DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and cacna1eb

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:XP_017206695.2 Gene:cacna1eb / 567702 ZFINID:ZDB-GENE-070705-133 Length:2168 Species:Danio rerio


Alignment Length:2005 Identity:772/2005 - (38%)
Similarity:1043/2005 - (52%) Gaps:448/2005 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   716 AGGQKGGAAAGAAGQKRQQRRGKPQPDR-----PQRALFCLSVKNPLRALCIRIVEWKPFEFLIL 775
            |.|:....:||...:.|......|.|.:     ..|:||..:..|.:|....||:||.|||::||
Zfish    14 AEGKAESESAGEIKRARTMALYNPIPAKHNCLTVNRSLFIFAENNMIRKYAKRIIEWPPFEYMIL 78

  Fly   776 LTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWN 840
            .||.||||.|::....||.|....::.|||.|..|:.||..|..:|::|.|||.|.|:|||||||
Zfish    79 ATIIANCIVLSLEQHLPGEDKTPMSKRLEKTEPYFIGIFCFEAGIKLVALGFVFHKGSYLRNGWN 143

  Fly   841 LLDFTIVVIGAISTALSQLMKDAFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIA 905
            ::||.:|:.|.::||.|. |....|::.|||.||||||:||||:||||:||.||:||||||..|.
Zfish   144 VMDFIVVLSGILATAGSH-MNIPVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIIKAMVPLLQIG 207

  Fly   906 LLVLFVIIIYAIIGLELFSGKLHKAC------RDEITGEYEENIRPCGVGYQCPPGYKCYGGWDG 964
            ||:.|.|:::||||||.:|||||..|      .|..|.:..|....||| .:||..|.|.|.|.|
Zfish   208 LLLFFAILMFAIIGLEFYSGKLHHTCLADLDILDNETVDSSEVDFACGV-RKCPDKYTCSGSWIG 271

  Fly   965 PNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGV 1029
            ||||||.|||...|:||||||:|:||||.|||:..||:|..|.|:|||.::|:|:|||:||:|||
Zfish   272 PNDGITQFDNILFAVLTVFQCITMEGWTAVLYNTNDALGPTWNWIYFIPLIIIGSFFVLNLVLGV 336

  Fly  1030 LSGEFSKERNKAKNRGDFQKLREKQQIEEDLRGYLDWITQAEDIEPDAVGGLISDGKGKQPNEMD 1094
            |||||:|||.:.:||..|.|||.:||:|.:|.||..||.:||::.      |..:.|....:.:|
Zfish   337 LSGEFAKERERVENRRAFMKLRRQQQVERELNGYRAWIDRAEEVM------LQEENKNSGRSALD 395

  Fly  1095 ------STENL-----GEE------------MPEVQMTESRWRKMKKDFDRVNRRMRRACRKAVK 1136
                  |.:|.     |||            .|.|.|...| |.......|..|.:|.:.|:.||
Zfish   396 VLKRATSKKNARRRGPGEEKYSEISTVAGGSRPRVGMRTPR-RGPAAYLRRKERMLRFSIRRMVK 459

  Fly  1137 SQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSL 1201
            :.:|||:::.||.|||..::..|:.|.:||...|.||...|:|||..||.||||.|||:.||.|.
Zfish   460 TDSFYWIVLSLVALNTISVSIVHHNQPEWLTVIQYYTEFVFLGLFLAEMFLKMYGLGFRLYFHSS 524

  Fly  1202 FNRFDCFVVIGSITETLLTNTGMMPP---LGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQ 1263
            ||.|||.|::|||.|.:   .|...|   .|:||||.:||||:||:||||.||.|||.||::|::
Zfish   525 FNCFDCGVIVGSIFEVV---WGFFRPGVSFGISVLRALRLLRIFKITKYWSSLRNLVVSLMSSMK 586

  Fly  1264 SIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMY 1328
            ||.|||.|||||||:|||||||:|||:|.|   |:....|||.|..:::|||||:||||||.|||
Zfish   587 SIISLLFLLFLFIVVFALLGMQLFGGRFIF---EDYTPTNFDTFPASIMTVFQILTGEDWNEVMY 648

  Fly  1329 VGINAYGGVSSYGALACIYFIILFICGNYILLNVFLAIAVDNLADADSLSEVEKEEE-------- 1385
            .||.:.||| .||..:.||||:|.:.|||.||||||||||||||:|..|::.|:|||        
Zfish   649 NGIRSQGGV-HYGMWSSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKEEEEEEEEFFNQRY 712

  Fly  1386 -------------PH------------------DESAQKKS--HSPT------------------ 1399
                         |:                  :|:|.|::  ..|.                  
Zfish   713 KSREFGLSERRRRPYLYRKRAIHRGRPSPAEAEEEAAGKQAAEEQPVNAFAGRRERRKKINMSVW 777

  Fly  1400 ----------------------PTID----GMDDH-----------------------------L 1409
                                  ||.|    |.|.|                             :
Zfish   778 EQRANQLRKRRQMASREVLFGGPTEDQDTPGSDHHQQHSLSTETSPLHLPESPMSVGMPLPEPPM 842

  Fly  1410 SIDIDM----------------------------------------------------------- 1415
            ||.|.:                                                           
Zfish   843 SITIPLPEPPESEPLSGSGLEERPSANNHHANTERRHRVARKFRAAAAAGVAEGGRHKRHRHRES 907

  Fly  1416 -------------EQQELDDEDKMDHETLSDEEVREMCEEEEEVDEE------------GM---- 1451
                         |:|..|.|.|.  |....:.:..||:.|.:::.:            |:    
Zfish   908 RTEARNAENHQQFERQAEDGEGKT--EEAQSKHMMNMCDPERQIENQEECQREFVCDLTGLSQAS 970

  Fly  1452 ---------------------ITARPRRMSEVN-----------------TATK-------ILPI 1471
                                 .:...:.|:||:                 |:.|       :|.:
Zfish   971 GHQEEDQAESQEAQLLRHKEDFSTESKYMTEVSDIENNGSYLNQDECMTETSLKRESSSQPLLEM 1035

  Fly  1472 PPGT-----------------------------------------------SFFLFSQTNRFRVF 1489
            .|.|                                               |.|:|...|..|..
Zfish  1036 APMTVSFKDVEASLSDKADDDDDDDMDDDDDYEDDENGGEKSTASKPERPDSMFIFKSKNPIRRI 1100

  Fly  1490 CHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGF 1554
            ||::.....|...||..|:.||..||||:|:..:.:.||||..|||.||.|||.|:|:|:|..|.
Zfish  1101 CHYVVTLRYFEMTILLVIVASSIALAAEDPVCTSSERNKVLRYFDYVFTGVFTFEMIIKMIDQGL 1165

  Fly  1555 VLHDGAFCRSAFNLLDLLVVCVSLISLV-------SSSNAISVVKILRVLRVLRPLRAINRAKGL 1612
            :||||::.|..:|:||.:||..:||:..       :....|..:|.||||||||||:.|.|...|
Zfish  1166 ILHDGSYFRDMWNILDFIVVVGALIAFALTNLLGNNKGRDIKTIKSLRVLRVLRPLKTIKRLPKL 1230

  Fly  1613 KHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFA 1677
            |.|..                                    |||.::|.:.||::|..|..|:||
Zfish  1231 KAVFD------------------------------------CVVTSLKNVFNILIVYKLFMFIFA 1259

  Fly  1678 VIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDDGDVHKPRLREREWSNNRFHFDDVAKGMLTLF 1742
            ||.|||||||||.|||||..||.||.|.|:.|..   .:..:::|||..:.||:|:|...:||||
Zfish  1260 VIAVQLFKGKFFYCTDGSMGTQKECQGYYIDYGR---DRKEVKKREWRRHEFHYDNVLWALLTLF 1321

  Fly  1743 TVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGE 1807
            ||||.||||.:|..|:|..:|:.||....|..::.:|:||.::..||.|||||..:|:|||.:|:
Zfish  1322 TVSTGEGWPQVLQHSVDVTEEDHGPSRGNRMEMSIFYVIYFVVFPFFFVNIFVALIIITFQEQGD 1386

  Fly  1808 QEYKNCDLDKNQRNCIEFALKAKPVRRYIP--KHGIQYKVWWFVTSSSFEYTIFILIMINTVTLA 1870
            :..:.|:|:||:|.||:||:.|||:.||:|  :..:||::|.||.|.|||||:.::|.:|||.|.
Zfish  1387 KMMEECNLEKNERACIDFAISAKPLTRYMPQNRQTLQYRLWHFVVSPSFEYTVLVMIALNTVVLM 1451

  Fly  1871 MKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSE 1935
            ||:|:.|..|..:|..||..||.:|:||.:.|:.||.|.|||.|.||:||||.||||..:||.  
Zfish  1452 MKYYSAPTAYDIVLKHLNTAFTVLFSLECILKIMAFGFMNYFRDTWNIFDFITVLGSITEIVV-- 1514

  Fly  1936 IKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQ 2000
                |...:                  |.|:::|.:|||..||:|||.:|..||.|||||::||:
Zfish  1515 ----DLQSV------------------NTINMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFK 1557

  Fly  2001 ALPYVALLIVLLFFIYAVVGMQVFGKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMM 2065
            |||||.|||.:||||||::||||||.|.|:..:.|..:|||:||..|:::||||||||:|||||:
Zfish  1558 ALPYVCLLIAMLFFIYAIIGMQVFGNIKLNDESHINQHNNFKTFFGALMLLFRSATGESWQEIML 1622

  Fly  2066 SC----SAQPDVKCDMNSDTPGEP--CGSSIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRD 2124
            ||    ..:||........:|...  ||:..||.||:||....|||::|||||||||||:|||||
Zfish  1623 SCLEGKECEPDPSITPPFTSPDHEGGCGTDFAYFYFVSFIFFSSFLMLNLFVAVIMDNFEYLTRD 1687

  Fly  2125 WSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPL 2189
            .|||||||||||:|:|.|||..|.|||.:..:..:|..:|||||.||.||.::|.||||.||||:
Zfish  1688 SSILGPHHLDEFVRIWGEYDRAACGRIHYNAMYEMLTHMSPPLGLGKKCPAKIAYKRLVLMNMPV 1752

  Fly  2190 NSDGTVLFNATLFAVVRTSLSIKTDGNIDD---ANSELRATIKQIWKRTNPKLLDQVVPPPGNDD 2251
            :.|.||.|.:||.:::||:|.||.....:|   .:.||:..|..||...:.|.||.:| |...|.
Zfish  1753 DEDMTVHFTSTLMSLIRTALEIKIARGGEDRLQLDMELQKEISFIWPHLSQKTLDLLV-PINKDT 1816

  Fly  2252 EVTVGKFYATYLIQDYFRRFKKRK---EQEGKE-------GHPDSNTVTLQAGLRTLHEVSP--A 2304
            ::||||.||:.:|.|:|::.|.:|   :.|.:.       .|...:.:| ..|...|..:||  .
Zfish  1817 DMTVGKIYASRMIMDFFKQSKAKKLRLQVEAQRAAALPLISHSAGSALT-SGGFVALSPISPQEL 1880

  Fly  2305 LKRAISGNLDELDQEPEPMHRRHHTLFGSVWSSIR--RHGNGTFRRSAKATASQS 2357
            |.:.|:...|  ..|.....:...:....||...|  .|......:|.||..|.|
Zfish  1881 LLQPITQRTD--SSEDYDASQVDESGLNGVWGEDRPPEHAFRARHKSYKAAVSHS 1933

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 154/280 (55%)
Ion_trans 1137..1379 CDD:395416 140/244 (57%)
Ion_trans 1496..1809 CDD:395416 132/319 (41%)
Ion_trans 1851..2126 CDD:395416 140/280 (50%)
GPHH 2135..2188 CDD:407139 28/52 (54%)
Ca_chan_IQ 2199..2271 CDD:400901 28/74 (38%)
cacna1ebXP_017206695.2 Ion_trans 70..349 CDD:306908 154/280 (55%)
Ion_trans 463..698 CDD:306908 140/241 (58%)
Ion_trans 1108..1387 CDD:306908 132/317 (42%)
Ion_trans 1432..1689 CDD:306908 140/280 (50%)
GPHH 1690..1760 CDD:318993 41/69 (59%)
Ca_chan_IQ 1762..1836 CDD:312334 28/74 (38%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100303
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.820

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