DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and cacna1e

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:XP_017212914.2 Gene:cacna1e / 564274 -ID:- Length:2444 Species:Danio rerio


Alignment Length:2272 Identity:808/2272 - (35%)
Similarity:1101/2272 - (48%) Gaps:579/2272 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   681 GEGDLGGGNNIMGIDSMGIANIPETMNGTTIGPSGAGGQKGGAAAGAAGQKRQQRRG----KPQP 741
            |.|| ||.......|:..::.                   ||.:......|.|:.|.    .|.|
Zfish   172 GAGD-GGSERSRNRDAPAVST-------------------GGVSPAFKQTKAQRARTMALYNPIP 216

  Fly   742 DRP-----QRALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQ 801
            .|.     .|:||.....|.:|....:|:||.|||::||.||.||||.||:....||.|.....:
Zfish   217 VRQNCFTVNRSLFIFGEDNIVRKYAKKIIEWPPFEYMILATIIANCIVLALEQHLPGEDKTPMAK 281

  Fly   802 TLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDV 866
            .|||.|..|:.:|..|..:||:|.|||.|.|:|||||||::||.:|..|.::||.:. |..:.|:
Zfish   282 RLEKTEPYFIGMFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFIVVSSGILATAGAH-MNISLDL 345

  Fly   867 KALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKAC 931
            :.|||.||||||:||||:||||:||.||:||||||..|.||:.|.|:::||||||.:||||||.|
Zfish   346 RTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHKQC 410

  Fly   932 ----RDEITGEYEENIRPCGVGYQCPPGYKCYGGWDGPNDGITNFDNFGLAMLTVFQCVTLEGWT 992
                :|....:..||..||| ...||..|.|.|.|.|||||||.|||...::||||||:|:||||
Zfish   411 EPVGKDSERADSPENEFPCG-SKLCPDHYNCSGYWTGPNDGITQFDNILFSLLTVFQCITMEGWT 474

  Fly   993 DVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERNKAKNRGDFQKLREKQQIE 1057
            .:||...||:||.|.|:|||.::|:|:|||:||:||||||||:|||.:.:||..|.|||.:||||
Zfish   475 TILYYTNDALGSTWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLRRQQQIE 539

  Fly  1058 EDLRGYLDWITQAEDIEPDAVGGLISDGKGKQPNEMDSTENL----------GEEMPEVQ----- 1107
            .:|.||..||.:||::.      |..:.|...|:.:|..:..          ....||.|     
Zfish   540 RELNGYRAWIDRAEEVM------LAEENKNSGPSALDVLKRATTIKRRGVDDARRAPEEQYADIS 598

  Fly  1108 -----MTESRWRKMKKD----FDRVNRRMRRACRKAVKSQAFYWLIIVLVFLNTGVLATEHYGQL 1163
                 :..:..|..|:.    |.|..|.:|.:.|:.||:|.|||.::.||.|||..:|..|:.|.
Zfish   599 SLGMPLNRASIRSAKRGPTSYFRRKERLLRISVRRMVKTQTFYWTVLGLVALNTLCVAIVHHKQP 663

  Fly  1164 DWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPP- 1227
            .||.:...|....|:|||..||.||||.||.:.||.|.||.|||.|::|||.|..   .|...| 
Zfish   664 QWLSSLLYYAEFLFLGLFLTEMFLKMYGLGPRLYFHSSFNCFDCGVIVGSIFEVF---WGFFRPG 725

  Fly  1228 --LGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGK 1290
              .|:||||.:||||:||:||||.||.|||.||:||::||.|||.|||||||:|||||||:|||:
Zfish   726 TSFGISVLRALRLLRIFKITKYWASLRNLVVSLMNSMKSIISLLFLLFLFIVVFALLGMQLFGGR 790

  Fly  1291 FNFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICG 1355
            |.||   |....|||.|..|::|||||:||||||.|||.||.:.|||.| |..:.:|||:|.:.|
Zfish   791 FIFD---EYTPTNFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVKS-GMWSSVYFIVLTLFG 851

  Fly  1356 NYILLNVFLAIAVDNLADADSLSEVEKEEE----------------------------------- 1385
            ||.||||||||||||||:|..|::.|:|||                                   
Zfish   852 NYTLLNVFLAIAVDNLANAQELTKDEEEEEEAFNQKHALQKAKEVGPMSSFMSSERRRRPYLYRK 916

  Fly  1386 ----------------------------------------------------------------- 1385
                                                                             
Zfish   917 RAIHRSRAAYSFEDAESLADARPFNASNSFMSRRERRRRLTMSVWEQRTSQLRRHRQMSSREILF 981

  Fly  1386 ----------------------------------------------------PHDESA------- 1391
                                                                |.||.|       
Zfish   982 SSPSEEQDGPPGCPLHRKPGLSPSGSKRRATETTSTTIMPEGTLEPPMPMDMPVDEQALPISIPE 1046

  Fly  1392 -----------------------------QKKSHSPT------------PTIDG----------- 1404
                                         .:.|.|.|            |.::|           
Zfish  1047 PPLAIPIPEPPMPVDACLPEPPVTLNLPLTEPSESKTSPEGALDINNHCPRLNGNRRQRAVRKHR 1111

  Fly  1405 ---MDDHLSID---------------------------IDMEQQE--LDDEDKMDHETLSDE--- 1434
               |.|.|:.|                           :|.::|:  .:.::|.|.|...|.   
Zfish  1112 PPAMGDMLTPDMGPRPRRPRHRELHTDPRGKETLQGDGVDGKEQKPGSEGDEKSDGEISPDGRGL 1176

  Fly  1435 EVREMCEEEEEVDEEGMITARPRRM---------------------------------------- 1459
            |.|:...:..|...|......||::                                        
Zfish  1177 EQRQNKPDNTESSTESKPANSPRKIPPLDSEPATLQLTDNTLQQSSQGTTCAGETDNNNHGSLNQ 1241

  Fly  1460 --SEVNTA-----TKILPI------------------------------PPGTSFFLFSQTNRFR 1487
              |.:||:     |...|.                              ||..|.|:|...|..|
Zfish  1242 DKSSLNTSIVIEVTDTQPSMELTSITGNSKDVEASKPEKEEETPDAPKGPPPVSMFIFKPNNPVR 1306

  Fly  1488 VFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDDLNKVLNKFDYFFTAVFTIELILKLISY 1552
            ..||::.|...|...||..|..||..||||:|:..|.|.||||..|||.||.|||.|:|:|:|..
Zfish  1307 RACHYVVNLRYFEMSILLVIAASSIALAAEDPVNTNSDRNKVLRYFDYVFTGVFTFEMIIKMIDQ 1371

  Fly  1553 GFVLHDGAFCRSAFNLLDLLVVCVSLISL----VSSSNA---ISVVKILRVLRVLRPLRAINRAK 1610
            |.|||.|::.|..:|:||.:||..:|::.    |..||.   |..:|.||||||||||:.|.|..
Zfish  1372 GLVLHYGSYFRDPWNILDFIVVVGALVAFALTNVMGSNTGRDIKTIKSLRVLRVLRPLKTIKRLP 1436

  Fly  1611 GLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFM 1675
            .||.|..                                    |||.::|.:.||::|..|..|:
Zfish  1437 KLKAVFD------------------------------------CVVTSLKNVFNILIVYKLFMFI 1465

  Fly  1676 FAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDDGDVHKPRLRE-REWSNNRFHFDDVAKGML 1739
            ||||.||||||||:.|||.||.|::||.|.|:.||     |.:.:| |||....||:|:|...:|
Zfish  1466 FAVIAVQLFKGKFYYCTDSSKDTENECKGYYIDYD-----KDKKKEKREWKRRDFHYDNVVWALL 1525

  Fly  1740 TLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQN 1804
            |||||||.||||.:|..|:|..:|:.||....|..::.:|:||.::..||.|||||..:|:|||.
Zfish  1526 TLFTVSTGEGWPQVLQHSVDVTEEDRGPSQGNRMEMSIFYVIYFVVFPFFFVNIFVALIIITFQE 1590

  Fly  1805 EGEQEYKNCDLDKNQRNCIEFALKAKPVRRYIP--KHGIQYKVWWFVTSSSFEYTIFILIMINTV 1867
            :|::..:.|.|:||:|.||:||:.|||:.||:|  :..:||::|.||.|.|||||:..:|.:||:
Zfish  1591 QGDKMMEECSLEKNERACIDFAISAKPLTRYMPQNRQTLQYRLWQFVVSPSFEYTVLTMIALNTI 1655

  Fly  1868 TLAMKFYNQPL-WYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDI 1931
            .|.||.::..| .|.::|..||.|||.:|::|.|.|:.||...|||.|.||:||||.||||..:|
Zfish  1656 VLMMKHHDPRLEGYDDVLKYLNTIFTVIFSVECVLKILAFGIMNYFRDTWNIFDFITVLGSITEI 1720

  Fly  1932 VYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFI 1996
            :..:.::..|                       .::.|.:|||..||:|||.:|..||.|||||:
Zfish  1721 LVDKFQTGKT-----------------------FNMGFLKLFRAARLIKLLRQGYTIRILLWTFV 1762

  Fly  1997 KSFQALPYVALLIVLLFFIYAVVGMQVFGKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQ 2061
            :||:|||||.|||.:||||||::||||||.|.::....|..:|||:||..|:::||||||||:||
Zfish  1763 QSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKINEKTQINEHNNFRTFFGALMLLFRSATGESWQ 1827

  Fly  2062 EIMMSCSAQPDVKCD--MNSDTP--GEPCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLT 2122
            |||:||..:.:.:.|  :||.|.  ...||:..||.||:||....|||::|||||||||||:|||
Zfish  1828 EIMLSCLGEKECEIDTSVNSTTKTIKNDCGTDFAYFYFVSFIFFSSFLMLNLFVAVIMDNFEYLT 1892

  Fly  2123 RDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNM 2187
            ||.|||||||||||:|:|.|||..|.|::.:.::..::|.|||||||||.||:|:||||||.|||
Zfish  1893 RDSSILGPHHLDEFVRIWGEYDRAACGKLHYKEMYKVVRTISPPLGFGKNCPYRVACKRLVLMNM 1957

  Fly  2188 PLNSDGTVLFNATLFAVVRTSLSIKTDGNIDDANS---ELRATIKQIWKRTNPKLLDQVVPPPGN 2249
            |::.|.:|.|.:||.|::||:|.||.....:|...   ||:..|..||...:.|.||.:||....
Zfish  1958 PVDEDMSVHFTSTLMALIRTALDIKIARGGEDRGQMDVELQKEISVIWPHLSQKSLDLLVPIHKA 2022

  Fly  2250 DDEVTVGKFYATYLIQDYFR--RFKKRKEQEGKEGHP---------------------------D 2285
            .| :|:||.||..:|.||::  :.||.::|..::.|.                           .
Zfish  2023 SD-MTIGKIYAAMMIMDYYKQNKAKKLRQQLEEQKHAPMFQRMDASSLPQDILCSAKALPFLTHS 2086

  Fly  2286 SNTVTLQAGLRTLHEVSPA---LKRAISGNLDELDQEPEPMHRR----HHTLFGSVW-------S 2336
            :.:...:.|...|..:||.   ::.....:::|.::...|.|.:    .|..|.||.       .
Zfish  2087 AGSALTRGGFVALSPISPQDLFMQPMTQDSMEEREEYQHPYHLQSMVPEHKEFSSVMCPTSMQAD 2151

  Fly  2337 SIRRHGNGTFRRSAKATASQSNGALAIGGSASAALGVGGSSLVLGSSDPAGGDYLYD-TLNRSVA 2400
            .::..|.|...|::      |...||:...||....:...|..........||:..: :|.|...
Zfish  2152 PLQVPGRGVSIRAS------SMPRLAVEPQASLENKLMKRSFSTIGDQCVNGDWQEEFSLERVSP 2210

  Fly  2401 DGVNNITRNIMQARLAAAGKLQDELQGAGSGGELRTF-GESISMR-PLAKNGGGAATVAGTLPPE 2463
            |                  :|:...|        |:| |...::| |:.|..|.:......|.|:
Zfish  2211 D------------------RLERPRQ--------RSFRGVRSNLREPVDKERGRSKERRHLLSPD 2249

  Fly  2464 ANAINYDNRNRG---------------ILLHPYNNVYAP-----NGALPGHERMIQSTPASP 2505
            .:..|.:.|::.               ..|...||..:|     :...|...|.:..||:.|
Zfish  2250 VSRCNSEERSQSQERRHSPSPSEGRKHTALRQGNNTGSPIASTSDSGTPRGRRQLPQTPSRP 2311

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 154/278 (55%)
Ion_trans 1137..1379 CDD:395416 141/244 (58%)
Ion_trans 1496..1809 CDD:395416 137/320 (43%)
Ion_trans 1851..2126 CDD:395416 135/279 (48%)
GPHH 2135..2188 CDD:407139 30/52 (58%)
Ca_chan_IQ 2199..2271 CDD:400901 28/76 (37%)
cacna1eXP_017212914.2 Ion_trans 247..524 CDD:306908 154/278 (55%)
Ion_trans 640..875 CDD:306908 140/241 (58%)
Atrophin-1 887..>1210 CDD:331285 25/322 (8%)
Ion_trans 1316..1549 CDD:306908 118/273 (43%)
Ion_trans 1639..1896 CDD:306908 135/279 (48%)
GPHH 1897..1967 CDD:318993 42/69 (61%)
Ca_chan_IQ 1969..2043 CDD:312334 28/74 (38%)
Transformer 2203..2368 CDD:253769 25/135 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100303
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
54.820

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