Protein Alignment Ca-alpha1D and Scn11a

DIOPT Version :10

• Sequence 1: NP_723952.2
• Gene: Ca-alpha1D / 34950
• FlyBaseID: FBgn0001991
• Length: 2705
• Species: Drosophila melanogaster
• Sequence 2: NP_062138.1
• Gene: Scn11a / 29701
• RGDID: 3630
• Length: 1765
• Species: Rattus norvegicus
• Alignment Length: 1825
• Identity: 457/1825 - (25%)
• Similarity: 804/1825 - (44%)
• Gaps: 412/1825 - (22%)

  Fly   745 QRALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEK--VE 807
            :||||.|...||||:|.|||.....|...|:.|:..||:.:|          |...::.:.  .|
  Rat   106 KRALFILGPFNPLRSLMIRISVHSVFSMFIICTVIINCMFMA----------NSMERSFDNDIPE 160

  Fly   808 YVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIG-AISTAL--SQLMKDAFDVKAL 869
            |||:.|:..|.|:||||.||::...::||:.||.|||  :||| ||:|..  ||:     ::.||
  Rat   161 YVFIGIYILEAVIKILARGFIVDEFSFLRDPWNWLDF--IVIGTAIATCFPGSQV-----NLSAL 218

  Fly   870 RAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKAC--- 931
            |.|||.|.|:.:|.:..|:|::.::|:::..|..:.:|.||.:.|:|::|.:||.|.|::.|
  Rat   219 RTFRVFRALKAISVISGLKVIVGALLRSVKKLVDVMVLTLFCLSIFALVGQQLFMGILNQKCIKH 283

  Fly   932 ---------RDEITGEYE-ENIRPCGV---GYQCPPGYKCYGGWDGPNDGITNFDNFGLAMLTVF 983
                     :|....|.: |:...||.   ...||.|..|......|::..|.|||||.:.|.:|
  Rat   284 NCGPNPASNKDCFEKEKDSEDFIMCGTWLGSRPCPNGSTCDKTTLNPDNNYTKFDNFGWSFLAMF 348

  Fly   984 QCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKE-RNKAKNRGDF 1047
            :.:|.:.|..:...|....|..:.: :|:.::.||:|:::||.|.|::..:.:: ||.|......
  Rat   349 RVMTQDSWERLYRQILRTSGIYFVF-FFVVVIFLGSFYLLNLTLAVVTMAYEEQNRNVAAETEAK 412

  Fly  1048 QKL-REKQQI--EED--------------------------------------LRGYLDWITQAE 1071
            :|: :|.||:  ||.                                      :||.......|.
  Rat   413 EKMFQEAQQLLREEKEALVAMGIDRSSLNSLQASSFSPKKRKFFGSKTRKSFFMRGSKTAQASAS 477

  Fly  1072 DIEPDAVGGLISDGKGKQPNEMDSTENLGEEMPEVQMTESRWRKMKKDFDRVNRRMRRA------ 1130
            |.|.||         .|.|..::.|:.|.:.:| |.:.:       :..|.::|  :||
  Rat   478 DSEDDA---------SKNPQLLEQTKRLSQNLP-VDLFD-------EHVDPLHR--QRALSAVSI 523

  Fly  1131 -----------------CRKAVKSQAFYW------------------------LIIVLVFLNTGV 1154
                             |.|.:.|:...|                        .|.:.:.:||..
  Rat   524 LTITMQEQEKFQEPCFPCGKNLASKYLVWDCSPQWLCIKKVLRTIMTDPFTELAITICIIINTVF 588

  Fly  1155 LATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLL 1219
            ||.||:...|.|....:..|..|.|:|..||.||:.:|....||...:|.||..|.:.|:.: :|
  Rat   589 LAVEHHNMDDNLKTILKIGNWVFTGIFIAEMCLKIIALDPYHYFRHGWNVFDSIVALLSLAD-VL 652

  Fly  1220 TNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGM 1284
            .||  :.....|.|..:|:|||||:.|.|.:|:.|:..:.:|:.::.:|.::|.:.:.||:::||
  Rat   653 YNT--LSDNNRSFLASLRVLRVFKLAKSWPTLNTLIKIIGHSVGALGNLTVVLTIVVFIFSVVGM 715

  Fly  1285 QVFGGKFNFDG----KEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALAC 1345
            ::||.|||...    :..:.|.:.|.|:.:.|.||:|:.|| |...|:..:....|    ..|..
  Rat   716 RLFGTKFNKTAYATQERPRRRWHMDNFYHSFLVVFRILCGE-WIENMWGCMQDMDG----SPLCI 775

  Fly  1346 IYFIILFICGNYILLNVFLAIAVDNLADADSLSEVEKEEEP------------------H----- 1387
            |.|:::.:.|..::||:|:|:.:::.::.:....:|.|...                  |
  Rat   776 IVFVLIMVIGKLVVLNLFIALLLNSFSNEEKDGSLEGETRKTKVQLALDRFRRAFSFMLHALQSF 840

  Fly  1388 --DESAQKKSHSPTPTIDGM--DDHLSIDIDMEQQELDDEDKMDHETLSDEEVREMCEEEEEV-- 1446
              .:..:|.|..|..|.:..  ::..||..|....:..|.|...:...:...:..:.|.|::|
  Rat   841 CCKKCRRKNSPKPKETTESFAGENKDSILPDARPWKEYDTDMALYTGQAGAPLAPLAEVEDDVEY 905

  Fly  1447 -------------------------------DEEG------------MITARPRRMSEV------ 1462
                                           |::|            :....||:.|:.
  Rat   906 CGEGGALPTSQHSAGVQAGDLPPETKQLTSPDDQGVEMEVFSEEDLHLSIQSPRKKSDAVSMLSE 970

  Fly  1463 -----------NTATKILP-------IPPGTS-FFLFSQTNR----------FRVFCHWLCNHSN 1498
                       |....:.|       .|.|.| .||..:|::          .|..|:.:..||.
  Rat   971 CSTIDLNDIFRNLQKTVSPKKQPDRCFPKGLSCHFLCHKTDKRKSPWVLWWNIRKTCYQIVKHSW 1035

  Fly  1499 FGNIILCCIMFSSAMLAAEN-PLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFC 1562
            |.:.|:..|:.||..|..|: .|.:...:.|:|...|..||.:|.:|:|||.:::||    ..:.
  Rat  1036 FESFIIFVILLSSGALIFEDVNLPSRPQVEKLLRCTDNIFTFIFLLEMILKWVAFGF----RRYF 1096

  Fly  1563 RSAFNLLDLLVVCVSLISLVSSSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIG 1627
            .||:..||.|:|.||::||::    :..:|..|.||.||||||:::.:|:|.||..:|.|:..|.
  Rat  1097 TSAWCWLDFLIVVVSVLSLMN----LPSLKSFRTLRALRPLRALSQFEGMKVVVYALISAIPAIL 1157

  Fly  1628 NIVLVTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCT 1692
            |::|| ||:.::                                   :|.::||.||.|||.:|.
  Rat  1158 NVLLV-CLIFWL-----------------------------------VFCILGVNLFSGKFGRCI 1186

  Fly  1693 DGSKMTQDECYGTYLVYDD-GDVHKPRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYV 1756
            :|:.:..      ||.:.: .:..:..:....|...:.:||:|....|.|..|:|::||..::..
  Rat  1187 NGTDINM------YLDFTEVPNRSQCNISNYSWKVPQVNFDNVGNAYLALLQVATYKGWLEIMNA 1245

  Fly  1757 SIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNE----GEQEYKNCDLDK 1817
            ::||.:::..|..........|::::||..:||.:|:|:|.:|..|..:    |.|:....:..|
  Rat  1246 AVDSREKDEQPDFEANLYAYLYFVVFIIFGSFFTLNLFIGVIIDNFNQQQKKLGGQDIFMTEEQK 1310

  Fly  1818 NQRNCIEFALK-------AKPVRRYIPKHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYN 1875
            ...|    |:|       .||:.|  |.:..|..|:..|||..|:..|..||::|.:.:..:..:
  Rat  1311 KYYN----AMKKLGTKKPQKPIPR--PLNKCQAFVFDLVTSQVFDVIILGLIVLNMIIMMAESAD 1369

  Fly  1876 QPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKD 1940
            ||....:..|.||:.|..:|.:|.:.|:.|.| ::||.:.||:||.::|:.|.|..:.|.::..|
  Rat  1370 QPKDVKKTFDILNIAFVVIFTIECLIKVFALR-QHYFTNGWNLFDCVVVVLSIISTLVSRLEDSD 1433

  Fly  1941 TSQIAECDIVEGCKSTKKSAGSNLISINF-------FRLFRVMRLVKLLSKGEGIRTLLWTFIKS 1998
                                      |:|       .||.|:.|:::|:....||||||:..:.|
  Rat  1434 --------------------------ISFPPTLFRVVRLARIGRILRLVRAARGIRTLLFALMMS 1472

  Fly  1999 FQALPYVALLIVLLFFIYAVVGMQVFGKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEI 2063
            ..:|..:.||:.|:.||||:.||..|.|:  ..|:.|....||:||..::|.||:..|...| :.
  Rat  1473 LPSLFNIGLLLFLVMFIYAIFGMSWFSKV--KKGSGIDDIFNFETFTGSMLCLFQITTSAGW-DT 1534

  Fly  2064 MMSCSAQPDVKCDMNS-DTPGEPCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRD-WS 2126
            :::...:....|:.:| |:..:|   .||..||:|:.::...:::|:::|||::||:..|.: ..
  Rat  1535 LLNPMLEAKEHCNSSSQDSCQQP---QIAVVYFVSYIIISFLIVVNMYIAVILENFNTATEESED 1596

  Fly  2127 ILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNS 2191
            .||....:.|..:|.::||:|...|::..:......:..||...|  |::.   :.:.|::|:..
  Rat  1597 PLGEDDFEIFYEVWEKFDPEASQFIQYSALSDFADALPEPLRVAK--PNKF---QFLVMDLPMVM 1656

  Fly  2192 DGTVLFNATLFAVVRTSLSIKTDGNIDDANSELRATIKQIWKRTNP--KLLDQVVPPPGNDDEVT 2254
            ...:.....|||.  |:..:.....:|    .::..:::.:...||  ||.:.:|......:|.
  Rat  1657 GDRLHCMDVLFAF--TTRVLGDSSGLD----TMKTMMEEKFMEANPFKKLYEPIVTTTKRKEEE- 1714

  Fly  2255 VGKFYATYLIQDYFRRFKKRKEQEGKEGHPDSNTVTLQAGLRTLHEVSPALKRAISGNLDELDQE 2319
                ....:||   |.::|..|:..|              ||.....|.:.:...:|:|..||..
  Rat  1715 ----QGAAVIQ---RAYRKHMEKMVK--------------LRLKDRSSSSHQVFCNGDLSSLDVA 1758

  Fly  2320 PEPMH 2324
            ...:|
  Rat  1759 KVKVH 1763

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1D	NP_723952.2	Ion_trans	767..1042	CDD:459842	91/296 (31%)
		Ion_trans	1137..1379	CDD:459842	74/269 (28%)
		Ion_trans	1496..1809	CDD:459842	90/318 (28%)
		Ion_trans	1851..2126	CDD:459842	81/283 (29%)
		GPHH	2135..2188	CDD:465306	11/52 (21%)
		Ca_chan_IQ	2198..2273	CDD:462591	14/76 (18%)
Scn11a	NP_062138.1	I. /evidence=ECO:0000305	115..403		97/305 (32%)
		Ion_trans	128..404	CDD:459842	89/293 (30%)
		II. /evidence=ECO:0000305	554..820		74/273 (27%)
		Ion_trans	571..807	CDD:459842	72/243 (30%)
		Na_trans_assoc	811..1029	CDD:461936	30/217 (14%)
		III. /evidence=ECO:0000305	1022..1319		97/350 (28%)
		Ion_trans	1033..1297	CDD:459842	89/313 (28%)
		Na_channel_gate	1289..1341	CDD:240441	13/57 (23%)
		IV. /evidence=ECO:0000305	1328..1619		94/325 (29%)
		Ion_trans	1345..1595	CDD:459842	81/282 (29%)