DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and Scn10a

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:NP_001192250.1 Gene:Scn10a / 20264 MGIID:108029 Length:1958 Species:Mus musculus


Alignment Length:2137 Identity:511/2137 - (23%)
Similarity:842/2137 - (39%) Gaps:621/2137 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   696 SMGIANI----PETMNGTTIGPSGAGGQKGGAAAGAAGQKRQQRRG---KPQPDRPQR------- 746
            |:|..|.    ||::         |..:|..||..||.:.|.::||   |.:..|||.       
Mouse     7 SVGTTNFRRFTPESL---------AEIEKQIAAHRAAKKGRPKQRGQKDKSEKPRPQLDLKACNQ 62

  Fly   747 ----------------------------------------------ALFCLSVKNPLRALCIRIV 765
                                                          ||:..|..|.:|...|::.
Mouse    63 LPRFYGELPAELVGEPLEDLDPFYSTHRTFIVLDKSRTISRFSATWALWLFSPFNLIRRTAIKVS 127

  Fly   766 EWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVIFTAECVMKILAYGFVLH 830
            ....|...|.:||..||:.: ..|..|           ||:||.|.|::|.|.::||||.||.|:
Mouse   128 VHSWFSIFITVTILVNCVCM-TRTDLP-----------EKLEYAFTVVYTFEALIKILARGFCLN 180

  Fly   831 NGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIL 895
            ...|||:.||.|||:::.:..:..|:     |...:..||.|||||.|:.||.:|.|:|::.:::
Mouse   181 EFTYLRDPWNWLDFSVITLAYVGAAI-----DLRGISGLRTFRVLRALKTVSVIPGLKVIVGALI 240

  Fly   896 KAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKAC---------RDEITGEYEEN--IRP---- 945
            .::..|..:.:|.:|.:.::|::||:||.|.|...|         .|.::.|...:  |:|    
Mouse   241 HSVRKLADVTILTVFCLSVFALVGLQLFKGNLKNKCIKNGTDPHKADNLSSEMAGDIFIKPGTTD 305

  Fly   946 ---CGVGY---QCPPGYKCYGGWDGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGS 1004
               ||.|.   .||..|.|....|.|:...|:||:|..|.|::|:.:|.:.|..:......|.|.
Mouse   306 PLLCGNGSDAGHCPNDYVCRKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRASGK 370

  Fly  1005 DWQWMYFISMVILGAFFVMNLILGVLSGEFSKERN------KAKNRGDFQKLREKQQIEEDLRGY 1063
            .:. ::|:.::.||:|:::||||.|::..:.::..      :||.: .|::..|..|.|:::...
Mouse   371 MYM-VFFVLVIFLGSFYLVNLILAVVTMAYEEQSQATIAEIEAKEK-KFKEALEVLQKEQEVLAA 433

  Fly  1064 LDWIT------------------------------------------------------------ 1068
            |...|                                                            
Mouse   434 LGIDTTSLYSHNGSPLAPKNANERRPRVKSRMSEGSTDDNRSLQSDPYNQRRMSFLGLSSGRRRA 498

  Fly  1069 ----------QAEDIE-PDAVGGLISDG--KGKQPNEMDS------------------------- 1095
                      .::|:. ||   |::.||  .|.|.:...|                         
Mouse   499 SHSSVFHFRAPSQDVSFPD---GILDDGVFHGDQESRRSSILLGRGAGQAGPLPRSPLPQSPNPG 560

  Fly  1096 ------------TENLGEEMPEVQMTESRWRKMKKDFDRVNR--RMRRA---------------- 1130
                        |..|....||....::..:|.....|.:|.  |.:||                
Mouse   561 PRRGEEGQRGVPTGELATGAPEGPALDAAGQKNFLSADYLNEPFRAQRAMSVVSIMTSVIEELEE 625

  Fly  1131 -------CRKAVKSQAFYW------------------------LIIVLVFLNTGVLATEHYGQLD 1164
                   |..::..:...|                        .|.:.:.:||..:|.|||...|
Mouse   626 SKLKCPPCLISLAQKYLIWECCPKWKKFKMVLFELVTDPFAELTITLCIVVNTVFMAMEHYPMTD 690

  Fly  1165 WLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLG 1229
            ..|...:..|:.|...||.||..|:.:.....||...:|.|||.:|..|:.|...:..|     .
Mouse   691 AFDAMLQAGNIVFTVFFTMEMAFKIIAFDPYYYFQKKWNIFDCVIVTVSLLELSTSKKG-----S 750

  Fly  1230 VSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNF- 1293
            :||||..|||||||:.|.|.:|:.|:..:.||:.::.:|..:|.:.:.||||:|.|:....:.. 
Mouse   751 LSVLRTFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTFILAIIVFIFALVGKQLLSENYGCR 815

  Fly  1294 -DG----KEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFI 1353
             ||    ..|:.|.:...|:.:.|.||:|:.|| |...|:|.:..     |...:....|:.:.:
Mouse   816 RDGISVWNGERLRWHMCDFFHSFLVVFRILCGE-WIENMWVCMEV-----SQDYICLTLFLTVMV 874

  Fly  1354 CGNYILLNVFLAIAVDNLADADSLSEVEKEEE--------------------------------- 1385
            .||.::||:|:|:.:::.: ||:|:..|.:.|                                 
Mouse   875 LGNLVVLNLFIALLLNSFS-ADNLTAPEDDGEVNNLQVALARIQVFGHRASRAITSYIRSHCRLR 938

  Fly  1386 -----------PHDESAQKKSHSPT-----------------------------------PTIDG 1404
                       |...|.:.::|..|                                   |..:|
Mouse   939 WPKVETQLGMKPPLTSCKAENHIATDAVNAAVGNLAKPALGGPKENHGDFITDPNVWVSVPIAEG 1003

  Fly  1405 MDDHLSIDIDME--------------QQEL----------------------------------- 1420
            ..|...::.|:|              ||||                                   
Mouse  1004 ESDLDELEEDVEHASQSSWQEESPKGQQELLQQVQKCEDHQAARSPPSGMSSEDLAPYLGERWQR 1068

  Fly  1421 -----------DDEDKMDHETLS----DEEVREMCEEEEEVDE------EGMITARPRRMSEVNT 1464
                       ||....:..|:.    :|.:|::.|..||:||      ||.....|  ..:|||
Mouse  1069 EESPRVPAEGVDDTSSSEGSTVDCPDPEEILRKIPELAEELDEPDDCFPEGCTRRCP--CCKVNT 1131

  Fly  1465 ATKILPIPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAE-NPLRANDDLNK 1528
            :    ..|..|.:       :.|..|:.:..||.|.:.|:..|:.||..||.| |.|.....:..
Mouse  1132 S----KFPWATGW-------QVRKTCYRIVEHSWFESFIIFMILLSSGALAFEDNYLEEKPRVKS 1185

  Fly  1529 VLNKFDYFFTAVFTIELILKLISYGFVLH-DGAFCRSAFNLLDLLVVCVSLISLVS---SSNAIS 1589
            ||...|..||.:|..|::||.::|||..: ..|:|     .||.|:|.:||.||::   ..:.::
Mouse  1186 VLEYTDRVFTFIFVFEMLLKWVAYGFKKYFTNAWC-----WLDFLIVNISLTSLIAKILEYSDVA 1245

  Fly  1590 VVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKC 1654
            .:|.||.||.||||||::|.:|::.||..::.|:.:|.|::|| ||:.::               
Mouse  1246 SIKALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLV-CLIFWL--------------- 1294

  Fly  1655 VVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDDGDVHKPRL 1719
                                :|:::||.||.|||.:|.|...........|::.......::...
Mouse  1295 --------------------IFSIMGVNLFAGKFSRCVDTRSNPFSVVNSTFVTNKSDCYNQNNT 1339

  Fly  1720 REREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYII 1784
            ....|.|.:.:||:||.|.|.|..|:||:||..::|.::||...|..|.......:..|::::||
Mouse  1340 GHFFWVNVKVNFDNVAMGYLALLQVATFKGWMDIMYAAVDSRDINSQPNWEESLYMYLYFVVFII 1404

  Fly  1785 IIAFFMVNIFVGFVIVTFQNEGEQEYKNCDL-----DKNQRNCIEFALKAKPVRRYIPKHGIQYK 1844
            ...||.:|:|||.:|..| |:.:::.:..|:     .|...|.:: .|.:|..::.||:...:|:
Mouse  1405 FGGFFTLNLFVGVIIDNF-NQQKKKIRGQDIFMTEEQKKYYNAMK-KLGSKKPQKPIPRPLNKYQ 1467

  Fly  1845 --VWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFR 1907
              |:..||..:|:..|..||.:|.:|:.::..||....|::|..:|..|.|||..|.|.|:.|.|
Mouse  1468 GFVFDIVTRQAFDIIIMALICLNMITMMVETDNQSEEKTKVLGRINQFFVAVFTGECVMKMFALR 1532

  Fly  1908 FKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRL 1972
             :.||.:.|||||||:|:.|...:::|.|.|                |.:......|:.:  .||
Mouse  1533 -QYYFTNGWNVFDFIVVILSISSLLFSAILS----------------SLESYFSPTLLRV--IRL 1578

  Fly  1973 FRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIALDGGNAITA 2037
            .|:.|:::|:...:||||||:..:.|..||..:.||:.|:.|||::.||..|..:..:.|  |..
Mouse  1579 ARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMASFANVIDEAG--IDD 1641

  Fly  2038 NNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCD---MNSDTPGEPCGSSIAYPYFISFY 2099
            ..||:||..::|.||:..|...|..::..........||   .||:.....|||......|.:.|
Mouse  1642 MFNFKTFGNSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNRPNSNGSKGNCGSPAVGILFFTTY 1706

  Fly  2100 VLCSFLI-INLFVAVIMDNFDYLTRD-WSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRK 2162
            ::.|||| :|:::|||::||:..|.: ...|.....|.|...|.::||:|...|....:......
Mouse  1707 IIISFLIVVNMYIAVILENFNVATEESTEPLSEDDFDMFYETWEKFDPEATQFIAFSALSDFADT 1771

  Fly  2163 ISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIKTDGNIDDANSELRAT 2227
            :|.||...|  |::   ..|:.|::||.....:.....|||..:..|.  ..|.:|...:.:.. 
Mouse  1772 LSGPLRIPK--PNQ---NILIQMDLPLVPGDKIHCLDILFAFTKNVLG--ESGELDSLKTNMEE- 1828

  Fly  2228 IKQIWKRTNPKLLDQVVPPPGNDDEVTVGKFYATYLIQDYFRRFKK--RKEQEGKEGHPDSNTVT 2290
                                         ||.||.|.:..:.....  |.:||      |.:...
Mouse  1829 -----------------------------KFMATNLSKASYEPIATTLRCKQE------DISATI 1858

  Fly  2291 LQAGLRTLHEVSPALKRAISGNLDELDQEPEPMHRRHHTLFGSVWSSIRRHGNGTFRRSAKATAS 2355
            :|...|..     .|:|::        ....|:|.......|   .|:.|.|..||       .:
Mouse  1859 IQKAYRNY-----MLQRSL--------MLSNPLHVPRAEEDG---VSLPREGYVTF-------MA 1900

  Fly  2356 QSNGALAIGGSASAALGVGGSSLVLGSSDPAGGDYLYDTLNRSVADGVNNITRNIMQ 2412
            ..||.|......::|           :|.|..    ||::.|.::|..|..|.:.||
Mouse  1901 NDNGGLPDKSETASA-----------TSFPPS----YDSVTRGLSDRANISTSSSMQ 1942

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 90/301 (30%)
Ion_trans 1137..1379 CDD:395416 77/271 (28%)
Ion_trans 1496..1809 CDD:395416 98/317 (31%)
Ion_trans 1851..2126 CDD:395416 90/279 (32%)
GPHH 2135..2188 CDD:407139 13/52 (25%)
Ca_chan_IQ 2199..2271 CDD:400901 11/71 (15%)
Scn10aNP_001192250.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 27..54 9/26 (35%)
I. /evidence=ECO:0000305 116..404 93/305 (30%)
Ion_trans 147..406 CDD:278921 84/276 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 444..483 0/38 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 539..583 3/43 (7%)
II. /evidence=ECO:0000305 646..910 78/275 (28%)
Ion_trans 681..893 CDD:278921 70/222 (32%)
Na_trans_assoc 903..1148 CDD:284034 34/257 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1006..1094 10/87 (11%)
III. /evidence=ECO:0000305 1141..1450 103/351 (29%)
Ion_trans 1170..1428 CDD:278921 91/299 (30%)
Na_channel_gate 1420..1472 CDD:240441 11/53 (21%)
IV. /evidence=ECO:0000305 1459..1758 103/319 (32%)
Ion_trans 1494..1733 CDD:278921 84/259 (32%)
GPHH 1743..1800 CDD:293510 16/61 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1901..1958 14/57 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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