DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ca-alpha1D and nalcn

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:XP_005167755.1 Gene:nalcn / 548345 ZFINID:ZDB-GENE-050410-12 Length:1743 Species:Danio rerio


Alignment Length:1852 Identity:412/1852 - (22%)
Similarity:710/1852 - (38%) Gaps:524/1852 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   767 W--KPF-EFLILLTIFANCIALAVYTP-----YPGSDSNVTNQTLEKVEY----VFLVIFTAECV 819
            |  ||: ..|:......:.|::.:.||     ||         .|:.|.:    :.:.::|||.:
Zfish    57 WINKPWVHSLLRACAIISVISVCMNTPKTFEHYP---------PLQYVTFALDTLLMFLYTAEMI 112

  Fly   820 MKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKAL-------------RA 871
            .|:...|.:....:|:::.|.:.|..:||...:|     |:...|::..|             ||
Zfish   113 AKMHIRGIIKGENSYVKDRWCMFDGFMVVFLWVS-----LVLQVFEIAELVDQMSPWGMLRIPRA 172

  Fly   872 FRVLRPLRLVSGVPSLQVVLNSILK-AMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDEI 935
            ..::|..|:.......:..:.:||| :...::.:.:.:||.:::|.|:|:::| |..:..|   :
Zfish   173 LIMIRVFRIYFRFELPRSRITNILKRSGEQIWSVTIFLLFFLLLYGILGVQMF-GTFNHHC---V 233

  Fly   936 TGEYEE-------------NIRPCGVGYQCPPGYKCYG----GWDGPNDGITNFDNFGLAMLTVF 983
            |.|.|:             :..|.|.|||||.|:||..    |......|.:.|:..|.::.||:
Zfish   234 TNETEKEKVTWNSLAIPDTHCSPNGEGYQCPVGFKCVDLEDYGLSRQELGYSGFNELGTSIFTVY 298

  Fly   984 QCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERNKAKNRGDFQ 1048
            :..:.|||..::|...|:......:.||::::...|:.|.|:.:.|:...|      |:.|..||
Zfish   299 EAASQEGWVFIMYRAIDSFPRWRSYFYFLTLIFFLAWLVKNVFIAVIIETF------AEIRVQFQ 357

  Fly  1049 KLREKQQIEEDLRGYLDWITQAEDIEPDAVGGLISDGKGKQPNEMDSTENLGEEMPEVQMTESRW 1113
            ::               |                  |.........:|:...|:      ....|
Zfish   358 QM---------------W------------------GSRSSTTSTATTQMFHED------ASGGW 383

  Fly  1114 RKMKKDFDRVNRRMRRACRKAVKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQEY-TNVFF 1177
            :.:..|.::.:.|.....::.::|..|:..|:.:|.::..|.|:.::.....|.|.:.| ..|.|
Zfish   384 QLVAVDVNKPHGRAPACLQQLMRSSVFHMFILSMVAVDVIVAASNYHRGDHKLTNDEFYLAEVAF 448

  Fly  1178 IGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVF 1242
            ..||..|.|||::.|||.||..|..::|:..:|:|       |...:.|.|..|.....::|||.
Zfish   449 TVLFDLEALLKIWCLGFTGYISSSLHKFESLLVVG-------TTLHIYPDLYHSQFTYFQVLRVV 506

  Fly  1243 KVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEKYRMNFDCF 1307
            ::.|...:|.:.|..:....:.:.||::.....:::.:.:.:|:|....:.|        .|..|
Zfish   507 RLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEDLD--------RFTTF 563

  Fly  1308 WQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYILLNVFLAIAVDNLA 1372
            .:|.:::|||:|.|.|..||...:.|.|  ..:..:..||||:..:....|||::|:|:.:|||.
Zfish   564 PRAFMSMFQILTQEGWVDVMDQTLVAVG--QMWAPVVAIYFILYHLFATLILLSLFVAVILDNLE 626

  Fly  1373 DADSLSEVE--KEEEPHDESAQK-----------------------KSHSPTPTIDGMDDHLSID 1412
            ..:.|.:::  |:.|.:.::.:|                       .|....|.|  .:..:...
Zfish   627 LDEDLKKLKQLKQSEANADTKEKLPLRLRIFEKFPNRPQMVKISKLPSDFTVPRI--RESFMKQF 689

  Fly  1413 IDMEQQELD---------DEDKMDHETLSDEEVREMCEEEEEVDE---EGMITARPRRMSEVN-T 1464
            ||.:||:..         .....||..      |...|:.:.:|:   :.:.:.|.|.:.|.. |
Zfish   690 IDRQQQDPSCLFRRLPSASSSSCDHSK------RSAIEDNKYIDQKLRKSVFSIRARNLMEKEIT 748

  Fly  1465 ATKIL--------------------------------------------PIPPGTS--------- 1476
            ..|||                                            .|..|.|         
Zfish   749 VNKILRACTRQRMLSGSFEGQPTKERSILSVQHHIRQERRSLRHGSTSQRISRGKSLETLTQDHS 813

  Fly  1477 ----------------------------------------------FFLFSQTNRFRVFCHWLC- 1494
                                                          .|:..:.:|||.||..:. 
Zfish   814 STVRYRNAQREDSEIKMIQEKKEQAEMKRKVQEEELRENHPYFDKPLFIVGREHRFRNFCRMIVR 878

  Fly  1495 ---NHSN-------------------FGNI-----------ILCCI--MFSSAMLAAENPLRAND 1524
               |.||                   .|.:           |..||  ||.|......:.     
Zfish   879 ARFNASNTDPNTGAVNSTKYHQLYDLLGLVTYLDWVMIVVTICSCISMMFESPFTRVMHV----- 938

  Fly  1525 DLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISLVSSSNAI- 1588
               ..|...:|.|....:|||.||:::.|......|..|....::|:.:..||||.|....|.: 
Zfish   939 ---PTLQIGEYVFVIFMSIELNLKIMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLCWLPNNVP 1000

  Fly  1589 --SVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYV 1651
              |..::|.:||..||||.......::.||:.|:...|.|             |.|         
Zfish  1001 PESGAQLLMMLRCFRPLRIFKLVPQMRKVVREVLKGFKEI-------------FLV--------- 1043

  Fly  1652 VKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTY---------- 1706
                        :|:|:|.:|  :||..|||||.||..||.|....::|:|:|.:          
Zfish  1044 ------------SILLLTLML--VFATFGVQLFAGKLAKCNDPHISSKDDCHGIFRINVSISKNL 1094

  Fly  1707 -LVYDDGDVHKPRLREREWSNNR-FHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIH 1769
             |...||:........|.|:|.| |:||:|...||.||.|.:.:||..:..|.|    ...||||
Zfish  1095 NLKLKDGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVRDVII----HRVGPIH 1155

  Fly  1770 NFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTF-QNEGEQEYKNCDLDKNQRNCIEFALK-AKPV 1832
            ..      |..:::.:.....:.:|||.||..| :|:|.   ....:|:.:...::..|| |:|:
Zfish  1156 GI------YIHVFVFLGCMIGLTLFVGVVIANFNENKGT---ALLTVDQRRWEDLKSRLKIAQPL 1211

  Fly  1833 RRYIPKH----GIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLW-----YTELLDALN 1888
              ::|..    |.:.|::.......|:..|.:|::..:|.|::|      |     .|..|..::
Zfish  1212 --HLPPRPENGGFRAKMYDITQHPFFKRGIAVLVLAQSVLLSVK------WDELGAVTFPLATMS 1268

  Fly  1889 MIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIV-LGSFIDIVYSEIKSKDTSQIAECDIVEG 1952
            ::||.:|.||...||.|.....|:....|.:|.::. ||....|::..:::..|..:..|.||  
Zfish  1269 VVFTFIFVLEVTMKLIAMSPAGYWQSRRNRYDLLVTSLGLIWIILHFALQNAYTYMMGTCVIV-- 1331

  Fly  1953 CKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYA 2017
                             ||.|.:      ..|...::.||.|.:.|.....::.:.:.||...||
Zfish  1332 -----------------FRFFTI------CGKHVTLKMLLLTVVVSMYKSFFIIVGMFLLLLCYA 1373

  Fly  2018 VVGMQVFGKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDTP 2082
            ..|:.:||.:..  |..|..:.||.|..:|:.||.|..|||.|.:||..|..||.. |     ||
Zfish  1374 FAGVVLFGTVKY--GENINRHANFSTAGKAITVLIRIVTGEDWNKIMHDCMVQPPF-C-----TP 1430

  Fly  2083 GE------PCGS-SIAYPYFISFYVLCSFLIINLFVAVIMDNFD--YLTRDWSILGPHHLDEFIR 2138
            .:      .||: :.|..||.||||:.:::::||.||:|::||.  |.|.:..:|..:.|..|..
Zfish  1431 DKHRYWETDCGNYAGALIYFCSFYVIIAYIMLNLLVAIIVENFSLFYSTEEDQLLSYNDLRHFQI 1495

  Fly  2139 LWSEYDPDAKG-----RIKHLDVVTLLR-KISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLF 2197
            :|:..|...:|     |:|.|  :.||| ::...|...||....| |..:..    |::.|.|.|
Zfish  1496 IWNMVDDKREGVIPTSRVKFL--LRLLRGRLEVDLDKDKLLFKHM-CYEMER----LHNGGDVTF 1553

  Fly  2198 NATLFAVVRTSLSIKTDGNIDD--ANSELRATIKQ--------IW-----KR------------- 2234
            :..|..:...|:.|:....:::  |..:|..||::        :|     ||             
Zfish  1554 HDVLSMLSYRSVDIRKSLQLEELLAREQLEYTIEEEVAKQTIRMWLKKCLKRIRAKQQQSCSIIL 1618

  Fly  2235 -------------TNPKLLDQVVPPPGNDDEVTVGKFYATYLIQDYFRRFKKRKEQEGKEGHPDS 2286
                         .||..::..||   ::|..|                     ..:.....|:.
Zfish  1619 SLRESQQQDLRRLLNPPSIETTVP---SEDTNT---------------------HNQDNPTQPEQ 1659

  Fly  2287 NTVTLQAGLRTLHEVSPALKRAISGNLDELDQ 2318
            |     :||:||  :||.|........|..|:
Zfish  1660 N-----SGLQTL--LSPTLSDRSGYRQDSADR 1684

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 71/317 (22%)
Ion_trans 1137..1379 CDD:395416 67/242 (28%)
Ion_trans 1496..1809 CDD:395416 94/360 (26%)
Ion_trans 1851..2126 CDD:395416 81/289 (28%)
GPHH 2135..2188 CDD:407139 15/58 (26%)
Ca_chan_IQ 2199..2271 CDD:400901 16/112 (14%)
nalcnXP_005167755.1 Ion_trans 85..355 CDD:278921 66/293 (23%)
Ion_trans 429..626 CDD:278921 59/213 (28%)
Ion_trans 926..1184 CDD:278921 86/311 (28%)
Ion_trans 1263..1481 CDD:278921 73/250 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
43.950

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