1721 EREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIII 1785
            :|||....||:|:|...:||||||||.||||.:|..|:||..||.||...:|..::.:|::|.::
Zfish  1293 KREWKKYDFHYDNVLWALLTLFTVSTGEGWPDVLKHSVDSTYENRGPSPGYRMEMSIFYVVYFVV 1357

  Fly  1786 IAFFMVNIFVGFVIVTFQNEGEQEYKNCDLDKNQRNCIEFALKAKPVRRYIP--KHGIQYKVWWF 1848
            ..||.|||||..:|:|||.:|::..::..|:||:|.||:||:.|||:.|::|  |...||::|.|
Zfish  1358 FPFFFVNIFVALIIITFQEQGDKMMEDYSLEKNERACIDFAINAKPLTRHMPQNKQSFQYRMWQF 1422

  Fly  1849 VTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFG 1913
            |.|..|||:|..||.:||:.|.||:......|.::|..||::||..|.:|.:.|:.||..:|:|.
Zfish  1423 VVSPPFEYSIMSLIALNTIILMMKYNGASDAYDKVLKNLNIVFTTFFFMESILKIIAFGVRNFFR 1487

  Fly  1914 DAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRL 1978
            ||||:|||:.|:||..||:.:|:.                        :|.|:::|.||||..||
Zfish  1488 DAWNIFDFVSVIGSITDILVTELV------------------------NNFINLSFLRLFRAARL 1528

  Fly  1979 VKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIALDGGNAITANNNFQT 2043
            :|||.:||.||.|||||::||:|||||.|||.:||||||::|||:||.:|||...||..:|||:|
Zfish  1529 IKLLRQGETIRILLWTFVQSFKALPYVCLLIAILFFIYAIIGMQLFGNLALDDEGAINEHNNFRT 1593

  Fly  2044 FQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGEPCGSSIAYPYFISFYVLCSFLIIN 2108
            |..|:::||||||||||.:||:||..  .:.|:  .:..|..|||::||.||:||..|||||::|
Zfish  1594 FFMALMLLFRSATGEAWHDIMLSCLG--GMPCE--PEEVGSECGSNVAYAYFVSFIFLCSFLMLN 1654

  Fly  2109 LFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLC 2173
            ||||||||||:|||||.||||||||||::|:|:||||.|.|||.:.|:.:|||.|.||||.||.|
Zfish  1655 LFVAVIMDNFEYLTRDSSILGPHHLDEYVRIWAEYDPAACGRIHYKDMYSLLRVIDPPLGLGKKC 1719

  Fly  2174 PHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIK-TDGNID--DANSELRATIKQIWKRT 2235
            |||:|||||:.|::|:..|.||.||:||.|::||:|.|| ..|..|  ..::|||..:..||...
Zfish  1720 PHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKHQMDAELRKEMMAIWPNL 1784

  Fly  2236 NPKLLDQVVPPPGNDDEVTVGKFYATYLIQDYFRRFKKRKEQEGKEGHPDSNTVTLQAGLRTLHE 2300
            :.|.||.:|.|..:..::||||.||..:|.:|:|:.|.:|.|..:|   :.|...|.     ...
Zfish  1785 SQKNLDLLVTPHKSATDLTVGKIYAAMMIMEYYRQSKAKKLQALRE---EQNRTPLM-----FQR 1841

  Fly  2301 VSPALKR----AISGNLDELDQEPEPMHRRHHTLFGSVWSSIRRHGNGTFRRSAKATASQSNGAL 2361
            :.|:..:    .::| |.||.|||          ..|:...:..:.:.::..|......|.:   
Zfish  1842 MEPSPNQEGGPGLNG-LPELPQEP----------VNSLPPEVGMNESQSWVTSRAQEMCQKS--- 1892

  Fly  2362 AIGGSASAALGVGGSSLVLGSSDPAGGDYLYDTLNRSVADGVNNITRNIMQARLAAAGKLQDELQ 2426
                             |..:.:|          :|...|..::...|.....:...|.:.|...
Zfish  1893 -----------------VPENWNP----------DRPYPDDHHDSRHNPQTVEMREFGPVGDGYS 1930

  Fly  2427 GAGSGGELRTFGESISMRPLAKN---------GGGAATVAGTLP--PEANAINYDNRNRGILLHP 2480
            .......:...|.:|||..|:.:         |...:|:..|.|  ...:::.:....||:.|..
Zfish  1931 DTEPYHPMEGHGRTISMPRLSADNQRRRHRPRGSNLSTITDTSPMRRSTSSLVHGRSGRGVRLDD 1995

  Fly  2481 YNNVYAPNGALPGHERMIQSTPASPYDQRRLPTSSDMNGLAESLIGGVLAAEGLGKYCDSEF-VG 2544
            |:           .||::     |....|..|...|.:...:.......:...|.:|.|::. :|
Zfish  1996 YS-----------LERVV-----SEEGHRHAPRRRDRDRDRDRDRSHRTSERSLARYTDADTGLG 2044

  Fly  2545 TAAREMREALDMTPEEMNL---AAHQILSNEHSLSLIGSSNGSIFG-----------GSAGGLGG 2595
            |......::.|:.|:|...   .|.....:.|.....||.:...:.           .|......
Zfish  2045 TDLSTTTQSGDLPPKERERERGRAKDRRHHHHHHHHHGSVDKDRYSHERDYHRHPQDRSDRQWSR 2109

  Fly  2596 AGSGGVGGLGGSSSIRNAFGGSGSGPSSLSPQHQPYSGTLNSPPIPDNRLRRVATVTTTNNNNKS 2660
            :.|.|.|...||||:      |||...|.|....|..|....|..|......|............
Zfish  2110 SPSEGRGHRQGSSSV------SGSPVPSTSGTSTPRRGRRQLPQTPSTPRPHVTYSPAVRKPPYG 2168

  Fly  2661 QVSQNNSNSLNVRANANSQMNMSPTG-QPVQQQSPLR 2696
            ...|.       |..:.|..|.||.| :|...:.|.|
Zfish  2169 SPGQG-------RLRSPSPRNFSPPGHEPPYHRPPSR 2198

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 148/275 (54%)
Ion_trans 1137..1379 CDD:395416 144/245 (59%)
Ion_trans 1496..1809 CDD:395416 130/321 (40%)
Ion_trans 1851..2126 CDD:395416 137/274 (50%)
GPHH 2135..2188 CDD:407139 32/52 (62%)
Ca_chan_IQ 2199..2271 CDD:400901 29/74 (39%)
cacna1abXP_021335317.1 Ion_trans 91..360 CDD:306908 148/275 (54%)
Ion_trans 465..703 CDD:306908 144/244 (59%)
Ion_trans 1099..1335 CDD:306908 111/274 (41%)
Ion_trans 1425..1672 CDD:306908 137/274 (50%)
GPHH 1673..1743 CDD:318993 44/69 (64%)
Ca_chan_IQ 1745..1820 CDD:312334 29/74 (39%)
Herpes_ICP4_C 1841..>2243 CDD:332854 77/428 (18%)
PAT1 <2144..2300 CDD:330585 13/62 (21%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100303
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.820

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