Protein Alignment Ca-alpha1D and para

DIOPT Version :9

• Sequence 1: NP_723952.2
• Gene: Ca-alpha1D / 34950
• FlyBaseID: FBgn0001991
• Length: 2705
• Species: Drosophila melanogaster
• Sequence 2: NP_001259619.1
• Gene: para / 32619
• FlyBaseID: FBgn0285944
• Length: 2145
• Species: Drosophila melanogaster
• Alignment Length: 2393
• Identity: 525/2393 - (21%)
• Similarity: 892/2393 - (37%)
• Gaps: 816/2393 - (34%)

  Fly   551 ITEEDD--DEDENADYGDFDRE---------------DQELDDEEPEGTTIDIDEQEQQHDQGDS 598
            :||:.|  .|:|.:.:..|.||               .:||:.:..||.......:::|
  Fly     1 MTEDSDSISEEERSLFRPFTRESLVQIEQRIAAEHEKQKELERKRAEGEVPQYGRKKKQ------ 59

  Fly   599 AEEEDDDEDVDEYFEEEEDDT------------QAFSP-FYSSSAELIDNFGGGAGKFFNIMDFE 650
            .|...||||.||  ..:.|.|            .:|.| ..|:..|.||.:      :.|::.|.
  Fly    60 KEIRYDDEDEDE--GPQPDPTLEQGVPIPVRLQGSFPPELASTPLEDIDPY------YSNVLTFV 116

  Fly   651 RGASGEGGFSPNGNGGPGSGDVSRTARYDSGEGDLGGGNNIMGIDSMGIANIPETMNGTTIGPSG 715
            ..:.|:              |:.|.:
  Fly   117 VVSKGK--------------DIFRFS--------------------------------------- 128

  Fly   716 AGGQKGGAAAGAAGQKRQQRRGKPQPDRPQRALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFA 780
                                        ..:|::.|...||:|.:.|.|:....|...|:.||..
  Fly   129 ----------------------------ASKAMWMLDPFNPIRRVAIYILVHPLFSLFIITTILV 165

  Fly   781 NCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFT 845
            |||.:.:          .|..|:|..|.:|..|:|.|..:|::|.||:|....|||:.||.|||.
  Fly   166 NCILMIM----------PTTPTVESTEVIFTGIYTFESAVKVMARGFILCPFTYLRDAWNWLDFV 220

  Fly   846 IVVIGAISTALSQLMKDAFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLF 910
            ::.:..::..:     |..::.|||.|||||.|:.|:.||.|:.::.::::::..|..:.:|.:|
  Fly   221 VIALAYVTMGI-----DLGNLAALRTFRVLRALKTVAIVPGLKTIVGAVIESVKNLRDVIILTMF 280

  Fly   911 VIIIYAIIGLELFSGKLHKACRDE---------ITGE------------YEE----------NIR 944
            .:.::|::||:::.|.|.:.|..:         :|.|            |.|          ||.
  Fly   281 SLSVFALMGLQIYMGVLTQKCIKKFPLDGSWGNLTDENWDYHNRNSSNWYSEDEGISFPLCGNIS 345

  Fly   945 PCGVGYQCPPGYKCYGGW-DGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQW 1008
            ..|   ||...|.|..|: ..||.|.|:||:||.|.|:.|:.:|.:.|.| ||.:.......|..
  Fly   346 GAG---QCDDDYVCLQGFGPNPNYGYTSFDSFGWAFLSAFRLMTQDFWED-LYQLVLRAAGPWHM 406

  Fly  1009 MYFISMVILGAFFVMNLILGVLSGEFSKERNKAK------------------------------- 1042
            ::||.::.||:|:::||||.:::..:.:.:.||:
  Fly   407 LFFIVIIFLGSFYLVNLILAIVAMSYDELQKKAEEEEAAEEEAIREAEEAAAAKAAKLEERANAQ 471

  Fly  1043 ------------------------------------NRGDFQKLREKQQIE-------------- 1057
                                                .:|:....:||..|.
  Fly   472 AQAAADAAAAEEAALHPEMAKSPTYSCISYELFVGGEKGNDDNNKEKMSIRSVEVESESVSVIQR 536

  Fly  1058 ----------------------------------------------------------------E 1058
                                                                            :
  Fly   537 QPAPTTAHQATKVRKVSTTSLSLPGSPFNIRRGSRSSHKYTIRNGRGRFGIPGSDRKPLVLSTYQ 601

  Fly  1059 DLRGYLDWITQAEDIEP-------------------------------------DAVGGLISDGK 1086
            |.:.:|.:...:..:.|                                     |.:||:...|.
  Fly   602 DAQQHLPYADDSNAVTPMSEENGAIIVPVYYGNLGSRHSSYTSHQSRISYTSHGDLLGGMAVMGV 666

  Fly  1087 GKQPNE-------------------------------------MDSTENLGE----EMPEVQMTE 1110
            .....|                                     ::.|:..|:    :.|.::..:
  Fly   667 STMTKESKLRNRNTRNQSVGATNGGTTCLDTNHKLDHRDYEIGLECTDEAGKIKHHDNPFIEPVQ 731

  Fly  1111 SRWRKMKKD-------FDRVNRRMRRACRKAV-----------------KSQA------------ 1139
            ::.....||       .::...|..||..:.|                 |.:|
  Fly   732 TQTVVDMKDVMVLNDIIEQAAGRHSRASDRGVSVYYFPTEDDDEDGPTFKDKALEVILKGIDVFC 796

  Fly  1140 -----FYWL------------------IIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLF 1181
                 :.||                  |.:.:.:||..:|.:|:.....::...:..|.||...|
  Fly   797 VWDCCWVWLKFQEWVSLIVFDPFVELFITLCIVVNTMFMAMDHHDMNKEMERVLKSGNYFFTATF 861

  Fly  1182 TCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVTK 1246
            ..|..:|:.::..:.||...:|.||..:|..|:.|     .|:....|:||||..|||||||:.|
  Fly   862 AIEATMKLMAMSPKYYFQEGWNIFDFIIVALSLLE-----LGLEGVQGLSVLRSFRLLRVFKLAK 921

  Fly  1247 YWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEKY------RMNFD 1305
            .|.:|:.|::.:..::.::.:|..:|.:.|.|||::|||:||.  |:...::::      |.||.
  Fly   922 SWPTLNLLISIMGRTMGALGNLTFVLCIIIFIFAVMGMQLFGK--NYHDHKDRFPDGDLPRWNFT 984

  Fly  1306 CFWQALLTVFQIMTGE----DWNAVMYVGINAYGGVSSYGALACI-YFIILFICGNYILLNVFLA 1365
            .|..:.:.||:::.||    .|:. |||           |.::|| :|:...:.||.::||:|||
  Fly   985 DFMHSFMIVFRVLCGEWIESMWDC-MYV-----------GDVSCIPFFLATVVIGNLVVLNLFLA 1037

  Fly  1366 IAVDNLA-----------DADSLSEV----------------------------EKEEEP----- 1386
            :.:.|..           |.:.::|.                            :..::|
  Fly  1038 LLLSNFGSSSLSAPTADNDTNKIAEAFNRIGRFKSWVKRNIADCFKLIRNKLTNQISDQPSGERT 1102

  Fly  1387 -----------------------------HDE---------SAQKKSHSPTPTIDGMDDHLSIDI 1413
                                         |||         ..::::.......|||:  .:|..
  Fly  1103 NQISWIWSEGKGVCRCISAEHGDNELELGHDEILADGLIKKGIKEQTQLEVAIGDGME--FTIHG 1165

  Fly  1414 DMEQQE-----------------------------LDDEDKMDHETLSDEEVREMCEE----EEE 1445
            ||:..:                             .|:..|...||:..||.|:..:|    :||
  Fly  1166 DMKNNKPKKSKYLNNATDDDTASINSYGSHKNRPFKDESHKGSAETMEGEEKRDASKEDLGLDEE 1230

  Fly  1446 VDEEG-----------MITARPRRMSEVNTAT-------KILPIPPGTSFFLFSQ-TNRFRVFCH 1491
            :||||           :|.|....:.:...|.       |..||..|.....|.| ....|:...
  Fly  1231 LDEEGECEEGPLDGDIIIHAHDEDILDEYPADCCPDSYYKKFPILAGDDDSPFWQGWGNLRLKTF 1295

  Fly  1492 WLCNHSNFGNIILCCIMFSSAMLAAEN-PLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGF- 1554
            .|..:..|...::..|:.||..||.|: .|.....|..:|...|..||.:|.:|:::|.::.||
  Fly  1296 QLIENKYFETAVITMILMSSLALALEDVHLPQRPILQDILYYMDRIFTVIFFLEMLIKWLALGFK 1360

  Fly  1555 VLHDGAFCRSAFNLLDLLVVCVSLISLVSS---SNAISVVKILRVLRVLRPLRAINRAKGLKHVV 1616
            |....|:|     .||.::|.||||:.|:|   :..|...|.:|.||.||||||::|.:|::.||
  Fly  1361 VYFTNAWC-----WLDFVIVMVSLINFVASLVGAGGIQAFKTMRTLRALRPLRAMSRMQGMRVVV 1420

  Fly  1617 QCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGV 1681
            ..::.|:.:|.|::|| ||:.::                                   :||::||
  Fly  1421 NALVQAIPSIFNVLLV-CLIFWL-----------------------------------IFAIMGV 1449

  Fly  1682 QLFKGKFFKCTD--GSKMT------QDECYGTYLVYDDGDVHKPRLRERE---WSNNRFHFDDVA 1735
            |||.||:|||.|  |:|::      ::.|                  |.|   |.|:..:||.|.
  Fly  1450 QLFAGKYFKCEDMNGTKLSHEIIPNRNAC------------------ESENYTWVNSAMNFDHVG 1496

  Fly  1736 KGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVI- 1799
            ...|.||.|:||:||..::..:|||.:.:..||......:..|::.:||..:||.:|:|:|.:|
  Fly  1497 NAYLCLFQVATFKGWIQIMNDAIDSREVDKQPIRETNIYMYLYFVFFIIFGSFFTLNLFIGVIID 1561

  Fly  1800 -------------VTFQNEGEQEYKNCDLDKNQRNCIEFALKAKPVRRYIPKHGIQYKVWWFVTS 1851
                         ..|..|.:::|.|.......:.    .|||.|..|:.|    |..|:..||.
  Fly  1562 NFNEQKKKAGGSLEMFMTEDQKKYYNAMKKMGSKK----PLKAIPRPRWRP----QAIVFEIVTD 1618

  Fly  1852 SSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAW 1916
            ..|:..|.:.|.:|..|:.:..|:....|..:||.||.||..:|:.|.:.|:.|.|: :||.:.|
  Fly  1619 KKFDIIIMLFIGLNMFTMTLDRYDASDTYNAVLDYLNAIFVVIFSSECLLKIFALRY-HYFIEPW 1682

  Fly  1917 NVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKL 1981
            |:||.::|:.|.:.:|.|             ||:|     |......|:.:  .|:.:|.|:::|
  Fly  1683 NLFDVVVVILSILGLVLS-------------DIIE-----KYFVSPTLLRV--VRVAKVGRVLRL 1727

  Fly  1982 LSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIALDGGNAITANNNFQTFQQ 2046
            :...:||||||:....|..||..:.||:.|:.||:|:.||..|..:....|  |....||:||.|
  Fly  1728 VKGAKGIRTLLFALAMSLPALFNICLLLFLVMFIFAIFGMSFFMHVKEKSG--INDVYNFKTFGQ 1790

  Fly  2047 AVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGEP--CGSSIAYPYFISFYVLCSFLI-IN 2108
            ::::||:.:|...|..::.:...:.  .||...:..|.|  |||:.....|:..|::.|||| ||
  Fly  1791 SMILLFQMSTSAGWDGVLDAIINEE--ACDPPDNDKGYPGNCGSATVGITFLLSYLVISFLIVIN 1853

  Fly  2109 LFVAVIMDNFDYLTRD-WSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKL 2172
            :::|||::|:...|.| ...|.....|.:..:|.::||:....|::..:...|..:.|||...|
  Fly  1854 MYIAVILENYSQATEDVQEGLTDDDYDMYYEIWQQFDPEGTQYIRYDQLSEFLDVLEPPLQIHK- 1917

  Fly  2173 CPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIKTDGNIDDANSELRATIKQIWKRTNP 2237
             |::.   :::||::|: ..|.:::...:...:......:....|::...     |.:|..|.:.
  Fly  1918 -PNKY---KIISMDIPI-CRGDLMYCVDILDALTKDFFARKGNPIEETGE-----IGEIAARPDT 1972

  Fly  2238 KLLDQVVPPPGNDDEVTVGKFYATYLIQDYFRRFKKRKE---------QEGKEGHPDSNTVTLQA 2293
            :..:.|........|.     |...|||..:|:.|.|.|         ..|..|.||:.
  Fly  1973 EGYEPVSSTLWRQREE-----YCARLIQHAWRKHKARGEGGGSFEPDTDHGDGGDPDAG------ 2026

  Fly  2294 GLRTLHEVSPALKRAISGNLDELDQEPEPMHRRHHTLFGSVWSSIRRHGNGTFRRSAKATASQSN 2358
                    .||...|..|:......             |||        |||...:|.|..|..|
  Fly  2027 --------DPAPDEATDGDAPAGGD-------------GSV--------NGTAEGAADADESNVN 2062

  Fly  2359 --GALAIGGSASAALGVGGSSLVLGSSDPAGGDYLYDTLNRSVADGVNNITRN 2409
              |..|...:|:||......:...||  |..|.....|.....:||.  :|:|
  Fly  2063 SPGEDAAAAAAAAAAAAAAGTTTAGS--PGAGSAGRQTAVLVESDGF--VTKN 2111

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1D	NP_723952.2	Ion_trans	767..1042	CDD:395416	90/306 (29%)
		Ion_trans	1137..1379	CDD:395416	76/298 (26%)
		Ion_trans	1496..1809	CDD:395416	99/342 (29%)
		Ion_trans	1851..2126	CDD:395416	87/278 (31%)
		GPHH	2135..2188	CDD:407139	12/52 (23%)
		Ca_chan_IQ	2199..2271	CDD:400901	11/71 (15%)
para	NP_001259619.1	Ion_trans	165..436	CDD:278921	85/289 (29%)
		Na_trans_cytopl	515..648	CDD:288761	6/132 (5%)
		Ion_trans	835..1028	CDD:278921	61/211 (29%)
		Na_trans_assoc	1054..1296	CDD:284034	36/243 (15%)
		Ion_trans	1318..1571	CDD:278921	93/311 (30%)
		Na_channel_gate	1561..1613	CDD:240441	11/59 (19%)
		Ion_trans	1636..1871	CDD:278921	82/259 (32%)
		GPHH	1880..1930	CDD:293510	13/54 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45439101
Domainoid	1	1.000	73	1.000	Domainoid score	I3264
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	311	1.000	Inparanoid score	I473
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R175
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.920