Protein Alignment Ca-alpha1D and cch1

DIOPT Version :9

• Sequence 1: NP_723952.2
• Gene: Ca-alpha1D / 34950
• FlyBaseID: FBgn0001991
• Length: 2705
• Species: Drosophila melanogaster
• Sequence 2: NP_593894.1
• Gene: cch1 / 2542812
• PomBaseID: SPAC6F6.01
• Length: 1854
• Species: Schizosaccharomyces pombe
• Alignment Length: 1849
• Identity: 393/1849 - (21%)
• Similarity: 694/1849 - (37%)
• Gaps: 529/1849 - (28%)

  Fly   737 GKPQP-DRPQRALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTN 800
            |.|:. :.|.|.|       |...:..:|.....:...|.:.|..:.:.|.:.:..|...|
pombe   160 GPPRANETPGRNL-------PFSPILRQIYNHPLYNIFIFVVIVLHAVLLMIRSDDPHDKS---- 213

  Fly   801 QTLEKVEYVFLVIFTAECVMKILAYGFVLHNG-------------------AYLRNGWNLLDFTI 846
            ||::.:..|..:::|.|.::||..:|| |::|                   :|||:.||.:||..
pombe   214 QTIDYLIIVIGILYTLEMLLKIYLFGF-LYDGSSSFYDFINSYTKKTPRTMSYLRHSWNRVDFVA 277

  Fly   847 VVIGAISTALSQLMKDAFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFV 911
            :|...|| .:.:..:..|.:.::.|  .||..||::.....:.:|.|:.::..||..:.....|.
pombe   278 IVALWIS-VIGKKQQGIFRLFSMIA--CLRLTRLLNITRKTETILKSLKESSTPLVQVVSFNAFF 339

  Fly   912 IIIYAIIGLELFSGKLHKACRDEITGEYEENIRPCGVGYQCPPGYKCYGGW-------------- 962
            .::.||:|::.|...|::.|  ...|:|.:.        ..|.|..|.|.|
pombe   340 GVMIAILGVQFFKASLNRQC--VWLGDYGDQ--------YLPTGQFCGGHWENGIKRAYLDKNGF 394

  Fly   963 --------------------DGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQ 1007
                                :.|.....:||||..::..:|..::..|:||::|.|.||
pombe   395 PSNVNPRGFICAEKSVCRVVENPYSNTVSFDNFFNSLELIFVIMSSNGFTDIMYDIMDA------ 453

  Fly  1008 WMYFIS--MVILGAFF----VMNLILGVLSGEFSKERNKAKNRGDFQKLREKQQIEEDLRGYLDW 1066
             .||:|  :.|:.|:|    :|:|::.|::..|...::..||:.: ||..:|..|...|
pombe   454 -EYFVSCLLFIISAYFLTLWLMSLVIAVVTSSFIDLQHSGKNQKE-QKSVDKHLIRNKL------ 510

  Fly  1067 ITQAEDIEPDAVGGLISDGKGKQPNEMDSTENLGEEMPEVQMTESRWRKMKKDFDRVNRRMRRAC 1131
                                                                            |
pombe   511 ----------------------------------------------------------------C 511

  Fly  1132 RKAVKSQAFYWL-IIVLVFLNTGVLATEHYGQLDWLDN----FQEYTNVFFIGLFTCEMLLKMYS 1191
            .|.:....|.|: .||..|:   .|.|:.|.|.....|    |  |..|.|  |...|::|:.::
pombe   512 EKYLFYSNFIWISFIVAQFV---TLCTQTYDQTSSTANRYLIF--YACVDF--LLAAEVILRFFA 569

  Fly  1192 L--GFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMP-PLG-VSVLRCVRLLRVFKVTKYWRSLS 1252
            .  .::.:|....|..|..:.:.::. |||.:....| ..| :|:....|:.|...:..|.|.::
pombe   570 YLPDYRLFFRRYTNLVDIVLAVLNLV-TLLPSIRKNPVAFGWLSIFAIARIYRCILLIPYTRKIA 633

  Fly  1253 NLVAS----LLNSIQSIASLLLLLFLFIVIF--ALLGMQVFGGKFNFDGKEEKYRMNFDCFWQAL 1311
            .|:.|    |||         |:|||.||:|  :|..:::|....| ||..:...::|...:::.
pombe   634 KLLFSNFKQLLN---------LMLFLVIVLFIASLCAVRLFQDLPN-DGDSDDDAISFATTYESF 688

  Fly  1312 LTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYILLNVFLAIAVDNLADADS 1376
            |.::||:|.|:|..||: .|.|.........:...:|.:.|:..|.::|::|:|:...|.|.::|
pombe   689 LYMYQILTSENWTDVMF-AIQARLAHLHLSWIPGAFFTLWFLFSNNVVLSMFIAVIQVNFAPSES 752

  Fly  1377 ----------LSEVEKEEEPHDES------AQKKSHSPTPTIDG------MDDHL---------- 1409
                      |:.:.:...|...|      .::.......|:|.      .:|::
pombe   753 DLKMEQLKMYLARLLRNYNPFQASLTLNALIKRNGSRKGKTVDESHYEWLYEDNIIKGFLRVTNI 817

  Fly  1410 --------SIDIDMEQQELDDEDKMDHETLSDEEVREMCEEE--EEVDEEGMITARPRRMSEVNT 1464
                    |:|...|.      .|.....||:...|.:..::  .:...:.:|..|..:...:.|
pombe   818 PPKEPLKPSLDTSPEL------SKYSLAKLSNNFKRFVMRDDPFSQAYFKRVIGIRWEKDMNLKT 876

  Fly  1465 A---------------TKILPIPP--GTSFFLFSQTNRFRVFCHWLCN---HSNFGNI------- 1502
            |               |:.|...|  ...|::...:||.|.||..|..   :..:|.:
pombe   877 AAKDMQAAKAFVRIKQTEFLKNHPKYNDVFWVIKPSNRIRRFCQRLVMPGVNERYGGVEPYQWVY 941

  Fly  1503 ------ILCCIMFSSAMLAAENPLRANDDLNKVLN--KFDYF------FTAVFTIELILKLISYG 1553
                  |..||:.:..:.....|:...|.|   ||  :..:|      |..:||||..:|:|:.|
pombe   942 RVIQVFIYACILTAVIIECIATPIYERDHL---LNDKQHAWFVWTEVAFATIFTIEAAIKIIADG 1003

  Fly  1554 FVLHDGAFCRSAFNLLDLLVVCVSLISL--VSSSNAISVVKILRVLRVLRPLRAINRAKGLKHVV 1616
            |.:...|:.||.:|.:|..|:....|:|  |.:|:|: :.:..|..:.||.||.||
pombe  1004 FCITPNAYLRSTWNCIDFFVLVTLWINLYAVLTSHAL-LSRAFRAFKALRVLRLIN--------- 1058

  Fly  1617 QCVIVAVKTIGNIVLVTCLLQFMF--AVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVI 1679
                           :|...|.||  |:|. ..||.....||.|          |.|:.  ||:.
pombe  1059 ---------------LTQTSQRMFHDALIS-GFFKIFSAAVVSA----------TLLIP--FALW 1095

  Fly  1680 GVQLFKGKFFKCTDGSKMTQDECYGTYL-VYDDGDVHKPRLREREWSN-NRFHFDDVAKGMLTLF 1742
            ...:|.|..:.|.|.:.::..:|...|. ..::.:|..||:    ||| ..:.||.....:|.||
pombe  1096 AKNVFGGLLYSCNDDNVLSASQCVLEYASTPNNWEVWAPRV----WSNPPDYDFDRFPHALLALF 1156

  Fly  1743 TVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGE 1807
            .:::.|||..::...:|....|..|..|.....|.:::::.::...:::.:|:..:|..:.....
pombe  1157 EIASIEGWVDIMRSVMDITGFNNQPQTNASSGNAMFFVLFNLVSMIYILTLFIAIIISNYAERTG 1221

  Fly  1808 QEYKNCDLDKNQRNCIEFALKAKPVRR------------------YIPKHGIQYKVWWFVTSSSF 1854
            ..:...:    ||..:|...|.|.:|.                  .:.||||     |..|.:..
pombe  1222 SAFFTAE----QRAWLELRRKIKSMRPSKRPAIRPLGLRGLCYDFAVQKHGI-----WRRTFTGL 1277

  Fly  1855 EYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVF 1919
             |.:.:|.::..      ||..|:.||.:.:::.:|.:..:.:....|:....|..:|...||:|
pombe  1278 -YIVHLLFLLTI------FYPCPIAYTYVRNSIFLILSICYTINICVKVYGLSFYYFFHSFWNMF 1335

  Fly  1920 DFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSK 1984
            |.::.|||.                 .|:|....|...:|.  .|:.....    |:..|.|:.|
pombe  1336 DVVVTLGSL-----------------TCNIAILAKFENRSL--TLLQTTLL----VLVTVHLIPK 1377

  Fly  1985 GEGIRTLLWTFIKSFQALPYVALLI---VLLFFIYAVVGMQVFG--KIALDGGNAITANNNFQTF 2044
            .:....|..|.:.|   ||.:..||   ::|:..:|:...|:||  |:.|:||    .|.||::.
pombe  1378 FDNFDQLSKTVVAS---LPSIFSLIATWIVLYITFAIAFNQIFGLTKLGLNGG----PNKNFRSI 1435

  Fly  2045 QQAVLVLFRSATGEAWQEIMMSCS-AQPDVKCDMNSDTPGEPCGSS-IAYPYFISFYVLCSFLII 2107
            :.|:::||....||.|.::|...: :.|:  |....|.....||:. .||..||::.::..::.:
pombe  1436 RNALVLLFTMTFGEGWNDVMHDYTISYPN--CVNGDDFYNSDCGNKPWAYGLFIAWNIISMYIFV 1498

  Fly  2108 NLFVAVIMDNFDYL-TRDWSILGPHHLD--EFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGF 2169
            |:|:.|:.|||.|: |:..|.......|  :|...|:.:||...|.|
pombe  1499 NMFITVVFDNFSYIHTKSSSFTNLQRNDFRQFKDSWAPFDPMVTGYI------------------ 1545

  Fly  2170 GKLCPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIKTDGNIDDANSELRATIKQIWKR 2234
                |.|.|.|.::|:....:           |.:.|            |.:: ||:.|.::..:
pombe  1546 ----PKRNAVKFVLSLRGVYD-----------FRIYR------------DEHT-LRSIISKVQSK 1582

  Fly  2235 T---------NP--------KLLDQVVPP-----------------------PGNDDE------- 2252
            |         ||        :.|||::..                       |||...
pombe  1583 TGQQSVPMLENPLMGSEINLEALDQIIDTIDVNVVKERRNVLNSLCTEIMTLPGNVISFSNILML 1647

  Fly  2253 VTVGKFY---ATYLIQDYFRR------FKKRKEQEGKEG-------------HPDSNTVTLQAGL 2295
            |.:.|..   ..:.|.||.||      .:|....|...|             |.:.....|:...
pombe  1648 VVLHKIVDHREAFPISDYIRRAYVLSELEKSIRMEKLLGLVETSIIRKTFLQHMEEKKKALENPF 1712

  Fly  2296 RTLHEVSPAL-KRAISGNLDELDQEPEPM 2323
            ..|.|||..| :..|...|.:.:.:||.:
pombe  1713 ILLSEVSEILPETPIQEVLRQHNADPEQL 1741

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1D	NP_723952.2	Ion_trans	767..1042	CDD:395416	73/333 (22%)
		Ion_trans	1137..1379	CDD:395416	68/266 (26%)
		Ion_trans	1496..1809	CDD:395416	79/339 (23%)
		Ion_trans	1851..2126	CDD:395416	70/282 (25%)
		GPHH	2135..2188	CDD:407139	11/52 (21%)
		Ca_chan_IQ	2199..2271	CDD:400901	22/127 (17%)
cch1	NP_593894.1	Ion_trans	201..485	CDD:278921	70/308 (23%)
		Ion_trans	533..748	CDD:278921	60/230 (26%)
		Ion_trans	968..1220	CDD:278921	74/296 (25%)
		Ion_trans	1289..1517	CDD:278921	68/259 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	114	1.000	Domainoid score	I1537
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45628
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R175
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.040