DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and Scn10a

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:NP_058943.2 Gene:Scn10a / 29571 RGDID:3629 Length:1956 Species:Rattus norvegicus


Alignment Length:2089 Identity:515/2089 - (24%)
Similarity:832/2089 - (39%) Gaps:639/2089 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   696 SMGIANI----PETMNGTTIGPSGAGGQKGGAAAGAAGQKRQQRRG---KPQPDRPQR------- 746
            |:|..|.    ||::         |..:|..||..||.:.|.:.||   |.:..|||.       
  Rat     7 SVGTTNFRRFTPESL---------AEIEKQIAAHRAAKKARTKHRGQEDKGEKPRPQLDLKACNQ 62

  Fly   747 ----------------------------------------------ALFCLSVKNPLRALCIRIV 765
                                                          ||:..|..|.:|...|::.
  Rat    63 LPKFYGELPAELVGEPLEDLDPFYSTHRTFMVLNKSRTISRFSATWALWLFSPFNLIRRTAIKVS 127

  Fly   766 EWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVIFTAECVMKILAYGFVLH 830
            ....|...|.:||..||:.: ..|..|           |||||||.||:|.|.::||||.||.|:
  Rat   128 VHSWFSIFITITILVNCVCM-TRTDLP-----------EKVEYVFTVIYTFEALIKILARGFCLN 180

  Fly   831 NGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIL 895
            ...|||:.||.|||:::.:..:..|:     |...:..||.|||||.|:.||.:|.|:|::.:::
  Rat   181 EFTYLRDPWNWLDFSVITLAYVGAAI-----DLRGISGLRTFRVLRALKTVSVIPGLKVIVGALI 240

  Fly   896 KAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKAC---------RDEITGEYEEN--IRP---- 945
            .::..|..:.:|.:|.:.::|::||:||.|.|...|         .|.::.|..|.  |:|    
  Rat   241 HSVRKLADVTILTVFCLSVFALVGLQLFKGNLKNKCIRNGTDPHKADNLSSEMAEYIFIKPGTTD 305

  Fly   946 ---CGVGY---QCPPGYKCYGGWDGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGS 1004
               ||.|.   .||.||.|....|.|:...|:||:|..|.|::|:.:|.:.|..:......|.|.
  Rat   306 PLLCGNGSDAGHCPGGYVCLKTPDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRASGK 370

  Fly  1005 DWQWMYFISMVILGAFFVMNLILGVLSGEFSKERN------KAKNRGDFQKLREKQQIEEDLRGY 1063
            .:. ::|:.::.||:|:::||||.|::..:.::..      :||.: .||:..|..|.|:::...
  Rat   371 MYM-VFFVLVIFLGSFYLVNLILAVVTMAYEEQSQATIAEIEAKEK-KFQEALEVLQKEQEVLAA 433

  Fly  1064 LDWIT------------------------------------------------------------ 1068
            |...|                                                            
  Rat   434 LGIDTTSLQSHSGSPLASKNANERRPRVKSRVSEGSTDDNRSPQSDPYNQRRMSFLGLSSGRRRA 498

  Fly  1069 ----------QAEDIE-PDAVGGLISDG--KGKQ------------------------PNEMDST 1096
                      .::||. ||   |:..||  .|.|                        |...:..
  Rat   499 SHGSVFHFRAPSQDISFPD---GITDDGVFHGDQESRRGSILLGRGAGQTGPLPRSPLPQSPNPG 560

  Fly  1097 ENLGEE----MPEVQMT-----------------------------------------------E 1110
            ...|||    :|..::|                                               |
  Rat   561 RRHGEEGQLGVPTGELTAGAPEGPALDTTGQKSFLSAGYLNEPFRAQRAMSVVSIMTSVIEELEE 625

  Fly  1111 S----------------------RWRKMKKD-FDRVNRRMRRACRKAVKSQAFYWLIIVL-VFLN 1151
            |                      :|||.|.. |:.|             :..|..|.|.| :.:|
  Rat   626 SKLKCPPCLISFAQKYLIWECCPKWRKFKMALFELV-------------TDPFAELTITLCIVVN 677

  Fly  1152 TGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITE 1216
            |..:|.|||...|..|...:..|:.|...||.||..|:.:.....||...:|.|||.:|..|:.|
  Rat   678 TVFMAMEHYPMTDAFDAMLQAGNIVFTVFFTMEMAFKIIAFDPYYYFQKKWNIFDCVIVTVSLLE 742

  Fly  1217 TLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFAL 1281
            ...:..|     .:||||..|||||||:.|.|.:|:.|:..:.||:.::.:|..:|.:.:.||||
  Rat   743 LSASKKG-----SLSVLRTFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTFILAIIVFIFAL 802

  Fly  1282 LGMQVFGGKFNF--DG----KEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSY 1340
            :|.|:....:..  ||    ..||.|.:...|:.:.|.||:|:.|| |...|:|.:..     |.
  Rat   803 VGKQLLSEDYGCRKDGVSVWNGEKLRWHMCDFFHSFLVVFRILCGE-WIENMWVCMEV-----SQ 861

  Fly  1341 GALACIYFIILFICGNYILLNVFLAIAVDNLADADSLSEVEKEEE-------------------- 1385
            .::..|.|:.:.:.||.::||:|:|:.:::.: ||:|:..|.:.|                    
  Rat   862 KSICLILFLTVMVLGNLVVLNLFIALLLNSFS-ADNLTAPEDDGEVNNLQLALARIQVLGHRASR 925

  Fly  1386 ------------------------PHDESAQKKSHSPT--------------------------- 1399
                                    |...|::.|:|..|                           
  Rat   926 AIASYISSHCRFRWPKVETQLGMKPPLTSSEAKNHIATDAVSAAVGNLTKPALSSPKENHGDFIT 990

  Fly  1400 --------PTIDGMDDHLSIDIDME--------------QQE----------------------- 1419
                    |..:|..|...::.|||              |||                       
  Rat   991 DPNVWVSVPIAEGESDLDELEEDMEQASQSSWQEEDPKGQQEQLPQVQKCENHQAARSPASMMSS 1055

  Fly  1420 -----------------------LDDEDKMDHETLS----DEEVREMCEEEEEVDE------EGM 1451
                                   :||....:..|:.    :|.:|::.|..:::||      ||.
  Rat  1056 EDLAPYLGESWKRKDSPQVPAEGVDDTSSSEGSTVDCPDPEEILRKIPELADDLDEPDDCFTEGC 1120

  Fly  1452 ITARPRRMSEVNTATKILPIPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAA 1516
            ....|  ...|||:..    |..|.:       :.|..|:.:..||.|.:.|:..|:.||..||.
  Rat  1121 TRRCP--CCNVNTSKS----PWATGW-------QVRKTCYRIVEHSWFESFIIFMILLSSGALAF 1172

  Fly  1517 E-NPLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLH-DGAFCRSAFNLLDLLVVCVSLI 1579
            | |.|.....:..||...|..||.:|..|::||.::|||..: ..|:|     .||.|:|.:||.
  Rat  1173 EDNYLEEKPRVKSVLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWC-----WLDFLIVNISLT 1232

  Fly  1580 SLVS---SSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFA 1641
            ||::   ..:.::.:|.||.||.||||||::|.:|::.||..::.|:.:|.|::|| ||:.::  
  Rat  1233 SLIAKILEYSDVASIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLV-CLIFWL-- 1294

  Fly  1642 VIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTD---------GSKM 1697
                                             :|:::||.||.|||.||.|         .|.|
  Rat  1295 ---------------------------------IFSIMGVNLFAGKFSKCVDTRNNPFSNVNSTM 1326

  Fly  1698 --TQDECY-----GTYLVYDDGDVHKPRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLY 1755
              .:.||:     |.:.                |.|.:.:||:||.|.|.|..|:||:||..::|
  Rat  1327 VNNKSECHNQNSTGHFF----------------WVNVKVNFDNVAMGYLALLQVATFKGWMDIMY 1375

  Fly  1756 VSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNE----GEQEYKNCDLD 1816
            .::||.:.|..|.......:..|::::||...||.:|:|||.:|..|..:    |.|:....:..
  Rat  1376 AAVDSGEINSQPNWENNLYMYLYFVVFIIFGGFFTLNLFVGVIIDNFNQQKKKLGGQDIFMTEEQ 1440

  Fly  1817 KNQRNCIEFALKAKPVRRYIPKHGIQYK--VWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLW 1879
            |...|.:: .|.:|..::.||:...:|:  |:..||..:|:..|.:||.:|.:|:.::...|...
  Rat  1441 KKYYNAMK-KLGSKKPQKPIPRPLNKYQGFVFDIVTRQAFDIIIMVLICLNMITMMVETDEQGEE 1504

  Fly  1880 YTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQI 1944
            .|::|..:|..|.|||..|.|.|:.|.| :.||.:.|||||||:|:.|...:::|.|        
  Rat  1505 KTKVLGRINQFFVAVFTGECVMKMFALR-QYYFTNGWNVFDFIVVILSIGSLLFSAI-------- 1560

  Fly  1945 AECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLI 2009
                    .||.:......|..:  .||.|:.|:::|:...:||||||:..:.|..||..:.||:
  Rat  1561 --------LKSLENYFSPTLFRV--IRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLL 1615

  Fly  2010 VLLFFIYAVVGMQVFGKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVK 2074
            .|:.|||::.||..|..:..:.|  |....||:||..::|.||:..|...|..::..........
  Rat  1616 FLVMFIYSIFGMASFANVVDEAG--IDDMFNFKTFGNSMLCLFQITTSAGWDGLLSPILNTGPPY 1678

  Fly  2075 CD---MNSDTPGEPCGSSIAYPYFISFYVLCSFLI-INLFVAVIMDNFDYLTRD-WSILGPHHLD 2134
            ||   .||:.....|||......|.:.|::.|||| :|:::|||::||:..|.: ...|.....|
  Rat  1679 CDPNLPNSNGSRGNCGSPAVGIIFFTTYIIISFLIVVNMYIAVILENFNVATEESTEPLSEDDFD 1743

  Fly  2135 EFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNA 2199
            .|...|.::||:|...|....:......:|.||...|  |::   ..|:.|::||.....:....
  Rat  1744 MFYETWEKFDPEATQFIAFSALSDFADTLSGPLRIPK--PNQ---NILIQMDLPLVPGDKIHCLD 1803

  Fly  2200 TLFAVVRTSL-------SIKTD-------GNIDDANSELRATIKQIWKRTNPK------------ 2238
            .|||..:..|       |:||:       .|:..|:.|..||..: ||:.:..            
  Rat  1804 ILFAFTKNVLGESGELDSLKTNMEEKFMATNLSKASYEPIATTLR-WKQEDLSATVIQKAYRSYM 1867

  Fly  2239 ------LLDQVVPPPGNDDEVTV-GKFYATYLIQDYFRRFKKRKEQEGKEGHPDS-NTVTLQAGL 2295
                  |.:.:..|...:|.|:: |:.|.|::...   ....:.|.......|.| ::||  .||
  Rat  1868 LHRSLTLSNTLHVPRAEEDGVSLPGEGYVTFMANS---GLPDKSETASATSFPPSYDSVT--RGL 1927

  Fly  2296 RTLHEVSPA 2304
            .....::|:
  Rat  1928 SDRANINPS 1936

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 95/301 (32%)
Ion_trans 1137..1379 CDD:395416 81/248 (33%)
Ion_trans 1496..1809 CDD:395416 103/337 (31%)
Ion_trans 1851..2126 CDD:395416 89/279 (32%)
GPHH 2135..2188 CDD:407139 13/52 (25%)
Ca_chan_IQ 2199..2271 CDD:400901 21/104 (20%)
Scn10aNP_058943.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 31..54 7/22 (32%)
I. /evidence=ECO:0000305 116..404 98/305 (32%)
Ion_trans 129..406 CDD:395416 95/294 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 441..484 0/42 (0%)
Na_trans_cytopl <482..614 CDD:403218 15/134 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 537..581 6/43 (14%)
II. /evidence=ECO:0000305 646..910 89/288 (31%)
Ion_trans 663..893 CDD:395416 78/240 (33%)
Na_trans_assoc 903..1148 CDD:399489 33/257 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1008..1094 9/85 (11%)
III. /evidence=ECO:0000305 1141..1450 108/366 (30%)
Ion_trans 1152..1428 CDD:395416 102/332 (31%)
Na_channel_gate 1420..1472 CDD:240441 11/52 (21%)
IV. /evidence=ECO:0000305 1459..1758 102/319 (32%)
Ion_trans 1476..1733 CDD:395416 89/277 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1906..1956 8/33 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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