DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and Cacna1i

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:XP_006521012.1 Gene:Cacna1i / 239556 MGIID:2178051 Length:2226 Species:Mus musculus


Alignment Length:2343 Identity:574/2343 - (24%)
Similarity:899/2343 - (38%) Gaps:766/2343 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   739 PQPDRPQRALFCLSVKNPLRALCIRIV--EWKPFEFLILLTIFANCIALAVYTPYPG----SDSN 797
            |.||....|.|||......|..||::|  .|  ||.:.:|.|..||:.|.:|.|...    ||..
Mouse    48 PHPDLAPVAFFCLRQTTSPRNWCIKMVCNPW--FECVSMLVILLNCVTLGMYQPCDDMECLSDRC 110

  Fly   798 VTNQTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKD 862
            ...|..:  :::| :.|..|.|:|::|.| :.....||.:.||.|||.||:.|.:..:|.   ..
Mouse   111 KILQVFD--DFIF-IFFAMEMVLKMVALG-IFGKKCYLGDTWNRLDFFIVMAGMVEYSLD---LQ 168

  Fly   863 AFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKL 927
            ..::.|:|..||||||:.::.|||:::::|.:|..:..|.::.||..||..|:.|||::|::|.|
Mouse   169 NINLSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLWAGLL 233

  Fly   928 HKACRDE----ITGEY---------EENIRP--CGVG--------YQCPP----GYKC------- 958
            ...|..|    |.|:.         |::..|  |.:.        ::.||    |.:|       
Mouse   234 RNRCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHEIPPLKEQGRECCLSKDDM 298

  Fly   959 --YG-------------GWD-----------GPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYS 997
              :|             .|:           .|:.|..||||.|.|.:.:||.:|||||.:::|.
Mouse   299 YDFGAGRQDLNASGLCVNWNRYYNVCRTGNANPHKGAINFDNIGYAWIVIFQVITLEGWVEIMYY 363

  Fly   998 IQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFS--KER---------------------- 1038
            :.|| .|.:.::|||.::|:|:||::||.|.|::.:||  |:|                      
Mouse   364 VMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLSSSTVASYA 427

  Fly  1039 -----------------NKAKNR--GDFQKLREKQQ----------------------------- 1055
                             .|||.|  |.:|.|:.::|                             
Mouse   428 EPGDCYEEIFQYVCHILRKAKRRALGLYQALQNRRQATGPGTPAPAKPGPHAKEPSHCKLCPRHS 492

  Fly  1056 --------IEEDLRGYLDWITQAED------------IEPDAVGGLIS---------------DG 1085
                    :.:.:...|     |.|            ..|..:|...|               :|
Mouse   493 PLDTTPHTLVQPISAIL-----ASDPSSCPRCQHEAGRRPSGLGSTDSGQEGSGSGGSAEAEANG 552

  Fly  1086 KGKQPNEMDSTENLGEEMPE----VQMTESRWRKMKKDFDRVNRRMRRACRKAVKSQAFYWLIIV 1146
            .|.|.:|...:..||:|..:    .::....||:           .|...|..|.|:.|...|::
Mouse   553 DGPQSSEDGVSSGLGKEEEQEDGAARLCGDVWRE-----------TRAKLRGIVDSKYFNRGIMM 606

  Fly  1147 LVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVI 1211
            .:.:||..:..||:.|.:.|.|..|..||.|..:|..||:||:.:.|...|..:.:|.||..:||
Mouse   607 AILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVI 671

  Fly  1212 GSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFI 1276
            .||.|.:....|     |:||||..|||||.|:.::..:|...:..|:.::.::|:..:||.|||
Mouse   672 ISIWEIVGQADG-----GLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFI 731

  Fly  1277 VIFALLGMQVFGGKFNF---DGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVS 1338
            .||::|||.:||.||:.   .|.....|.|||....|::|||||:|.||||.|:      |.|::
Mouse   732 FIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVL------YNGMA 790

  Fly  1339 SYGALACIYFIILFICGNYILLNVFLAIAVD----------NLADAD----SLSEVEKEEEPHDE 1389
            |....|.:||:.|...|||:|.|:.:||.|:          :.:|.|    :|.|::|..|..|.
Mouse   791 STTPWASLYFVALMTFGNYVLFNLLVAILVEGFQAEGDANRSYSDEDQSSSNLEELDKLPEGLDS 855

  Fly  1390 S----------------------------------AQKKSHSPTPTIDGMDDHLSIDIDMEQQ-- 1418
            |                                  |.:.|..|.|.:..::...|..:.:.:.  
Mouse   856 SRDLKLCPIPMTPNGHLDPSLPLGGHLGPAGAMGAAPRLSLQPDPVLVALESRKSSVMSLGRMSY 920

  Fly  1419 ----------------------------------------------------------------- 1418
                                                                             
Mouse   921 DQRSLSSSRSSYYGPWGRSGTWASRRSSWNSLKHKPPSAEHESLLSGERGGSCVRACEGAREDAP 985

  Fly  1419 -------------------------------ELDDEDKMD------------------------H 1428
                                           .||..|.:|                        |
Mouse   986 PRAAPLHAPHTHHAHHGPHLAHRHRHHRRTLSLDTRDSVDLAELVPVVGAHSRAAWRAAGQAPGH 1050

  Fly  1429 E--------------TLSDEEVREMCEEEEEVDEEGMITARPRRMSEVNTATKILP----IPPGT 1475
            |              |..|:. |:..|:|||:|.  .:..|.|:|.:|     ..|    :....
Mouse  1051 EDCNGRMPNIAKDVFTKMDDR-RDRGEDEEEIDY--TLCFRVRKMIDV-----YKPDWCEVREDW 1107

  Fly  1476 SFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENP-LRANDDLNKVLNKFDYFFTA 1539
            |.:|||..|:||:.|..:..|..|..::|..|..:...:|.|.| :.|.......|...:|.|||
Mouse  1108 SVYLFSPENKFRILCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTA 1172

  Fly  1540 VFTIELILKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISLVSS------SNAISVVKILRVLR 1598
            :|..|:.||::|.|....:.|:.||::|:||..:|.||:|.:|.|      :..:.|:::||:||
Mouse  1173 IFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSVASAGGAKILGVLRVLRLLR 1237

  Fly  1599 VLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIG 1663
            .|||||.|:||.|||.||:.:|.::|.||||||:.|    .|.:|                    
Mouse  1238 TLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICC----AFFII-------------------- 1278

  Fly  1664 NIMLVTYLLQFMFAVIGVQLFKGKFFKC--TDGSKMT-QDECYGTYLVYDDGDVHKPRLREREWS 1725
                        |.::|||||||||:.|  .|...:| :.:|...               ...|.
Mouse  1279 ------------FGILGVQLFKGKFYHCLGVDTRNITNRSDCVAA---------------NYRWV 1316

  Fly  1726 NNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFM 1790
            :::::||::.:.:::||.:::.:||..::|..:|:...:..|:.|..|.:..|:|.:::|::||:
Mouse  1317 HHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFV 1381

  Fly  1791 VNIFVGFVIVTF----QNEGEQEYKNCD------LDKNQRNCIEFALKAKPVRRYIPKHGIQYKV 1845
            :|:|||.|:..|    |::..:|.:..:      |:|.:|       ||:.:..|......:..:
Mouse  1382 LNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRR-------KAQRLPYYATYCPTRLLI 1439

  Fly  1846 WWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKN 1910
            ....||...:..|..:|.:|.||::::.||||......|...|.:||.||.||.|.||.||..:.
Mouse  1440 HSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRR 1504

  Fly  1911 YFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRV 1975
            :|.|.||..|..|||.|.:.|...||:......|                  |...|...|:.|:
Mouse  1505 FFKDRWNQLDLAIVLLSVMGITLEEIEINAALPI------------------NPTIIRIMRVLRI 1551

  Fly  1976 MRLVKLLSKGEGIRTLLWTFIKSFQALPYV---ALLIVLLFFIYAVVGMQVFGKIALDGGN---A 2034
            .|::|||....|:|.||.|.:   ||||.|   .||.:|||||||.:|:::|||:..:..|   .
Mouse  1552 ARVLKLLKMATGMRALLDTVV---QALPQVGNLGLLFMLLFFIYAALGVELFGKLVCNDENPCEG 1613

  Fly  2035 ITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGEPCGSSIAYP---YFI 2096
            ::.:..|:.|..|.|.||:.:||:.|..||      .|...|...|.  ..|.||:.:.   ||:
Mouse  1614 MSRHATFENFGMAFLTLFQVSTGDNWNGIM------KDTLRDCTHDE--RSCLSSLQFVSPLYFV 1670

  Fly  2097 SFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEY------------------ 2143
            ||.:...|::||:.|||:|.:.|...::  ......:|..|.|...:                  
Mouse  1671 SFVLTAQFVLINVVVAVLMKHLDDSNKE--AQEDAEMDAEIELEMAHGLGPGPGPCPCPCPCPCP 1733

  Fly  2144 -----------DPDAKGR---------------IKH----------LDVVTLLRK---------- 2162
                       .|.|.||               .:|          ||.|:|:.|          
Mouse  1734 CPCPGPRMPTSSPGAPGRGSGGAGVGGDTESHLCRHCYSPAQETLWLDSVSLIIKDSLEGELTII 1798

  Fly  2163 ----------ISPPLGFGKLCPHRMACKRLVSMNMP----------------------------L 2189
                      .|.|.|..| |.|......:...:.|                            |
Mouse  1799 DNLSGSIFHHYSSPAGCDK-CHHDKQEGPVAQRSRPRLPHPSPRVTRGHHLPPQVQLAETEAFSL 1862

  Fly  2190 NSD--GTVLFNATLFAVVRTSLSIKTDGNIDDANSELRATIKQIWKRTNPKLLDQVVPPP----- 2247
            |||  .:||..                   ||.:.|......|     .||.....:.||     
Mouse  1863 NSDRSSSVLLG-------------------DDLSLEDPTACPQ-----GPKESKGELEPPEPMQA 1903

  Fly  2248 GNDDE---------VTVGKFYATYL----------IQDYFRRFKKRKEQEGKEGHPDSNTVTLQA 2293
            |:.||         |:.|.  .:.|          :|.:.:.  :..:.......||.::..||.
Mouse  1904 GDLDECFFPFAGEPVSAGP--ESLLCEMGAIPFNPVQSWLKH--ESNQAPPSPFSPDGSSPLLQM 1964

  Fly  2294 GLRTLHEVSPALKRA-----ISGNLDELDQEPEPMHRRHHTLFGSVWSSIRRHG-NGTFRRSAKA 2352
            .....|....|.::.     .||.|.::            .|.|| |:|:|... |.|..|.|. 
Mouse  1965 PAEFFHPAVSASQKGQEPGMSSGTLPKI------------ALQGS-WASLRSPSVNCTLLRQAT- 2015

  Fly  2353 TASQSNGALAIGGSASAALGVGGSSLVLGSSDPAGGDYLYDTLNRSVADGVNNITRNIM------ 2411
                                |..:||....|..||.  |..||..|:.  :::..|..:      
Mouse  2016 --------------------VSDTSLDASPSSSAGS--LQTTLEDSLT--LSDSPRRALGPPVQV 2056

  Fly  2412 ---QARLAAAGKLQDELQGAG---------------SGGELR---TFGESISMRPLAKNGGGAAT 2455
               :|.|:.|.:.:..|:|.|               |||...   |:.:  ||.|..:.|.|.|.
Mouse  2057 PGPRASLSPATRRRLSLRGRGLFSLRGLRAHQRSHSSGGSTSPGCTYHD--SMDPSDEEGRGGAG 2119

  Fly  2456 VAGTLPPEANAINYDNRNRGILLHPYNNVYAPNGALPGHERMIQSTPASPYDQRRLPTSSDMNGL 2520
            ..|.....:..::..:......|.|   ...|.|..|.  |...||.:......|...:..:.||
Mouse  2120 GGGAGSEHSETLSSLSLTSLFCLPP---TLPPPGLTPA--RKFSSTSSLAAGPGRPGATVSVRGL 2179

  Fly  2521 AES 2523
            |.|
Mouse  2180 ARS 2182

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 104/379 (27%)
Ion_trans 1137..1379 CDD:395416 93/258 (36%)
Ion_trans 1496..1809 CDD:395416 98/326 (30%)
Ion_trans 1851..2126 CDD:395416 97/283 (34%)
GPHH 2135..2188 CDD:407139 18/126 (14%)
Ca_chan_IQ 2199..2271 CDD:400901 15/95 (16%)
Cacna1iXP_006521012.1 Ion_trans 76..407 CDD:366146 103/340 (30%)
Ion_trans 597..824 CDD:366146 90/237 (38%)
Ion_trans 1128..1400 CDD:366146 98/322 (30%)
Ion_trans 1445..1700 CDD:366146 97/285 (34%)
PHA03307 1867..>2226 CDD:223039 77/389 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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