DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and cacna1aa

DIOPT Version :10

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:NP_001429978.1 Gene:cacna1aa / 562059 ZFINID:ZDB-GENE-040724-26 Length:2483 Species:Danio rerio


Alignment Length:2479 Identity:859/2479 - (34%)
Similarity:1172/2479 - (47%) Gaps:678/2479 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   649 FERGASGEGGFSPNGN-----GGPGSGDVSRTARYDSGEGDLGGGNNIMGIDSMGIANIPETMNG 708
            ||..:||..|| |...     |....|| ...:||..|.|...||                    
Zfish   103 FEWVSSGCSGF-PQVQRHVQIGMARFGD-EVPSRYGGGPGHAQGG-------------------- 145

  Fly   709 TTIGPSGAGGQKGGAAAGAAGQKRQQRRGKPQPDRP----------------QRALFCLSVKNPL 757
                 .|.||.:.|...||  |:|..::...|..|.                .|:||..|..|.:
Zfish   146 -----PGRGGSRQGGPPGA--QQRMYKQSMAQRARTMALYNPIPVRQNCFTVNRSLFIFSEDNFV 203

  Fly   758 RALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVIFTAECVMKI 822
            |....:|.||.|||::||.||.||||.||:....|..|....::.||..|..|:.||..|..:||
Zfish   204 RKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLEDTEPYFIGIFCFESGIKI 268

  Fly   823 LAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAFRVLRPLRLVSGVPSL 887
            ||.||..|.|:|||||||::||.:|:.|.:||..|.     ||::.|||.||||||:||||:|||
Zfish   269 LALGFAFHKGSYLRNGWNVMDFVVVLTGILSTVGSD-----FDLRTLRAVRVLRPLKLVSGIPSL 328

  Fly   888 QVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDEITGEYEENIRPCGVGYQ- 951
            ||||.||:|||:||..|.||:.|.|:::||||||.:.||.|..|.|:||.|..|.. |||.... 
Zfish   329 QVVLKSIMKAMIPLLQIGLLLFFAILMFAIIGLEFYMGKFHTTCFDKITDEIREEF-PCGEEVPA 392

  Fly   952 --CPPGYKCYGGWDGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISM 1014
              ||.|..|...|.|||.|||.|||...|:||||||:|:|||||:||...||.||.|.|||||.:
Zfish   393 RICPNGTVCKKYWLGPNYGITQFDNILFAVLTVFQCITMEGWTDLLYYSNDAAGSAWNWMYFIPL 457

  Fly  1015 VILGAFFVMNLILGVLSGEFSKERNKAKNRGDFQKLREKQQIEEDLRGYLDWITQAEDI------ 1073
            :|:|:||::||:||||||||:|||.:.:||.:|.||:.:||||.:|.|||:||.:||::      
Zfish   458 IIIGSFFMLNLVLGVLSGEFAKERERVENRSEFLKLKRQQQIERELNGYLEWICKAEEVILADED 522

  Fly  1074 -EPDAVGGLISDGKGKQP----------NEMDSTENLGEEMPEVQMTESRWRKMKKDFDRVNRRM 1127
             :||  ..:..||..::|          :..|...::|.......:..|:..  ...|.:..||:
Zfish   523 NDPD--DRMPFDGSRRRPTIKKSKTDLLDAEDGDGDIGSPFARGSLKSSKLE--GSSFHKKERRL 583

  Fly  1128 RRACRKAVKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSL 1192
            |...|:.||:|||||.::.||.|||..:|..||.|.:.|.:|..:....|:|:|..||.:|||.|
Zfish   584 RFFIRRIVKTQAFYWTVLCLVGLNTLCVAVVHYDQPETLSDFLYFAEFIFLGIFMSEMCIKMYGL 648

  Fly  1193 GFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPP---LGVSVLRCVRLLRVFKVTKYWRSLSNL 1254
            |.:.||.|.||.|||.|:.|||.|.|   ..|:.|   .|:||||.:||||:|||||||.||.||
Zfish   649 GTRPYFHSSFNCFDCIVICGSIFEVL---WAMIQPGTSFGISVLRALRLLRIFKVTKYWASLRNL 710

  Fly  1255 VASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEKYRMNFDCFWQALLTVFQIMT 1319
            |.|||||::||.|||.|||||||:|||||||:|||:|||:.....  .|||.|..|::|||||:|
Zfish   711 VVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFEAGTPP--TNFDTFPAAIMTVFQILT 773

  Fly  1320 GEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYILLNVFLAIAVDNLADADSLSEVEKEE 1384
            |||||.|||.||.:.|||.. |.:..::||:|.:.|||.||||||||||||||:|..|::.|:||
Zfish   774 GEDWNMVMYDGIESQGGVKK-GMVFSVFFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEE 837

  Fly  1385 E---------------------------------PH---------------------DESAQKKS 1395
            |                                 ||                     |...|:|:
Zfish   838 EQAANKKMALQTAKEVAEVSPLSAANLSIAASCQPHNHKGQNVTVNSERLDATEHFLDCKEQQKN 902

  Fly  1396 HSPTPTI---------------------------------------DGMDDHLSIDIDMEQQEL- 1420
            |....::                                       ..|..||...:.::.||. 
Zfish   903 HKGCKSVWEQRTSELRRQTLVNSREALYNELDPEDRWKVSYSRHIRPDMKTHLDRPLVVDPQENR 967

  Fly  1421 ----------DDEDKMDHETLSD---------------------------------------EEV 1436
                      |.:.:..|:.|..                                       ||.
Zfish   968 NNNTNKTRPGDGQPQHSHQLLHKQPNFNEAETGGGGGSESWPALERGDSTGSRRSLLGSEHYEEG 1032

  Fly  1437 REM-----------------------------------------CE--------------EEEEV 1446
            ||.                                         ||              |.|..
Zfish  1033 RESHRRHQHSQHCSQARQHRKAAEGGGEPGGRRHRSKAKERGPECEHSDGGERKHRRHRHEGEGR 1097

  Fly  1447 DEEG---------------MITARP------RRMSE------------------------VNTA- 1465
            .|.|               :.|.||      |:.|:                        .||| 
Zfish  1098 KERGVRHRNRRDGHASGPTLSTTRPIQKTLSRQDSQYSEDLDNAMNNKLATQPHDSLLNLANTAH 1162

  Fly  1466 -------------------------TKI------------------------------------- 1468
                                     |.|                                     
Zfish  1163 SAGLAHTGTESSLILTNPSSTIANVTSIGHLGMKPEYTAVDIPPMFPSSNAILQVNKNANTEPLP 1227

  Fly  1469 -------------------LPIPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAML 1514
                               .|:||.||.|:.:.||.||..||::.....|...||..|..||..|
Zfish  1228 KKEDTKGDDDDDEKDDGGPKPMPPYTSMFILTTTNPFRRLCHYIVTLRYFEMCILLVIAMSSIAL 1292

  Fly  1515 AAENPLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLI 1579
            |||:|:......|.||..|||.||.|||.|:::|::..|.|||.|::.|..:|:||.:||..:|:
Zfish  1293 AAEDPVWPESPRNNVLRYFDYVFTGVFTFEMLIKMVDLGLVLHQGSYFRDLWNILDFIVVSGALV 1357

  Fly  1580 SLVSSSNA----ISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMF 1640
            :...:.|:    ||.:|.||||||||||:.|.|...||.|..                       
Zfish  1358 AFAFTGNSKGKDISTIKSLRVLRVLRPLKTIKRLPKLKAVFD----------------------- 1399

  Fly  1641 AVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGT 1705
                         |||.::|.:.||::|..|..|:|||:.||||||:||.|||.||..:.:|.|.
Zfish  1400 -------------CVVNSLKNVLNILIVYMLFMFIFAVVAVQLFKGRFFYCTDESKEFERDCRGE 1451

  Fly  1706 YLVYD-DGDVHKPRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIH 1769
            ||||: |.:|   |.::|||....||:|:|...:||||||||.||||.:|..|:|:..||.||..
Zfish  1452 YLVYERDNEV---RSQKREWKKYDFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATYENQGPSP 1513

  Fly  1770 NFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQEYKNCDLDKNQRNCIEFALKAKPVRR 1834
            .:|..::.:|::|.::..||.|||||..:|:|||.:|::..::..|:||:|.||:||:.|||:.|
Zfish  1514 GYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEDYSLEKNERACIDFAINAKPLTR 1578

  Fly  1835 YIP--KHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFAL 1897
            ::|  |...||::|.||.|..|||||..||.:||:.|.||:....|.|.::|..||::||::|::
Zfish  1579 HMPQNKQTFQYRMWEFVVSPPFEYTIMALIALNTIVLMMKYDGASLTYEDVLKYLNIVFTSLFSM 1643

  Fly  1898 EFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGS 1962
            |.:.|:.||...|||.||||:||.:.||||..||:.:|:                        |:
Zfish  1644 ECILKIIAFGALNYFKDAWNIFDCVTVLGSITDILVTEL------------------------GN 1684

  Fly  1963 NLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKI 2027
            |.|:::|.||||..||:|||.:||.||.|||||::||:|||||.|||.:||||||::|||:||.|
Zfish  1685 NFINLSFLRLFRAARLIKLLRQGETIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQLFGNI 1749

  Fly  2028 ALD--GGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGEPCGSSI 2090
            .::  ..:|||.:|||:||.||:::||||||||||.:||:||..:.  .||:.||.....|||..
Zfish  1750 KIEENSDSAITQHNNFRTFFQALMLLFRSATGEAWHDIMLSCLGKK--PCDILSDNLKPECGSEF 1812

  Fly  2091 AYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLD 2155
            ||.||:||..|||||::|||||||||||:|||||.||||||||||::|:|:||||.|.|||.:.|
Zfish  1813 AYLYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRIWAEYDPAACGRIHYKD 1877

  Fly  2156 VVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIK-TDGNID- 2218
            :.:|||.|.||||.||.||||:|||||:.|::|:..|.||.||:||.|::||:|.|| ..|.:| 
Zfish  1878 MYSLLRVIDPPLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGVDK 1942

  Fly  2219 -DANSELRATIKQIWKRTNPKLLDQVVPPPGNDDEVTVGKFYATYLIQDYFRRFKKRKEQEGKEG 2282
             ..::|||..:..||...:.|.||.:|.|..:..::||||.||..:|.:|:|:.|.::.|     
Zfish  1943 HQMDAELRKEMMAIWPNLSQKNLDLLVTPHKSATDLTVGKIYAAMMIMEYYRQSKAKRTQ----- 2002

  Fly  2283 HPDSNTVTLQAGLRTLHEVSPALKRAISGNLDELDQEPEPMHRRHHTLFGSVWSSIRRHGNGTFR 2347
                          .||:                :|...|:                     .|:
Zfish  2003 --------------ALHD----------------EQNRTPL---------------------MFQ 2016

  Fly  2348 RSAKATASQSNGALAIGGSASAALGVGGSSLVLGSSDPAGGDYLYDTLNRSVADGVNNITRNIMQ 2412
            |....:.||.             :|.|.:.|......||.    :..::..:.:..:.:|....:
Zfish  2017 RLEPPSPSQD-------------VGPGLTGLPDTQMHPAN----HLPVDERIPESQSWVTARAQE 2064

  Fly  2413 ARLAAAGKLQDELQGAGSGGELRTFGESISMRPLAKNGGGAATVAGTLPPEANAINYDNRNRGIL 2477
            .. ..||....|.|......:.|...:::.||.:.::|                  |.:..:   
Zfish  2065 IS-QKAGNWSPEGQHPDDTTDNRRQSQTVEMREMGRDG------------------YSDTEQ--- 2107

  Fly  2478 LHPYNNVYAPNGALPGHERMIQSTPASPYD-QRRLPTSSDMNGLAESLIGGVLAAEGLGKYCDSE 2541
                   |.|   :.||.| ..|.|..|.| |:.:..:|.|...|.||        |.|:     
Zfish  2108 -------YLP---MEGHGR-AASMPRLPADNQQPITDNSPMKRSASSL--------GHGR----- 2148

  Fly  2542 FVGTAAREMR---EALD-MTPEEMNLAAHQILSNEHSLSLIGSSNGSIFGGSAGGLG-----GAG 2597
                |.|.||   .|:: :.|||.:...|:.....|..|   ..:.|.:..:..|||     ...
Zfish  2149 ----AGRSMRGEDYAMERVIPEEGHRHGHRHRDRSHRAS---ERSLSRYTDADTGLGTDLSTTTQ 2206

  Fly  2598 SGGV-----------------------GGLG----GSSSIRNAFGGSGSGPS----SLSPQ---- 2627
            ||.:                       |.|.    |....|..:|...|...    |.||.    
Zfish  2207 SGDLPSKERDRGRAKDRKHHHHHHHHHGSLDKEHYGHERDRGEYGHRQSRERDRRWSRSPSEGRE 2271

  Fly  2628 ---HQPYSGTLNSPPIPDNRLRRVATVTTTNNNNKSQVSQNNSNSLNVRANANSQMNMSPTGQPV 2689
               |:..|.:::..|:|.      .:.|:|....:.|:.|       ..|.....:..||..:..
Zfish  2272 CLTHRQGSSSVSGSPVPS------TSGTSTPRRGRRQLPQ-------TPATPRPHVTYSPVVRKP 2323

  Fly  2690 QQQSPLRGQ 2698
            ...:|..||
Zfish  2324 ISSTPPPGQ 2332

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:459842 153/277 (55%)
Ion_trans 1137..1379 CDD:459842 140/244 (57%)
Ion_trans 1496..1809 CDD:459842 130/317 (41%)
Ion_trans 1851..2126 CDD:459842 143/276 (52%)
GPHH 2135..2188 CDD:465306 32/52 (62%)
Ca_chan_IQ 2198..2273 CDD:462591 30/77 (39%)
cacna1aaNP_001429978.1 None

Return to query results.
Submit another query.