DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and Cacna1e

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:XP_038946935.1 Gene:Cacna1e / 54234 RGDID:2246 Length:2465 Species:Rattus norvegicus


Alignment Length:2603 Identity:871/2603 - (33%)
Similarity:1192/2603 - (45%) Gaps:747/2603 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   586 IDEQEQQHDQGDSAEEEDDDEDV--------------DEYFEEEEDDTQAF----------SPFY 626
            :.|:|....|..:..|.|..::|              |.:|..:|.:...:          |||.
  Rat    41 LPEEEAWRPQQCALLEADASDEVGMLPASPRSAVSGFDNFFPVQEGEGPGWEGSTTLDAGSSPFL 105

  Fly   627 SSSAELIDNFGGGAGKFFNIM-----------------DFERGASGEGGFSPNGNGGPGSGDVSR 674
            ..|.|::....||..:..:|:                 ::|....||....    |.|||||   
  Rat   106 PVSPEVMKRRRGGLIEQRDIIKAHEAHKMQSTPQARRKEWEMARFGEAVVV----GRPGSGD--- 163

  Fly   675 TARYDSGEGDLGGGNNIMGIDSMGIANIPETMNGTTIGPSGAGGQKGGAAAGAAGQKRQQRRG-- 737
                    ||.....|               ..||.:..||        .|.|..|.:.||..  
  Rat   164 --------GDSDQSRN---------------RQGTPVPASG--------PAAAYKQSKAQRARTM 197

  Fly   738 ---KPQPDRP-----QRALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGS 794
               .|.|.|.     .|:||.....|.:|....::::|.|||::||.||.||||.||:....|..
  Rat   198 ALYNPIPVRQNCFTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPED 262

  Fly   795 DSNVTNQTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQL 859
            |....::.|||.|..|:.||..|..:||:|.||:.|.|:|||||||::||.:|:.|.::||.:. 
  Rat   263 DKTPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTH- 326

  Fly   860 MKDAFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFS 924
            .....|::.|||.||||||:||||:||||:||.||:||||||..|.||:.|.|:::||||||.:|
  Rat   327 FNTHVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYS 391

  Fly   925 GKLHKACRDEITGEYE--ENIRPCGVGYQCPPGYKCYGGWDGPNDGITNFDNFGLAMLTVFQCVT 987
            ||||:||....:|..|  :...|||| ..||.||:| ..|.|||||||.|||...|:||||||:|
  Rat   392 GKLHRACFMNNSGILEGFDPPHPCGV-QGCPAGYEC-KDWIGPNDGITQFDNILFAVLTVFQCIT 454

  Fly   988 LEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERNKAKNRGDFQKLRE 1052
            :||||.|||:..||:|:.|.|:|||.::|:|:|||:||:||||||||:|||.:.:||..|.|||.
  Rat   455 MEGWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLRR 519

  Fly  1053 KQQIEEDLRGYLDWITQAEDIEPDAVGGLISDGKGKQPNEMDSTENLGEEMPEVQMTESRWRKMK 1117
            :||||.:|.||..||.:||::       :::     :.|:...|..| |.:....:..||...|.
  Rat   520 QQQIERELNGYRAWIDKAEEV-------MLA-----EENKNSGTSAL-EVLRRATIKRSRTEAMT 571

  Fly  1118 KD-------------------------------FDRVNRRMRRACRKAVKSQAFYWLIIVLVFLN 1151
            :|                               |....|.:|.:.|..||||.|||:::.:|.||
  Rat   572 RDSSDEHCVDISSVGTPLARASIKSTKVDGASYFRHKERLLRISIRHMVKSQVFYWIVLSVVALN 636

  Fly  1152 TGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITE 1216
            |..:|..|:.|..||.:...|....|:|||..||.||||.:|.:.||.|.||.||..|.:|||.|
  Rat   637 TACVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFE 701

  Fly  1217 TLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFAL 1281
            .:..........|:||||.:||||:||:||||.||.|||.||::|::||.|||.|||||||:|||
  Rat   702 VVWAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFAL 766

  Fly  1282 LGMQVFGGKFNF-DGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALAC 1345
            ||||:|||:||| ||...   .|||.|..|::|||||:||||||.|||.||.:.||||| |..:.
  Rat   767 LGMQLFGGRFNFNDGTPS---ANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSS-GMWSA 827

  Fly  1346 IYFIILFICGNYILLNVFLAIAVDNLADADSLSEVEKEEE-----------------------PH 1387
            ||||:|.:.|||.||||||||||||||:|..|::.|:|||                       |.
  Rat   828 IYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQKHALQKAKEVSPMSAPNMPS 892

  Fly  1388 DESAQKKSH-------------------------------------------------------- 1396
            .|..:::.|                                                        
  Rat   893 IERDRRRRHHMSMWEPRSSHLRERRRRHHMSVWEQRTSQLRRHMQMSSQEALNKEEAPPMNPLNP 957

  Fly  1397 ----SP-----------------------------------------------TPTIDGMDDHLS 1410
                ||                                               |..:|.....||
  Rat   958 LNPLSPLNPLNAHPSLYRRPRPIEGLALGLGLEKCEEERISRGGSLKGDIGGLTSVLDNQRSPLS 1022

  Fly  1411 I--------------DIDMEQQE------------------------------------------ 1419
            :              :.|..|||                                          
  Rat  1023 LGKREPPWLPRSCHGNCDPTQQETGGGETVVTFEDRARHRQSQRRSRHRRVRTEGKESASASRSR 1087

  Fly  1420 -------LDD----EDKMDHETLSDEEVREMCEEEEE----------------------VDE--- 1448
                   ||:    :.:.:||..|....:|....|||                      :||   
  Rat  1088 SASQERSLDEGVSIDGEKEHEPQSSHRSKEPTIHEEERTQDLRRTNSLMVPRGSGLVGALDEAET 1152

  Fly  1449 ----------------------EG---------------------------MITARPRRMSEVNT 1464
                                  ||                           |.|...:..:|..:
  Rat  1153 PLVQPQPELEVGKDAALTEQEAEGSSEQALLADVQLDVGRGISQSEPDLSCMTTNMDKATTESTS 1217

  Fly  1465 ATKILP---------------------------------------------------IPPGTSFF 1478
            .|..:|                                                   :.|.:|.|
  Rat  1218 VTVAIPDMDPLVDSTVVNISNKTDGEASPLKEAETKEEEEEVEKKKQKKEKRETGKAMVPHSSMF 1282

  Fly  1479 LFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDDLNKVLNKFDYFFTAVFTI 1543
            :||.||..|..||::.|...|...||..|..||..||||:|:..|.:.||||..|||.||.|||.
  Rat  1283 IFSTTNPIRKACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTF 1347

  Fly  1544 ELILKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISLVSSSNA--------ISVVKILRVLRVL 1600
            |:::|:|..|.:|.||::.|..:|:||.:||..:|::. :.:||        |..:|.|||||||
  Rat  1348 EMVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAF-ALANALGTNKGRDIKTIKSLRVLRVL 1411

  Fly  1601 RPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNI 1665
            |||:.|.|...||.|..                                    |||.::|.:.||
  Rat  1412 RPLKTIKRLPKLKAVFD------------------------------------CVVTSLKNVFNI 1440

  Fly  1666 MLVTYLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDDGDVHKPRLREREWSNNRFH 1730
            ::|..|..|:||||.|||||||||.|||.||.|:.||.|.|:   |.:.:|..::.|||..:.||
  Rat  1441 LIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEKECIGNYV---DHEKNKMEVKGREWKRHEFH 1502

  Fly  1731 FDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFV 1795
            :|::...:||||||||.||||.:|..|:|..:|:.||..:.|..::.:|::|.::..||.|||||
  Rat  1503 YDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFV 1567

  Fly  1796 GFVIVTFQNEGEQEYKNCDLDKNQRNCIEFALKAKPVRRYIP--KHGIQYKVWWFVTSSSFEYTI 1858
            ..:|:|||.:|::..:.|.|:||:|.||:||:.|||:.||:|  :|..||:||.||.|.||||||
  Rat  1568 ALIIITFQEQGDKMMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTI 1632

  Fly  1859 FILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFII 1923
            ..:|.:|||.|.||:|:.|..|...|..||:.||.||:||.|.|:.||.|.|||.|.||:||||.
  Rat  1633 MAMIALNTVVLMMKYYSAPWTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFIT 1697

  Fly  1924 VLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGI 1988
            |:||..:|:.::.|..:||                  |.|:   :|.:|||..||:|||.:|..|
  Rat  1698 VIGSITEIILTDSKLVNTS------------------GFNM---SFLKLFRAARLIKLLRQGYTI 1741

  Fly  1989 RTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIALDGGNAITANNNFQTFQQAVLVLFR 2053
            |.|||||::||:|||||.|||.:||||||::||||||.|.||..:.|..:|||::|..::::|||
  Rat  1742 RILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFR 1806

  Fly  2054 SATGEAWQEIMMSCSAQPDVKCDMNSDTP-----GEPCGSSIAYPYFISFYVLCSFLIINLFVAV 2113
            |||||||||||:||..:..  |:.::..|     .|.||:.:||.||:||...||||::||||||
  Rat  1807 SATGEAWQEIMLSCLGEKG--CEPDTTAPSGQNESERCGTDLAYVYFVSFIFFCSFLMLNLFVAV 1869

  Fly  2114 IMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMA 2178
            |||||:|||||.|||||||||||:|:|:|||..|.|||.:.::..:|..:|||||.||.||.::|
  Rat  1870 IMDNFEYLTRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVA 1934

  Fly  2179 CKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIK-TDGNID--DANSELRATIKQIWKRTNPKLL 2240
            .||||.||||:..|.||.|.:||.|::||:|.|| ..|..|  ..:|||:.....||...:.|:|
  Rat  1935 YKRLVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKML 1999

  Fly  2241 DQVVPPPGNDDEVTVGKFYATYLIQDYFRRFKKRKEQEGKEGHPD-----------------SNT 2288
            |.:||.|...| :||||.||..:|.||:::.|.:|:::..|...:                 ||.
  Rat  2000 DLLVPMPKASD-LTVGKIYAAMMIMDYYKQSKVKKQRQQLEEQKNAPMFQRMEPSSLPQEIISNA 2063

  Fly  2289 VTL-------------QAGLRTLHEVSP-------ALKRAISGNLDEL-----DQEPEPMHRRHH 2328
            ..|             ::|..::..:||       .:..|..|...|.     ::|||....:  
  Rat  2064 KALPYLQQDPVSGLSGRSGYPSMSPLSPQEIFQLACMDPADDGQFQEQQSLVNEREPEVSELK-- 2126

  Fly  2329 TLFGSVWSSIRRHG----------NGTFRRSAKATASQSNGALAIGGSASAALGV-----GGSSL 2378
                ||.||  .||          .|:.|.|:....:.....:....|...:...     ..||.
  Rat  2127 ----SVQSS--NHGIYLPPDTQEHAGSGRASSMPRLTMDPQVVTDPSSMRRSFSTIRDKRSNSSW 2185

  Fly  2379 VLGSSDPAGGDYLYDTLNRSVADGVNNITRNIMQARLAA------AGKLQDELQGAGSGGELRTF 2437
            :...|.....:..|.:..||....:          ||:|      :|...|..:   |||..|  
  Rat  2186 LEEFSMERSSENTYKSRRRSYHSSL----------RLSAHRLNSDSGHKSDTHR---SGGRER-- 2235

  Fly  2438 GESISMRPLAKNGGGAATVAGTLPPEANAINYDNRNRGILLHPYNNVYAPNGALPGHERMIQSTP 2502
            |.|...:.|             |.|:.:..|.:.|                |.....|...:...
  Rat  2236 GRSKERKHL-------------LSPDVSRCNSEER----------------GTQADWESPERRQS 2271

  Fly  2503 ASPYDQR-RLPTSSDMNGLAESLIGGVLAAEGLGKYCDSEFVGTAAREMREALDMTPEEMNLAAH 2566
            .||.:.| :.|.......|:||.|..:            ....|..|..|:...:.|:...|.::
  Rat  2272 RSPSEGRSQTPNRQGTGSLSESSIPSI------------SDTSTPRRSRRQLPPVPPKPRPLLSY 2324

  Fly  2567 QILSNEHSLSLIGSSNGSIFGGSAGGLGGAGSGGVGG-------LGGSSSIRNAFGGS-----GS 2619
            ..|...                 .||:.....|..||       |..:|:.......|     |.
  Rat  2325 SSLMRH-----------------TGGISPPPDGSEGGSPLASQALESNSACLTESSNSLHPQQGQ 2372

  Fly  2620 GPSSLSPQH---QPY------------------------------SGTLNSPP-------IPDNR 2644
            .|   ||||   :||                              |.|:.|.|       :|:..
  Rat  2373 HP---SPQHYISEPYLALHEDSHASDCGEEETLTFEAAVATSLGRSNTIGSAPPLRHSWQMPNGH 2434

  Fly  2645 LRR 2647
            .||
  Rat  2435 YRR 2437

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 153/276 (55%)
Ion_trans 1137..1379 CDD:395416 139/242 (57%)
Ion_trans 1496..1809 CDD:395416 130/320 (41%)
Ion_trans 1851..2126 CDD:395416 144/279 (52%)
GPHH 2135..2188 CDD:407139 28/52 (54%)
Ca_chan_IQ 2199..2271 CDD:400901 31/74 (42%)
Cacna1eXP_038946935.1 Ion_trans 235..509 CDD:395416 153/276 (55%)
Ion_trans 622..861 CDD:395416 139/242 (57%)
Ion_trans 1301..1535 CDD:395416 112/273 (41%)
Ion_trans 1625..1882 CDD:395416 144/279 (52%)
GPHH 1891..1944 CDD:407139 28/52 (54%)
Ca_chan_IQ 1955..2028 CDD:400901 31/73 (42%)
Atrophin-1 2170..>2429 CDD:397323 58/334 (17%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100303
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
54.820

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