DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and Scn8a

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:NP_062139.2 Gene:Scn8a / 29710 RGDID:3638 Length:1978 Species:Rattus norvegicus


Alignment Length:1998 Identity:484/1998 - (24%)
Similarity:838/1998 - (41%) Gaps:559/1998 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   747 ALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFL 811
            ||:.||..|.:|.:.|:|:....|..:|:.||..||:.:....|...|         :.|||.|.
  Rat   111 ALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTFSNPPEWS---------KNVEYTFT 166

  Fly   812 VIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAFRVLR 876
            .|:|.|.::||:|.||.:....:||:.||.|||:::::..::..:     |..:|.|||.|||||
  Rat   167 GIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYVTEFV-----DLGNVSALRTFRVLR 226

  Fly   877 PLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKAC---------- 931
            .|:.:|.:|.|:.::.::::::..|..:.:|.:|.:.::|:|||:||.|.|...|          
  Rat   227 ALKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCVVWPINFNES 291

  Fly   932 ------RDEITGEYEEN----------IRP--CG----VGYQCPPGYKCYGGWDGPNDGITNFDN 974
                  |.....||..|          :.|  ||    .| |||.|::|......||.|.|:||.
  Rat   292 YLENGTRGFDWEEYINNKTNFYMVPGMLEPLLCGNSSDAG-QCPEGFQCMKAGRNPNYGYTSFDT 355

  Fly   975 FGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERN 1039
            |..|.|.:|:.:|.:.|.::......|.|..:. ::|:.::.:|:|:::||||.|::..: :|:|
  Rat   356 FSWAFLALFRLMTQDYWENLYQLTLRAAGKTYM-IFFVLVIFVGSFYLVNLILAVVAMAY-EEQN 418

  Fly  1040 KAKNRGDFQKLREKQQIEEDLRGYLDWI-------------TQAEDIEPDAVGGLISDGKG---- 1087
            :|       .|.|.:|.|.:.:..|:.:             |.|..:..||:.....||.|    
  Rat   419 QA-------TLEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEEEGEDGVGSPRS 476

  Fly  1088 ---------------------KQPNEMDSTENLGEEMPE-VQMTESRWRKMKKDF----DRVNR- 1125
                                 ::..|:...|..|:  || |..:||.....:|.|    :|:.| 
  Rat   477 SSELSKLSSKSAKERRNRRKKRKQKELSEGEEKGD--PEKVFKSESEDGMRRKAFRLPDNRIGRK 539

  Fly  1126 ----------------------------------------------------------------- 1125
                                                                             
  Rat   540 FSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESEGRRDSLFIP 604

  Fly  1126 ---RMRRA----------C----------RKAVKSQAF--------------------------- 1140
               |.||:          |          |::||..:.                           
  Rat   605 IRARERRSSYSGYSGYSQCSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGPGSHIGRLLPEATTEV 669

  Fly  1141 ----------------------------------------------------------------- 1140
                                                                             
  Rat   670 EIKKKGPGSLLVSMDQLASYGRKDRINSIMSVVTNTLVEELEESQRKCPPCWYKFANTFLIWECH 734

  Fly  1141 -YWL------------------IIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEML 1186
             ||:                  |.:.:.|||..:|.||:......::.....|:.|.|:||.||.
  Rat   735 PYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNLVFTGIFTAEMF 799

  Fly  1187 LKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSL 1251
            ||:.::....||...:|.||.|:|..|:.|..|.:..     |:||||..|||||||:.|.|.:|
  Rat   800 LKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVE-----GLSVLRSFRLLRVFKLAKSWPTL 859

  Fly  1252 SNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGG-------KFNFDGKEEKYRMNFDCFWQ 1309
            :.|:..:.||:.::.:|.|:|.:.:.|||::|||:||.       |.|.:.|..::.||  .|:.
  Rat   860 NMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQECKLPRWHMN--DFFH 922

  Fly  1310 ALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYILLNVFLAI-----AVD 1369
            :.|.||:::.|| |...|:..:...|     .|:..|.|:::.:.||.::||:|||:     :.|
  Rat   923 SFLIVFRVLCGE-WIETMWDCMEVAG-----QAMCLIVFMMVMVIGNLVVLNLFLALLLSSFSAD 981

  Fly  1370 NLADAD----------SLSEVEK-----------------------EEEPHDESAQKKSH----- 1396
            |||..|          |:..::|                       |.:|.||..:||::     
  Rat   982 NLAATDDDGEMNNLQISVIRIKKGVAWTKVKVHAFMQAHFKQREADEVKPLDELYEKKANCIANH 1046

  Fly  1397 -------------SPTPTIDGM----------DDHLSI-------------------------DI 1413
                         :...|..|:          :||:|.                         |:
  Rat  1047 TGVDIHRNGDFQKNGNGTTSGIGSSVEKYIIDEDHMSFINNPNLTVRVPIAVGESDFENLNTEDV 1111

  Fly  1414 DMEQQELDDEDKMDHETLSDE--------EVREMCEE--EEEVDEEGMIT---ARPRRMSEVNTA 1465
            ..|......:||:| :|.|.|        ||.|:..|  ||.:|.:...|   .:..:..:||..
  Rat  1112 SSESDPEGSKDKLD-DTSSSEGSTIDIKPEVEEVPVEQPEEYLDPDACFTEGCVQRFKCCQVNIE 1175

  Fly  1466 TKILPIPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAEN-PLRANDDLNKV 1529
            ..:     |.|:::..:|      |..:..|:.|...|:..|:.||..||.|: .:.....:..:
  Rat  1176 EGL-----GKSWWILRKT------CFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTI 1229

  Fly  1530 LNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISLVSSS---NAISVV 1591
            |...|..||.:|.:|::||..:||||    .|..:|:..||.|:|.|||:||::::   :.:..:
  Rat  1230 LEYADKVFTYIFILEMLLKWTAYGFV----KFFTNAWCWLDFLIVAVSLVSLIANALGYSELGAI 1290

  Fly  1592 KILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKCVV 1656
            |.||.||.||||||::|.:|::.||..::.|:.:|.|::|| ||:.::                 
  Rat  1291 KSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLV-CLIFWL----------------- 1337

  Fly  1657 VAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDDGDVHK---PR 1718
                              :|:::||.||.||:..|.:   .|.:..:...:|.:..|..|   ..
  Rat  1338 ------------------IFSIMGVNLFAGKYHYCFN---ETSEIRFEIDIVNNKTDCEKLMEGN 1381

  Fly  1719 LREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYI 1783
            ..|..|.|.:.:||:|..|.|.|..|:||:||..::|.::||.|.:..|.:.....:..|::|:|
  Rat  1382 STEIRWKNVKINFDNVGAGYLALLQVATFKGWMDIMYAAVDSRKPDEQPDYEGNIYMYIYFVIFI 1446

  Fly  1784 IIIAFFMVNIFVGFVIVTFQNE----GEQEYKNCDLDKNQRNCIEFALKAKPVRRYIPK--HGIQ 1842
            |..:||.:|:|:|.:|..|..:    |.|:....:..|...|.:: .|.:|..::.||:  :.||
  Rat  1447 IFGSFFTLNLFIGVIIDNFNQQKKKFGGQDIFMTEEQKKYYNAMK-KLGSKKPQKPIPRPLNKIQ 1510

  Fly  1843 YKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFR 1907
            ..|:.|||..:|:..|.:||.:|.||:.::...|......:|..:|::|...|..|.|.|:.|.|
  Rat  1511 GIVFDFVTQQAFDIVIMMLICLNMVTMMVETDTQSKQMENILYWINLVFVIFFTCECVLKMFALR 1575

  Fly  1908 FKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRL 1972
             ..||...||:|||::|:.|.:.:..:             ||:|     |......|..:  .||
  Rat  1576 -HYYFTIGWNIFDFVVVILSIVGMFLA-------------DIIE-----KYFVSPTLFRV--IRL 1619

  Fly  1973 FRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIALDGGNAITA 2037
            .|:.|:::|:...:||||||:..:.|..||..:.||:.|:.||:::.||..|..:..:.|  |..
  Rat  1620 ARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFGMSNFAYVKHEAG--IDD 1682

  Fly  2038 NNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGE----PCGS-SIAYPYFIS 2097
            ..||:||..:::.||:..|...|..:::....:|. .|.::.:.||.    .||: |:...:|:|
  Rat  1683 MFNFETFGNSMICLFQITTSAGWDGLLLPILNRPP-DCSLDKEHPGSGFKGDCGNPSVGIFFFVS 1746

  Fly  2098 FYVLCSFLIINLFVAVIMDNFDYLTRDWS-ILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLR 2161
            :.::...:::|:::|:|::||...|.:.: .|.....:.|..:|.::||||...|::..:.....
  Rat  1747 YIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKFDPDATQFIEYCKLADFAD 1811

  Fly  2162 KISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIKTDGNIDDANSELRA 2226
            .:..||...|  |:.:   .|::|::|:.|...:.....|||..:..|.  ..|.:|    .||.
  Rat  1812 ALEHPLRVPK--PNTI---ELIAMDLPMVSGDRIHCLDILFAFTKRVLG--DSGELD----ILRQ 1865

  Fly  2227 TIKQIWKRTNPKLL--DQVVPPPGNDDE----VTVGKFYATYLIQDYF--RRFKKRKEQEG---- 2279
            .:::.:..:||..:  :.:........|    |.:.:.|..:|.:..|  |:....|.:.|    
  Rat  1866 QMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQRAYRGHLARRGFICRKMASNKLENGGTHR 1930

  Fly  2280 --KEGHPDSNTVTLQAGLRTLHEVSPALK----RAISGNLDELDQEPE 2321
              ||..|.:      |.|.:...|:...|    ||..|..:...::.|
  Rat  1931 DKKESTPST------ASLPSYDSVTKPDKEKQQRAEEGRRERAKRQKE 1972

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 90/306 (29%)
Ion_trans 1137..1379 CDD:395416 87/374 (23%)
Ion_trans 1496..1809 CDD:395416 97/323 (30%)
Ion_trans 1851..2126 CDD:395416 78/279 (28%)
GPHH 2135..2188 CDD:407139 13/52 (25%)
Ca_chan_IQ 2199..2271 CDD:400901 16/79 (20%)
Scn8aNP_062139.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..62
I. /evidence=ECO:0000305 114..442 102/351 (29%)
Ion_trans 131..421 CDD:395416 91/313 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 446..530 16/85 (19%)
Na_trans_cytopl 504..700 CDD:403218 18/197 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 576..597 0/20 (0%)
II. /evidence=ECO:0000305 733..1005 87/284 (31%)
Ion_trans 750..963 CDD:395416 72/225 (32%)
Na_trans_assoc 989..1190 CDD:399489 34/212 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1105..1146 11/41 (27%)
III. /evidence=ECO:0000305 1178..1493 104/369 (28%)
Ion_trans 1195..1471 CDD:395416 96/318 (30%)
Na_channel_gate 1463..1515 CDD:240441 12/52 (23%)
IV. /evidence=ECO:0000305 1502..1799 93/320 (29%)
Ion_trans 1520..1774 CDD:395416 78/277 (28%)
GPHH 1786..1833 CDD:407139 13/51 (25%)
IQ 1892..1913 CDD:197470 4/20 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1923..1978 12/56 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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