DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and cac

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster


Alignment Length:1890 Identity:801/1890 - (42%)
Similarity:1082/1890 - (57%) Gaps:258/1890 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   729 GQKRQQRRGKPQPDRPQRALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPG 793
            |.|:::.    .|.....:||.|:..||:|.....|:||.|||:.:||||.|||:.||:....||
  Fly     3 GPKKEEN----PPGGGPTSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPG 63

  Fly   794 SDSNVTNQTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQ 858
            .|..|..|.|||.|..||.||..|..:||||.|.|||..:||||.||::||.:||.| ..|...|
  Fly    64 GDKTVLAQKLEKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTG-FMTQYPQ 127

  Fly   859 LMKDAFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELF 923
            :..:. |::.|||.||||||:||||:|||||||.||:|||.||..|.|||||.|:|:||||||.:
  Fly   128 IGPEV-DLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFY 191

  Fly   924 SGKLHKAC-----RDEITGEYEENIRPCGV---------GYQC-PPGYKCYGGWDGPNDGITNFD 973
            ||.|||.|     .:::..|.|.. .||..         .:.| .....|...|:|||.|||:||
  Fly   192 SGALHKTCYSLEDPNKLVKEGESE-TPCNTDNILEKATGSFVCNNTTSMCLEKWEGPNSGITSFD 255

  Fly   974 NFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKER 1038
            |.|.||||||||:|:||||.:||...||:||.:.|:||:.::::|:||::||:||||||||:|||
  Fly   256 NIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKER 320

  Fly  1039 NKAKNRGDFQKLREKQQIEEDLRGYLDWITQAEDI--------EPDAV-------------GGLI 1082
            .|.:||.:|.|||.:||:|.:|.||::||.:||::        |.:.:             ..|.
  Fly   321 EKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEERTTEEEKMHIMEARRRNAAKRKKLK 385

  Fly  1083 SDGKGKQPN--EMDSTENLGEEMPEVQMTESRWRKMKKDFDRVNRRMRRACRKAVKSQAFYWLII 1145
            |.||.|..:  |.::.|:.|::  ....|.|:.:.....|.|..:|.|...|..||:|.|||.:|
  Fly   386 SLGKSKSTDTEEEEAEEDYGDD--GYLKTRSKPQGSCTGFWRAEKRFRFWIRHTVKTQWFYWFVI 448

  Fly  1146 VLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVV 1210
            |||||||..:|.|||||..:|..|..|....|:|||..||.:|||:||.:.||.|.||||||.|:
  Fly   449 VLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVI 513

  Fly  1211 IGSITETLLTNT--GMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLF 1273
            .|||.|.:.:..  |   ..|:||||.:||||:|||||||.||.|||.|||||::||.|||.|||
  Fly   514 SGSIFEVIWSEVKGG---SFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLF 575

  Fly  1274 LFIVIFALLGMQVFGGKFNFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVS 1338
            |||:||||||||:|||:||..|...:  .||:.|..||||||||:||||||.|||.||.:.||..
  Fly   576 LFILIFALLGMQLFGGQFNLPGGTPE--TNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQ 638

  Fly  1339 SYGALACIYFIILFICGNYILLNVFLAIAVDNLADADSLSEVEKEEEPHDESAQKKSHSPTPTID 1403
            . |.:..||||:|.:.|||.||||||||||||||:|..|:..|:|:...|:..|.:         
  Fly   639 K-GMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEEQVEEDKEKQLQ--------- 693

  Fly  1404 GMDDHLSIDIDMEQQELDDEDKMDHETLSDEEVREMCEEEEEVDEEGMITARPRRMSEVNTATKI 1468
                  .::.:||..:.|.....:.:........:..::|||..||..:|..|:           
  Fly   694 ------ELEKEMEALQADGVHVENGDGAVAPSKSKGKKKEEEKKEEEEVTEGPK----------- 741

  Fly  1469 LPIPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDDLNKVLNKF 1533
             |:.|.:|.|:.|.||..|...||:.|...|...|:..|..||..||||:|:|.|...||:||.|
  Fly   742 -PMLPYSSMFILSPTNPIRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDPVRENSRRNKILNYF 805

  Fly  1534 DYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISL---VSSSNA---ISVVK 1592
            ||.||.|||||::||::..|.:||.|::.|..:|::|.:||..:.:|.   :|.|:|   :|.:|
  Fly   806 DYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIK 870

  Fly  1593 ILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKCVVV 1657
            .||||||||||:.|.|...||.|..||:.::|   |:|                           
  Fly   871 SLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLK---NVV--------------------------- 905

  Fly  1658 AIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDDGDVHKPRLRER 1722
                  ||::|..|.||:|:|||||||.||||.|||.||.|..||.|:|..|::.:: .|:...|
  Fly   906 ------NILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEEDEL-LPKQELR 963

  Fly  1723 EWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIA 1787
            .|....||:|:||..|||||.|.|.||||.:|..|:.:..|:.|||.|||..::.:||:|.|:..
  Fly   964 VWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFP 1028

  Fly  1788 FFMVNIFVGFVIVTFQNEGEQEYKNCDLDKNQRNCIEFALKAKPVRRYIPK--HGIQYKVWWFVT 1850
            ||.|||||..:|:|||.:||.|.::.::||||::||:|.:.|:|:.||:||  :..:||||..|.
  Fly  1029 FFFVNIFVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRNTFKYKVWRIVV 1093

  Fly  1851 SSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDA 1915
            |:.|||.|.:||:.||:.|.||::||...|.:.|..:||.||.:|::|.|.|:..|..||:|.|.
  Fly  1094 STPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDP 1158

  Fly  1916 WNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVK 1980
            ||:||.|.||||.:|.::.|.                        |||.|::.|.||||..||:|
  Fly  1159 WNIFDLITVLGSIVDALWMEF------------------------GSNSINVGFLRLFRAARLIK 1199

  Fly  1981 LLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIALDG-GNAITANNNFQTF 2044
            ||.:|..||.|||||::||:|||||.|||.:||||||::||||||.|.|.. .|:||.:||||:|
  Fly  1200 LLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSF 1264

  Fly  2045 QQAVLVLFRSATGEAWQEIMMSCSAQPDVK---CDMNSD-TPGEPCGSSIAYPYFISFYVLCSFL 2105
            .|.|::|||.||||||..||::|     :|   ||.::: .|||.|||::||.||:||...||||
  Fly  1265 IQGVMLLFRCATGEAWPNIMLAC-----LKGKACDDDAEKAPGEYCGSTLAYAYFVSFIFFCSFL 1324

  Fly  2106 IINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFG 2170
            ::|||||||||||||||||.||||.||||||:|:|:||||:|.|:|.:.::..:|:.:.||||||
  Fly  1325 MLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFG 1389

  Fly  2171 KLCPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIK--TDGNIDDANSELRATIKQIWK 2233
            ..||:|:|.|:|:.|||||:.:..|.|..||||::|.:||||  ....:|.|:.|||.||..||.
  Fly  1390 NKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIKMRAPEEMDQADMELRETITNIWP 1454

  Fly  2234 RTNPKLLDQVVPPPG--NDDEVTVGKFYATYLIQDYFR--RFKK------RKEQEGKEGHPDSNT 2288
            ....|:|:.:|||..  |..:::|||.||.:||.:.:|  ||.:      ..|.:....||...:
  Fly  1455 LQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESWRSTRFGQLDSGMPMLELQDASRHPSQES 1519

  Fly  2289 VT------LQAGLRTL--HEVSPALKRAISGNLDELDQEPEPMHRRHHTL-----FGSVWSSI-- 2338
            :|      |..|...:  |..||:|:.    |...|.:.|.|..|.|..:     |....|::  
  Fly  1520 LTGADAGHLHPGHSYMNGHRRSPSLRH----NGSPLARSPSPRRRGHQYIHHDIGFSDTVSNVVE 1580

  Fly  2339 -------RRHGNGTFRR-----SAKATASQSNGALAIGGSASAALGV-------GGSSLVLGSSD 2384
                   .||||...|.     ||..:.::|......||..|.:...       |.:||...|..
  Fly  1581 MVKETRHPRHGNSHPRYPRGSWSASTSPARSPSPSRYGGHLSRSKRTQLPYPTYGTTSLCQRSRS 1645

  Fly  2385 PAGGDYLYDTLNRSVADGVNNITRNIMQARLAAAGKLQD--ELQGAGSGGELRTFGESISMRPLA 2447
            |                               :..:||:  |....|.|.::.......|...||
  Fly  1646 P-------------------------------SPARLQEMRERDRLGYGIDMGVTHVQHSYPTLA 1679

  Fly  2448 KNGGGAATVAGTLPPEANAINYDNRNRGILLHPYNNVYAPNGALPGHERMIQSTPASPYDQRRLP 2512
            ....|   :...|||.      .::...:.|.|.|..:....|.|.|..  .|||.|.:.   ||
  Fly  1680 SRRAG---IGRRLPPT------PSKPSTLQLKPTNINFPKLNASPTHTH--HSTPHSVHS---LP 1730

  Fly  2513 TSSDM 2517
            ...|:
  Fly  1731 HHRDL 1735

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 152/289 (53%)
Ion_trans 1137..1379 CDD:395416 147/243 (60%)
Ion_trans 1496..1809 CDD:395416 137/318 (43%)
Ion_trans 1851..2126 CDD:395416 144/279 (52%)
GPHH 2135..2188 CDD:407139 26/52 (50%)
Ca_chan_IQ 2199..2271 CDD:400901 32/77 (42%)
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 152/289 (53%)
Ion_trans 441..677 CDD:334124 146/241 (61%)
Ion_trans 769..1050 CDD:334124 137/317 (43%)
Ion_trans 1094..1345 CDD:334124 144/279 (52%)
GPHH 1346..1416 CDD:339854 37/69 (54%)
Ca_chan_IQ 1418..1492 CDD:337190 31/73 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C45439099
Domainoid 1 1.000 73 1.000 Domainoid score I3264
eggNOG 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 311 1.000 Inparanoid score I473
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1411at7147
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100303
Panther 1 1.100 - - P PTHR45628
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
98.930

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