DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and cacna1ha

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:XP_021330381.1 Gene:cacna1ha / 560875 ZFINID:ZDB-GENE-130103-1 Length:2198 Species:Danio rerio


Alignment Length:2407 Identity:558/2407 - (23%)
Similarity:929/2407 - (38%) Gaps:824/2407 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   775 LLTIFANCIALAVYTPYPG----SDSNVTNQTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYL 835
            :|.|..||:.|.:|.|...    |:..:..|..:...:.|   |..|.|:|::|.|....|| ||
Zfish     1 MLVILLNCVTLGMYQPCEDLKCQSEWCIVLQAFDDCIFAF---FAVEMVIKMIALGIFGING-YL 61

  Fly   836 RNGWNLLDFTIVVIGAISTALSQLMKDAFD--VKALRAFRVLRPLRLVSGVPSLQVVLNSILKAM 898
            .:.||.|||.||:.|.:..:|     |..:  :.|:|..|||||||.::.|||:::::..:|..:
Zfish    62 GDTWNRLDFFIVMAGMMEYSL-----DGHNASLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTL 121

  Fly   899 VPLFHIALLVLFVIIIYAIIGLELFSGKLHKAC------RDEITGEY----------EEN----- 942
            ..|.::.||..||..|:.|:|::|::|.|...|      ||:....|          |:|     
Zfish   122 PMLGNVLLLCFFVFFIFGIVGVQLWAGLLRNRCFMPSKVRDQYNLSYMSLYYENEDGEDNPFICS 186

  Fly   943 ------IRPCGVGYQCPP---GYKC----------YGGWDG----------------------PN 966
                  ::.|..   .||   |.:|          |.|..|                      |:
Zfish   187 SSKDNGMKRCSA---VPPLKEGVECTLNASFLGHVYSGLSGTGNYSCVNWNQYYSECKPGDLNPH 248

  Fly   967 DGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLS 1031
            .|..||||.|.|.:.:||.:|||||.|::|.:.|| .|.:.::|||.::|:|:||::||.|.|::
Zfish   249 KGAVNFDNIGYAWIAIFQVITLEGWVDIMYYVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIA 312

  Fly  1032 GEF--SKER----------------------------------------NKAKNR-----GDFQK 1049
            .:|  :|:|                                        .|.|.|     ..:|.
Zfish   313 TQFAETKQRENMLMKEQRARYRSNDSTLASYSEPGSCYEEMLKYVSHLYRKVKRRLSRIYNSWQS 377

  Fly  1050 LREKQQIEEDL------------RGYLDWITQAEDI----------------------------- 1073
            .|.| ::..:.            |||..|:.....:                             
Zfish   378 KRRK-KVNPNTGAGGGANGHSRHRGYGHWVQSIHSLIQQHQRQHCHLSNGSPSPVATTGSSEALE 441

  Fly  1074 --------------EPDAVGGLISDGKG----------KQPNEMDSTE---------NLGEEMPE 1105
                          :|.|...|.|..:.          :.|.|...|.         |.|...|.
Zfish   442 MRSITAGQQLTVSSQPTATHNLSSSTQSVHSIYQGDFREAPQERTPTNVAVPALSRLNGGMNYPT 506

  Fly  1106 V------------QMTESRWR-------KMKKDFDRVNRRM------------------------ 1127
            :            .:.:.|.:       ::.:|||::::::                        
Zfish   507 ILPSLICNYSGGGSLGKERGKSDANTGHEVIQDFDKLHQQIEAHSHSRVLLQMAGVVPTQLLLEV 571

  Fly  1128 ---------------------------------------------------------------RR 1129
                                                                           |.
Zfish   572 MSCPYCVRALESMDLEIGDSDYPRSEGDMVYEFSYDAGFITGRSAHHKMQEKQNRLVQFWEDFRE 636

  Fly  1130 ACRKAVKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGF 1194
            ...:.|.|:.|...|::.:.:||..:..|::.|.:.|.|..|.:|:.|..:|..|||.|:.:.|.
Zfish   637 RLTRIVDSKYFNRGIMIAILINTLSMGIEYHEQPEELTNILEISNIVFTSMFVLEMLFKLLAFGI 701

  Fly  1195 QGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLL 1259
            .||..:.:|.||..:|:.|:.|.:....|     |:||||..|||||.|:.::..:|...:..|:
Zfish   702 FGYIRNPYNIFDGVIVVISVWEIIGHADG-----GLSVLRTFRLLRVLKLVRFLPALRRQLLVLM 761

  Fly  1260 NSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNF---DGKEEKYRMNFDCFWQALLTVFQIMTGE 1321
            .::.::|:..:||.|||..|::|||.:||.||:.   :|.....|.|||....|::|||||:|.|
Zfish   762 KTMDNVATFCMLLMLFIFTFSILGMHLFGCKFSLKMENGDTIPDRKNFDSLLWAIVTVFQILTQE 826

  Fly  1322 DWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYILLNVFLAIAVD--------NLADAD--- 1375
            |||.|:      |.|::|....|.:||:.|...|||:|.|:.:||.|:        |.:|.|   
Zfish   827 DWNVVL------YNGMASTSPWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDANKSDGDEEK 885

  Fly  1376 -SLSEVEKEEEPHDESAQKKSHS------------------------------------PTP--- 1400
             |::..||.|:.  :|::..|.|                                    |||   
Zfish   886 TSVNSEEKMEQL--QSSEPLSISDPDLKFYSLMLSANGHVDPCGTLPPPIIMRTAATPMPTPKSS 948

  Fly  1401 ---------TIDGMDDHLSIDID-MEQQELD---------------------------------- 1421
                     |.......:|||.: .:|:.|.                                  
Zfish   949 LGPESVFDLTESRRGSAVSIDPNAFDQKSLSSPRRSPCHPRGSGSNWGSRRSSWNSLGRAPSLKR 1013

  Fly  1422 -------------------DEDKMDHETLSD--------------EEVREMCE------------ 1441
                               ::|.::.|.|::              .|:.:|.|            
Zfish  1014 KDTSGERESLLSGEGRGSFEDDDIEAEKLTNISGGSLQHPSSLDIPELPQMGEYLDCNGRSQHIL 1078

  Fly  1442 --------EEEEVDEEGMITARPRRMSEVNTATKILPIPPGT------SFFLFSQTNRFRVFCHW 1492
                    :|:.:.||.:..:...|:.....|.|    |...      |.:|||..|:||:.|..
Zfish  1079 ADLSASLNKEDSIAEEDLDDSFCFRLRRTLAAYK----PKWCKDHEEWSLYLFSPHNKFRMMCQK 1139

  Fly  1493 LCNHSNFGNIILCCIMFSSAMLAAENP-LRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVL 1556
            |.:|..|..::|..|..:...:|.|.| ::.::.|..:::  :|.||.:|..|:.:|:::.||..
Zfish  1140 LISHKMFDYVVLVFIFLNCITIALERPHIQQSERLFLLVS--NYVFTVIFVAEMTVKVVALGFYS 1202

  Fly  1557 HDGAFCRSAFNLLDLLVVCVSLI----SLVSSSNAI-SVVKILRVLRVLRPLRAINRAKGLKHVV 1616
            .:.::.:|.:|:||.::|.||||    ||..:.|.| .::::||:||.|||||.|:||.|||.||
Zfish  1203 GNQSYLKSTWNVLDGVLVFVSLIDILVSLAWTGNRIFGILRVLRLLRTLRPLRVISRAPGLKLVV 1267

  Fly  1617 QCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGV 1681
            :.:|.:::.||||||:.|..             ::|                       |.::||
Zfish  1268 ETLITSLRPIGNIVLICCAF-------------FIV-----------------------FGILGV 1296

  Fly  1682 QLFKGKFFKCTDGSKMTQDECYGTYLVYDDGDVHKPRLREREWSNNRFHFDDVAKGMLTLFTVST 1746
            ||||||||.|..|.         |..:.:..|..:..|:   |...:::||::.:.:::||.:|.
Zfish  1297 QLFKGKFFHCEGGD---------TRNITNKSDCLQANLK---WIRRKYNFDNLGQALMSLFVLSC 1349

  Fly  1747 FEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTF----QNEGE 1807
            .:||..::|..:|:...:..|..|..|.:..|:|.:::|::||::|:|||.|:..|    |::.|
Zfish  1350 KDGWVNIMYDGLDAVGVDQQPERNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQDQEE 1414

  Fly  1808 QEYKNCDL------DKNQR---NCIEFALKA------KPVRRYIPKHGIQYKVWWFVTSSSFEYT 1857
            .|.:..:|      :|.:|   ||...||:.      .|.|.||......:.:..|:|.      
Zfish  1415 VEARLLELKRQKLMEKKRRSKENCGSEALRRPYYADYSPARLYIHTLCTNHYLDLFITG------ 1473

  Fly  1858 IFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFI 1922
               :|.||.||::::.:|||.:..|.|...|.:||.:|.:|.:.||.||..:.:|.|.||..|..
Zfish  1474 ---IICINVVTMSIEHFNQPSYLDEALKYCNYVFTIIFIIEALLKLVAFGIRRFFKDRWNQLDLA 1535

  Fly  1923 IVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEG 1987
            |||.|.:.|...|||......|                  |...|...|:.|:.|::|||....|
Zfish  1536 IVLLSIMGITLEEIKMNAALPI------------------NPTIIRIMRVLRIARVLKLLKMATG 1582

  Fly  1988 IRTLLWTFIKSFQALPYV---ALLIVLLFFIYAVVGMQVFGKIALDGGN---AITANNNFQTFQQ 2046
            :|:||.|.:   ||||.|   .||.:|||||||.:|:::|||:.....|   .::.:..|:.|..
Zfish  1583 MRSLLDTVM---QALPQVGNLGLLFMLLFFIYAALGVELFGKLECTENNPCEGLSPHATFENFGM 1644

  Fly  2047 AVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGE-PCGSSIAYP---YFISFYVLCSFLII 2107
            |.|.|||.:||:.|..||         |..:....|.| .|.|.:.:.   ||::|.::..|:::
Zfish  1645 AFLTLFRVSTGDNWNGIM---------KDTLRECLPSETQCLSYLPWVSPIYFVTFVLMAQFVLV 1700

  Fly  2108 NLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKI--------- 2163
            |:.|||:|               .||:|..:...| |.:....|| |.::...|::         
Zfish  1701 NVVVAVLM---------------KHLEESNKEAKE-DAEMDAAIK-LAILKETRRLSTISASATA 1748

  Fly  2164 --------------SPPLGFGK-------LCPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRT 2207
                          ||....|.       |.|.:|:..|:.|  :|.:|        .:|..||.
Zfish  1749 GPEGRATYIEPHPDSPEQDEGMQRTQGNLLSPRKMSVSRMHS--LPNDS--------YMFRPVRP 1803

  Fly  2208 SLS------IKTD------GNIDDANSELRATIKQI-------WKRTN--PKLLDQVVPPPGNDD 2251
            :.:      ::|.      |:|...:|:...::..:       ..:.|  ||     :|||... 
Zfish  1804 ASAPYPLEEVETCQDYLELGSITSVHSQPCESLSLLQVPGVPPHSQFNCLPK-----IPPPMPS- 1862

  Fly  2252 EVTVGKFYATYLIQDYFRRFKKRKEQEGKEGHPDS-NTVTLQAGLRT----LH--------EVSP 2303
                    .|:.|....||.:..|.......:.|| ..|..|.|:.|    ||        :.||
Zfish  1863 --------PTHSIDRILRRQRAIKNDSIDMHNFDSKENVERQKGITTGSFKLHVPQITGISQGSP 1919

  Fly  2304 ALKRAISGNLDELDQEPEPMHRRHHTLFGSVWSSIRRHGNGTFRRSAKATASQSNGALAIGGSAS 2368
            .|..  .|......|:|...|                  |.:.|..:.|::|:            
Zfish  1920 LLPP--RGPSVHTFQQPHSQH------------------NISSRPPSLASSSR------------ 1952

  Fly  2369 AALGVGGSSLVLGSSDPAGGDYLYDTLNRSVADGVNNITRNIMQARLAAAGKLQDELQGAGSGGE 2433
                         |:.|:|.  ::|:     ||..:...|:|     .:..:|...:........
Zfish  1953 -------------STSPSGS--MFDS-----ADPTDEEVRHI-----NSTARLWIGVHAEARSHS 1992

  Fly  2434 LRTFGESISMRPL-AKNGGGAATVAGTLPPEANAINYDNRNRGILLHPYNN----------VYAP 2487
            |..:..|.::.|: .||...||.:....|.:..:::    ..|.|..||.:          ..:.
Zfish  1993 LSPYSTSGTLLPIPVKNCSSAANLTIKDPKKCFSVD----TEGFLERPYASDDHRRHSIEICSSG 2053

  Fly  2488 NGALPGHE-----------------RMIQSTP-----ASPYDQRRLPTSSDMNGLAESLIGGVLA 2530
            :..|.|.|                 |..:.:|     ..|:::...|:.:.|..|::|::     
Zfish  2054 DDGLFGQELCEKRHVPTRGKSLHIPRKTKMSPPCISIEPPFEKDVSPSHASMKKLSDSML----- 2113

  Fly  2531 AEGLGKYCDSEFVGTAAREMREALDMTPEEMNLAAHQILSNE----HSLSLIGSSNGSIFGGSAG 2591
               |.:...|..:..    .|::||: ||. .|:...::..|    |....:...:.:...|.||
Zfish  2114 ---LRRRTPSYDLAL----QRDSLDL-PEN-QLSTQPLIKVERHPSHCAEYLSLPHPAPMSGLAG 2169

  Fly  2592 GL 2593
            .|
Zfish  2170 VL 2171

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 103/376 (27%)
Ion_trans 1137..1379 CDD:395416 90/256 (35%)
Ion_trans 1496..1809 CDD:395416 97/322 (30%)
Ion_trans 1851..2126 CDD:395416 91/284 (32%)
GPHH 2135..2188 CDD:407139 15/82 (18%)
Ca_chan_IQ 2199..2271 CDD:400901 16/92 (17%)
cacna1haXP_021330381.1 Ion_trans 1..323 CDD:306908 102/334 (31%)
Ion_trans 644..871 CDD:306908 86/237 (36%)
Ion_trans 1143..1413 CDD:306908 96/319 (30%)
Ion_trans 1464..1695 CDD:306908 87/269 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.920

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