DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ca-alpha1D and Tpcn2

DIOPT Version :9

Sequence 1:	NP_723952.2	Gene:	Ca-alpha1D / 34950	FlyBaseID:	FBgn0001991	Length:	2705	Species:	Drosophila melanogaster
Sequence 2:	XP_038935131.1	Gene:	Tpcn2 / 309139	RGDID:	1311779	Length:	867	Species:	Rattus norvegicus

Alignment Length:	892	Identity:	153/892 - (17%)
Similarity:	289/892 - (32%)	Gaps:	351/892 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   760 LCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGS-----DSNVTNQ-------TLEKVEYVFLV 812
            :|.|::.:         |||. .:||| :...|.|     |....:|       ..|.:|.:.|:
  Rat    63 VCQRVLGF---------TIFL-ILALA-FVEVPSSFTRTADVRYRSQPWQPPCGLTETIEALCLL 116

  Fly   813 IFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAFRVLRP 877
            :|.|:..:|    |:::......:|.|.|..|.::|:..:...:|..:...   ::||..|:|||
  Rat   117 VFLADLSVK----GYLVGQAQLQQNLWLLAYFVVLVVSVVDWIVSLSLNCE---ESLRVRRLLRP 174

  Fly   878 LRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDEITGEYEEN 942
            ..|:.....::..|..|..::..:..:.||:...:.::.:||:.||:    .|.:||...:
  Rat   175 FFLLQNSSMMKKTLKCIRWSLPEMASVGLLLTIHLCLFTVIGMLLFT----IAEKDEAQNK---- 231

  Fly   943 IRPCGVGYQCPPGYKCYGGWDGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVL---YSIQDAMGS 1004
                                    :.:|.|.|...|:.::...:|.....||:   |:...|..
  Rat   232 ------------------------ERLTYFRNLPEALTSLLVLLTTSNNPDVMIPAYTQNRAYA- 271

  Fly  1005 DWQWMYFISMVILGAFFVMNLILGVLSGEFSKERNKAKNRGDFQKLREKQQIEEDL--RGYLDWI 1067
                ::||...::|:.|:|||:..::..:|         ||...|..:.......|  |...:.:
  Rat   272 ----LFFIIFTLIGSLFLMNLLTAIIYNQF---------RGYLMKSLQTSLFRRRLGARAAYEVL 323

  Fly  1068 T-QAEDIEPDAVGGLISDGKGKQPNEMDSTENLGEEMPEVQMTESRWR----------------- 1114
            | ||      ...|..|:..|..|      ||....:.:.|:.:...:
  Rat   324 TLQA------GPNGTTSELVGVNP------ENFLRVLQKTQLNKIHKQAIIQKVHSYEGRPILAD 376

  Fly  1115 KMKKDFDRVNRRM--RRACRKAVKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFF 1177
            :.:|.||.|::.:  .|..:...:|.          ||.|......| ...|:|.|.....|:..
  Rat   377 EFQKLFDEVDKGIVKERPPKPQYQSP----------FLQTAQFIFSH-RYFDYLGNLIALGNLLS 430

  Fly  1178 I-----GL----FTCEMLL----------------------------------------KMYSLG 1193
            |     ||    :..|.|.                                        ..:..|
  Rat   431 ICVPGAGLKPAAWGTERLCPGDSQLHFHLVLPAGAAVQGVRAGPTGLPVLPQQRVRWPPDHHPAG 495

  Fly  1194 FQGYF--------------------------VSLFNRFDC------------------------F 1208
            |..::                          :|.|..:.|                        .
  Rat   496 FGDFYSGRVPIAAPRMELSSAGLPRSWALTTISAFKLWGCSERCGPGCGRCGCDCGRYDWQLGAL 560

  Fly  1209 VVIGSITETLLTNT-----GMM------------------------------------------- 1225
            .|:||:..|:|:..     |||
  Rat   561 AVLGSVAMTVLSVAVAVLGGMMVAVVMAAWALGMSRVWLGSVSHLLGAFSAWCPYSDYCCLVTPA 625

  Fly  1226 --------------------------PPLG-------VSVLRCVRLLRVFKVTKYWRSLSNLVAS 1257
                                      .||.       |::|..:|.||:....|....:::.:..
  Rat   626 ASSLSPSASPNLVTRLRYLLRKPEQYGPLSLWDMTRLVNILIVIRFLRIIPSIKPTAVVASTILG 690

  Fly  1258 LLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEE-----------------KYRMNFD 1305
            |:.::::...:|::::   .:||::|:.:|.|.....|...                 .:..|||
  Rat   691 LIQNLRAFGGILVVVY---YVFAMIGINLFRGVIVPPGNSSLVPDNSSAPCGSFEQLGYWPNNFD 752

  Fly  1306 CFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYILLNVFLAIAVDN 1370
            .|..||:|::.:|...:|..:    :.||...|  |..:.:||::.::..:.|.:|:|||:.::|
  Rat   753 DFAAALITLWDVMVVNNWQVI----LEAYKHYS--GPWSMVYFVLWWLVSSVIWINLFLALLLEN 811

  Fly  1371 -------------LADADSLS-EVEKE-------EEPHDESAQKKSH 1396
                         |.....:: |:..|       |||.:|...:|.|
  Rat   812 FLHRWDPQGHKQLLVGTKQITYEMSVELMFRDILEEPKEEELMEKLH 858

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1D	NP_723952.2	Ion_trans	767..1042	CDD:395416	58/289 (20%)
		Ion_trans	1137..1379	CDD:395416	65/452 (14%)
		Ion_trans	1496..1809	CDD:395416
		Ion_trans	1851..2126	CDD:395416
		GPHH	2135..2188	CDD:407139
		Ca_chan_IQ	2199..2271	CDD:400901
Tpcn2	XP_038935131.1	Ion_trans	66..297	CDD:395416	58/285 (20%)
Tpcn2	XP_038935131.1	Ion_trans	<661..812	CDD:395416	34/159 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910