Protein Alignment Ca-alpha1D and cacna1fb

DIOPT Version :10

• Sequence 1: NP_723952.2
• Gene: Ca-alpha1D / 34950
• FlyBaseID: FBgn0001991
• Length: 2705
• Species: Drosophila melanogaster
• Sequence 2: XP_021333942.1
• Gene: cacna1fb / 559964
• ZFINID: ZDB-GENE-031104-1
• Length: 2068
• Species: Danio rerio
• Alignment Length: 2205
• Identity: 1081/2205 - (49%)
• Similarity: 1347/2205 - (61%)
• Gaps: 406/2205 - (18%)

  Fly   589 QEQQHDQGDSAEEEDDDEDVDEYFEEEEDDTQAFSPFYSSSAELIDNFGGGAGKFFNIMDFERGA 653
            :|.:...|.|.|||:...:.:|  ||||
Zfish     3 EENRKRNGYSNEEEEGGGEAEE--EEEE------------------------------------- 28

  Fly   654 SGEGGFSPNGNGGPGSGDVSRTARYDSGEGDLGGGNNIMGIDSMGIANIPETMNGTTIGPSGAGG 718
            .||||      ||...||......:|.              :.....|..||:..||
Zfish    29 GGEGG------GGGDEGDKEEKDEWDE--------------EDRPKMNRTETLMSTT-------- 65

  Fly   719 QKGGAAAGAAGQK------RQQRRGKPQPDRPQRALFCLSVKNPLRALCIRIVEWKPFEFLILLT 777
                  :..|.||      ::|.:|..|..|..|||:||.:.||:|...:.:||||||:..|||.
Zfish    66 ------SSTATQKKKSQHVKKQVQGSNQVQRAPRALYCLKLNNPIRRAALHLVEWKPFDIFILLA 124

  Fly   778 IFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLL 842
            |||||:||.|..|:|..|||.||..||:||||||:|||.|..:||||||.|:|..:|:|||||||
Zfish   125 IFANCVALGVSKPFPEDDSNATNHDLEQVEYVFLIIFTIETFLKILAYGLVMHPSSYIRNGWNLL 189

  Fly   843 DFTIVVIGAISTALSQLMKDA-------------FDVKALRAFRVLRPLRLVSGVPSLQVVLNSI 894
            ||.||::|..|..|..:...:             .||||||||||||||||||||||||:|||||
Zfish   190 DFVIVIVGLFSVVLETVTHKSGETTSHTPGKPGGLDVKALRAFRVLRPLRLVSGVPSLQIVLNSI 254

  Fly   895 LKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDEITGEY-EENIRPC---GVGYQC-PP 954
            :||||||.||:||||||||||||||||||.|::|:.|....|..| :::..||   |.|.|| ..
Zfish   255 MKAMVPLLHISLLVLFVIIIYAIIGLELFIGRMHRTCFFIGTDNYADDDPLPCAFAGHGRQCYVN 319

  Fly   955 GYKCYGGWDGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGA 1019
            |.:|.|.|:|||.||||||||..||||||||:|:||||||||.:.||:|.:..|:||:|:||.|:
Zfish   320 GSECRGKWEGPNGGITNFDNFFFAMLTVFQCITMEGWTDVLYWMNDAIGFELPWVYFVSLVIFGS 384

  Fly  1020 FFVMNLILGVLSGEFSKERNKAKNRGDFQKLREKQQIEEDLRGYLDWITQAEDI-EPDAVGG--- 1080
            |||:||:||||||||||||.|||.||||||||||||:||||.||:||||||||| |.|..|.
Zfish   385 FFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQQMEEDLCGYMDWITQAEDIDEFDEDGNRRV 449

  Fly  1081 ----LISDGKGK-----QPNE-----------MDSTENLGEEMPEVQMTESRWRKMK----KDFD 1121
                |....:||     ..||           .::|||:.||..:. ......|.||    :...
Zfish   450 TLRDLADKKRGKFGWFSHSNETHASLPASETASENTENIDEEHTDC-CAACCARIMKIPCCRALR 513

  Fly  1122 RVNRRMRRACRKAVKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEML 1186
            |.||.:||.||.||||..||||:::||||||.:.|:|||.|.:||.:.|:..|...:.|||.|||
Zfish   514 RWNRCIRRNCRTAVKSVTFYWLVLILVFLNTALSASEHYNQPEWLTDVQDIANKVLLSLFTVEML 578

  Fly  1187 LKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSL 1251
            |||||||.|.|||:.|||||||||.|.|.||:|....:|||||:||||||||||:||||::|.:|
Zfish   579 LKMYSLGLQVYFVAFFNRFDCFVVCGGILETVLVEMEIMPPLGISVLRCVRLLRIFKVTRHWTAL 643

  Fly  1252 SNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEKYRMNFDCFWQALLTVFQ 1316
            ||||||||||::||||||||||||::||||||||:||||||||..:.| |..||.|.|||||.||
Zfish   644 SNLVASLLNSMKSIASLLLLLFLFLIIFALLGMQLFGGKFNFDETQTK-RSTFDSFPQALLTCFQ 707

  Fly  1317 IMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYILLNVFLAIAVDNLA--DADSLSE 1379
            |:||||||.|||.||.||||....|.:.|:||:|||||||||||||||||||||||  |.|:...
Zfish   708 ILTGEDWNVVMYDGIMAYGGPVFPGMIVCLYFVILFICGNYILLNVFLAIAVDNLAGGDGDNKKN 772

  Fly  1380 VEKEE---EPHDESAQKKSHSPTPTIDGMDDHLSIDIDMEQQELDDEDKMDHETLSDEEVREMCE 1441
            .||:|   ||.:|                 ::..:.:||                 |||..|..|
Zfish   773 EEKKEGEAEPAEE-----------------ENGEVKVDM-----------------DEEYEEEEE 803

  Fly  1442 EEEEVDEEGMITARPRRMSEVNTA------TKILPIPPGTSFFLFSQTNRFRVFCHWLCNHSNFG 1500
            .||..||||.|        ::|.|      .||||||.|::||..|:||..||.||.|.:|..|.
Zfish   804 PEEGDDEEGKI--------QLNVADFAPPKEKILPIPEGSAFFCLSKTNPIRVGCHTLIHHHIFT 860

  Fly  1501 NIILCCIMFSSAMLAAENPLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSA 1565
            |:||..|:.||..||||:|:||:...|.||...||.||::||:|::||:..:|..||:|:|||:.
Zfish   861 NLILVFIILSSISLAAEDPIRAHSFRNNVLGYADYAFTSIFTVEILLKMTVHGAFLHEGSFCRNW 925

  Fly  1566 FNLLDLLVVCVSLISLVSSSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIV 1630
            |||||||||.|||:|....|:|||||||||||||||||||||||||||||||||.
Zfish   926 FNLLDLLVVSVSLVSFFLHSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVF---------- 980

  Fly  1631 LVTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTDGS 1695
                                      |||:||||||:||.|||||||.||||||||||::|||.:
Zfish   981 --------------------------VAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEA 1019

  Fly  1696 KMTQDECYGTYLVYDDGDVHKPRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDS 1760
            |.|.::|.||::||.||||..|.:|||.|.|:.|:||:|..||:.|||||||||||.|||.:||:
Zfish  1020 KNTPEQCKGTFVVYKDGDVSHPMVRERIWLNSDFNFDNVLMGMMALFTVSTFEGWPALLYKAIDA 1084

  Fly  1761 NKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQEYKNCDLDKNQRNCIEF 1825
            |.||.|||:|:|..::.::|:|||||||||:||||||||:||:.:||.|:|||:||||||.|:|:
Zfish  1085 NGENHGPIYNYRVEISIFFIVYIIIIAFFMMNIFVGFVIITFREQGEAEFKNCELDKNQRQCVEY 1149

  Fly  1826 ALKAKPVRRYIPKHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMI 1890
            ||||:|::.||||:.:|||.|..:.|:.|||.:|:||::||||||::.|:|..::::::|.|||:
Zfish  1150 ALKAQPLKLYIPKNPVQYKFWSIINSTGFEYVMFVLILLNTVTLAVQHYDQSKFFSQVMDILNMV 1214

  Fly  1891 FTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKS 1955
            ||.:|.:|.:.||.|.|.::||.||||.||.:||:||.:|||.:|..|
Zfish  1215 FTGLFTVEMIIKLMALRLRHYFVDAWNSFDALIVVGSVVDIVVTEFSS----------------- 1262

  Fly  1956 TKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVG 2020
               |..|:.:||.|||||||||||||||||||||||||||:||.||||||||||.::||||||:|
Zfish  1263 ---SEDSSRVSITFFRLFRVMRLVKLLSKGEGIRTLLWTFVKSLQALPYVALLIAMIFFIYAVIG 1324

  Fly  2021 MQVFGKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSD-TPGE 2084
            ||.|||||:.....|..|||||||.||||:|||.||||||||||:  ::.|..:||..|| .|||
Zfish  1325 MQTFGKIAMQDHTQINRNNNFQTFPQAVLLLFRCATGEAWQEIML--ASLPGKRCDAESDFEPGE 1387

  Fly  2085 --PCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDA 2147
              .|||:||..|||||::||:|||||||||||||||||||||||||||||||||.|:||||||:|
Zfish  1388 EFSCGSNIAIVYFISFFMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEA 1452

  Fly  2148 KGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIK 2212
            ||||||||||.|||:|.||||||||||||:||||||:||||||:||||.|||||||:|||:|.||
Zfish  1453 KGRIKHLDVVALLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNADGTVTFNATLFALVRTALKIK 1517

  Fly  2213 TDGNIDDANSELRATIKQIWKRTNPKLLDQVVPPPGNDDEVTVGKFYATYLIQDYFRRFKKRKEQ 2277
            ||||.|..|.|||..||:|||||.||:||:|:|||. ::||||||||||:|||||||:|:||||:
Zfish  1518 TDGNPDQENEELRIIIKKIWKRTKPKVLDEVIPPPA-EEEVTVGKFYATFLIQDYFRKFRKRKEK 1581

  Fly  2278 EGKEGHPDSNTVTL---QAGLRTLHEVSPALKRAISGNLDE----LDQE---------------- 2319
            .|.|...:.|...|   |||||||.|:.|.::.|::.:|:|    ||:|
Zfish  1582 VGLEEEGNGNPTALQLCQAGLRTLQELGPEMRLAMNEDLEEEEEGLDEEQEEDDAHYKNENGYAH 1646

  Fly  2320 PEPMHRRHHTLFGS--VWSSIRRHGNGTF-----RRSAKATASQSNGALAIGG-----SASAALG 2372
            .||:.|...:...:  :.:.:...|:|..     |||:.|.....||||....     |..:::.
Zfish  1647 TEPLSRSRRSSLATTPIGAPVPVPGDGILNGGLGRRSSLAKTPNGNGALENENFRRRDSMRSSIH 1711

  Fly  2373 VGGSSLVLGS-------------------SDP-----AGGDY----------------------- 2390
            ....:.|:..                   |.|     .||:|
Zfish  1712 YQHKNGVIDQLPKRPSYYKYPRRDSRDRFSSPLSRREEGGEYPGEQRFYGKDEDSESVISRERHG 1776

  Fly  2391 -------------LYD-----------TLNRSVADGVNNITRNIMQAR---LAAAGKLQDELQGA 2428
                         :||           ....|..||.....|.::.|.   ..|:..:|. |:..
Zfish  1777 YPEDSTIFQGHRDMYDGHSMRHPVYGNHYGNSYGDGRRTARRRLLPATPTGRKASFNIQC-LRRQ 1840

  Fly  2429 GSGGEL---------------RTFGESI--SMRPLAKNG-GGAATVAGTLPPEANAIN------- 2468
            ||..:|               |:.|.|.  |.|..|::. |..|:.|.|.|.....:.
Zfish  1841 GSSDDLPIPGTYHQNSPPCRARSQGYSSYDSRRSSARSSTGSTASWANTGPRRGRLLYAPLILVE 1905

  Fly  2469 ------------YDNRNRGI-----LLHPYNNVYAPNGALPGHERMIQSTPASPYDQRRLPTS-- 2514
                        :|.:..|:     :.||.:..|:...|..|.:      |...|...|:||.
Zfish  1906 EEGAAGAGGVGIWDKKPGGVGVPASVRHPGSGWYSGPSAGGGGQ------PYRAYTTLRVPTQLS 1964

  Fly  2515 ---SDMNGLAESLIGGVLAAEGLGKYC-DSEFVGTAAREMREALDMTPEEMNLAAHQILS 2570
               |:..|.|:||:..||.:||||.|. |.:||..|.||:.:|..||.:||..||..:|:
Zfish  1965 PHYSEKRGSADSLVEAVLISEGLGLYAKDPKFVAFAKREIADACHMTIDEMESAASDLLN 2024

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1D	NP_723952.2	Ion_trans	767..1042	CDD:459842	183/292 (63%)
		Ion_trans	1137..1379	CDD:459842	167/243 (69%)
		Ion_trans	1496..1809	CDD:459842	181/312 (58%)
		Ion_trans	1851..2126	CDD:459842	167/277 (60%)
		GPHH	2135..2188	CDD:465306	44/52 (85%)
		Ca_chan_IQ	2198..2273	CDD:462591	54/74 (73%)
cacna1fb	XP_021333942.1	Ion_trans	114..407	CDD:459842	183/292 (63%)
		Ion_trans	532..763	CDD:459842	162/231 (70%)
		Ion_trans	856..1093	CDD:459842	156/272 (57%)
		Ion_trans	1178..1431	CDD:459842	166/274 (61%)
		GPHH	1440..1493	CDD:465306	44/52 (85%)
		Ca_chan_IQ	1503..1577	CDD:462591	54/74 (73%)
		CAC1F_C	1600..2067	CDD:465298	96/432 (22%)