DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and scn8a

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:XP_031751845.1 Gene:scn8a / 549640 XenbaseID:XB-GENE-1011299 Length:1987 Species:Xenopus tropicalis


Alignment Length:1969 Identity:477/1969 - (24%)
Similarity:837/1969 - (42%) Gaps:560/1969 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   747 ALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFL 811
            ||:.||..||||...|:|:....|..:|:.||..||:.:....|...|         ::|||.|.
 Frog   111 ALYILSPFNPLRKFAIKILIHSLFSMIIMCTILTNCVFMTFSNPPEWS---------KQVEYTFT 166

  Fly   812 VIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAFRVLR 876
            .|:|.|.::||:|.||.:....:||:.||.|||:::::..::..:     |..:|.|||.|||||
 Frog   167 GIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYVTEFV-----DLGNVSALRTFRVLR 226

  Fly   877 PLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKAC------RDEI 935
            .|:.:|.:|.|:.::.::::::..|..:.:|.:|.:.::|:|||:||.|.|.:.|      .|::
 Frog   227 ALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGHLRRKCVAWPVDMDQM 291

  Fly   936 ----------TGEYEEN----------IRP--CGVGY---QCPPGYKCYGGWDGPNDGITNFDNF 975
                      ..||..|          |.|  ||.|.   |||.||.|......||.|.|:||.|
 Frog   292 YLANGSKGFDFDEYIMNDTNFFKVHGAIDPLLCGNGSDAGQCPEGYTCMKAGRNPNYGYTSFDTF 356

  Fly   976 GLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVL---------- 1030
            ..|.|.:|:.:|.:.|.::......|.|..:. ::|:.::.:|:|:::||||.|:          
 Frog   357 SWAFLALFRLMTQDFWENLYQLTLRASGKTYM-IFFVLVIFVGSFYLVNLILAVVAMAYEEQNQA 420

  Fly  1031 -------------------------------------------------------SGEFSKERNK 1040
                                                                   |.||||..:|
 Frog   421 TLEEAERKENEFKAMLEQMKRMQEEAQAAANATSAGTVTEDAVEDEDGEARMSHTSSEFSKPSSK 485

  Fly  1041 -AKNRGDFQKLREKQQIEE-DLRGYLDWITQAEDIE---------PD---------------AVG 1079
             ||.|.:.:|.|:::::.| :.:|..:.:.::|..:         ||               ::.
 Frog   486 SAKERRNRRKKRKQKELSEGEEKGDSEKVYKSESEDGVKRRGFWYPDNRLGRRFSIMNQSLLSIP 550

  Fly  1080 G-----------------------------------LISDGKGKQP------------NEMDS-- 1095
            |                                   .:.:.:|::.            |..:|  
 Frog   551 GSPYLSRHNSKSSIFSFRGRFRDPVSENEFADDEHSTVEESEGRRDSLFIPVRGHDRRNSYNSGY 615

  Fly  1096 ---------TENL----------------------------GEEMPEV----------------- 1106
                     .:||                            |..:|||                 
 Frog   616 SQGSRSSRILQNLRRNPKRNSTVDCNGVVSLIGGPGSNIPGGRLLPEVKIDKAATDDSPTTEVEV 680

  Fly  1107 -------------QMTESRWRK------------MKKDFDRVNRRMRRACRKAVKSQAFY----- 1141
                         |:|.|..||            :.::.:...|:......|...:...:     
 Frog   681 KRKPSGSLRVSMDQLTASFGRKRANSILSVVTQTLVEELEESQRKCPPCWYKFADTYLIWTCCPL 745

  Fly  1142 WL------------------IIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLK 1188
            |:                  |.:.:.|||..:|.|||......:|.....|:.|.|:||.||.||
 Frog   746 WIRIKTIVNMIVMDPFVDLTITICIVLNTLFMAMEHYPMTPHFENVLVVGNLVFTGIFTAEMFLK 810

  Fly  1189 MYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSN 1253
            :.::....||...:|.||.|:|..|:.|     .|:....|:||||..|||||||:.|.|.:|:.
 Frog   811 LIAMDPYYYFQEGWNIFDGFIVSLSLME-----LGLQDVEGLSVLRSFRLLRVFKLAKSWPTLNM 870

  Fly  1254 LVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEKYRMNFDC---------FWQ 1309
            |:..:.||:.::.:|.|:|.:.:.|||::|||:||..:    |:...::|.:|         |:.
 Frog   871 LIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY----KDCVCKINPECVLPRWHMNDFFH 931

  Fly  1310 ALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYILLNVFLAI-----AVD 1369
            :.|.||:::.|| |...|:..:...|     .|:..|.|:::.:.||.::||:|||:     :.|
 Frog   932 SFLIVFRVLCGE-WIETMWDCMEVAG-----QAMCIIVFMMVMVIGNLVVLNLFLALLLSSFSAD 990

  Fly  1370 NLADAD----------SLSEVEK-----------------------EEEPHDESAQKKSH----- 1396
            |||..|          |:..::|                       |.:|.||..:||.:     
 Frog   991 NLAATDDDGEMNNLQISVIRIKKGIAWIKLKAHDFMQKHFKKKDADEVKPLDEMYEKKMNCLANN 1055

  Fly  1397 -------------SPTPTIDGM----------DDHLSI---------------DIDMEQQELDD- 1422
                         :...|..|:          :||:|.               :.|.|....:| 
 Frog  1056 TGADIHRDMDYPKNGNGTTSGIGSSVEKYMIDEDHMSFIHNPNLTVKVPIAVGESDFENLNTEDF 1120

  Fly  1423 ---------EDKMDHETLSDE----EVREMCEE------EEEVDEEGMIT----ARPRRMSEVNT 1464
                     :||:| :|.|.|    :::...||      ||.:|.:...|    || .:..:|:.
 Frog  1121 SSASDEEGSKDKLD-DTSSSEGSTIDIKPEAEEVPVEQPEEYLDPDNCFTEGCVAR-FKCCQVSV 1183

  Fly  1465 ATKILPIPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENP-LRANDDLNK 1528
            ...:     |.|::...:|      |..:..|:.|...|:..|:.||..||.|:. :.....:..
 Frog  1184 EEGL-----GKSWWTLRKT------CFLIVEHNWFETFIIFMILLSSGALAFEDVYIEQRKTIRT 1237

  Fly  1529 VLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISLVSSS---NAISV 1590
            :|...|..||.:|.:|::||.::||||    .|..:|:..||.|:|.|||:||::::   :.:..
 Frog  1238 ILEYADKVFTYIFILEMLLKWLAYGFV----KFFTNAWCWLDFLIVDVSLVSLIANALGYSELGA 1298

  Fly  1591 VKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKCV 1655
            :|.||.||.||||||::|.:|::.||..::.|:.:|.|::|| ||:.::                
 Frog  1299 IKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLV-CLIFWL---------------- 1346

  Fly  1656 VVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKC----TDGSKMTQD-----ECYGTYLVYDD 1711
                               :|:::||.||.||::.|    .:|....:|     :|:        
 Frog  1347 -------------------IFSIMGVNLFAGKYYYCYNETAEGMFEIEDVENETQCF-------- 1384

  Fly  1712 GDVHKPRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVA 1776
             |:......|..|.|.:.:||:|..|.|.|..|:||:||..::|.::||.|.:..|.:.....:.
 Frog  1385 -DLIGNNYTEVRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKVHQQPKYEDNIYMY 1448

  Fly  1777 AYYIIYIIIIAFFMVNIFVGFVIVTFQNE----GEQEYKNCDLDKNQRNCIEFALKAKPVRRYIP 1837
            .|::|:||..:||.:|:|:|.:|..|..:    |.|:....:..|...|.:: .|.:|..::.||
 Frog  1449 IYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMK-KLGSKKPQKPIP 1512

  Fly  1838 K--HGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFV 1900
            :  :..|..::..:|..:|:..|.|||.:|.||:.::..:|..:...:|..:|::|...|..|.|
 Frog  1513 RPLNKFQGAIFDIITQQAFDIVIMILICLNMVTMMVETDDQSDYTDNVLYWINVVFIVFFTTECV 1577

  Fly  1901 FKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLI 1965
            .||.|.| ..||...||:|||::|:.|.:.:..:::                  .||......|.
 Frog  1578 LKLCALR-HYYFTIGWNIFDFVVVILSIVGMFLADL------------------ITKYFVSPTLF 1623

  Fly  1966 SINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIALD 2030
            .:  .||.|:.|:::|:...:||||||:..:.|..||..:.||:.|:.||:::.||..|..:..:
 Frog  1624 RV--IRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKKE 1686

  Fly  2031 GGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGE----PCGS-SI 2090
            .|  |....||:||..:::.||:..|...|..:::....:|. .||.:.:.||.    .||: |:
 Frog  1687 AG--IDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPP-DCDAHKENPGSQVKGDCGNPSV 1748

  Fly  2091 AYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWS-ILGPHHLDEFIRLWSEYDPDAKGRIKHL 2154
            ...:|:|:.::...:::|:::|:|::||...|.:.: .|.....:.|..:|.::||||...|:..
 Frog  1749 GIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQFIQFS 1813

  Fly  2155 DVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIKTDGNIDD 2219
            .:......:..||...|  |:.:   .|::|::|:.|...:.....|||..:..|.  ..|.:| 
 Frog  1814 KLPDFADALEHPLRIPK--PNTI---ELIAMDLPMVSGDRIHCLDILFAFTKRVLG--ESGELD- 1870

  Fly  2220 ANSELRATIKQIWKRTNPKLL--DQVVPPPGNDDE----VTVGKFYATYLIQDYFRRFKKRKEQE 2278
               .||..:::.:..:||..:  :.:........|    |.:.:.|..:|::   |.|..||...
 Frog  1871 ---ILRQQMEERFVASNPSKVSYEPITTTLRRKQEDVSAVVIQQAYRRHLVK---RGFISRKRST 1929

  Fly  2279 G-----------KEGHPDS 2286
            |           |||.|.:
 Frog  1930 GKMENGGTNMDKKEGTPST 1948

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 96/371 (26%)
Ion_trans 1137..1379 CDD:395416 86/288 (30%)
Ion_trans 1496..1809 CDD:395416 97/329 (29%)
Ion_trans 1851..2126 CDD:395416 79/279 (28%)
GPHH 2135..2188 CDD:407139 13/52 (25%)
Ca_chan_IQ 2199..2271 CDD:400901 15/77 (19%)
scn8aXP_031751845.1 Ion_trans 131..421 CDD:395416 90/304 (30%)
Na_trans_cytopl 503..709 CDD:403218 20/205 (10%)
Ion_trans 759..972 CDD:395416 72/227 (32%)
Na_trans_assoc 998..1199 CDD:399489 34/213 (16%)
Ion_trans 1204..1480 CDD:395416 96/324 (30%)
Na_channel_gate 1472..1524 CDD:240441 10/52 (19%)
Ion_trans 1529..1783 CDD:395416 79/277 (29%)
GPHH 1795..1842 CDD:407139 13/51 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.950

Return to query results.
Submit another query.