DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and Scn5a

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:XP_006512056.1 Gene:Scn5a / 20271 MGIID:98251 Length:2085 Species:Mus musculus


Alignment Length:2084 Identity:494/2084 - (23%)
Similarity:848/2084 - (40%) Gaps:628/2084 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   747 ALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFL 811
            ||:.||..:|:|...::|:....|..||:.||..||:.:|.:.|.|.:         :.|||.|.
Mouse   175 ALYVLSPFHPVRRAAVKILVHSLFSMLIMCTILTNCVFMAQHDPPPWT---------KYVEYTFT 230

  Fly   812 VIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAFRVLR 876
            .|:|.|.::||||.||.||...:||:.||.|||:::|:     |.:....|..:|.|||.|||||
Mouse   231 AIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIVM-----AYTTEFVDLGNVSALRTFRVLR 290

  Fly   877 PLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKL-HKACRD--EITG- 937
            .|:.:|.:..|:.::.::::::..|..:.:|.:|.:.::|:|||:||.|.| ||..|:  |:.| 
Mouse   291 ALKTISVISGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTELNGT 355

  Fly   938 ----------------------EY-----EENIRPCGVGYQ---CPPGYKCYGGWDGPNDGITNF 972
                                  .|     ..::..||....   ||.||:|....:.|:.|.|:|
Mouse   356 NGSVEADGIVWNSLDVYLNDPANYLLKNGTTDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSF 420

  Fly   973 DNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKE 1037
            |:|..|.|.:|:.:|.:.|..:......:.|..:. ::|:.::.||:|:::||||.|::..: :|
Mouse   421 DSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYM-IFFMLVIFLGSFYLVNLILAVVAMAY-EE 483

  Fly  1038 RNKA------KNRGDFQKLREKQQIEED---LRGYLDWITQAE-DIEPDA--------------- 1077
            :|:|      :....||:..|..:.|.:   :|| :|.::::. ::.|.|               
Mouse   484 QNQATIAETEEKEKRFQEAMEMLKKEHEALTIRG-VDTVSRSSLEMSPLAPVTNHERRSKRRKRL 547

  Fly  1078 VGGLISDGKGKQP-----------NEMDSTENLG-----------------------------EE 1102
            ..|....|..:.|           |::..|..|.                             :|
Mouse   548 SSGTEDGGDDRLPKSDSEDGPRALNQLSLTHGLSRTSMRPRSSRGSIFTFRRRDQGSEADFADDE 612

  Fly  1103 MPEVQMTESR-------W----------------------------------------------- 1113
            ......:||.       |                                               
Mouse   613 NSTAGESESHRTSLLVPWPLRRPSTQGQPGFGTSAPGHVLNGKRNSTVDCNGVVSLLGAGDAEAT 677

  Fly  1114 -------RKMKKD---------------------------FDRVNRRMRRACRKAVKSQAF---- 1140
                   |.:..|                           |:....|.|.....:|.:.|.    
Mouse   678 SPGSHLLRPIVLDRPPDTTTPSEEPGGPQMLTPQAPCADGFEEPGARQRALSAVSVLTSALEELE 742

  Fly  1141 ------------------------YWL------------------IIVLVFLNTGVLATEHYGQL 1163
                                    .|:                  |.:.:.|||..:|.|||...
Mouse   743 ESHRKCPPCWNRFAQHYLIWECCPLWMSIKQKVKFVVMDPFADLTITMCIVLNTLFMALEHYNMT 807

  Fly  1164 DWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPL 1228
            ...:...:..|:.|.|:||.||..|:.:|....||...:|.||..:||.|:.|..|:..|     
Mouse   808 AEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLSRMG----- 867

  Fly  1229 GVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNF 1293
            .:||||..|||||||:.|.|.:|:.|:..:.||:.::.:|.|:|.:.:.|||::|||:||..:: 
Mouse   868 NLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYS- 931

  Fly  1294 DGKEEKYRMN----------FDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYF 1348
               |.::|::          .| |:.|.|.:|:|:.|| |...|:..:...|     .:|..:.|
Mouse   932 ---ELRHRISDSGLLPRWHMMD-FFHAFLIIFRILCGE-WIETMWDCMEVSG-----QSLCLLVF 986

  Fly  1349 IILFICGNYILLNVFLAIAVDNLADADSLS----------------------------------- 1378
            :::.:.||.::||:|||:.:.:.: ||:|:                                   
Mouse   987 LLVMVIGNLVVLNLFLALLLSSFS-ADNLTAPDEDGEMNNLQLALARIQRGLRFVKRTTWDFCCG 1050

  Fly  1379 -------------------------------EVEKEEEPHDESAQKKSHSPTPTIDGMDDHLSID 1412
                                           ||||......|:..::...|.....|..:.:.:.
Mouse  1051 LLRRRPKKPAALATHSQLPSCIAAPRSPPPPEVEKAPPARKETRFEEDKRPGQGTPGDTEPVCVP 1115

  Fly  1413 IDMEQQELDDEDKMDHETLSDEEVREMCEEEEEVDEEGMITAR-PRRMSEV-------------- 1462
            |.:.:.:.||:::.:..:|..||.....::|.:|...|....: ||..|:|              
Mouse  1116 IAVAESDTDDQEEDEENSLGTEEEESSKQQESQVVSGGHEPPQEPRAWSQVSETTSSEAEASTSQ 1180

  Fly  1463 ---------------------------------NTATKILPIP---------------------- 1472
                                             |||..:..||                      
Mouse  1181 ADWQQEREAEPRAPGCGETPEDSYSEGSTADMTNTADLLEQIPDLGEDVKDPEDCFTEGCVRRCP 1245

  Fly  1473 ---------PGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDDLNK 1528
                     ||..::      |.|..|:.:..||.|...|:..|:.||..||.|:.........|
Mouse  1246 CCMVDTTQAPGKVWW------RLRKTCYRIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIK 1304

  Fly  1529 VLNKF-DYFFTAVFTIELILKLISYGFVLH-DGAFCRSAFNLLDLLVVCVSLISLVSSS---NAI 1588
            ||.:: |..||.||.:|::||.::|||..: ..|:|     .||.|:|.|||:|||:::   ..:
Mouse  1305 VLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWC-----WLDFLIVDVSLVSLVANTLGFAEM 1364

  Fly  1589 SVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVK 1653
            ..:|.||.||.||||||::|.:|::.||..::.|:.:|.|::|| ||:.::              
Mouse  1365 GPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLV-CLIFWL-------------- 1414

  Fly  1654 CVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDD------- 1711
                                 :|:::||.||.|||.:|.:   .|:.:....|.:.::       
Mouse  1415 ---------------------IFSIMGVNLFAGKFGRCIN---QTEGDLPLNYTIVNNKSECESF 1455

  Fly  1712 ---GDVHKPRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRP 1773
               |:::        |:..:.:||:|..|.|.|..|:||:||..::|.::||......|......
Mouse  1456 NVTGELY--------WTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQPQWEDNL 1512

  Fly  1774 IVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNE----GEQEYKNCDLDKNQRNCIEFALKAKPVRR 1834
            .:..|::::||..:||.:|:|:|.:|..|..:    |.|:....:..|...|.:: .|.:|..::
Mouse  1513 YMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMK-KLGSKKPQK 1576

  Fly  1835 YIPKHGIQYKVWWF--VTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFAL 1897
            .||:...:|:.:.|  ||..:|:.||..||.:|.||:.::..:|......:|..:|::|.|:|..
Mouse  1577 PIPRPLNKYQGFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKVNILAKINLLFVAIFTG 1641

  Fly  1898 EFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGS 1962
            |.:.|:||.| ..||.::||:|||::|:.|.:..|.|:|..|                       
Mouse  1642 ECIVKMAALR-HYYFTNSWNIFDFVVVILSIVGTVLSDIIQK----------------------- 1682

  Fly  1963 NLISINFF---RLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVF 2024
            ...|...|   ||.|:.|:::|:...:||||||:..:.|..||..:.||:.|:.|||::.||..|
Mouse  1683 YFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMANF 1747

  Fly  2025 GKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCD---MNSDTPGEPC 2086
            ..:..:.|  |....|||||..::|.||:..|...|..::..........||   .||:.....|
Mouse  1748 AYVKWEAG--IDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGSRGNC 1810

  Fly  2087 GSSIAYPYFISFYVLCSFLI-INLFVAVIMDNFDYLTRD-WSILGPHHLDEFIRLWSEYDPDAKG 2149
            ||......|.:.|::.|||| :|:::|:|::||...|.: ...|.....|.|..:|.::||:|..
Mouse  1811 GSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQ 1875

  Fly  2150 RIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIKTD 2214
            .|::|.:......:|.||...|  |::::   |::|::|:.|...:.....|||..:..|.  ..
Mouse  1876 FIEYLALSDFADALSEPLRIAK--PNQIS---LINMDLPMVSGDRIHCMDILFAFTKRVLG--ES 1933

  Fly  2215 GNIDDANSELRATIKQIWKRTNPKLLDQVVPPPGNDDEVTVGKFYATYLIQDYFRRFKKRKEQEG 2279
            |.:|    .|:..:::.:...||..:..                                     
Mouse  1934 GEMD----ALKIQMEEKFMAANPSKISY------------------------------------- 1957

  Fly  2280 KEGHPDSNTVTLQAGLRTLHEVSPA--LKRAISGNLDELDQEPEPMHRRHHTLFGSVWSSIRRHG 2342
               .|.:.|      ||..||...|  ::||.                |.|.|..||     :|.
Mouse  1958 ---EPITTT------LRRKHEEVSATVIQRAF----------------RRHLLQRSV-----KHA 1992

  Fly  2343 NGTFRRSAKAT------ASQSNGALA--IGGSASAALGVGGSSLVLGSSDPAGGDYLYDTLNRSV 2399
            :..||:.|.::      |.:..|.:|  :..:.|...|...||.:..:|.|..    ||::.|:.
Mouse  1993 SFLFRQQAGSSGLSDEDAPEREGLIAYMMNENFSRRSGPLSSSSISSTSFPPS----YDSVTRAT 2053

  Fly  2400 ADGV 2403
            :|.:
Mouse  2054 SDNL 2057

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 95/314 (30%)
Ion_trans 1137..1379 CDD:395416 83/363 (23%)
Ion_trans 1496..1809 CDD:395416 97/331 (29%)
Ion_trans 1851..2126 CDD:395416 88/282 (31%)
GPHH 2135..2188 CDD:407139 14/52 (27%)
Ca_chan_IQ 2199..2271 CDD:400901 9/71 (13%)
Scn5aXP_006512056.1 Ion_trans 195..488 CDD:366146 94/308 (31%)
Na_trans_cytopl 550..732 CDD:371806 15/181 (8%)
Ion_trans 781..994 CDD:366146 71/228 (31%)
Na_trans_assoc 1020..1268 CDD:368948 30/253 (12%)
Ion_trans 1272..1547 CDD:366146 96/326 (29%)
Na_channel_gate 1539..1591 CDD:240441 10/52 (19%)
Ion_trans 1596..1850 CDD:366146 88/279 (32%)
GPHH 1862..1909 CDD:374878 14/51 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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