DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and cacna1aa

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:XP_021330047.1 Gene:cacna1aa / 562059 ZFINID:ZDB-GENE-040724-26 Length:2371 Species:Danio rerio


Alignment Length:2449 Identity:845/2449 - (34%)
Similarity:1160/2449 - (47%) Gaps:664/2449 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   676 ARYDSGEGDLGGGNNIMGIDSMGIANIPETMNGTTIGPSGAGGQKGGAAAGAAGQKRQQRRGKPQ 740
            :||..|.|...||                         .|.||.:.|...||  |:|..::...|
Zfish    10 SRYGGGPGHAQGG-------------------------PGRGGSRQGGPPGA--QQRMYKQSMAQ 47

  Fly   741 PDRP----------------QRALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYT 789
            ..|.                .|:||..|..|.:|....:|.||.|||::||.||.||||.||:..
Zfish    48 RARTMALYNPIPVRQNCFTVNRSLFIFSEDNFVRKYAKKITEWPPFEYMILATIIANCIVLALEQ 112

  Fly   790 PYPGSDSNVTNQTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAIST 854
            ..|..|....::.||..|..|:.||..|..:||||.||..|.|:|||||||::||.:|:.|.:||
Zfish   113 HLPDGDKTPMSERLEDTEPYFIGIFCFESGIKILALGFAFHKGSYLRNGWNVMDFVVVLTGILST 177

  Fly   855 ALSQLMKDAFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIG 919
            ..|.     ||::.|||.||||||:||||:|||||||.||:|||:||..|.||:.|.|:::||||
Zfish   178 VGSD-----FDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILMFAIIG 237

  Fly   920 LELFSGKLHKACRDEITGEYEENIRPCGVGYQ---CPPGYKCYGGWDGPNDGITNFDNFGLAMLT 981
            ||.:.||.|..|.|:||.|..|.. |||....   ||.|..|...|.|||.|||.|||...|:||
Zfish   238 LEFYMGKFHTTCFDKITDEIREEF-PCGEEVPARICPNGTVCKKYWLGPNYGITQFDNILFAVLT 301

  Fly   982 VFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERNKAKNRGD 1046
            ||||:|:|||||:||...||.||.|.|||||.::|:|:||::||:||||||||:|||.:.:||.:
Zfish   302 VFQCITMEGWTDLLYYSNDAAGSAWNWMYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRSE 366

  Fly  1047 FQKLREKQQIEEDLRGYLDWITQAEDI-------EPDAVGGLISDGKGKQP----------NEMD 1094
            |.||:.:||||.:|.|||:||.:||::       :||  ..:..||..::|          :..|
Zfish   367 FLKLKRQQQIERELNGYLEWICKAEEVILADEDNDPD--DRMPFDGSRRRPTIKKSKTDLLDAED 429

  Fly  1095 STENLGEEMPEVQMTESRWRKMKKDFDRVNRRMRRACRKAVKSQAFYWLIIVLVFLNTGVLATEH 1159
            ...::|.......:..|:..  ...|.:..||:|...|:.||:|||||.::.||.|||..:|..|
Zfish   430 GDGDIGSPFARGSLKSSKLE--GSSFHKKERRLRFFIRRIVKTQAFYWTVLCLVGLNTLCVAVVH 492

  Fly  1160 YGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGM 1224
            |.|.:.|.:|..:....|:|:|..||.:|||.||.:.||.|.||.|||.|:.|||.|.|   ..|
Zfish   493 YDQPETLSDFLYFAEFIFLGIFMSEMCIKMYGLGTRPYFHSSFNCFDCIVICGSIFEVL---WAM 554

  Fly  1225 MPP---LGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQV 1286
            :.|   .|:||||.:||||:|||||||.||.|||.|||||::||.|||.|||||||:|||||||:
Zfish   555 IQPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQL 619

  Fly  1287 FGGKFNFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIIL 1351
            |||:|||:.....  .|||.|..|::|||||:||||||.|||.||.:.|||.. |.:..::||:|
Zfish   620 FGGQFNFEAGTPP--TNFDTFPAAIMTVFQILTGEDWNMVMYDGIESQGGVKK-GMVFSVFFIVL 681

  Fly  1352 FICGNYILLNVFLAIAVDNLADADSLSEVEKEEEPHDESAQKK----------SHSP-------- 1398
            .:.|||.||||||||||||||:|..|::.|:|||   ::|.||          ..||        
Zfish   682 TLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEE---QAANKKMALQTAKEVAEVSPLSAANLSI 743

  Fly  1399 ---TPTIDGMD--DHLSIDIDMEQQ--------------------------------ELDDEDK- 1425
               |...:.:|  :|.   :|.::|                                |||.||: 
Zfish   744 AAVTVNSERLDATEHF---LDCKEQQKNHKGCKSVWEQRTSELRRQTLVNSREALYNELDPEDRW 805

  Fly  1426 ---------------MDHETLSD------------------------------------------ 1433
                           :|...:.|                                          
Zfish   806 KVSYSRHIRPDMKTHLDRPLVVDPQENRNNNTNKTRPGDGQPQHSHQLLHKQPNFNEAETGGGGG 870

  Fly  1434 -------------------------EEVREM---------------------------------- 1439
                                     ||.||.                                  
Zfish   871 SESWPALERGDSTGSRRSLLGSEHYEEGRESHRRHQHSQHCSQARQHRKAAEGGGEPGGRRHRSK 935

  Fly  1440 -------CE--------------EEEEVDEEG---------------MITARP------RRMSE- 1461
                   ||              |.|...|.|               :.|.||      |:.|: 
Zfish   936 AKERGPECEHSDGGERKHRRHRHEGEGRKERGVRHRNRRDGHASGPTLSTTRPIQKTLSRQDSQY 1000

  Fly  1462 -----------------------VNTA--------------------------TKI--------- 1468
                                   .|||                          |.|         
Zfish  1001 SEDLDNAMNNKLATQPHDSLLNLANTAHSAGLAHTGTESSLILTNPSSTIANVTSIGHLGMKPEY 1065

  Fly  1469 -----------------------------------------------LPIPPGTSFFLFSQTNRF 1486
                                                           .|:||.||.|:.:.||.|
Zfish  1066 TAVDIPPMFPSSNAILQVNKNANTEPLPKKEDTKGDDDDDEKDDGGPKPMPPYTSMFILTTTNPF 1130

  Fly  1487 RVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDDLNKVLNKFDYFFTAVFTIELILKLIS 1551
            |..||::.....|...||..|..||..||||:|:......|.||..|||.||.|||.|:::|::.
Zfish  1131 RRLCHYIVTLRYFEMCILLVIAMSSIALAAEDPVWPESPRNNVLRYFDYVFTGVFTFEMLIKMVD 1195

  Fly  1552 YGFVLHDGAFCRSAFNLLDLLVVCVSLISLV--------SSSNAISVVKILRVLRVLRPLRAINR 1608
            .|.|||.|::.|..:|:||.:||..:|::..        |....||.:|.||||||||||:.|.|
Zfish  1196 LGLVLHQGSYFRDLWNILDFIVVSGALVAFAFTGGSGGSSKGKDISTIKSLRVLRVLRPLKTIKR 1260

  Fly  1609 AKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQ 1673
            ...||.|..                                    |||.::|.:.||::|..|..
Zfish  1261 LPKLKAVFD------------------------------------CVVNSLKNVLNILIVYMLFM 1289

  Fly  1674 FMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYD-DGDVHKPRLREREWSNNRFHFDDVAKG 1737
            |:|||:.||||||:||.|||.||..:.:|.|.||||: |.:|   |.::|||....||:|:|...
Zfish  1290 FIFAVVAVQLFKGRFFYCTDESKEFERDCRGEYLVYERDNEV---RSQKREWKKYDFHYDNVLWA 1351

  Fly  1738 MLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTF 1802
            :||||||||.||||.:|..|:|:..||.||...:|..::.:|::|.::..||.|||||..:|:||
Zfish  1352 LLTLFTVSTGEGWPQVLKHSVDATYENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITF 1416

  Fly  1803 QNEGEQEYKNCDLDKNQRNCIEFALKAKPVRRYIP--KHGIQYKVWWFVTSSSFEYTIFILIMIN 1865
            |.:|::..::..|:||:|.||:||:.|||:.|::|  |...||::|.||.|..|||||..||.:|
Zfish  1417 QEQGDKMMEDYSLEKNERACIDFAINAKPLTRHMPQNKQTFQYRMWEFVVSPPFEYTIMALIALN 1481

  Fly  1866 TVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFID 1930
            |:.|.||:....|.|.::|..||::||::|::|.:.|:.||...|||.||||:||.:.||||..|
Zfish  1482 TIVLMMKYDGASLTYEDVLKYLNIVFTSLFSMECILKIIAFGALNYFKDAWNIFDCVTVLGSITD 1546

  Fly  1931 IVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTF 1995
            |:.:|:                       ..:|.|:::|.||||..||:|||.:||.||.|||||
Zfish  1547 ILVTEL-----------------------GMNNFINLSFLRLFRAARLIKLLRQGETIRILLWTF 1588

  Fly  1996 IKSFQALPYVALLIVLLFFIYAVVGMQVFGKIALD--GGNAITANNNFQTFQQAVLVLFRSATGE 2058
            ::||:|||||.|||.:||||||::|||:||.|.::  ..:|||.:|||:||.||:::||||||||
Zfish  1589 VQSFKALPYVCLLIAMLFFIYAIIGMQLFGNIKIEENSDSAITQHNNFRTFFQALMLLFRSATGE 1653

  Fly  2059 AWQEIMMSCSAQPDVKCDMNSDTPGEPCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTR 2123
            ||.:||:||..:.  .||:.||.|...|||..||.||:||..|||||::|||||||||||:||||
Zfish  1654 AWHDIMLSCLGKK--PCDILSDNPKPECGSEFAYLYFVSFIFLCSFLMLNLFVAVIMDNFEYLTR 1716

  Fly  2124 DWSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMP 2188
            |.||||||||||::|:|:||||.|.|||.:.|:.:|||.|.||||.||.||||:|||||:.|::|
Zfish  1717 DSSILGPHHLDEYVRIWAEYDPAACGRIHYKDMYSLLRVIDPPLGLGKKCPHRVACKRLLRMDLP 1781

  Fly  2189 LNSDGTVLFNATLFAVVRTSLSIKT----DGNID--DANSELRATIKQIWKRTNPKLLDQVVPPP 2247
            :..|.||.||:||.|::||:|.||.    :|.:|  ..::|||..:..||...:.|.||.:|.|.
Zfish  1782 VADDNTVHFNSTLMALIRTALDIKIAKGGEGGVDKHQMDAELRKEMMAIWPNLSQKNLDLLVTPH 1846

  Fly  2248 GNDDEVTVGKFYATYLIQDYFRRFKKRKEQEGKEGHPDSNTVTLQAGLRTLHEVSPALKRAISGN 2312
            .:..::||||.||..:|.:|:|:.|.::.|                   .||:            
Zfish  1847 KSATDLTVGKIYAAMMIMEYYRQSKAKRTQ-------------------ALHD------------ 1880

  Fly  2313 LDELDQEPEPMHRRHHTLFGSVWSSIRRHGNGTFRRSAKATASQSNGALAIGGSASAALGVGGSS 2377
                :|...|:                     .|:|....:.||.             :|.|.:.
Zfish  1881 ----EQNRTPL---------------------MFQRLEPPSPSQD-------------VGPGLTG 1907

  Fly  2378 LVLGSSDPAGGDYLYDTLNRSVADGVNNITRNIMQARLAAAGKLQDELQGAGSGGELRTFGESIS 2442
            |......||.    :..::..:.:..:.:|....:.. ..||....|.|......:.|...:::.
Zfish  1908 LPDTQMHPAN----HLPVDERIPESQSWVTARAQEIS-QKAGNWSPEGQHPDDTTDNRRQSQTVE 1967

  Fly  2443 MRPLAKNG-------------GGAATVAGTLPPEANAINYDNRNRGILLHPYNNVYAP------- 2487
            ||.:.::|             |.||::     |...|.|...|.:|  .|...|:..|       
Zfish  1968 MREMGRDGYSDTEQYLPMEGHGRAASM-----PRLPADNQQPRRKG--RHRGENLTQPITDNSPM 2025

  Fly  2488 --NGALPGHERMIQSTPASPYDQRR-LPTSSDMNGLAESLIGGVLAAEGLGKYCDSEF-VGTAAR 2548
              :.:..||.|..:|.....|...| :|.....:|..........:...|.:|.|::. :||...
Zfish  2026 KRSASSLGHGRAGRSMRGEDYAMERVIPEEGHRHGHRHRDRSHRASERSLSRYTDADTGLGTDLS 2090

  Fly  2549 EMREALDMTPEEMNLAA-------------HQILSNEHSLSLIGSSNGSIFGGSAGGLGGAGSGG 2600
            ...::.|:..:|.:...             |..|..||.                          
Zfish  2091 TTTQSGDLPSKERDRGRAKDRKHHHHHHHHHGSLDKEHY-------------------------- 2129

  Fly  2601 VGGLGGSSSIRNAFGGSGSGPS----SLSPQ-------HQPYSGTLNSPPIPDNRLRRVATVTTT 2654
                 |....|..:|...|...    |.||.       |:..|.:::..|:|.      .:.|:|
Zfish  2130 -----GHERDRGEYGHRQSRERDRRWSRSPSEGRECLTHRQGSSSVSGSPVPS------TSGTST 2183

  Fly  2655 NNNNKSQVSQNNSNSLNVRANANSQMNMSPTGQPVQQQSPLRGQ 2698
            ....:.|:.|       ..|.....:..||..:.....:|..||
Zfish  2184 PRRGRRQLPQ-------TPATPRPHVTYSPVVRKPISSTPPPGQ 2220

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 153/277 (55%)
Ion_trans 1137..1379 CDD:395416 140/244 (57%)
Ion_trans 1496..1809 CDD:395416 130/321 (40%)
Ion_trans 1851..2126 CDD:395416 143/276 (52%)
GPHH 2135..2188 CDD:407139 32/52 (62%)
Ca_chan_IQ 2199..2271 CDD:400901 29/77 (38%)
cacna1aaXP_021330047.1 Ion_trans 90..362 CDD:306908 153/277 (55%)
Ion_trans 471..709 CDD:306908 140/243 (58%)
Ion_trans 1141..1377 CDD:306908 111/274 (41%)
Ion_trans 1467..1719 CDD:306908 143/276 (52%)
GPHH 1720..1790 CDD:318993 44/69 (64%)
Ca_chan_IQ 1792..1870 CDD:312334 29/77 (38%)
SOBP <2151..2361 CDD:317654 17/83 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100303
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.820

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