DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and Nalcn

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:XP_036014574.1 Gene:Nalcn / 338370 MGIID:2444306 Length:1787 Species:Mus musculus


Alignment Length:1730 Identity:397/1730 - (22%)
Similarity:700/1730 - (40%) Gaps:451/1730 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   767 W--KPF-EFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYV-------FLVIFTAECVMK 821
            |  ||: ..|:.:....:.|::.:.||       :|.:....::||       .:.::|||.:.|
Mouse    48 WINKPWVHSLLRICAIISVISVCMNTP-------MTFEHYPPLQYVTFTLDTLLMFLYTAEMIAK 105

  Fly   822 ILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAF---RVLRPLRLVSG 883
            :...|.|..:.:|:::.|.:.|..:|....:|..| |:.:.|..|..:..:   |:.|||.::..
Mouse   106 MHIRGIVKGDSSYVKDRWCVFDGFMVFCLWVSLVL-QVFEIADIVDQMSPWGMLRIPRPLIMIRA 169

  Fly   884 --------VPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELF-SGKLHKACRDEITG-- 937
                    :|..::. |.:.::...::.:::.:||.:::|.|:|:::| :...|....|...|  
Mouse   170 FRIYFRFELPRTRIT-NILKRSGEQIWSVSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNV 233

  Fly   938 --------------EYEENIRPCGVGYQCPPGYKCYG----GWDGPNDGITNFDNFGLAMLTVFQ 984
                          |.||       |||||||:||..    |......|.:.|:..|.::.||::
Mouse   234 TWNSLAIPDTHCSPELEE-------GYQCPPGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYE 291

  Fly   985 CVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERNKAKNRGDFQK 1049
            ..:.|||..::|...|:......:.|||:::...|:.|.|:.:.|:...|      |:.|..||:
Mouse   292 ASSQEGWVFLMYRAIDSFPRWRSYFYFITLIFFLAWLVKNVFIAVIIETF------AEIRVQFQQ 350

  Fly  1050 LREKQQIEEDLRGYLDWITQA--------EDIEPDAVGGLISDGKGKQPNEMDSTENLGEEMPEV 1106
            :               |.|::        :....||.||                          
Mouse   351 M---------------WGTRSSTTSTATTQMFHEDAAGG-------------------------- 374

  Fly  1107 QMTESRWRKMKKDFDRVNRRMRRACRKAVKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQE 1171
                  |:.:..|.::...|.....:|.::|..|:..|:.:|.::..|.|:.:|...::...:.|
Mouse   375 ------WQLVAVDVNKPQGRAPACLQKMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDE 433

  Fly  1172 Y--TNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLR 1234
            :  ..|.|..||..|.|||::.|||.||..|..::|:..:|||       |...:.|.|..|...
Mouse   434 FYLAEVAFTVLFDLEALLKIWCLGFTGYISSSLHKFELLLVIG-------TTLHVYPDLYHSQFT 491

  Fly  1235 CVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEK 1299
            ..::|||.::.|...:|.:.|..:....:.:.||::.....:::.:.:.:|:|......|     
Mouse   492 YFQVLRVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELD----- 551

  Fly  1300 YRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYILLNVFL 1364
               .|..|.:|.:::|||:|.|.|..||...:||.|.:  :..|..||||:..:....|||::|:
Mouse   552 ---RFTTFPRAFMSMFQILTQEGWVDVMDQTLNAVGHM--WAPLVAIYFILYHLFATLILLSLFV 611

  Fly  1365 AIAVDNLADADSLSEVE--KEEEPHDESAQK-----------------------KSHSPTPTIDG 1404
            |:.:|||...:.|.:::  |:.|.:.::.:|                       .|....|.|  
Mouse   612 AVILDNLELDEDLKKLKQLKQSEANADTKEKLPLRLRIFEKFPNRPQMVKISKLPSDFTVPKI-- 674

  Fly  1405 MDDHLSIDIDMEQQELDDEDKMDHETLS---DEEVREMCEEEEEVDE---EGMITARPRRMSEVN 1463
            .:..:...||.:||:.....::...|.|   |...:...|:.:.:|:   :.:.:.|.|.:.|..
Mouse   675 RESFMKQFIDRQQQDTCCLFRILPSTSSSSCDNPKKPTAEDNKYIDQKLRKSVFSIRARNLLEKE 739

  Fly  1464 TA-TKIL--------------------------------------------PIPPGTS------- 1476
            || ||||                                            .|..|.|       
Mouse   740 TAVTKILRACTRQRMLSGSFEGQPAKERSILSVQHHIRQERRSLRHGSNSQRISRGKSLETLTQD 804

  Fly  1477 ------------------------------------------------FFLFSQTNRFRVFCHWL 1493
                                                            .|:..:.:|||.||..:
Mouse   805 HSNTVRYRNAQREDSEIKMIQEKKEQAEMKRKVQEEELRENHPYFDKPLFIVGREHRFRNFCRVV 869

  Fly  1494 CN--------------------HSNFG-------------NIILC-CI--MFSSAMLAAENPLRA 1522
            ..                    |..:.             .:.:| ||  ||       |:|.| 
Mouse   870 VRARFNASKTDPVTGAVKNTKYHQLYDLLGLVTYLDWVMITVTICSCISMMF-------ESPFR- 926

  Fly  1523 NDDLNKVLNK-----FDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISLV 1582
                 :|::.     .:|.|....:|||.||:::.|......|..|....::|:.:..||||.|.
Mouse   927 -----RVMHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAVIRDFGGVMDIFIYLVSLIFLC 986

  Fly  1583 ---SSSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIG 1644
               .:..|.|..::|.|||.|||||.......::.||:.:....|.|             |.|  
Mouse   987 WMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQMRKVVRELFSGFKEI-------------FLV-- 1036

  Fly  1645 VQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVY 1709
                               :|:|:|.:|  :||..|||||.||..||.|.:.:.:::|.|.:.: 
Mouse  1037 -------------------SILLLTLML--VFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRI- 1079

  Fly  1710 DDGDVHKP---RLR----------EREWSNNR-FHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDS 1760
             :..|.|.   :||          .|.|:|.| |:||:|...||.||.|.:.:||..:..|.|  
Mouse  1080 -NVSVSKNLNLKLRPGEKKPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVRDVII-- 1141

  Fly  1761 NKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTF-QNEGEQEYKNCDLDKNQRNCIE 1824
              ...||||..      |..:::.:.....:.:|||.||..| :|:|.   ....:|:.:...::
Mouse  1142 --HRVGPIHGI------YIHVFVFLGCMIGLTLFVGVVIANFNENKGT---ALLTVDQRRWEDLK 1195

  Fly  1825 FALK-AKPVRRYIP----KHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKF-YNQPLWYTEL 1883
            ..|| |:|:  ::|    ..|.:.|::.......|:.||.:|::..:|.|::|: .:.|:  |..
Mouse  1196 SRLKIAQPL--HLPPRPDNDGFRAKMYDITQHPFFKRTIALLVLAQSVLLSVKWDVDDPV--TVP 1256

  Fly  1884 LDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIV-LGSFIDIVYSEIKSKDTSQIAEC 1947
            |..::::||.:|.||...|:.|.....::....|.:|.::. ||....:::..:.:..|..:..|
Mouse  1257 LATMSVVFTFIFVLEVTMKIIAMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGAC 1321

  Fly  1948 DIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLL 2012
            .||                   ||.|      .:..|...::.||.|.:.|.....::.:.:.||
Mouse  1322 VIV-------------------FRFF------SICGKHVTLKMLLLTVVVSMYKSFFIIVGMFLL 1361

  Fly  2013 FFIYAVVGMQVFGKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDM 2077
            ...||..|:.:||.:..  |..|..:.||.:..:|:.||||..|||.|.:||..|..||.. |  
Mouse  1362 LLCYAFAGVVLFGTVKY--GENINRHANFSSAGKAITVLFRIVTGEDWNKIMHDCMVQPPF-C-- 1421

  Fly  2078 NSDTPGE------PCGS-SIAYPYFISFYVLCSFLIINLFVAVIMDNFD--YLTRDWSILGPHHL 2133
               ||.|      .||: :.|..||.||||:.:::::||.||:|::||.  |.|.:..:|..:.|
Mouse  1422 ---TPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLNLLVAIIVENFSLFYSTEEDQLLSYNDL 1483

  Fly  2134 DEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFN 2198
            ..|..:|:..|...:|.|....|..|||.:...|.. .|...::..|.:......|::.|.|.|:
Mouse  1484 RHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGRLEV-DLDKDKLLFKHMCYEMERLHNGGDVTFH 1547

  Fly  2199 ATLFAVVRTSLSIKTDGNIDD--ANSELRATI-KQIWKRT 2235
            ..|..:...|:.|:....:::  |..:|..|| :::.|:|
Mouse  1548 DVLSMLSYRSVDIRKSLQLEELLAREQLEYTIEEEVAKQT 1587

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 71/316 (22%)
Ion_trans 1137..1379 CDD:395416 69/243 (28%)
Ion_trans 1496..1809 CDD:395416 95/351 (27%)
Ion_trans 1851..2126 CDD:395416 80/285 (28%)
GPHH 2135..2188 CDD:407139 12/52 (23%)
Ca_chan_IQ 2199..2271 CDD:400901 9/40 (23%)
NalcnXP_036014574.1 Ion_trans 52..347 CDD:395416 71/316 (22%)
Ion_trans 399..619 CDD:395416 67/236 (28%)
Ion_trans 903..1177 CDD:395416 92/334 (28%)
Ion_trans 1225..1474 CDD:395416 80/283 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.950

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