DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and Cacna1a

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:XP_038953406.1 Gene:Cacna1a / 25398 RGDID:2244 Length:2463 Species:Rattus norvegicus


Alignment Length:2487 Identity:858/2487 - (34%)
Similarity:1167/2487 - (46%) Gaps:724/2487 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   663 GNGGPGSGDVSRTARYDSGEGDLGGGNNIMGIDSMGIANIPETMNGTTIGPSGAGGQKGGAAAGA 727
            |:..||        ||.:|.|..|....::    :|.|           |..||||.:.|...||
  Rat    94 GDEMPG--------RYGAGGGGSGPAAGVV----VGAA-----------GGRGAGGSRQGGQPGA 135

  Fly   728 AGQKRQQ--RRGK------PQPDRP-----QRALFCLSVKNPLRALCIRIVEWKPFEFLILLTIF 779
            ....:|.  :|.:      |.|.|.     .|:||..|..|.:|....:|.||.|||::||.||.
  Rat   136 QRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATII 200

  Fly   780 ANCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDF 844
            ||||.||:....|..|....::.|:..|..|:.||..|..:||:|.||..|.|:|||||||::||
  Rat   201 ANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIVALGFAFHKGSYLRNGWNVMDF 265

  Fly   845 TIVVIGAISTALSQLMKDAFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVL 909
            .:|:.|.::|..::     ||::.|||.||||||:||||:|||||||.||:|||:||..|.||:.
  Rat   266 VVVLTGILATVGTE-----FDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLF 325

  Fly   910 FVIIIYAIIGLELFSGKLHKACRDEITGEYE-ENIRPCGV---GYQCPPGYKCYGGWDGPNDGIT 970
            |.|:|:||||||.:.||.|..|.:|.|.:.: |:..|||.   ...||.|.||...|:|||:|||
  Rat   326 FAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGIT 390

  Fly   971 NFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFS 1035
            .|||...|:||||||:|:|||||:||:..||.|:.|.|:|||.::|:|:||::||:||||||||:
  Rat   391 QFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFA 455

  Fly  1036 KERNKAKNRGDFQKLREKQQIEEDLRGYLDWITQAEDI-----EPDAVGGLISDGKGKQPN-EMD 1094
            |||.:.:||..|.|||.:||||.:|.||::||::||::     |.|.......||..::.. :..
  Rat   456 KERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDVEQRHPFDGALRRATLKKS 520

  Fly  1095 STENLGEEMPEVQMTE------------SRWRKMKKD--FDRVNRRMRRACRKAVKSQAFYWLII 1145
            .|:.|..|..|.|:.:            .:..|::..  |.:..||||...|:.||:|||||.::
  Rat   521 KTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVL 585

  Fly  1146 VLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVV 1210
            .||.|||..:|..||.|.:||.:|..|....|:|||..||.:|||.||.:.||.|.||.|||.|:
  Rat   586 SLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVI 650

  Fly  1211 IGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLF 1275
            ||||.|.:..........|:||||.:||||:|||||||.||.|||.|||||::||.|||.|||||
  Rat   651 IGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLF 715

  Fly  1276 IVIFALLGMQVFGGKFNFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSY 1340
            ||:|||||||:|||:||||  |.....|||.|..|::|||||:||||||.|||.||.:.|||.. 
  Rat   716 IVVFALLGMQLFGGQFNFD--EGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQG- 777

  Fly  1341 GALACIYFIILFICGNYILLNVFLAIAVDNLADADSLSEVEKEEE-------------------- 1385
            |.:..||||:|.:.|||.||||||||||||||:|..|::.|:|||                    
  Rat   778 GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAANQKLALQKAKEVAEVSP 842

  Fly  1386 ----------------------------------------------------------------- 1385
                                                                             
  Rat   843 LSAANMSIAVKEQQKNQKPAKSVWEQRTSEMRKQNLLASREALYGDAAERWPTTYARPLRPDVKT 907

  Fly  1386 ---------PHD----------------------ESA---------------------------- 1391
                     |.:                      |||                            
  Rat   908 HLDRPLVVDPQENRNNNTNKSRAPEALRQTARPRESARDPDARRAWPSSPERAPGREGPYGRESE 972

  Fly  1392 -QKKSHSP-------------------------TPTIDG-------------------------- 1404
             |::.|:|                         .|..:|                          
  Rat   973 PQQREHAPPREHVPWDADPERAKAGDAPRRHTHRPVAEGEPRRHRARRRPGDEPDDRPERRPRPR 1037

  Fly  1405 ----------------------------MDD---------------------HLS----IDIDME 1416
                                        .||                     :||    |..|:.
  Rat  1038 DATRPARAADGEGDDGERKRRHRHGPPAHDDRERRHRRRKESQGSGVPMSGPNLSTTRPIQQDLG 1102

  Fly  1417 QQEL---DDEDKM------------DHETLSDE-------------------------------- 1434
            :|:|   :|.|.|            .|::|...                                
  Rat  1103 RQDLPLAEDLDNMKNNKLATGEPASPHDSLGHSGLPPSPAKIGNSTNPGPALATNPQNAASRRTP 1167

  Fly  1435 -------------------------------------------EVREMC---------------- 1440
                                                       |:...|                
  Rat  1168 NNPGNPSNPGPPKTPENSLIVTNPSSTQPNSAKTARKPEHMAVEIPPACPPLNHTVVQVNKNANP 1232

  Fly  1441 ----------EEEEEVD--EEGMITARPRRMSEVNTATKILPIPPGTSFFLFSQTNRFRVFCHWL 1493
                      :||||.|  |:|     |:            |:||.:|.|:.|.||..|..||::
  Rat  1233 DPLPKKEEEKKEEEEADPGEDG-----PK------------PMPPYSSMFILSTTNPLRRLCHYI 1280

  Fly  1494 CNHSNFGNIILCCIMFSSAMLAAENPLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLHD 1558
            .|...|...||..|..||..||||:|::.|...|.||..|||.||.|||.|:::|:|..|.|||.
  Rat  1281 LNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQ 1345

  Fly  1559 GAFCRSAFNLLDLLVVCVSLISLVSSSNA--------ISVVKILRVLRVLRPLRAINRAKGLKHV 1615
            ||:.|..:|:||.:||..:|::...:|:.        |:.:|.||||||||||:.|.|...||.|
  Rat  1346 GAYFRDLWNILDFIVVSGALVAFAFTSSTRGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAV 1410

  Fly  1616 VQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIG 1680
            ..                                    |||.::|.:.||::|..|..|:|||:.
  Rat  1411 FD------------------------------------CVVNSLKNVFNILIVYMLFMFIFAVVA 1439

  Fly  1681 VQLFKGKFFKCTDGSKMTQDECYGTYLVYDDGDVHKPRLREREWSNNRFHFDDVAKGMLTLFTVS 1745
            |||||||||.|||.||..:.:|.|.||:|:..:|   :.|:|||....||:|:|...:|||||||
  Rat  1440 VQLFKGKFFHCTDESKEFERDCRGKYLLYEKNEV---KARDREWKKYDFHYDNVLWALLTLFTVS 1501

  Fly  1746 TFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQEY 1810
            |.||||.:|..|:|:..||.||...:|..::.:|::|.::..||.|||||..:|:|||.:|::..
  Rat  1502 TGEGWPQVLKHSVDATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMM 1566

  Fly  1811 KNCDLDKNQRNCIEFALKAKPVRRYIP--KHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKF 1873
            :...|:||:|.||:||:.|||:.|::|  |...||::|.||.|..|||||..:|.:||:.|.|||
  Rat  1567 EEYSLEKNERACIDFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKF 1631

  Fly  1874 YNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKS 1938
            |...:.|...|...|::||::|:||.|.|:.||...|||.||||:|||:.||||..||:.:|..:
  Rat  1632 YGASVAYENALRVFNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGN 1696

  Fly  1939 KDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALP 2003
            .                      :|.|:::|.||||..||:|||.:|..||.|||||::||:|||
  Rat  1697 P----------------------NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALP 1739

  Fly  2004 YVALLIVLLFFIYAVVGMQVFGKIALDGGN--------AITANNNFQTFQQAVLVLFRSATGEAW 2060
            ||.|||.:||||||::||||||.|.:||.:        .||.:|||:||.||:::||||||||||
  Rat  1740 YVCLLIAMLFFIYAIIGMQVFGNIGIDGEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAW 1804

  Fly  2061 QEIMMSC-SAQPDVKCDMNSDTPGEPCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRD 2124
            ..||:|| |.:|   ||.||......||:..||.||:||..|||||::|||||||||||:|||||
  Rat  1805 HNIMLSCLSGKP---CDKNSGIQKPECGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRD 1866

  Fly  2125 WSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPL 2189
            .||||||||||::|:|:||||.|.||:.:.|:..:||.:|||||.||.||.|:|.|||:.|::|:
  Rat  1867 SSILGPHHLDEYVRVWAEYDPAAWGRMPYPDMYQMLRHMSPPLGLGKKCPARVAYKRLLRMDLPV 1931

  Fly  2190 NSDGTVLFNATLFAVVRTSLSIK-TDGNID--DANSELRATIKQIWKRTNPKLLDQVVPPPGNDD 2251
            ..|.||.||:||.|::||:|.|| ..|..|  ..::|||..:..||...:.|.||.:|.|..:.|
  Rat  1932 ADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTD 1996

  Fly  2252 EVTVGKFYATYLIQDYFRRFKKRK-----EQEGK---------------EGHPDSNTVTLQAGLR 2296
             :||||.||..:|.:|:|:.|.:|     |::.:               ||.|..|.:       
  Rat  1997 -LTVGKIYAAMMIMEYYRQSKAKKLQAMREEQNRTPLMFQRMEPPSPTQEGGPSQNAL------- 2053

  Fly  2297 TLHEVSPALKRAISGNL----DELDQEPEPMHRRHHTLF--GSVWSSIRRHGNGTFRRSAKATAS 2355
                  |:.:....|.|    ..:.:.|..:.:|...:|  ...||..|                
  Rat  2054 ------PSTQLDPGGGLMAQESSMKESPSWVTQRAQEMFQKTGTWSPER---------------- 2096

  Fly  2356 QSNGALAIGGSASAALGVGGSSLVLGSSDP---------AGGDYLYDTLNRSVADGVNNITRNIM 2411
                               |..:.:.:|.|         .|.|...|:.:....:|         
  Rat  2097 -------------------GPPIDMPNSQPNSQSVEMREMGTDGYSDSEHYLPMEG--------- 2133

  Fly  2412 QARLAAAGKLQDELQ---GAGSGGELRTFGESISMRPLAKNGGGAATVAG------------TLP 2461
            |.|.|:..:|..|.|   |...|..|.|..::..|:       .:|:|.|            .:|
  Rat  2134 QTRAASMPRLPAENQRRRGRPRGNNLSTISDTSPMK-------RSASVLGPKARRLDDYSLERVP 2191

  Fly  2462 PEAN-AINYDNRNRG-----ILLHPYNNV----------YAPNGALPGHERMIQSTPASPYDQRR 2510
            ||.| ..:...|:||     ..|..|.:|          ...:|.||..:|  ......|.|::.
  Rat  2192 PEENQRYHQRRRDRGHRTSERSLGRYTDVDTGLGTDLSMTTQSGDLPSKDR--DQDRGRPKDRKH 2254

  Fly  2511 L-----------PTSSDMNGLAESLIGGVLAAEGLGKYCDSEFVGTA-AREMREALDMTPEEMNL 2563
            .           |.:.|....|:                :....|.| |||.|  ...:|.|   
  Rat  2255 RPHHHHHHHHHHPPAPDRERYAQ----------------ERPDTGRARAREQR--WSRSPSE--- 2298

  Fly  2564 AAHQILSNEHSLSLIGSSNGSIFGGSAGGLGGAGSGGVGGLGGSSSIRNAFGGSGSGPS---SLS 2625
                  ..||:....|||  |:.|..|....|..:...|        |.....:...|.   |.|
  Rat  2299 ------GREHATHRQGSS--SVSGSPAPSTSGTSTPRRG--------RRQLPQTPCTPRPLVSYS 2347

  Fly  2626 P-QHQPYSGTLNSPPIP 2641
            | ..:|.:..:..||.|
  Rat  2348 PAPRRPAARRMAGPPAP 2364

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 147/278 (53%)
Ion_trans 1137..1379 CDD:395416 145/241 (60%)
Ion_trans 1496..1809 CDD:395416 131/320 (41%)
Ion_trans 1851..2126 CDD:395416 146/283 (52%)
GPHH 2135..2188 CDD:407139 28/52 (54%)
Ca_chan_IQ 2199..2271 CDD:400901 30/74 (41%)
Cacna1aXP_038953406.1 Ion_trans 188..462 CDD:395416 147/278 (53%)
Ion_trans 578..816 CDD:395416 145/240 (60%)
PHA03247 <879..1260 CDD:223021 33/397 (8%)
Ion_trans 1284..1564 CDD:395416 131/318 (41%)
Ion_trans 1609..1868 CDD:395416 146/283 (52%)
GPHH 1877..1930 CDD:407139 28/52 (54%)
Ca_chan_IQ 1941..2014 CDD:400901 29/73 (40%)
PHA03307 2040..>2444 CDD:223039 80/428 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100303
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.820

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