DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and Scn4a

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:NP_037310.2 Gene:Scn4a / 25722 RGDID:3636 Length:1840 Species:Rattus norvegicus


Alignment Length:1808 Identity:467/1808 - (25%)
Similarity:826/1808 - (45%) Gaps:395/1808 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   747 ALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFL 811
            ||:.||..:.:|.:.|:::....|...|::||..||:.:.:..|...|         :.|||.|.
  Rat   110 ALYLLSPFSIVRRVAIKVLIHALFSMFIMITILTNCVFMTMSNPPSWS---------KHVEYTFT 165

  Fly   812 VIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAFRVLR 876
            .|:|.|.::|:||.||.:.:..:||:.||.|||:::.:..::..:     |..::.|||.|||||
  Rat   166 GIYTFESLIKMLARGFCIDDFTFLRDPWNWLDFSVITMAYVTEFV-----DLGNISALRTFRVLR 225

  Fly   877 PLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKAC---------- 931
            .|:.::.:|.|:.::.::::::..|..:.:|.:|.:.::|::||:||.|.|.:.|          
  Rat   226 ALKTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPMNDT 290

  Fly   932 ----------------------------------RDEITGEYEENIRPCGVGY------------ 950
                                              ....|.::|..|...|..|            
  Rat   291 NTTWYGNDTWYSNDTWYGNDTWYINDTWNSQESWAGNSTFDWEAYINDEGNFYFLEGSNDALLCG 355

  Fly   951 ------QCPPGYKCYGGWDGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWM 1009
                  .||.||:|......||.|.|::|.|..|.|.:|:.:|.:.|.::......|.|..:. :
  Rat   356 NSSDAGHCPEGYECIKAGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKTYM-I 419

  Fly  1010 YFISMVILGAFFVMNLILGVLSGEFSKERNKAKNRGDFQKLREKQQIEEDLRGYLDWITQAE--- 1071
            :|:.::.||:|:::||||.|::..:: |:|:|....|.:|..|.||:.|..:.:.:.:.:|:   
  Rat   420 FFVVIIFLGSFYLINLILAVVAMAYA-EQNEATLAEDQEKEEEFQQMLEKYKKHQEEVEKAKAAQ 483

  Fly  1072 --------DIEP----DAVGGLISDGKGKQPNEMDSTEN-LGEEMPEVQMTESR----WRKMKKD 1119
                    |.:|    |..|.|.:.|:...|....|.:: :.:.|.|::....:    |.|....
  Rat   484 ALESGEEADGDPTHNKDCNGSLDASGEKGPPRPSCSADSAISDAMEELEEAHQKCPPWWYKCAHK 548

  Fly  1120 FDRVNRRMRRACRKAVKSQAFYWLII----------VLVFLNTGVLATEHYGQLDWLDNFQEYTN 1174
            .     .:...|...||.:...:||:          :.:.|||..:|.|||...:..||.....|
  Rat   549 V-----LIWNCCAPWVKFKHIIYLIVMDPFVDLGITICIVLNTLFMAMEHYPMTEHFDNVLSVGN 608

  Fly  1175 VFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLL 1239
            :.|.|:||.||:||:.::....||...:|.||.|:|..|:.|..|.|.     .|:||||..|||
  Rat   609 LVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSFIVTLSLVELGLANV-----QGLSVLRSFRLL 668

  Fly  1240 RVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEKYRMNF 1304
            ||||:.|.|.:|:.|:..:.||:.::.:|.|:|.:.:.|||::|||:||..:    ||...::..
  Rat   669 RVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSY----KECVCKIAS 729

  Fly  1305 DC---------FWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYILL 1360
            ||         |:.:.|.||:|:.|| |...|:..:...|     .|:....|:::.:.||.::|
  Rat   730 DCNLPRWHMNDFFHSFLIVFRILCGE-WIETMWDCMEVAG-----QAMCLTVFLMVMVIGNLVVL 788

  Fly  1361 NVFLAI-----AVDNLADAD--------------------------------------------- 1375
            |:|||:     :.|:||.:|                                             
  Rat   789 NLFLALLLSSFSADSLAASDEDGEMNNLQIAIGRIKWGIGFAKTFLLGLLRGKILSPKEIILSLG 853

  Fly  1376 -----------SLSEVEKEEEPHDESAQKKSH---------SPTPTIDGMD-------DHLSIDI 1413
                       |..|.||:|.|.::...|.:|         .|..:|: :|       .:|:|.:
  Rat   854 EPGGAGENAEESTPEDEKKEPPPEDKELKDNHILNHVGLTDGPRSSIE-LDHLNFINNPYLTIHV 917

  Fly  1414 DMEQQELDDEDKMDHET---LSDEEVRE-----------MC---------EEEEEVDEEGMITAR 1455
            .:..:|.|.|...:.||   ...|::::           :|         |:.||..||.....:
  Rat   918 PIASEESDLEMPTEEETDAFSEPEDIKKPLQPLYDGNSSVCSTADYKPPEEDPEEQAEENPEGEQ 982

  Fly  1456 PRRMSEVNTATKILP-----IPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLA 1515
            |.... .....|..|     |..|.....::    .|..|..:..|:.|...|:..|:.||..||
  Rat   983 PEECF-TEACVKRCPCLYVDISQGRGKMWWT----LRRACFKIVEHNWFETFIVFMILLSSGALA 1042

  Fly  1516 AEN-PLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGF-VLHDGAFCRSAFNLLDLLVVCVSL 1578
            .|: .:.....:..:|...|..||.:|.:|::||.::||| |....|:|     .||.|:|.||:
  Rat  1043 FEDIYIEQRRVIRTILEYADKVFTYIFILEMLLKWVAYGFKVYFTNAWC-----WLDFLIVDVSI 1102

  Fly  1579 ISLVSS---SNAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMF 1640
            ||||::   .:.:..:|.||.||.||||||::|.:|::.||..::.|:.:|.|::|| ||:.:: 
  Rat  1103 ISLVANWLGYSELGPIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLV-CLIFWL- 1165

  Fly  1641 AVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTDGSKM-------- 1697
                                              :|:::||.||.|||:.|.:.:..        
  Rat  1166 ----------------------------------IFSIMGVNLFAGKFYYCVNTTTSERFDISVV 1196

  Fly  1698 -TQDECYGTYLVYDDGDVHKPRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSN 1761
             .:.||..  |:| .|.|        .|.|.:.::|:|..|.|:|..|:||:||..::|.::||.
  Rat  1197 NNKSECES--LMY-TGQV--------RWMNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSR 1250

  Fly  1762 KENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQEY--KNCDLDKNQRNCIE 1824
            ::...|.:.....:..|::|:||..:||.:|:|:|.:|..| |:.::::  |:..:.:.|:....
  Rat  1251 EKEEQPDYEVNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNF-NQQKKKFGGKDIFMTEEQKKYYN 1314

  Fly  1825 FALK-------AKPVRRYIPKHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTE 1882
             |:|       .||:.|  |::.||..|:.|||...|:.:|.|||.:|.||:.::..:|.....:
  Rat  1315 -AMKKLGSKKPQKPIPR--PQNKIQGMVYDFVTKQVFDISIMILICLNMVTMMVETDDQSQLKVD 1376

  Fly  1883 LLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAEC 1947
            :|..:||:|..:|..|.|.|:.|.| ..||...||:|||::|:.|.:.:..|::..|        
  Rat  1377 ILYNINMVFIIIFTGECVLKMFALR-HYYFTIGWNIFDFVVVILSIVGLALSDLIQK-------- 1432

  Fly  1948 DIVEGCKSTKKSAGSNLISINFF---RLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLI 2009
                           ..:|...|   ||.|:.|:::|:...:||||||:..:.|..||..:.||:
  Rat  1433 ---------------YFVSPTLFRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLL 1482

  Fly  2010 VLLFFIYAVVGMQVFGKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIM--MSCSAQPD 2072
            .|:.|||::.||..|..:..:.|  |....||:||..:::.||...|...|..::  :..|..||
  Rat  1483 FLVMFIYSIFGMSNFAYVKKESG--IDDMFNFETFGNSIICLFEITTSAGWDGLLNPILNSGPPD 1545

  Fly  2073 VKCDMNSDTPGE----PCGS-SIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWS-ILGPH 2131
              ||...:.||.    .||: ||...:|.|:.::...:::|:::|:|::||:..|.:.| .|...
  Rat  1546 --CDPTLENPGTNVRGDCGNPSIGICFFCSYIIISFLIVVNMYIAIILENFNVATEESSEPLSED 1608

  Fly  2132 HLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVL 2196
            ..:.|...|.::||||...|.:..:...:..:..||...|  |:::   :|:::::|:.....:.
  Rat  1609 DFEMFYETWEKFDPDATQFIDYSRLSDFVDTLQEPLKIAK--PNKI---KLITLDLPMVPGDKIH 1668

  Fly  2197 FNATLFAVVRTSLSIKTDGNIDDANSELRATIKQIWKRTNPKLL--DQVVPPPGNDDE----VTV 2255
            ....|||:.:..|.  ..|.:|    .|:.|:::.:...||..:  :.:........|    :.:
  Rat  1669 CLDILFALTKEVLG--DSGEMD----ALKQTMEEKFMAANPSKVSYEPITTTLKRKQEEVCAIKI 1727

  Fly  2256 GKFYATYLIQDYFRR--FKKRKEQEGK-EGHPD-----SNTVTLQAGLRTLHE 2300
            .:.|..:|:|...::  :..|..|:|. :|.|:     :||:....|    ||
  Rat  1728 QRAYRRHLLQRSVKQASYMYRHSQDGNGDGAPEKEGLLANTMNKMYG----HE 1776

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 84/336 (25%)
Ion_trans 1137..1379 CDD:395416 88/321 (27%)
Ion_trans 1496..1809 CDD:395416 98/326 (30%)
Ion_trans 1851..2126 CDD:395416 84/284 (30%)
GPHH 2135..2188 CDD:407139 12/52 (23%)
Ca_chan_IQ 2199..2271 CDD:400901 14/79 (18%)
Scn4aNP_037310.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 36..63
I. /evidence=ECO:0000305 113..448 87/350 (25%)
Ion_trans 130..451 CDD:395416 84/336 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 481..522 8/40 (20%)
II. /evidence=ECO:0000305 554..826 90/286 (31%)
Ion_trans 571..784 CDD:395416 74/227 (33%)
Na_trans_assoc 810..1019 CDD:399489 32/214 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 854..884 7/29 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 925..983 11/57 (19%)
III. /evidence=ECO:0000305 1006..1319 104/370 (28%)
Ion_trans 1023..1297 CDD:395416 98/326 (30%)
Na_channel_gate 1289..1341 CDD:240441 13/55 (24%)
Important for rapid channel inactivation. /evidence=ECO:0000269|PubMed:28012039 1303..1305 0/1 (0%)
IV. /evidence=ECO:0000305 1328..1626 100/327 (31%)
Ion_trans 1346..1602 CDD:395416 84/283 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1775..1840 2/2 (100%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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