DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and NaCP60E

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:NP_001261172.1 Gene:NaCP60E / 37981 FlyBaseID:FBgn0085434 Length:2896 Species:Drosophila melanogaster


Alignment Length:3008 Identity:579/3008 - (19%)
Similarity:992/3008 - (32%) Gaps:1291/3008 - (42%)


- Green bases have known domain annotations that are detailed below.


  Fly   746 RALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVF 810
            ::||.....:|.|.:|:.|...:.|::.::.||..|||.||:            .:|:|:.||:|
  Fly   104 KSLFLFYPWSPARRVCVYIATNQFFDYCVMATILFNCIFLAM------------TETVEEAEYIF 156

  Fly   811 LVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAFRVL 875
            |.|::.|.|:||:|.||:|:...||||.||.|||.::..|..:..:     :..::..||.||||
  Fly   157 LAIYSIEMVIKIIAKGFLLNKYTYLRNPWNWLDFVVITSGYATIGM-----EVGNLAGLRTFRVL 216

  Fly   876 RPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDEITGE-- 938
            |.|:.||.:|.|:.::|::|.:...|..:..|.:|.::::|:..|:::.|:|...|..::..:  
  Fly   217 RALKTVSIMPGLKTIINALLHSFRQLAEVMTLTIFCLMVFALFALQVYMGELRNKCVRQVPTDWT 281

  Fly   939 ------------------YEENIRP--CG--VGYQ-CPPGYKCYGGWDGPNDGITNFDNFGLAML 980
                              |:|:..|  ||  .|.: ||..|.|....:.||.|.||||||..:||
  Fly   282 NVSHTDWQIWVNDTDNWLYDEDELPVLCGNLTGARHCPFEYVCLCVGENPNHGYTNFDNFMWSML 346

  Fly   981 TVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLIL------------------ 1027
            |.||.:||:.|.:| |::..|........:|..:|..|:|:::||:|                  
  Fly   347 TTFQLITLDYWENV-YNMVLATCGPMSVSFFTVVVFFGSFYLINLMLAVVALSYEEEAEITNEER 410

  Fly  1028 -------------------------------------GVLSGEFSKERNKAK------------- 1042
                                                 |||...:||::.:.|             
  Fly   411 KKDLLDHRDDSTFSFDPSVLNVKKLNKNNKKKIDSRKGVLLASYSKKKTRRKKTKGGKEGGTNGN 475

  Fly  1043 ---NRGD---------------------------FQKLREKQQIEE------------------- 1058
               :.||                           .|..::.||:|:                   
  Fly   476 GNGSNGDDNKSHSATPSPGPSPRHSATERPSALTMQAQKQYQQMEQQHKLAKSGSGGSNNPMAPT 540

  Fly  1059 -----------------------DLRGYLDWITQAEDIEPDAVG----------GLISDGKGKQP 1090
                                   |.:|.|  |..:.....::.|          |::.|.:    
  Fly   541 PKGRISFQDSGMGVKNPNMLYPSDYKGQL--IANSGQPSSNSSGVNRESSQDDSGVVDDHE---- 599

  Fly  1091 NEMDSTENLGE-EMPEVQMTESRWRKMK-----------------KDF-----------DRVNRR 1126
             |.|:|.::|. ...|:.::....|.:|                 ::|           ||...|
  Fly   600 -EQDTTNDMGHVSTVELALSPREVRLIKCNGNIARIKNHNVYALHQEFSSEVVVIDDLPDRNCDR 663

  Fly  1127 MRRACR-------------KAVKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFI 1178
            ....|.             |.|:...|...|.:.:.|||..||.||:|..:...|..:..|..|.
  Fly   664 CVHWCTDYESWLQFQNCLYKVVRDPLFELAITLCIVLNTAFLAMEHHGMSESFRNALDVGNKVFT 728

  Fly  1179 GLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFK 1243
            .:||.|.::|:.:|. :.:|:..:|.||..:|..|:.:.:.....     |:||||.:|||||.|
  Fly   729 SIFTFECIVKLMALS-KDFFLCGWNIFDLLIVTASLLDIIFELVD-----GLSVLRGLRLLRVLK 787

  Fly  1244 VTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEKY------RM 1302
            :.:.|.::..|::.::::|.::.:|.|:|.:.|.|||::|||:    |:.|...||:      |.
  Fly   788 LAQSWTTMKVLLSIIISTIGALGNLTLILVIVIYIFAVIGMQL----FSKDYTPEKFDPDPVPRW 848

  Fly  1303 NFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACI-YFIILFICGNYILLNVFLAI 1366
            ||:.|:.:.:.:|:|:.|| |...::..:.|   ....||..|. .|:...:.||:::||:|||:
  Fly   849 NFNDFFHSFMMIFRILCGE-WIEPLWDCMRA---EEEQGASTCFAIFLPTLVMGNFMVLNLFLAL 909

  Fly  1367 AVDNL---------------------------------------------------------ADA 1374
            .:::.                                                         |.|
  Fly   910 LLNSFNSEELKSKKEEVGEESKLARSIERVRDLIRKKRQERKDRKERKFAEKFQQIVLDAQQAHA 974

  Fly  1375 DSLSE-----VEKEEEP--------------------------------HD-------------- 1388
            .:||.     :|:.::|                                ||              
  Fly   975 QTLSHQAAVGLERGDKPGVLAETKFHRLSYQESMNRPVSGSDFGFQIPLHDGLHTIVDGLEYDDT 1039

  Fly  1389 ----ESAQKKSHSPTPTID---------------------------------------------- 1403
                |..|.::|...||.|                                              
  Fly  1040 GDLPEQIQLQAHPLPPTSDSMPPTYESAMMATTGGSFSSVNGNGTCQNLTPFVQAERRLQHQISS 1104

  Fly  1404 ----------------------------------------------------------GMDDH-- 1408
                                                                      |.::|  
  Fly  1105 GVSTQQYDSREEATYTESIELLGQYNSTDTDPYANDQRSGCGSFNRGDSLQDNSSRRYGSEEHDE 1169

  Fly  1409 -----------------LSID--------------------------------IDMEQQE-LDDE 1423
                             .|:|                                :.:||.| |..:
  Fly  1170 AFLKYQKSLLTRSPSYRKSLDRLSQSSGQSQRSLLKSEEAEMRRHSSGQSLNSMSIEQDELLSQQ 1234

  Fly  1424 DKMDHETLS--DEEVREMCEEEEEV-------------------------DEEGMI--------- 1452
            ..:..|.|:  .:|:.:..:||||:                         :.|.|:         
  Fly  1235 GNLREELLNCDQKELFQFLQEEEELQKGTKLRRISNVMRSRRPSSQMGQPENETMVEHSEFDNII 1299

  Fly  1453 --------------TARPRRMSEV-------NTATK---------------------ILPIPPGT 1475
                          |:..|::|.:       :.|||                     :||:.|..
  Fly  1300 QSFEKELEEIKRSTTSLERKLSNLSEPSPAADEATKAIMEHIAIITGASERSAADEVVLPLNPYD 1364

  Fly  1476 SFFL-----------------------------------FSQTNRFRVFC--------------- 1490
            |:.|                                   ||.:|..|..|               
  Fly  1365 SYDLSSVPRRSQSVSAAAQRQSVKLKRRSLEKQRKIDEDFSISNEIRKICDQIHAPFVAMEAMAV 1429

  Fly  1491 ----------------------------------------------------------------- 1490
                                                                             
  Fly  1430 AATSASQAQPNQSPFLRRKVDPFTVQFDRFKRLSLIERVEEVPEEEKPISTLRIESEKMPRKFLH 1494

  Fly  1491 ----------------------------------------------------------------- 1490
                                                                             
  Fly  1495 GPDQLRLDSLSLKSTNSYENLLIQKQKLGMATPPAVPATPPTSLKSSIEPPTLAQISSLKTTPPL 1559

  Fly  1491 ----------------------------------------------------------------- 1490
                                                                             
  Fly  1560 AALTEHQQHFHATSIQAAPTPAHTHAHSQAHAHSMAGQRRRMEHPQSTLDKAASFQSARTESHSS 1624

  Fly  1491 ----------------------------------------------------------------- 1490
                                                                             
  Fly  1625 GAADASSALALAMAQKTEQSQSTAPDATQKPSAFTRLTEKPWHCLVSYVDDLTVGGRRNSQGAYN 1689

  Fly  1491 ----------------------------------------------HW---------LCNHSNFG 1500
                                                          ||         :.:...|.
  Fly  1690 DPMTFPSYGATKAAKVPDDCFPQKCYDHFYFRCPWFMSCMDTQSAKHWTRVRTAVLTVVDTPAFE 1754

  Fly  1501 NIILCCIMFSSAMLAAEN-PLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRS 1564
            ..:|..|..||..|..|: .|..|..|.:||...::.|..:|.:|:|||.::.||    ..:..|
  Fly  1755 WFVLVLIFASSITLCFEDINLDKNKTLKRVLYWINFSFCLIFVVEMILKWLALGF----SKYFTS 1815

  Fly  1565 AFNLLDLLVVCVSLISLVSSSNA-ISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGN 1628
            .:.:||.::|.||:.||:...|. :.|::.||.||.|||||||:|.:|::.||..::.|:.:|.|
  Fly  1816 FWTILDFIIVFVSVFSLLIEENENLKVLRSLRTLRALRPLRAISRWQGMRIVVNALMYAIPSIFN 1880

  Fly  1629 IVLVTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTD 1693
            ::|| ||:.::                                   :|:::|||.|.||||||.:
  Fly  1881 VLLV-CLVFWL-----------------------------------IFSIMGVQFFGGKFFKCVN 1909

  Fly  1694 --GSKMTQDECYGTYLVYDDGDVHKPRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYV 1756
              |..:...|      |.|..|..:   :...|.|::..||.|..|.|.|..|:|||||..::..
  Fly  1910 EMGELLPITE------VNDKWDCIE---QNYTWINSKITFDHVGMGYLALLQVATFEGWMEVMAD 1965

  Fly  1757 SIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQEYKNCDLD----K 1817
            ::|:...:..|..........|::|:|:..:||.:|:|:|.:|..| |..:::|:...|:    :
  Fly  1966 AVDARGVDLQPQREANLYAYIYFVIFIVCGSFFTLNLFIGVIIDNF-NMLKKKYEGGVLEMFLTE 2029

  Fly  1818 NQRNCIEFALKAKPVRRYIPKHGIQYKVWWFV-------TSSSFEYTIFILIMINTVTLAMKFYN 1875
            :|::   :....|.:.|..|:..|:..:..|:       .|..||..||:||.:|.:|:.::.|:
  Fly  2030 SQKH---YYTAMKKLGRKKPQKVIKRPINHFLAMFYDLSNSRRFEIAIFVLIFLNMLTMGIEHYD 2091

  Fly  1876 QPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKD 1940
            ||.....:|:..|..||.||.||.:.|:...|: :||...||||||::||.|...|:..:|.   
  Fly  2092 QPHAVFFILEVSNAFFTTVFGLEAIVKIVGLRY-HYFTVPWNVFDFLLVLASIFGILMEDIM--- 2152

  Fly  1941 TSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYV 2005
                  .|:         .....|:.:  .|:||:.|:::|:...:|||.||:..:.|..||..:
  Fly  2153 ------IDL---------PISPTLLRV--VRVFRIGRILRLIKAAKGIRKLLFALVVSLPALFNI 2200

  Fly  2006 ALLIVLLFFIYAVVGMQVFGKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQ 2070
            ..|:.|:.||||::||.:||.:.|.|  |:....|||||.:::.:|||..|...|.:::.|...|
  Fly  2201 GALLGLITFIYAILGMSLFGNVKLQG--ALDDMVNFQTFGRSMQLLFRLMTSAGWNDVLESLMIQ 2263

  Fly  2071 PDVKCD--MNSDTPGEPCGSS-IAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSI-LGPH 2131
            |. .||  ::..|.|. ||.. :|..||.||.::...::||:::|:|::||:...::..| :...
  Fly  2264 PP-DCDPFIHGHTNGN-CGHPLLAITYFTSFIIISYMIVINMYIAIILENFNQAHQEEEIGIVED 2326

  Fly  2132 HLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVL 2196
            .|:.|...||:|||.|...|....:...:..:.||||..|  |:.:|   |||.|:|::....:.
  Fly  2327 DLEMFYIRWSKYDPHATQFIHFSQLSDFIASLDPPLGISK--PNNVA---LVSFNLPISKGNKIH 2386

  Fly  2197 FNATLFAVVRTSLSIKTDGNIDDANSELRATIKQIWKRTNPKLLDQVVPPPGNDDEVTVGKFYAT 2261
            ....|.|:|:..|     |::::.::     .||:.::.:.|...|.  |...:.|:...     
  Fly  2387 CLDILHALVKHVL-----GHVEETDN-----FKQLQEQMDVKFKKQF--PTRKELEIVSS----- 2434

  Fly  2262 YLIQDYFRRFKKRKEQEGKEGHPDSNTVTLQAGLRTLHEVSPALKRAISGNLDELDQEPEPMHRR 2326
                   .|..||:|:..|         |:|.|.:.........:|:.||  |...|...|    
  Fly  2435 -------TRIWKRQEKAAK---------TIQTGWKEYLRRKREKERSNSG--DSATQTSSP---- 2477

  Fly  2327 HHTLFGSVWSS-----------IRRHGNGTFRRSAKATASQSNGALAIGGSASAALGVGGSSLVL 2380
                  ..|.|           :.|.|.....|::...:|:::.|..:...|             
  Fly  2478 ------GGWQSKLSALNFFHLQVSRRGTACSSRASSRKSSRASDASDLSELA------------- 2523

  Fly  2381 GSSDPAGGDYLYDTLNRSVADGVNNITRNIMQARLAAAGKLQDELQGAGS-------GGELRTF- 2437
                   |.:|  .|...:..|.:.:.::|.|.        .|||...||       ....|:| 
  Fly  2524 -------GPWL--NLPLMLVSGADEVVKDIKQQ--------NDELGKRGSIFVEAPRASRRRSFY 2571

  Fly  2438 ----------GESISM----RPLAKNG-----------GGAATVAGTLP-----PEANAINYDNR 2472
                      .:|::.    |..|.|.           .|.|:...|.|     |.|.:.:..:|
  Fly  2572 NFFLRHQDAVDDSLTSPSVHRKTAMNNTTNTTSNSASTSGTASSTATAPATGCGPAATSASDSDR 2636

  Fly  2473 NRGILLHPYNNVYAPNGALPGHERMIQSTPASPYDQRRLPTSSDMNGLAESLIGGVLAAEGLGKY 2537
            ::.:          ..|:.|..:|      ||.:.:::.|....            |:|:...:.
  Fly  2637 HQAV----------GGGSAPSRKR------ASSFIRKKPPLERG------------LSAQSALRV 2673

  Fly  2538 CDSEFVGTAAREMREALDMTPEEMNLAAHQILSNEHSLSLIGSSNGSIF--------------GG 2588
            ..:.||..|:.........:||:.        ::.||||| ...|.::.              ..
  Fly  2674 NKNAFVSEASAPEVIVTRPSPEQQ--------THPHSLSL-RPDNATLVHVLVHRESEEYKEEDE 2729

  Fly  2589 SAGGLGGAGSGGVGGLGGSS-----SIRNAFGGSGSGPSSL-------------SPQHQPYSGTL 2635
            |:..:.|.|:|...||...|     .||..   :||..||:             ||:..| .|..
  Fly  2730 SSPSVSGNGNGFGVGLDMLSKQPPPQIRIT---TGSVESSMDTCAMPTVQIMVDSPKDPP-RGDF 2790

  Fly  2636 NSPPIPDNRLRRVATVTTTN----------NNNKSQVSQNNSNSLNVRANANS---QMNMSPTGQ 2687
            :|.||.|     |......|          :.|..:.:.:..|..:..|...|   :....|...
  Fly  2791 SSAPIDD-----VGAPIDVNVQGDTSQVFYDYNPEKATDDQGNGQDETAQFESLPDRQRXPPVNT 2850

  Fly  2688 PVQQQSPLRGQGNQTYSS 2705
            |::.......:|:::.||
  Fly  2851 PLRDSEKRSSRGSRSSSS 2868

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 97/354 (27%)
Ion_trans 1137..1379 CDD:395416 76/305 (25%)
Ion_trans 1496..1809 CDD:395416 95/316 (30%)
Ion_trans 1851..2126 CDD:395416 93/277 (34%)
GPHH 2135..2188 CDD:407139 19/52 (37%)
Ca_chan_IQ 2199..2271 CDD:400901 11/71 (15%)
NaCP60ENP_001261172.1 Ion_trans 152..371 CDD:278921 75/224 (33%)
Ion_trans 705..902 CDD:278921 63/210 (30%)
Ion_trans 1768..2019 CDD:278921 90/300 (30%)
Na_channel_gate 2009..2063 CDD:240441 10/57 (18%)
Ion_trans 2085..2320 CDD:278921 84/259 (32%)
GPHH 2331..2386 CDD:293510 20/59 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45439095
Domainoid 1 1.000 73 1.000 Domainoid score I3264
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 311 1.000 Inparanoid score I473
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
54.920

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