DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and cacna1sb

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:NP_999891.1 Gene:cacna1sb / 405791 ZFINID:ZDB-GENE-051227-1 Length:1847 Species:Danio rerio


Alignment Length:1940 Identity:968/1940 - (49%)
Similarity:1267/1940 - (65%) Gaps:202/1940 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   712 GPSGAGGQKGGAAAGAAG-------QKRQQRR---------GKPQPDRPQRALFCLSVKNPLRAL 760
            |..|.||..||..||.|.       .||:||.         |.|   ||.|.||...::||.|..
Zfish     5 GGGGGGGPGGGGVAGLASFIMNEEELKRKQREKLKKLLATGGNP---RPPRTLFFFKLRNPFRKA 66

  Fly   761 CIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVIFTAECVMKILAY 825
            |..||||||||.:|||||||||:||||:.|.|..|:|.||.|||.:||:||||||.||.:||:||
Zfish    67 CTNIVEWKPFEIIILLTIFANCVALAVFLPMPEEDTNNTNLTLESLEYIFLVIFTLECFLKIIAY 131

  Fly   826 GFVLHNGAYLRNGWNLLDFTIVVIGAIS---------TALSQLMKDAFDVKALRAFRVLRPLRLV 881
            |.:.|.||||||.||:|||.||.:|..:         |.:.:.....||:|||||||||||||||
Zfish   132 GLLFHEGAYLRNCWNILDFVIVFMGLFTLVVDTIDTITGVQKEKGGGFDMKALRAFRVLRPLRLV 196

  Fly   882 SGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDEITG--EYEENIR 944
            |||||||||::|:||:|:|||||.|||.|::.||||:|||||..|:||.|..:.|.  ...||.:
Zfish   197 SGVPSLQVVMSSVLKSMLPLFHILLLVFFMVTIYAIMGLELFKCKMHKTCYYQGTNIIALRENEK 261

  Fly   945 P-----CGVGYQCP-PGYKCYGGWDGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMG 1003
            |     .|.|.:|. .|.:|..||.|||.|||:|||||.||||||||:|.|.||||||.|.||||
Zfish   262 PSPCAQAGNGRRCTINGTECRDGWPGPNFGITHFDNFGFAMLTVFQCITTESWTDVLYWINDAMG 326

  Fly  1004 SDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERNKAKNRGDFQKLREKQQIEEDLRGYLDWIT 1068
            :||.|:||:|:::||:||::||:||||||||:|||.|:::||::|.|||:||::|||:||::|||
Zfish   327 NDWPWIYFLSLIMLGSFFILNLVLGVLSGEFTKEREKSRSRGEWQVLRERQQMDEDLKGYMEWIT 391

  Fly  1069 QAE--DIEPDAVGGLISDGKGKQPNEMDSTENLGEEMPEVQMTESRWRKMKKDFDRVNRRMRRAC 1131
            .||  |.:.||: .|:....|.:.:.:...|.:.:.:...::.. ||          |..:||.|
Zfish   392 HAEVMDGDSDAM-LLLRKDTGSETDSLYKMEGINKVVYFYRLAR-RW----------NIVIRRKC 444

  Fly  1132 RKAVKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQG 1196
            ...|||::|.|.::::|.|||.|:||||:.|.:.|.|||:..||..:..||.||::|||:.|.:.
Zfish   445 HGWVKSKSFNWWVLIVVLLNTLVIATEHHNQTEGLTNFQDTANVILLACFTIEMIMKMYAFGPRS 509

  Fly  1197 YFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNS 1261
            ||:|:|||||||||...|.|.:|..:|:|.|||:||:||:||||:||:||||.||:|||.|||||
Zfish   510 YFMSIFNRFDCFVVTIGILEIILVGSGIMTPLGISVMRCIRLLRLFKLTKYWTSLNNLVVSLLNS 574

  Fly  1262 IQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAV 1326
            ::||||||||||||||||||||||||||||||..:..: |.|||.|.|||::|||::|||:|:.:
Zfish   575 VKSIASLLLLLFLFIVIFALLGMQVFGGKFNFPDRPIQ-RSNFDNFPQALISVFQVLTGEEWDTI 638

  Fly  1327 MYVGINAYGGVSSYGALACIYFIILFICGNYILLNVFLAIAVDNLADADSLSEVEKEEEPHDESA 1391
            ||.||.|:||..|.|.|..||||||::|||::||||||||||||||:|:||:..:||..  :|.|
Zfish   639 MYNGIMAHGGPKSPGILVSIYFIILYVCGNFVLLNVFLAIAVDNLAEAESLAAAQKERA--EERA 701

  Fly  1392 QKKSHSPTPTIDGMDDHLSIDIDMEQQELDD------EDKMDHETLSDEEVR------EMCEEEE 1444
            :||...|.|.....:..|.....||.::..:      :.|:|....:..||:      :...::|
Zfish   702 RKKLMKPLPEKTEEEKALMAKRLMESRQKTEGMPTTAKLKIDEFESNVNEVKDPFPPADFPGDDE 766

  Fly  1445 EVDEEGMITARPRRMSEVNTATKILPIPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMF 1509
            |.:.|..|:.|||.|:::.....::|:|..:|||:|...|:||..||.:.||:.|.||||..|:.
Zfish   767 EEEPEIPISPRPRPMADLQLKETVVPMPEASSFFIFGPQNKFRKLCHRIINHTTFTNIILLFILL 831

  Fly  1510 SSAMLAAENPLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLVV 1574
            ||..||||:|:..:...||||...|..||.|||||::||:..||..||.|:|||::||:|||:||
Zfish   832 SSISLAAEDPIDPHSFRNKVLAYADIVFTTVFTIEIVLKMTVYGAFLHPGSFCRNSFNILDLIVV 896

  Fly  1575 CVSLISLVSSSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFM 1639
            .|||:|:...|:.|||||||||||||||||||||||||||||||:.||:||||||||||.||.||
Zfish   897 AVSLLSMGMESSTISVVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAIKTIGNIVLVTMLLDFM 961

  Fly  1640 FAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYG 1704
            |:            |                        ||||||||..|.|||..:.|.::|.|
Zfish   962 FS------------C------------------------IGVQLFKGTLFYCTDPLQKTAEQCQG 990

  Fly  1705 TYLVYDDGDVHKPRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIH 1769
            |:|.:....:|...:.:|.|.|:.|:||:|..|||.|||:|||||||.:||.:|||...:.||::
Zfish   991 TFLKHVQNSLHDTEIHQRRWVNSDFNFDNVLNGMLALFTISTFEGWPEILYKAIDSYDVDTGPLY 1055

  Fly  1770 NFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQEYKNCDLDKNQRNCIEFALKAKPVRR 1834
            |.|..::.::|||||||||||:||||||||||||.:||||||||:||||||.|:::||||:|::.
Zfish  1056 NNRVGISIFFIIYIIIIAFFMMNIFVGFVIVTFQRQGEQEYKNCELDKNQRQCVQYALKARPLKC 1120

  Fly  1835 YIPKHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEF 1899
            |||::..||:||:.|||..|||.:|.|||:||::|.|::.|||.:.|:|.|.||:|||.:|..|.
Zfish  1121 YIPENPHQYRVWYLVTSCYFEYLMFFLIMLNTLSLGMQYCNQPFYITKLSDNLNVIFTVLFTGEM 1185

  Fly  1900 VFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEI-KSKDTSQIAECDIVEGCKSTK-----K 1958
            :.||.||:.|.||||.||||||:||:||.:|:|.||: ::.:.|....|  :.||....     .
Zfish  1186 IVKLIAFKAKGYFGDPWNVFDFVIVIGSIVDVVLSEVDRTLEASGGLWC--LHGCSEVDPMQAIA 1248

  Fly  1959 SAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQV 2023
            .|.:..:||.|||||||:||:|||::.||||.|||||||||||||:|.||||:|||||||:|||:
Zfish  1249 EAENVKLSITFFRLFRVLRLIKLLNRSEGIRNLLWTFIKSFQALPHVGLLIVMLFFIYAVIGMQM 1313

  Fly  2024 FGKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSD-TPGE--P 2085
            ||||||..|..|..|||||||.||||:|||.||||.|.:||:  ::.....||..|| .|||  .
Zfish  1314 FGKIALVDGTEINRNNNFQTFPQAVLLLFRVATGEQWPKIML--ASMYGKLCDPKSDYGPGEEYT 1376

  Fly  2086 CGSSIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDAKGR 2150
            ||||||..||:|||:||:||:||||||:|||||||||.|||||||||||||.::|.||||:|.||
Zfish  1377 CGSSIAVCYFLSFYMLCAFLVINLFVAIIMDNFDYLTHDWSILGPHHLDEFKKIWGEYDPEATGR 1441

  Fly  2151 IKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIKTDG 2215
            |||||||||||:|.|||||||.|||..|||||:||||||||||||.|||||||:|||:|.|||:|
Zfish  1442 IKHLDVVTLLRRIQPPLGFGKFCPHHAACKRLISMNMPLNSDGTVTFNATLFALVRTALKIKTEG 1506

  Fly  2216 NIDDANSELRATIKQIWKRTNPKLLDQVVPPPGNDDEVTVGKFYATYLIQDYFRRFKKRKEQEGK 2280
            |.:.||.||||.||.|||||:.||||||:||.| :|||||||||||:|||::||:|.:|:|:...
Zfish  1507 NFEQANEELRAIIKSIWKRTSMKLLDQVIPPIG-EDEVTVGKFYATFLIQEHFRKFMQRQEELYG 1570

  Fly  2281 EGHPDSNTVTLQAGLRTL-HEVSPALKRAISGNL---DELDQEPEPMHRRHHTLFGSVWSSIRRH 2341
            ......|...::||||:: .|.:|.|.|||||:|   ||:::..|           |....|.|.
Zfish  1571 YRPTKKNADEIKAGLRSIEEEAAPELHRAISGDLIAEDEMERAME-----------SGEEGIYRR 1624

  Fly  2342 GNGTFRRSAKATASQSNGALAIGGSASAAL----------GVGGSSLVLGSSDPAGGDYLYDTLN 2396
            ..|.|..:|...:|:.:..|:...::...|          |....|:.|.::     ::..|  |
Zfish  1625 TGGLFGLNADPFSSEPSSPLSTQVTSQRPLQFAENRPEDAGSPPDSVFLPNT-----EFFPD--N 1682

  Fly  2397 RSVADGVNNITRNIMQARLAAAGKLQDELQGAGSGGELRTFGESIS---------MRPLAKNGGG 2452
            .......|| ..|.::                    |.....||:|         :|..:...||
Zfish  1683 MPTTSNTNN-NANFIE--------------------EFTFESESLSASRNYSYEDIRDSSLYVGG 1726

  Fly  2453 AATVAGTLPPEANAINYDNRNRGILLHPYNNVYAPNGALPGHERMIQSTPASPYDQRRLPTSSDM 2517
            |:.|......:.|......:      .|||    |:.....::|  .:..|||...:.:..:...
Zfish  1727 ASNVNDRRLSDFNVKTNSTQ------FPYN----PSCEESKNQR--SAAEASPATDKLIQQALRD 1779

  Fly  2518 NGLAESLIGGVLAAEGLGKYCDSEFVGTAAREMREALDMTPEEMNLAAHQILSNE 2572
            .|| |||      ||      |.:||....:|:.||:::..:::...|..|::.:
Zfish  1780 GGL-ESL------AE------DPQFVSVTRKELAEAVNIGLQDIESVAQGIVNGQ 1821

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 177/291 (61%)
Ion_trans 1137..1379 CDD:395416 152/241 (63%)
Ion_trans 1496..1809 CDD:395416 169/312 (54%)
Ion_trans 1851..2126 CDD:395416 166/283 (59%)
GPHH 2135..2188 CDD:407139 40/52 (77%)
Ca_chan_IQ 2199..2271 CDD:400901 52/71 (73%)
cacna1sbNP_999891.1 Ion_trans 91..365 CDD:278921 162/273 (59%)
Ion_trans 468..682 CDD:278921 137/214 (64%)
Ion_trans 836..1095 CDD:278921 160/294 (54%)
Ion_trans 1155..1417 CDD:278921 156/265 (59%)
GPHH 1425..1488 CDD:293510 50/62 (81%)
Ca_chan_IQ 1490..1561 CDD:285917 52/71 (73%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 371 1.000 Domainoid score I852
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1984 1.000 Inparanoid score I53
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 1 1.000 - - otm24284
orthoMCL 1 0.900 - - OOG6_100303
Panther 1 1.100 - - O PTHR45628
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X533
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
109.970

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