DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ca-alpha1D and Scn5a

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:XP_038936827.1 Gene:Scn5a / 25665 RGDID:3637 Length:2020 Species:Rattus norvegicus


Alignment Length:2077 Identity:495/2077 - (23%)
Similarity:851/2077 - (40%) Gaps:615/2077 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   747 ALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFL 811
            ||:.||..:|:|...::|:....|..||:.||..||:.:|.:.|.|.:         :.|||.|.
  Rat   111 ALYVLSPFHPVRRAAVKILVHSLFSMLIMCTILTNCVFMAQHDPPPWT---------KYVEYTFT 166

  Fly   812 VIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAFRVLR 876
            .|:|.|.::||||.||.||...:||:.||.|||:::|:     |.:....|..:|.|||.|||||
  Rat   167 AIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIVM-----AYTTEFVDLGNVSALRTFRVLR 226

  Fly   877 PLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKL-HKACRD--EITG- 937
            .|:.:|.:..|:.::.::::::..|..:.:|.:|.:.::|:|||:||.|.| ||..|:  |:.| 
  Rat   227 ALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTELNGT 291

  Fly   938 ----------------------EY-----EENIRPCGVGYQ---CPPGYKCYGGWDGPNDGITNF 972
                                  .|     ..::..||....   ||.||:|....:.|:.|.|:|
  Rat   292 NGSVEADGLVWNSLDVYLNDPANYLLKNGTTDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSF 356

  Fly   973 DNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKE 1037
            |:|..|.|.:|:.:|.:.|..:......:.|..:. ::|:.::.||:|:::||||.|::..: :|
  Rat   357 DSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYM-IFFMLVIFLGSFYLVNLILAVVAMAY-EE 419

  Fly  1038 RNKA------KNRGDFQKLREKQQIEED---LRGYLDWITQAE-DIEPDA--------------- 1077
            :|:|      :....||:..|..:.|.:   :|| :|.::.:. ::.|.|               
  Rat   420 QNQATIAETEEKEKRFQEAMEMLKKEHEALTIRG-VDTVSHSSLEMSPLAPVTNHERKSKRRKRL 483

  Fly  1078 VGGLISDGKGKQP-----------NEMDSTENLG-----------------------------EE 1102
            ..|....|..:.|           |::..|..|.                             :|
  Rat   484 SSGTEDGGDDRLPKSDSEDGPRALNQLSLTHGLSRTSMRPRSSRGSIFTFRRRDQGSEADFADDE 548

  Fly  1103 MPEVQMTESR-------W----------------------------------------------- 1113
            ......:||.       |                                               
  Rat   549 NSTAGESESHRTSLLVPWPLRHPSAQGQPGPGASAPGYVLNGKRNSTVDCNGVVSLLGAGDAEAT 613

  Fly  1114 -------RKMKKD---------------------------FDRVNRRMRRACRKAVKSQAF---- 1140
                   |.|..|                           |:....|.|.....:|.:.|.    
  Rat   614 SPGSYLLRPMVLDRPPDTTTPSEEPGGPQMLTPQAPCADGFEEPGARQRALSAVSVLTSALEELE 678

  Fly  1141 ------------------------YWL------------------IIVLVFLNTGVLATEHYGQL 1163
                                    .|:                  |.:.:.|||..:|.|||...
  Rat   679 ESHRKCPPCWNRFAQHYLIWECCPLWMSIKQKVKFVVMDPFADLTITMCIVLNTLFMALEHYNMT 743

  Fly  1164 DWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPL 1228
            ...:...:..|:.|.|:||.||..|:.:|....||...:|.||..:||.|:.|..|:..|     
  Rat   744 AEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMG----- 803

  Fly  1229 GVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNF 1293
            .:||||..|||||||:.|.|.:|:.|:..:.||:.::.:|.|:|.:.:.|||::|||:||..:: 
  Rat   804 NLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYS- 867

  Fly  1294 DGKEEKYRMN----------FDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYF 1348
               |.::|::          .| |:.|.|.:|:|:.|| |...|:..:...|     .:|..:.|
  Rat   868 ---ELRHRISDSGLLPRWHMMD-FFHAFLIIFRILCGE-WIETMWDCMEVSG-----QSLCLLVF 922

  Fly  1349 IILFICGNYILLNVFLAIAVDNLADADSLSEVEKEEEPHD------------------------- 1388
            :::.:.||.::||:|||:.:.:.: ||:|:..:::.|.::                         
  Rat   923 LLVMVIGNLVVLNLFLALLLSSFS-ADNLTAPDEDGEMNNLQLALARIQRGLRFVKRTTWDFCCG 986

  Fly  1389 -------ESAQKKSHS------------PTPTID----------------------GMDDHLSID 1412
                   :.|...:||            |.|.::                      |..:.:.:.
  Rat   987 ILRRRPKKPAALATHSQLPSCITAPRSPPPPEVEKVPPARKETRFEEDKRPGQGTPGDSEPVCVP 1051

  Fly  1413 IDMEQQELDDEDKMDHETLSDEEVREMCEEEEEVDEEGMITARPRRMSEVNTAT----------- 1466
            |.:.:.:.:|:::.:..:|..||.....:|.:.|.........||..|:|:..|           
  Rat  1052 IAVAESDTEDQEEDEENSLGTEEESSKQQESQVVSGGHEPYQEPRAWSQVSETTSSEAGASTSQA 1116

  Fly  1467 ------KILPIPPG---TSFFLFSQ------TN-------------------------------- 1484
                  |..|..||   |....:|:      ||                                
  Rat  1117 DWQQEQKTEPQAPGCGETPEDSYSEGSTADMTNTADLLEQIPDLGEDVKDPEDCFTEGCVRRCPC 1181

  Fly  1485 --------------RFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDDLNKVLNKF-D 1534
                          |.|..|:.:..||.|...|:..|:.||..||.|:.........|||.:: |
  Rat  1182 CMVDTTQSPGKVWWRLRKTCYRIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYAD 1246

  Fly  1535 YFFTAVFTIELILKLISYGFVLH-DGAFCRSAFNLLDLLVVCVSLISLVSSS---NAISVVKILR 1595
            ..||.||.:|::||.::|||..: ..|:|     .||.|:|.|||:|||:::   ..:..:|.||
  Rat  1247 KMFTYVFVLEMLLKWVAYGFKKYFTNAWC-----WLDFLIVDVSLVSLVANTLGFAEMGPIKSLR 1306

  Fly  1596 VLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKCVVVAIK 1660
            .||.||||||::|.:|::.||..::.|:.:|.|::|| ||:.::                     
  Rat  1307 TLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLV-CLIFWL--------------------- 1349

  Fly  1661 TIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDD----------GDVH 1715
                          :|:::||.||.|||.:|.:   .|:.:....|.:.::          |:::
  Rat  1350 --------------IFSIMGVNLFAGKFGRCIN---QTEGDLPLNYTIVNNKSECESFNVTGELY 1397

  Fly  1716 KPRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYI 1780
                    |:..:.:||:|..|.|.|..|:||:||..::|.::||......|.......:..|::
  Rat  1398 --------WTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEDNLYMYIYFV 1454

  Fly  1781 IYIIIIAFFMVNIFVGFVIVTFQNE----GEQEYKNCDLDKNQRNCIEFALKAKPVRRYIPKHGI 1841
            ::||..:||.:|:|:|.:|..|..:    |.|:....:..|...|.:: .|.:|..::.||:...
  Rat  1455 VFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMK-KLGSKKPQKPIPRPLN 1518

  Fly  1842 QYKVWWF--VTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLA 1904
            :|:.:.|  ||..:|:.||..||.:|.||:.::..:|......:|..:|::|.|:|..|.:.|:|
  Rat  1519 KYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKVNILAKINLLFVAIFTGECIVKMA 1583

  Fly  1905 AFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINF 1969
            |.| ..||.::||:|||::|:.|.:..|.|:|..|                       ...|...
  Rat  1584 ALR-HYYFTNSWNIFDFVVVILSIVGTVLSDIIQK-----------------------YFFSPTL 1624

  Fly  1970 F---RLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIALDG 2031
            |   ||.|:.|:::|:...:||||||:..:.|..||..:.||:.|:.|||::.||..|..:..:.
  Rat  1625 FRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANFAYVKWEA 1689

  Fly  2032 GNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCD---MNSDTPGEPCGSSIAYP 2093
            |  |....|||||..::|.||:..|...|..::..........||   .||:.....|||.....
  Rat  1690 G--IDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGSRGNCGSPAVGI 1752

  Fly  2094 YFISFYVLCSFLI-INLFVAVIMDNFDYLTRD-WSILGPHHLDEFIRLWSEYDPDAKGRIKHLDV 2156
            .|.:.|::.|||| :|:::|:|::||...|.: ...|.....|.|..:|.::||:|...|::|.:
  Rat  1753 LFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYLAL 1817

  Fly  2157 VTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIKTDGNIDDAN 2221
            ......:|.||...|  |::::   |::|::|:.|...:.....|||..:..|.  ..|.:|   
  Rat  1818 SDFADALSEPLRIAK--PNQIS---LINMDLPMVSGDRIHCMDILFAFTKRVLG--ESGEMD--- 1872

  Fly  2222 SELRATIKQIWKRTNPKLLDQVVPPPGNDDEVTVGKFYATYLIQDYFRRFKKRKEQEGKEGHPDS 2286
             .|:..:::.:...||..:..                                        .|.:
  Rat  1873 -ALKIQMEEKFMAANPSKISY----------------------------------------EPIT 1896

  Fly  2287 NTVTLQAGLRTLHEVSPA--LKRAISGNLDELDQEPEPMHRRHHTLFGSVWSSIRRHGNGTFRRS 2349
            .|      ||..||...|  ::||.                |.|.|..||     :|.:..||:.
  Rat  1897 TT------LRRKHEEVSATVIQRAF----------------RRHLLQRSV-----KHASFLFRQQ 1934

  Fly  2350 AKAT------ASQSNGALA--IGGSASAALGVGGSSLVLGSSDPAGGDYLYDTLNRSVADGV 2403
            |..:      |.:..|.:|  :.|:.|.......||.:..:|.|..    ||::.|:.:|.:
  Rat  1935 AGGSGLSDEDAPEREGLIAYMMNGNFSRRSAPLSSSSISSTSFPPS----YDSVTRATSDNL 1992

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 95/314 (30%)
Ion_trans 1137..1379 CDD:395416 83/297 (28%)
Ion_trans 1496..1809 CDD:395416 97/331 (29%)
Ion_trans 1851..2126 CDD:395416 88/282 (31%)
GPHH 2135..2188 CDD:407139 14/52 (27%)
Ca_chan_IQ 2199..2271 CDD:400901 9/71 (13%)
Scn5aXP_038936827.1 Ion_trans 131..424 CDD:395416 94/308 (31%)
Na_trans_cytopl 484..668 CDD:403218 16/183 (9%)
Ion_trans 717..930 CDD:395416 71/228 (31%)
Na_trans_assoc 956..1203 CDD:399489 30/246 (12%)
Ion_trans 1207..1482 CDD:395416 96/326 (29%)
Na_channel_gate 1474..1526 CDD:240441 10/52 (19%)
Ion_trans 1531..1785 CDD:395416 88/279 (32%)
GPHH 1797..1844 CDD:407139 14/51 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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