Protein Alignment Ca-alpha1D and Cacna1b

DIOPT Version :10

• Sequence 1: NP_723952.2
• Gene: Ca-alpha1D / 34950
• FlyBaseID: FBgn0001991
• Length: 2705
• Species: Drosophila melanogaster
• Sequence 2: NP_001182128.1
• Gene: Cacna1b / 257648
• RGDID: 628852
• Length: 2354
• Species: Rattus norvegicus
• Alignment Length: 2531
• Identity: 875/2531 - (34%)
• Similarity: 1164/2531 - (45%)
• Gaps: 679/2531 - (26%)

  Fly   631 ELIDNFGGGAGKFFNIMDFERGASGEGGFSPNGNGGPGSGDVSRTARYDSGEGDLGGGNNIMGID 695
            ||...:||..|.       ||...|..|    |.|||             |:|.|..|..::...
  Rat     7 ELGGRYGGTGGG-------ERARGGGAG----GAGGP-------------GQGGLPPGQRVLYKQ 47

  Fly   696 S-------MGIAN-IPETMNGTTIGPSGAGGQKGGAAAGAAGQKRQQRRGKPQPDRPQRALFCLS 752
            |       |.:.| ||...|..|:                                 .|:||..|
  Rat    48 SIAQRARTMALYNPIPVKQNCFTV---------------------------------NRSLFVFS 79

  Fly   753 VKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVIFTAE 817
            ..|.:|....||.||.|||::||.||.||||.||:....|..|....::.|:..|..|:.||..|
  Rat    80 EDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFE 144

  Fly   818 CVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAFRVLRPLRLVS 882
            ..:||:|.|||.|.|:|||||||::||.:|:.|.::||.:.     ||::.|||.||||||:|||
  Rat   145 AGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTD-----FDLRTLRAVRVLRPLKLVS 204

  Fly   883 GVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDEITGEYEENIRPCG 947
            |:|||||||.||:||||||..|.||:.|.|:::||||||.:.||.||||....|........|||
  Rat   205 GIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDAEPVGDFPCG 269

  Fly   948 ---VGYQCPPGYKCYGGWDGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWM 1009
               ....|....:|...|.|||.|||||||...|:||||||:|:|||||:||:..||.|:.|.|:
  Rat   270 KEAPARLCDSDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTWNWL 334

  Fly  1010 YFISMVILGAFFVMNLILGVLSGEFSKERNKAKNRGDFQKLREKQQIEEDLRGYLDWITQAEDI- 1073
            |||.::|:|:||::||:||||||||:|||.:.:||..|.|||.:||||.:|.|||:||.:||::
  Rat   335 YFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAEEVM 399

  Fly  1074 --EPDAVGGLISDGKGKQPNEMD------STENLGEEMPEVQMTESRW-----------RKMKKD 1119
              |.|      .:.:.|.|  :|      :|:....::...:..|.|:           |...|.
  Rat   400 LAEED------KNAEEKSP--LDAVLKRAATKKSRNDLIHAEEGEDRFVDLCAAGSPFARASLKS 456

  Fly  1120 --------FDRVNRRMRRACRKAVKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVF 1176
                    |.|..:..|...|:.||:|:|||:::.:|.|||..:|..||.|...|.....:....
  Rat   457 GKTESSSYFRRKEKMFRFLIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPQRLTTALYFAEFV 521

  Fly  1177 FIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRV 1241
            |:|||..||.||||.||.:.||.|.||.||..|::|||.|.:..........|:||||.:||||:
  Rat   522 FLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSIFEVVWAAIKPGTSFGISVLRALRLLRI 586

  Fly  1242 FKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEKYRMNFDC 1306
            |||||||.||.|||.|||||::||.|||.|||||||:|||||||:|||:|||  ::|....|||.
  Rat   587 FKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF--QDETPTTNFDT 649

  Fly  1307 FWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYILLNVFLAIAVDNL 1371
            |..|:||||||:||||||||||.||.:.||||. |..:..|||:|.:.|||.|||||||||||||
  Rat   650 FPAAILTVFQILTGEDWNAVMYHGIESQGGVSK-GMFSSFYFIVLTLFGNYTLLNVFLAIAVDNL 713

  Fly  1372 ADADSLSEVEKEEE--------------------------------------------------P 1386
            |:|..|::.|:|.|                                                  |
  Rat   714 ANAQELTKDEEEMEEAANQKLALQKAKEVAEVSPMSAANISIAAFVKQTRGTVSRSSSVSSVNSP 778

  Fly  1387 HDESAQ---------------------------------------------KKSHSPTPTI---- 1402
            ...||:                                             .|:|...|.:
  Rat   779 QQNSAKARSVWEQRASQLRLQNLRASCEALYSEMDPEERLRYASTRHVRPDMKTHMDRPLVVEPG 843

  Fly  1403 --------------------DGMD----DHLSIDIDM---------EQQELD------------- 1421
                                :|.|    .|...|.|.         ||...|
  Rat   844 RDGLRGPAGNKSKPEGTEATEGADPPRRHHRHRDRDKTSASTPAGGEQDRTDCPKAESTETGARE 908

  Fly  1422 ----------------------DEDKMDHETLSDEEV---------------------------- 1436
                                  :..:..|...|.||.
  Rat   909 ERARPRRSHSKEAPGADTQVRCERSRRHHRRGSPEEATEREPRRHRAHRHAQDSSKEGKEGTAPV 973

  Fly  1437 ---------------------------------------------REMCEEE------------- 1443
                                                         ||:.|:|
  Rat   974 LVPKGERRARHRGPRTGPRETENSEEPTRRHRAKHKVPPTLEPPEREVAEKESNVVEGDKETRNH 1038

  Fly  1444 -----------------------------------EEVDEEGMITARPRRMSEVNTATKI----- 1468
                                               |:.|.:..:|....:.|:.:|...:
  Rat  1039 QPKEPRCDLEAIAVTGVGSLHMLPSTCLQKVDEQPEDADNQRNVTRMGSQPSDPSTTVHVPVTLT 1103

  Fly  1469 ------------------------------------LPIPPGTSFFLFSQTNRFRVFCHWLCNHS 1497
                                                .||.|.:|.|..|.||..|.|||::....
  Rat  1104 GPPGEATVVPSANTDLEGQAEGKKEAEADDVLRRGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMR 1168

  Fly  1498 NFGNIILCCIMFSSAMLAAENPLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFC 1562
            .|..:||..|..||..||||:|:|.:...|..|...||.||.|||.|:::|:|..|.:||.||:.
  Rat  1169 YFEMVILVVIALSSIALAAEDPVRTDSFRNNALKYMDYIFTGVFTFEMVIKMIDLGLLLHPGAYF 1233

  Fly  1563 RSAFNLLDLLVVCVSLISLV---SSSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVK 1624
            |..:|:||.:||..:|::..   |....|:.:|.||||||||||:.|.|...||.|..
  Rat  1234 RDLWNILDFIVVSGALVAFAFSGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFD------- 1291

  Fly  1625 TIGNIVLVTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFF 1689
                                         |||.::|.:.||::|..|..|:||||.|||||||||
  Rat  1292 -----------------------------CVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFF 1327

  Fly  1690 KCTDGSKMTQDECYGTYLVYDDGDVHKPRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLL 1754
            .|||.||..:.:|.|.||.|:..:|   ..:.|:|....||:|:|...:||||||||.||||.:|
  Rat  1328 YCTDESKELERDCRGQYLDYEKEEV---EAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVL 1389

  Fly  1755 YVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQEYKNCDLDKNQ 1819
            ..|:|:..|..||...||..::.:|::|.::..||.|||||..:|:|||.:|::....|.|:||:
  Rat  1390 KHSVDATYEEQGPSPGFRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNE 1454

  Fly  1820 RNCIEFALKAKPVRRYIP--KHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTE 1882
            |.||:||:.|||:.||:|  |...|||.|.||.|..|||.|..:|.:|||.|.||||:.|..|..
  Rat  1455 RACIDFAISAKPLTRYMPQNKQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYEL 1519

  Fly  1883 LLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAEC 1947
            :|..||::||::|:||.:.|:.||...|||.||||||||:.||||..||:.:|        |||.
  Rat  1520 MLKCLNIVFTSMFSLECILKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTE--------IAET 1576

  Fly  1948 DIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLL 2012
                          :|.|:::|.||||..||:|||.:|..||.|||||::||:|||||.|||.:|
  Rat  1577 --------------NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAML 1627

  Fly  2013 FFIYAVVGMQVFGKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDM 2077
            |||||::||||||.||||.|.:|..:|||:||.||:::||||||||||.|||:||..  :..||.
  Rat  1628 FFIYAIIGMQVFGNIALDDGTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLG--NRACDP 1690

  Fly  2078 NSDTPGEPCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSE 2142
            :::  ...|||..||.||:||..|||||::|||||||||||:|||||.|||||||||||||:|:|
  Rat  1691 HAN--ASECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAE 1753

  Fly  2143 YDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPL-NSDGTVLFNATLFAVVR 2206
            |||.|.|||.:.|:..:|:.:|||||.||.||.|:|.||||.||||: |.|.||.|.:||.|::|
  Rat  1754 YDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIR 1818

  Fly  2207 TSLSIK-----TDGNIDDANSELRATIKQIWKRTNPKLLDQVVPPPGNDDEVTVGKFYATYLIQD 2266
            |:|.||     |..:..||  |||..|..:|.....|.||.:| ||...||:||||.||..:|.|
  Rat  1819 TALEIKLAPAGTKQHQCDA--ELRKEISSVWANLPQKTLDLLV-PPHKPDEMTVGKVYAALMIFD 1880

  Fly  2267 YFRRFKKRKEQ--EGKEGHPDSNTVTLQAGLR-TLHEVSPALKRAISGNLDELDQEPEPMHRRHH 2328
            ::::.|..::|  :...|......|:|...|: ||.:..||:.|
  Rat  1881 FYKQNKTTRDQTHQAPGGLSQMGPVSLFHPLKATLEQTQPAVLR--------------------- 1924

  Fly  2329 TLFGSVWSSIRRHGNGTFRRSAKATASQSNGALAIGGS-------------------ASAALGVG 2374
                         |...|.|...||:..:.||:....|                   |.|.|..|
  Rat  1925 -------------GARVFLRQKSATSLSNGGAIQTQESGIKESLSWGTQRTQDVLYEARAPLERG 1976

  Fly  2375 GSS-LVLGSSDPAGGDYLYDTLNRSVADGVNNITRNIMQARLAAAGKLQDELQGAGSGGELRTFG 2438
            .|: :.:|.......|.....:.....||....... .|.|.|:..:|..|.|.|.:...::...
  Rat  1977 HSAEIPVGQPGALAVDVQMQNMTLRGPDGEPQPGLE-SQGRAASMPRLAAETQPAPNASPMKRSI 2040

  Fly  2439 ESISMRPLAKNGGGAATVAGTLPPEANAINY---------DNRNRGILLHPYNNV---YAPNGA- 2490
            .:::.||   :|..........||.:...::         |.:.|.:...|..:|   .||:.|
  Rat  2041 STLAPRP---HGTQLCNTVLDRPPPSQVSHHHHHRCHRRRDKKQRSLEKGPSLSVDTEGAPSTAA 2102

  Fly  2491 ---LPGHE-----RMIQSTPASPYDQRRLPTSSDMNGLAESLIGGVLAAEGLGKYCDSEFVGTAA 2547
               ||..|     |..:........:||.|:||              ::|....|....|.....
  Rat  2103 GSGLPHGEGSTGCRRERKQERGRSQERRQPSSS--------------SSEKQRFYSCDRFGSREP 2153

  Fly  2548 REMREALDMTPEEMNLAAHQILSNEHSLSLIGSSNGSIFGGSAGGLGGAGSGGVGG--------- 2603
            .:.:.:|...|.....|   :....|.     ..:||:.|.......||.:.|.||
  Rat  2154 PQPKPSLSSHPISPTAA---LEPGPHP-----QGSGSVNGSPLMSTSGASTPGRGGRRQLPQTPL 2210

  Fly  2604 ---------LGGSSSIRNAFGGSG---SGPSSLS-------------PQHQPY-SGT-LNSPPIP 2641
                     ...||.:..|.|.||   ..|..||             |..||. ||: :.|.|..
  Rat  2211 TPRPSITYKTANSSPVHFAEGQSGLPAFSPGRLSRGLSEHNALLQKEPLSQPLASGSRIGSDPYL 2275

  Fly  2642 DNRLRRVATVTTTNNNNKSQVSQNN--SNSLN----VRANANSQMNMSPTGQPVQQQSPLR 2696
            ..||             .|:.|.:|  .::|.    |..|:......|.......|..|||
  Rat  2276 GQRL-------------DSEASAHNLPEDTLTFEEAVATNSGRSSRTSYVSSLTSQSHPLR 2323

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1D	NP_723952.2	Ion_trans	767..1042	CDD:459842	147/277 (53%)
		Ion_trans	1137..1379	CDD:459842	140/241 (58%)
		Ion_trans	1496..1809	CDD:459842	127/315 (40%)
		Ion_trans	1851..2126	CDD:459842	150/274 (55%)
		GPHH	2135..2188	CDD:465306	32/52 (62%)
		Ca_chan_IQ	2198..2273	CDD:462591	32/79 (41%)
Cacna1b	NP_001182128.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..37		15/53 (28%)
		I	82..359		147/281 (52%)
		Ion_trans	94..367	CDD:459842	147/277 (53%)
		Binding to the beta subunit	379..396		10/16 (63%)
		II	469..713		139/246 (57%)
		Ion_trans	482..721	CDD:459842	140/241 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	820..1041		19/220 (9%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1071..1096		5/24 (21%)
		Ion_trans	1168..1398	CDD:459842	108/268 (40%)
		Ion_trans	1488..1737	CDD:459842	150/274 (55%)
		GPHH	1746..1799	CDD:465306	32/52 (62%)
		Ca_chan_IQ	1810..1887	CDD:462591	32/79 (41%)
		PHA03307	1971..>2273	CDD:223039	66/327 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1999..2220		45/246 (18%)