Protein Alignment Ca-alpha1D and na

DIOPT Version :9

• Sequence 1: NP_723952.2
• Gene: Ca-alpha1D / 34950
• FlyBaseID: FBgn0001991
• Length: 2705
• Species: Drosophila melanogaster
• Sequence 2: NP_001096981.2
• Gene: na / 45338
• FlyBaseID: FBgn0002917
• Length: 2233
• Species: Drosophila melanogaster
• Alignment Length: 2367
• Identity: 511/2367 - (21%)
• Similarity: 858/2367 - (36%)
• Gaps: 709/2367 - (29%)

  Fly   628 SSAELIDNFGGGAGKFFNIMDFERGASGEGGFSPN-------GNGGPGSGDVSRTARYDSGEGDL 685
            :|...|.|.|.|:|         .|:|...|..|.       |.||.||   |.||...||.|..
  Fly   198 NSPTTIVNSGSGSG---------GGSSVAFGMQPQQQQQSLAGGGGGGS---SATAAPSSGGGHN 250

  Fly   686 ------------GGGNNIMGIDSMGIANIPETMNGTTIGPSGAGGQKGGAAA------------- 725
                        |||.|::|                  |..|.||..|||||
  Fly   251 NGAGLGPVVGGGGGGLNLLG------------------GLGGMGGMGGGAAAAGMGICGGISSTV 297

  Fly   726 GAA----------------------GQKRQQRRGKPQPDRPQRALFCLSVKNPLRALCIRI-VEW 767
            |:|                      |:|:..:.|:|          .|:...|..:|.... :||
  Fly   298 GSAAITGVPPIGLGIATGIGNKIMLGRKQSLKGGEP----------FLADYGPEESLNESADIEW 352

  Fly   768 KP---FEFLILLTIFANCIALAVYTP-----YP-------GSDSNVTNQTLEKVEYVFLVIFTAE 817
            ..   ...|:.|....:..::::.||     ||       .||:.||            ::||||
  Fly   353 VNKLWVRRLMRLCALVSLTSVSLNTPKTFERYPSLQFITFASDTAVT------------LLFTAE 405

  Fly   818 CVMKILAYGFVLHNGA-YLRNGWNLLDFTIVVIGAISTALS--QLMKDAFDVKALRAFRVLRPLR 879
            .:.|:...| |||... ||::.|...|.::|....||..|.  ::::.......|...|..|||.
  Fly   406 MIAKMHIRG-VLHGEVPYLKDHWCQFDASMVSFLWISIILQIFEVLEIVPKFSYLSIMRAPRPLI 469

  Fly   880 LVS--------GVPSLQVVLNSILK-AMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDEI 935
            ::.        .:|..::  |.|.| :...::::.|..||.:.:|.::|::.| |:|...|....
  Fly   470 MIRFLRVFLKFSMPKSRI--NQIFKRSSQQIYNVTLFFLFFMSLYGLLGVQFF-GELKNHCVMNN 531

  Fly   936 TGEYEENIRP-------------CGV----GYQCPPGYKCYG---------GWDGPNDGITNFDN 974
            | ||:...||             |.:    ||||.||..|..         |::|       |::
  Fly   532 T-EYDLYKRPILTINSLAIPDTFCSMDPDSGYQCSPGMVCMKMDFLSSYVIGFNG-------FED 588

  Fly   975 FGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERN 1039
            ...::.||:|..:.|||..::|...|::.:.....||.:|:...|:.|.|:.:.|::..|::.|.
  Fly   589 IATSIFTVYQAASQEGWVFIMYRAIDSLPAWRAAFYFSTMIFFLAWLVKNVFIAVITETFNEIRV 653

  Fly  1040 KAKN----RGDFQKLREKQQIEEDLRGYLDWITQAEDIEPDAVGGLISDGKGKQPNEMDSTENLG 1100
            :.:.    ||..||....|.:..:..|:     :...|:.:..|||
  Fly   654 QFQQMWGARGHIQKTAASQILSGNDTGW-----RLVTIDDNKHGGL------------------- 694

  Fly  1101 EEMPEVQMTESRWRKMKKDFDRVNRRMRRACRKAVKSQAFYWLIIVLVFLNTGVLAT---EHYGQ 1162
              .||                        .|...::|..|..|::.::..|..|.||   :|.|:
  Fly   695 --APE------------------------TCHAILRSPYFRMLVMSVILANGIVTATMTFKHDGR 733

  Fly  1163 LDWLDNFQEYTNVFFIGL-FTC----EMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNT 1222
            .  .|.|  |...::|.| |||    |.|.|:|.||::||:....::|:..:..|    |.|...
  Fly   734 P--RDVF--YERYYYIELVFTCLLDLETLFKIYCLGWRGYYKHSIHKFELLLAAG----TTLHIV 790

  Fly  1223 GMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVF 1287
            .|..|.|::..:.:|::|:.|.:.   .|...|..:....:.:.||::.....::|.:.:.||:|
  Fly   791 PMFYPSGLTYFQVLRVVRLIKASP---MLEGFVYKIFGPGKKLGSLIIFTMCLLIISSSISMQLF 852

  Fly  1288 GGKFNFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILF 1352
            ....:|        ..|:.|.:|.:::|||:|.|.|..||  .........:...|..:|||:..
  Fly   853 CFLCDF--------TKFESFPEAFMSMFQILTQEAWVEVM--DETMIRTSKTLTPLVAVYFILYH 907

  Fly  1353 ICGNYILLNVFLAIAVDNLADADSLSEVEKEEEPHDESAQKKS-------------HSPTPTI-- 1402
            :....|:|::|:|:.:|||...:.:.:: |:.:..::||:.|.             .||..||
  Fly   908 LFVTLIVLSLFVAVILDNLELDEDIKKL-KQLKFREQSAEIKETLPFRLRIFEKFPDSPQMTILH 971

  Fly  1403 ------------DGMDDHLSIDIDME----------------------QQE-------------- 1419
                        :....|..|:::.|                      :|:
  Fly   972 RIPNDFMLPKVRESFMKHFVIELETEDSLVENCKRPMSECWESNVVFRKQKPVRIMNKTAKVRAA 1036

  Fly  1420 ------------LDDED-----------------------------------KMDHETLSDEEVR 1437
                        ::|.:                                   ::|.:......:|
  Fly  1037 GSSLRKLAITHIINDSNNQRLMLGDSAMLPVVGTKGGGGLKSQGTITHSKPWRVDQKKFGSRSIR 1101

  Fly  1438 --------EMCEEEEEVDEEGMITARPR----RMSEVNTATKILPIPP----------------- 1473
                    ::.:..|.:.|.|.|.|.||    |....:...|:|....
  Fly  1102 RSVRSGSIKLKQTYEHLMENGDIAAAPRANSGRARPHDLDIKLLQAKRQQAEMRRNQREEDLREN 1166

  Fly  1474 ----GTSFFLFSQTNRFRVFCHWLCN-----------------------HSNFGNI--------- 1502
                .|..||..:.:|||..|..:.:                       |:..|.:
  Fly  1167 HPFFDTPLFLVPRESRFRKICQKIVHARYDARLKDPLTGKERKVQYKSLHNFLGLVTYLDWVMIF 1231

  Fly  1503 --ILCCIMFSSAMLAAENPLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSA 1565
              .|.||   |.|....| .|..|  :..|...:|.|....::||.||:::.|......|:.:..
  Fly  1232 ATTLSCI---SMMFETPN-YRVMD--HPTLQIAEYGFVIFMSLELALKILADGLFFTPKAYIKDV 1290

  Fly  1566 FNLLDLLVVCVSL-----ISLVSSSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKT 1625
            ...||:.:..||.     :.|...:|  |..::|.:||.:||||.......::.||..:....|
  Fly  1291 AAALDVFIYVVSTSFLCWMPLNIPTN--SAAQLLMILRCVRPLRIFTLVPHMRKVVYELCRGFK- 1352

  Fly  1626 IGNIVLVTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFK 1690
              .|:||:.||                                 .||.|:||..||||:.|:..:
  Fly  1353 --EILLVSTLL---------------------------------ILLMFIFASYGVQLYGGRLAR 1382

  Fly  1691 CTDGSKMTQDECYGTY----------LVYDDGDVHKPRLREREWSN-NRFHFDDVAKGMLTLFTV 1744
            |.|.:...:::|.|.:          |.....:.:...|..|.|:| .||:||::...|||||.|
  Fly  1383 CNDPTISRREDCVGVFMRRVFVTKMKLTPGPDESYPAMLVPRVWANPRRFNFDNIGDAMLTLFEV 1447

  Fly  1745 STFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTF-QNEGE- 1807
            .:|:||..:..|.|.:    .||:|      |.|..|||.:.....:.:|||.||..: :|:|.
  Fly  1448 LSFKGWLDVRDVLIKA----VGPVH------AVYIHIYIFLGCMIGLTLFVGVVIANYSENKGTA 1502

  Fly  1808 ----QEYKNCDLDKNQRNCIEFALKAKPVRRYIPKHGIQYKVWWFVTSSSFEYTIFILIMINTVT 1868
                .:.:.|||.|..:......|..:|..|.|  ....|.:...:.   |:..|.::::||::.
  Fly  1503 LLTVDQRRWCDLKKRLKIAQPLHLPPRPDGRKI--RAFTYDITQHII---FKRVIAVVVLINSML 1562

  Fly  1869 LAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVY 1933
            |::.:....: :||.|..::.:.|.||.:|.|.|..||..:.|:....|.:|.::.:...|.|:.
  Fly  1563 LSITWIKGEV-HTERLVIVSAVLTFVFVVEVVMKNIAFTPRGYWQSRRNRYDLLVTVAGVIWIIL 1626

  Fly  1934 SEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKS 1998
            ..|...|.|..               .|..::.:.||.:......:|:|....|:     :..||
  Fly  1627 QTILRNDLSYF---------------FGFMVVILRFFTITGKHTTLKMLMLTVGV-----SVCKS 1671

  Fly  1999 FQALPYVALLIVLLFFIYAVVGMQVFGKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEI 2063
            |    ::...:.||.|.||:.|..:||.:..  |..|....||.:....|.:|||..|||.|.:|
  Fly  1672 F----FIIFGMFLLVFFYALAGTILFGTVKY--GEGIGRRANFGSPVTGVAMLFRIVTGEDWNKI 1730

  Fly  2064 MMSCSAQPDVKCDMNSDTPGEPCGS-SIAYPYFISFYVLCSFLIINLFVAVIMDNFD--YLTRDW 2125
            |..|..||.. |.:.::.....||: :.:..||.:|||:.:::::||.||:||:||.  |...:.
  Fly  1731 MHDCMVQPPY-CTLGNNYWETDCGNFTASLIYFCTFYVIITYIVLNLLVAIIMENFSLFYSNEED 1794

  Fly  2126 SILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMAC----KRLVSMN 2186
            ::|....:..|...|:..|...:|.|....|..:||          |...|:.|    .||:...
  Fly  1795 ALLSYADIRNFQNTWNIVDIHQRGVIPVRRVKFILR----------LLKGRLECDPQKDRLLFKY 1849

  Fly  2187 M-----PLNSDGTVLFNATLFAVVRTSLSIKTDGNIDD--ANSELRATIKQIWKRTNPKLLDQVV 2244
            |     .|::...|.|:..:..:...|:.|:....:::  |..|..
  Fly  1850 MCYELDKLHNGEDVTFHDVINMLSYRSVDIRKALQLEELLAREEFE------------------- 1895

  Fly  2245 PPPGNDDEVTVGKFYATYLIQDYFRRFKKRKEQEG-----KEGHPDSNTVTLQAGLRTLHEVSPA 2304
                             ||:::...:...|...||     :..:......:|.||||..:| .|.
  Fly  1896 -----------------YLVEEEVAKMTIRTWLEGCLKKIRAQNASKQQNSLIAGLRATNE-QPV 1942

  Fly  2305 LKRAISGNLDELDQEPEPMHRRHHTLFGSVWSSIRRHGNGTFRRSAKATASQSNGALAIGGSASA 2369
            ::       ..:.::..|:                    |...:||.:|.|   ||:|
  Fly  1943 MR-------PNIQEDKAPL--------------------GAVDKSAISTIS---GAVA------- 1970

  Fly  2370 ALGVGGSSLVLGSSDPAGGDY--LYDTLNRSVADGVNNITRNIMQARLAAAGKLQDELQGAGSGG 2432
                       |:..|....:  .:.:......||.::....:..:..:.||      .|:.:.|
  Fly  1971 -----------GACPPTSDAFSPTFSSTENEEKDGSSSAVVQLPHSETSIAG------TGSSATG 2018

  Fly  2433 ELRTFGESISMRPLAKNGGGAATVAG------TLPPEANAINYDNRNRGI----LLHPYNNVYAP 2487
            .....|.|..:      |.|..||..      |:.....|:|..:.....    .|.|.::....
  Fly  2019 AATATGTSSGL------GVGPPTVQSTARHVMTVGKRGYALNRSDSTGSSAGRKFLAPTSSDPQQ 2077

  Fly  2488 NGALPGHERM-IQSTPASPYDQRRLPTSSDMNGLAESLIGGVLAAEGLGKYCDSEFVGTAAREMR 2551
            ...|...||: |.|..........||.:..:..||:...||..|.:      .|.|......|:.
  Fly  2078 RSTLSDKERLHITSQQRKKNSMTTLPHAGQLGQLAKQRGGGGEATK------SSSFFAQLNSEIG 2136

  Fly  2552 EALDMTPEEMNLAAHQILSNEHSLSLIGSSNGSIFGGSAGGLGGAGSGGVGGLGGSSSIRNAFGG 2616
            :....|   :|.||       .:.:|.|..:|.       |.|..|.||.|| .|...:.:..||
  Fly  2137 QFHYPT---INAAA-------AAAALHGYGHGH-------GHGHGGHGGHGG-HGEHQMHHHHGG 2183

  Fly  2617 SGSGPSSLSPQHQPYSGTLNSPPIPDN 2643
            :...||::..|....||.|    :|.|
  Fly  2184 ALGSPSAMMSQMIGGSGKL----LPFN 2206

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1D	NP_723952.2	Ion_trans	767..1042	CDD:395416	79/327 (24%)
		Ion_trans	1137..1379	CDD:395416	66/249 (27%)
		Ion_trans	1496..1809	CDD:395416	90/345 (26%)
		Ion_trans	1851..2126	CDD:395416	75/277 (27%)
		GPHH	2135..2188	CDD:407139	14/61 (23%)
		Ca_chan_IQ	2199..2271	CDD:400901	6/73 (8%)
na	NP_001096981.2	Ion_trans	373..654	CDD:278921	76/304 (25%)
		Ion_trans	734..927	CDD:278921	56/213 (26%)
		Ion_trans	1240..1497	CDD:278921	82/307 (27%)
		Ion_trans	1571..1793	CDD:278921	70/249 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439091
Domainoid	1	1.000	91	1.000	Domainoid score	I1740
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R175
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.880