DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ca-alpha1D and Catsper1

DIOPT Version :9

Sequence 1:	NP_723952.2	Gene:	Ca-alpha1D / 34950	FlyBaseID:	FBgn0001991	Length:	2705	Species:	Drosophila melanogaster
Sequence 2:	NP_647462.1	Gene:	Catsper1 / 225865	MGIID:	2179947	Length:	686	Species:	Mus musculus

Alignment Length:	297	Identity:	74/297 - (24%)
Similarity:	125/297 - (42%)	Gaps:	73/297 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly  1840 GIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQ----PLWYTELLDALNMIFTAVFALEFV 1900
            |:|..:.....|..||..|||::.:|||.|..:.:.:    ..||..:||:   ||.:::.||.|
Mouse   339 GLQQMILSLTQSLGFETFIFIVVCLNTVILVAQTFTELEIRGEWYFMVLDS---IFLSIYVLEAV 400

  Fly  1901 FKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLI 1965
            .||.|...: ||.|.||..||.|::.:.:|.|..:|                          |.:
Mouse   401 LKLIALGLE-YFYDPWNNLDFFIMVMAVLDFVLLQI--------------------------NSL 438

  Fly  1966 SINFFR--LFRVMRLVKLLSKGEGIRTL----LWTFIKSFQ-----ALPYVALLIVLLF---FIY 2016
            |.:|:.  |||::::.|.:.....||.|    :.|.:....     :||.:..::.|:|   |::
Mouse   439 SYSFYNHSLFRILKVFKSMRALRAIRVLRRLSILTSLHEVAGTLSGSLPSITAILTLMFTCLFLF 503

  Fly  2017 AVVGMQVFGKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDT 2081
            :||...:|..         :....||.....:..||...|.:.|..|.:...||
Mouse   504 SVVLRALFQD---------SDPKRFQNIFTTLFTLFTMLTLDDWSLIYIDNRAQ----------- 548

  Fly  2082 PGEPCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNF 2118
                 |:....|..:.:.|:..|:.:||.:||::|||
Mouse   549 -----GAWYIIPILMIYIVIQYFIFLNLVIAVLVDNF 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1D	NP_723952.2	Ion_trans	767..1042	CDD:395416
		Ion_trans	1137..1379	CDD:395416
		Ion_trans	1496..1809	CDD:395416
		Ion_trans	1851..2126	CDD:395416	72/286 (25%)
		GPHH	2135..2188	CDD:407139
		Ca_chan_IQ	2199..2271	CDD:400901
Catsper1	NP_647462.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..57
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	97..177
		MPLKIP	99..>201	CDD:292140
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	207..271
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	289..318
		Ion_trans	386..581	CDD:278921	60/250 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910