DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and cacna1ba

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:XP_009299772.1 Gene:cacna1ba / 555941 ZFINID:ZDB-GENE-060531-44 Length:2378 Species:Danio rerio


Alignment Length:2492 Identity:847/2492 - (33%)
Similarity:1178/2492 - (47%) Gaps:673/2492 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   713 PSGAGGQKGGAAAGAAGQKRQQRRGKPQPDR---------------------------PQRALFC 750
            |:..||..||:.|| .|:...::.|.|...|                           ..|:||.
Zfish     9 PTRYGGGGGGSPAG-PGRGATRQPGPPGGPRVYKQTMAQRARTMAIYNPIPVKQNCLTVNRSLFI 72

  Fly   751 LSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVIFT 815
            .|..|.:|....:|.||.|||::||.||.||||.|.:....|..|....::.|:..|..|:.||.
Zfish    73 FSEDNIIRKYAKKITEWPPFEYMILATIIANCIVLGLEQHLPALDKTPMSKRLDDTEPYFIGIFC 137

  Fly   816 AECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAFRVLRPLRL 880
            .|..:||:|.||..|.|:|||||||::||.:|:.|.::     ::...||::.|||.||||||:|
Zfish   138 FEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILT-----IVGPDFDLRTLRAVRVLRPLKL 197

  Fly   881 VSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDEITGEYEENIRP 945
            |||:|||||||.||:||||||..|.||:.|.|:::|||||:.:.||.|:.|....|||..:.. |
Zfish   198 VSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLDFYMGKFHRTCFRTDTGEQVDEF-P 261

  Fly   946 CGV---GYQCPPGYKCYGGWDGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQ 1007
            ||:   .:.|..|.:|...|.|||.|||||||...|:||||||:|:|||.|:||:..||.|:.|.
Zfish   262 CGLESPAWTCENGTECREYWIGPNFGITNFDNILFAVLTVFQCITMEGWVDILYNANDASGNTWN 326

  Fly  1008 WMYFISMVILGAFFVMNLILGVLSGEFSKERNKAKNRGDFQKLREKQQIEEDLRGYLDWITQAED 1072
            |:|||.::|:|:||::||:||||||||:|||.:.:.|.:|.|||.:||||.:|.|||:||.:||:
Zfish   327 WLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVEKRQEFLKLRRQQQIERELTGYLEWICKAEE 391

  Fly  1073 I----------EPDAVGGLISDGKGKQPNEMDSTENLGEE--MPEVQMTESRWRKMKKD------ 1119
            :          :.|.|...    |.|..|....|.:||.:  :|.::    |.:|.|.|      
Zfish   392 VMLAEEDKNAEDKDDVAWY----KRKCNNPGGFTRSLGADFGLPVLK----RAKKSKNDLINAEE 448

  Fly  1120 ---------------------------------FDRVNRRMRRACRKAVKSQAFYWLIIVLVFLN 1151
                                             |.|..:|.|...|:.||:|:|||.::.:|.||
Zfish   449 GEDHFTDISSVAPQGSPFTRTSVKSSKIESLSYFRRKEKRFRFFIRRMVKAQSFYWTVLCIVGLN 513

  Fly  1152 TGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITE 1216
            |..:|..||.|.:||..........|:|||..||.||||.||.:.||.|.||.||..|::|||.|
Zfish   514 TLCVAIVHYDQPEWLTYALYLAEFVFLGLFLIEMSLKMYGLGPRTYFHSSFNCFDFGVIVGSIFE 578

  Fly  1217 TLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFAL 1281
            .:..........|:||||.:||||:|||||||.||.|||.|||||::||.|||.|||||||:|||
Zfish   579 VIWAAVKPGASFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFAL 643

  Fly  1282 LGMQVFGGKFNFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACI 1346
            ||||:|||:|||:  :|....|||.|..|:||||||:||||||||||.||.:.|||.. |....:
Zfish   644 LGMQLFGGQFNFE--DETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVHR-GMFCSV 705

  Fly  1347 YFIILFICGNYILLNVFLAIAVDNLADADSLSEVEKEEEPHDESAQKK----------------- 1394
            |||:|.:.|||.||||||||||||||:|   .|:.|:||..:|:..||                 
Zfish   706 YFIVLTLFGNYTLLNVFLAIAVDNLANA---QELTKDEEEQEEAISKKLALQKAKEVKEVSPMSA 767

  Fly  1395 ------------------------SHSP------------------------------------- 1398
                                    ||||                                     
Zfish   768 ANISITAFIRPNPGALSCSSSNSSSHSPKEQQRSLKMMSVWEQRTTQIRKHMLASSEALYQEELN 832

  Fly  1399 -----------------------TPTIDG-MDDHLSIDIDMEQQELDDE---------------- 1423
                                   .|..|| :..|...|   :.|:|..|                
Zfish   833 PRLMSNLPLRTDIKTHLDRPLVVEPRCDGPISPHSGWD---KPQDLQGEGSTPEERVPPVFEPPQ 894

  Fly  1424 -----------DKMDHET-------------------LSDEEVREMCEE---------------- 1442
                       :::.:||                   .|.|.....|:|                
Zfish   895 SHPPRKHHRHRERLSNETNENGDTGHAKEGRHHVHHSRSKEHDGTRCKEGKGDRSRSREGGRRHH 959

  Fly  1443 -EEEVDE---------------------EGMITA------------------------------- 1454
             :..|||                     .|:::|                               
Zfish   960 HQSSVDEGVGGGEREHRHHHSHRHNREGNGVVSAGGKSERRSRQKEGSRSGTREGERCSRGENGG 1024

  Fly  1455 -------RPRR------------------------------------------------------ 1458
                   |||.                                                      
Zfish  1025 NGGRRRHRPRTSKAQSTLEGEEQHVNGEEEGKSQSHRHMDMGGDSMAVNPHQPSVGSRWCLEKPE 1089

  Fly  1459 -------------------------------------------MSEVN----TATKILPIPPGTS 1476
                                                       |:|.|    ..:.|.||.|.:|
Zfish  1090 DSDNKRNIGQTGGMSTHIPVTVTSPPGETTLIPMNSIDSETVPMTEKNLEDLNQSSIRPILPFSS 1154

  Fly  1477 FFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDDLNKVLNKFDYFFTAVF 1541
            .|:|:.||..|..||::.:...|...||..|..||..||||:|::||...|.||...||.||.||
Zfish  1155 MFIFNPTNPVRRLCHYIVSLRYFEMCILVVIAMSSIALAAEDPVQANAPRNNVLKYLDYVFTGVF 1219

  Fly  1542 TIELILKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISLVSSS--------------NAISVVK 1592
            |.|:::|::..|.:||.|::.|..:|:||.:||..:|::...||              ..||.:|
Zfish  1220 TFEMVIKMVDLGLILHPGSYFRDLWNILDFIVVSGALVAFAFSSFMGSHQSVNRGTKGKDISTIK 1284

  Fly  1593 ILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKCVVV 1657
            .||||||||||:.|.|...||.|..||:.::|.:.||::|                 |:      
Zfish  1285 SLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIV-----------------YI------ 1326

  Fly  1658 AIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDDGDVHKPRLRER 1722
                         |..|:||||.|||||||||.|||.||..:.:|.|.:|.||..||   ..:.|
Zfish  1327 -------------LFMFIFAVIAVQLFKGKFFYCTDESKGLEKDCRGLFLDYDKDDV---TAQPR 1375

  Fly  1723 EWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIA 1787
            ||....||:|:|....||||||||.||||.:|..|:|:..|:.||...:|..::.:|::|.::..
Zfish  1376 EWKKYEFHYDNVLWAFLTLFTVSTGEGWPTVLKHSVDATFEDQGPSPGYRIEMSIFYVVYFVVFP 1440

  Fly  1788 FFMVNIFVGFVIVTFQNEGEQEYKNCDLDKNQRNCIEFALKAKPVRRYIPKH--GIQYKVWWFVT 1850
            ||.|||||..:|:|||.:|::....|.|:||:|.||:||:.|||:.||:|::  ..||::|.||.
Zfish  1441 FFFVNIFVALIIITFQEQGDKVLSECSLEKNERACIDFAINAKPLTRYMPQNQQSFQYRLWKFVV 1505

  Fly  1851 SSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDA 1915
            |..|||:|.|:|.:|||.|.|||:..|.:|..:|..||::||.:|:||.:.|:.||...||..||
Zfish  1506 SPPFEYSIMIMIALNTVVLMMKFHGAPDFYEAMLKYLNIVFTVLFSLECILKIIAFGPLNYLKDA 1570

  Fly  1916 WNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVK 1980
            ||||||:.||||..||:.:||.:.:..                      ::.:|.||||..||:|
Zfish  1571 WNVFDFVTVLGSITDILVTEINTTERQ----------------------LNFSFLRLFRAARLIK 1613

  Fly  1981 LLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIALDGGNAITANNNFQTFQ 2045
            ||.:|..||.|||||::||:|||||.|||.:||||||::||||||.|.|:...||..:|||:||.
Zfish  1614 LLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIDLNDDTAINRHNNFRTFL 1678

  Fly  2046 QAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGEPCGSSIAYPYFISFYVLCSFLIINLF 2110
            ||:::||||||||||.:||:||.::.  .||.:|.|.|:.|||..||.||:||..|||||::|||
Zfish  1679 QALMLLFRSATGEAWHDIMLSCLSER--TCDPSSGTLGKECGSDFAYFYFVSFIFLCSFLMLNLF 1741

  Fly  2111 VAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPH 2175
            ||||||||:|||||.|||||||||||||:|:||||.|.||||:||:..:|..:|||||.||.||.
Zfish  1742 VAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEYDPAACGRIKYLDMYEMLLHMSPPLGLGKKCPP 1806

  Fly  2176 RMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIK-TDGNIDD--ANSELRATIKQIWKRTNP 2237
            |:|.||||.||||:..|.:|.|.:||.|::||:|.|| ..|.:..  :::||:..:..:|...:.
Zfish  1807 RIAYKRLVKMNMPIADDNSVHFTSTLMALIRTALEIKLASGMVAQRLSDAELKKELSTVWPNLSQ 1871

  Fly  2238 KLLDQVVPPPGNDDEVTVGKFYATYLIQDYFRRFKKRK----EQEGKEGHPDSNTVTLQAGLRTL 2298
            |.:|.:| .|...:|:||||.||..:|.||:::.:.::    :|:.||          |||..:.
Zfish  1872 KTMDLLV-TPHKPNELTVGKVYAALMIFDYYKQNRAKRLQMQQQQLKE----------QAGPGSQ 1925

  Fly  2299 HEVSPALK----------RAISG--NLDELDQEPEPMHRRHHTLFGSVWSSIRRHGNGTFRRSAK 2351
            ::||..|:          :.::|  :..|...:..|.            |:...:|..|...:.|
Zfish  1926 NKVSALLEPILPLTHMQDQPVNGVDSASECQAQTRPS------------STTLNNGRTTLDNTIK 1978

  Fly  2352 ATAS-QSNGALAIGGSASAALGVGGSSLVLGSSDPAGGDYLYDTLN-RSVADGVNNITRNIM--Q 2412
            .::| .|..:..:..|....:..|      .|.|.:..:...:::. |.:.:..|.:|...:  |
Zfish  1979 GSSSWASEKSKEVQKSKRRPMSRG------QSEDASNANTAQESVEMRKMENSANTVTSGGLEGQ 2037

  Fly  2413 ARLAAAGKLQDELQGAGSGGELRTFGESISMRPLAKNGGGAATVAGTLPPEANAINY-------- 2469
            .|.|:..||..|:|.:.|.....|..|.|...|:.::   |:|.|...|.|.|..:|        
Zfish  2038 GRAASMPKLNAEMQRSHSRQSPGTLLEPIPDSPMRRS---ASTFAPQRPHEVNLNDYILEKPVQE 2099

  Fly  2470 -----------------DNRNRGILLHPYNNVYAPNGALPGHERMIQSTPASPYDQRRLPTSSDM 2517
                             |.:.|.:...|           .||.: ...|.....::|        
Zfish  2100 RHHHHHHHHRCHHRRDRDKKQRSLDRSP-----------TGHHK-TTGTATDSVEER-------- 2144

  Fly  2518 NGLAESLIGGVLAAEGLGKYCDSEFVGTAAREMREALDMTPEEMNLAAHQILSNEH--SLSLIGS 2580
                         |...|:          :.|.:.......::...:..:..|.||  |.|.:.|
Zfish  2145 -------------AHDRGR----------SHERKHHSSSGEKQRYYSCDRYASREHCSSKSAVAS 2186

  Fly  2581 SNGSIFGGSAGGLGGAGSGGVGG------LGGSSSIRNAFGGSGSGPSS-LSPQHQPYSGTLNSP 2638
            ...|........|...|||...|      .|.|:..|    |....|.: |:|:......|.||.
Zfish  2187 CATSPSETQEANLNKQGSGWAKGSPVLLTSGASTPSR----GRRQLPQTPLTPRPSVAYRTANSS 2247

  Fly  2639 PIPDNRLRRVATVTT------------TNNNNKSQVSQNNSNSLNVRANANSQMNMSPTGQPV-- 2689
            |:     :.:||.|:            .:.:|...:|.:.|:|....:..||:..:.|...|.  
Zfish  2248 PV-----QLLATTTSLLPPSPGRLSRGLSEHNALLLSGSISSSPAPVSRINSEPFLGPPDHPAGL 2307

  Fly  2690 ---------QQQSPLRGQGNQT 2702
                     :..||..|:..||
Zfish  2308 QPEAFAVFQENPSPQMGRSPQT 2329

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 142/277 (51%)
Ion_trans 1137..1379 CDD:395416 139/241 (58%)
Ion_trans 1496..1809 CDD:395416 130/326 (40%)
Ion_trans 1851..2126 CDD:395416 145/274 (53%)
GPHH 2135..2188 CDD:407139 34/52 (65%)
Ca_chan_IQ 2199..2271 CDD:400901 26/74 (35%)
cacna1baXP_009299772.1 Ion_trans 132..361 CDD:278921 125/234 (53%)
Ion_trans 517..738 CDD:278921 132/226 (58%)
Ion_trans 1192..1416 CDD:278921 106/262 (40%)
Ion_trans 1524..1757 CDD:278921 135/256 (53%)
GPHH 1765..1828 CDD:293510 39/62 (63%)
Ca_chan_IQ 1830..1904 CDD:285917 26/74 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100303
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.820

Return to query results.
Submit another query.