DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and Cacna1i

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:XP_038935723.1 Gene:Cacna1i / 56827 RGDID:68944 Length:2226 Species:Rattus norvegicus


Alignment Length:2368 Identity:583/2368 - (24%)
Similarity:906/2368 - (38%) Gaps:790/2368 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   739 PQPDRPQRALFCLSVKNPLRALCIRIV--EWKPFEFLILLTIFANCIALAVYTPYPG----SDSN 797
            |.||....|.|||......|..||::|  .|  ||.:.:|.|..||:.|.:|.|...    ||..
  Rat    48 PHPDLAPVAFFCLRQTTSPRNWCIKMVCNPW--FECVSMLVILLNCVTLGMYQPCDDMECLSDRC 110

  Fly   798 VTNQTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKD 862
            ...|..:  :::| :.|..|.|:|::|.| :.....||.:.||.|||.||:.|.:..:|.   ..
  Rat   111 KILQVFD--DFIF-IFFAMEMVLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLD---LQ 168

  Fly   863 AFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKL 927
            ..::.|:|..||||||:.::.|||:::::|.:|..:..|.::.||..||..|:.|||::|::|.|
  Rat   169 NINLSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLL 233

  Fly   928 HKAC----------------------RDE------ITGEYEENIRPCGVGYQCPP----GYKC-- 958
            ...|                      .||      :||  :..|..|   ::.||    |.:|  
  Rat   234 RNRCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLTG--DNGIMGC---HEIPPLKEQGRECCL 293

  Fly   959 -------YG-------------GWD-----------GPNDGITNFDNFGLAMLTVFQCVTLEGWT 992
                   :|             .|:           .|:.|..||||.|.|.:.:||.:|||||.
  Rat   294 SKDDVYDFGAGRQDLNASGLCVNWNRYYNVCRTGNANPHKGAINFDNIGYAWIVIFQVITLEGWV 358

  Fly   993 DVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFS--KER----------------- 1038
            :::|.:.|| .|.:.::|||.::|:|:||::||.|.|::.:||  |:|                 
  Rat   359 EIMYYVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLSSST 422

  Fly  1039 ----------------------NKAKNR--GDFQKLREKQQ------------------------ 1055
                                  .|||.|  |.:|.|:.::|                        
  Rat   423 VASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQNRRQAMGPGTPAPAKPGPHAKEPSHCKL 487

  Fly  1056 -------------IEEDLRGYLDWITQAED------------IEPDAVGGLIS------------ 1083
                         :.:.:...|     |.|            ..|..:|...|            
  Rat   488 CPRHSPLDPTPHTLVQPISAIL-----ASDPSSCPHCQHEAGRRPSGLGSTDSGQEGSGSGGSAE 547

  Fly  1084 ---DGKGKQPNEMDSTENLGEEMPE----VQMTESRWRKMKKDFDRVNRRMRRACRKAVKSQAFY 1141
               :|.|.|.:|...:.:||:|..:    .::....||:           .|...|..|.|:.|.
  Rat   548 AEANGDGPQSSEDGVSSDLGKEEEQEDGAARLCGDVWRE-----------TRAKLRGIVDSKYFN 601

  Fly  1142 WLIIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFD 1206
            ..|::.:.:||..:..||:.|.:.|.|..|..||.|..:|..||:||:.:.|...|..:.:|.||
  Rat   602 RGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFD 666

  Fly  1207 CFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLL 1271
            ..:||.||.|.:....|     |:||||..|||||.|:.::..:|...:..|:.::.::|:..:|
  Rat   667 SIIVIISIWEIVGQADG-----GLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCML 726

  Fly  1272 LFLFIVIFALLGMQVFGGKFNF---DGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINA 1333
            |.|||.||::|||.:||.||:.   .|.....|.|||....|::|||||:|.||||.|:      
  Rat   727 LMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVL------ 785

  Fly  1334 YGGVSSYGALACIYFIILFICGNYILLNVFLAIAVD----------NLADAD----SLSEVEKEE 1384
            |.|::|....|.:||:.|...|||:|.|:.:||.|:          :.:|.|    :|.|.:|..
  Rat   786 YNGMASTTPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNLEEFDKLP 850

  Fly  1385 EPHDES----------------------------------AQKKSHSPTPTIDGMDDHLSIDIDM 1415
            |..|.|                                  |.:.|..|.|.:..:|...|..:.:
  Rat   851 EGLDNSRDLKLCPIPMTPNGHLDPSLPLGAHLGPAGTMGTAPRLSLQPDPVLVALDSRKSSVMSL 915

  Fly  1416 EQQ-------------------------------------------------------------- 1418
            .:.                                                              
  Rat   916 GRMSYDQRSLSSSRSSYYGPWGRSGTWASRRSSWNSLKHKPPSAEHESLLSGEGGGSCVRACEGA 980

  Fly  1419 ------------------------------------ELDDEDKMD-------------------- 1427
                                                .||..|.:|                    
  Rat   981 REEAPTRTAPLHAPHTHHAHHGPHLAHRHRHHRRTLSLDTRDSVDLGELVPVVGAHSRAAWRGAG 1045

  Fly  1428 ----HETLSD-------------EEVREMCEEEEEVDEEGMITARPRRMSEVNTATKILP----I 1471
                ||..:.             ::.|:..|:|||:|.  .:..|.|:|.:|     ..|    :
  Rat  1046 QAPGHEDCNGRMPNIAKDVFTKMDDCRDRGEDEEEIDY--TLCFRVRKMIDV-----YKPDWCEV 1103

  Fly  1472 PPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENP-LRANDDLNKVLNKFDY 1535
            ....|.:|||..|:||:.|..:..|..|..::|..|..:...:|.|.| :.|.......|...:|
  Rat  1104 REDWSVYLFSPENKFRILCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNY 1168

  Fly  1536 FFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISLVSS------SNAISVVKIL 1594
            .|||:|..|:.||::|.|....:.|:.||::|:||..:|.||:|.:|.|      :..:.|:::|
  Rat  1169 IFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSVASAGGAKILGVLRVL 1233

  Fly  1595 RVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKCVVVAI 1659
            |:||.|||||.|:||.|||.||:.:|.::|.||||||:.|    .|.:|                
  Rat  1234 RLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICC----AFFII---------------- 1278

  Fly  1660 KTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKC--TDGSKMT-QDECYGTYLVYDDGDVHKPRLRE 1721
                            |.::|||||||||:.|  .|...:| :.:|...               .
  Rat  1279 ----------------FGILGVQLFKGKFYHCLGVDTRNITNRSDCVAA---------------N 1312

  Fly  1722 REWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIII 1786
            ..|.:::::||::.:.:::||.:::.:||..::|..:|:...:..|:.|..|.:..|:|.:::|:
  Rat  1313 YRWVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIV 1377

  Fly  1787 AFFMVNIFVGFVIVTF----QNEGEQEYKNCD------LDKNQRNCIEFALKAKPVRRYIPKHGI 1841
            :||::|:|||.|:..|    |::..:|.:..:      |:|.:|       ||:.:..|......
  Rat  1378 SFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRR-------KAQRLPYYATYCPT 1435

  Fly  1842 QYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAF 1906
            :..:....||...:..|..:|.:|.||::::.||||......|...|.:||.||.||.|.||.||
  Rat  1436 RLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAF 1500

  Fly  1907 RFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFR 1971
            ..:.:|.|.||..|..|||.|.:.|...||:......|                  |...|...|
  Rat  1501 GLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPI------------------NPTIIRIMR 1547

  Fly  1972 LFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYV---ALLIVLLFFIYAVVGMQVFGKIALDGGN 2033
            :.|:.|::|||....|:|.||.|.:   ||||.|   .||.:|||||||.:|:::|||:..:..|
  Rat  1548 VLRIARVLKLLKMATGMRALLDTVV---QALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDEN 1609

  Fly  2034 ---AITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGEPCGSSIAYP-- 2093
               .::.:..|:.|..|.|.||:.:||:.|..||      .|...|...|.  ..|.||:.:.  
  Rat  1610 PCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIM------KDTLRDCTHDE--RSCLSSLQFVSP 1666

  Fly  2094 -YFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEY-------------- 2143
             ||:||.:...|::||:.|||:|.:.|...::  ......:|..|.|...:              
  Rat  1667 LYFVSFVLTAQFVLINVVVAVLMKHLDDSNKE--AQEDAEMDAEIELEMAHGLGPCPGPCPGPCP 1729

  Fly  2144 ---------------DPDAKGR---------------IKH----------LDVVTLLRKIS---- 2164
                           .|.|.||               .:|          ||.|:|:.|.|    
  Rat  1730 CPCPCPCPGPRLPTSSPGAPGRGSGGAGAGGDTESHLCRHCYSPAQETLWLDSVSLIIKDSLEGE 1794

  Fly  2165 ----------------PPLGFGKLCPHRMACKRLVSMNMP------------------------- 2188
                            .|.|.|| |.|......:...:.|                         
  Rat  1795 LTIIDNLSGSVFHHYASPDGCGK-CHHDKQEGPVAQRSRPRLPHPSPRVTRGHHLPLQVQLAETE 1858

  Fly  2189 ---LNSDGTVLFNATLFAVVRTSLSIKTDGNIDDANSELRATIKQIWKRTNPKLLDQVVPPP--- 2247
               ||||.:            :|:.:..|.:::|..:          ....||.....:.||   
  Rat  1859 AFSLNSDRS------------SSILLGDDLSLEDPTA----------CPQGPKESKGELEPPEPM 1901

  Fly  2248 --GNDDE---------VTVGKFYATYL----------IQDYFRRFKKRKEQEGKEGHPDSNTVTL 2291
              |:.||         |:.|.  .:.|          :|.:.:....:..|  ....||.::..|
  Rat  1902 QAGDLDECFFPFASEPVSTGP--ESLLCEMGAIPFNPVQSWLKHESSQAPQ--SPFSPDGSSPLL 1962

  Fly  2292 QAGLRTLHEVSPALKRAISGNLDELDQEPE------PMHRRHHTLFGSVWSSIRRHG-NGTFRRS 2349
            |......|   ||:..:..|      |||.      |    ...|.|| |:|:|... |.|..|.
  Rat  1963 QMPAEFFH---PAVSASQKG------QEPGMSAGTLP----KIALQGS-WASLRSPSVNCTLLRQ 2013

  Fly  2350 A-------KATASQSNG--------ALAIGGSASAALG----VGGSSLVLGSSDPAGGDYLYDTL 2395
            |       .|:.|.|.|        :|.:..|...|||    |.|..   .|..||         
  Rat  2014 ATVSDASLDASPSSSAGSLQTTLEDSLTLSDSPRRALGPPVQVPGPR---ASLSPA--------- 2066

  Fly  2396 NRSVADGVNNITRNIMQARLAAAGKLQDELQGAGSGGELRTFGESI--------SMRPLAKNGGG 2452
                       ||.    ||:..|:....|:|..:.....:.|.|.        ||.|..:.|.|
  Rat  2067 -----------TRR----RLSLRGRGLFSLRGLRAHQRSHSSGGSTSPGCTHHDSMDPSDEEGRG 2116

  Fly  2453 AATVAGTLPPEANAINYDNRNRGILLHPYNNVYAPNGALPGHERMIQST---------PASPYDQ 2508
            .|...|.....:..::..:......|.|   ...|.|..|.  |...||         |.|....
  Rat  2117 GAGGGGAGSEHSETLSSLSLTSLFCLPP---TLPPPGLTPA--RKFNSTSSLAAGPGRPGSTVSA 2176

  Fly  2509 R---RLPT-----SSDMNGLAESLIGGV 2528
            |   |.|:     |.|..|.|: |:.|:
  Rat  2177 RGLVRSPSWAADRSKDPPGQAQ-LVSGL 2203

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 104/384 (27%)
Ion_trans 1137..1379 CDD:395416 93/258 (36%)
Ion_trans 1496..1809 CDD:395416 98/326 (30%)
Ion_trans 1851..2126 CDD:395416 97/283 (34%)
GPHH 2135..2188 CDD:407139 19/126 (15%)
Ca_chan_IQ 2199..2271 CDD:400901 14/95 (15%)
Cacna1iXP_038935723.1 Ion_trans 76..407 CDD:395416 103/345 (30%)
Ion_trans 597..824 CDD:395416 90/237 (38%)
Ion_trans 1128..1400 CDD:395416 98/322 (30%)
Ion_trans 1445..1700 CDD:395416 97/285 (34%)
PHA03307 1833..>2066 CDD:223039 54/275 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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