DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and unc-2

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:NP_001355464.1 Gene:unc-2 / 180570 WormBaseID:WBGene00006742 Length:2171 Species:Caenorhabditis elegans


Alignment Length:2054 Identity:822/2054 - (40%)
Similarity:1116/2054 - (54%) Gaps:306/2054 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   723 AAAGAAGQKRQQRRGKPQPDRPQRALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAV 787
            |.:|...:|.......|..::...:||..:..|.:|.....|:||.|||:.|||||..||:.|::
 Worm   207 AESGTFVRKTTLSSNAPVKEKGPSSLFIFAEDNIIRRNAKAIIEWGPFEYFILLTIIGNCVVLSM 271

  Fly   788 YTPYPGSDSNVTNQTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAI 852
            ....|.:|....::.||:.|..|:.||..|||:|::|:||.||.|:|||:|||::||.:||.|.:
 Worm   272 EQHLPKNDKKALSEWLERTEPYFMGIFCLECVLKVIAFGFALHKGSYLRSGWNIMDFIVVVSGVV 336

  Fly   853 -------STALSQLMKDAFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLF 910
                   :|..:....|:.|::.|||.||||||:||||:|||||||.|||.||.||..|.|||||
 Worm   337 TMLPFSPATQTANQPVDSVDLRTLRAVRVLRPLKLVSGIPSLQVVLKSILCAMAPLLQIGLLVLF 401

  Fly   911 VIIIYAIIGLELFSGKLHKACRDEITGEYE---ENIRPC-------GVGYQCP-PGYKCYGGWDG 964
            .|||:||||||.:||..|.||.:| .||.|   |...||       || |.|. .|..|...|.|
 Worm   402 AIIIFAIIGLEFYSGAFHSACYNE-RGEIENVSERPMPCTNKTSPMGV-YNCDVKGTTCLQKWIG 464

  Fly   965 PNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGV 1029
            ||.|||:|||.|.||:|||||:|:||||.|:|...|::||.:.|.|||.:::||:||::||:|||
 Worm   465 PNYGITSFDNIGFAMITVFQCITMEGWTTVMYYTNDSLGSTYNWAYFIPLIVLGSFFMLNLVLGV 529

  Fly  1030 LSGEFSKERNKAKNRGDFQKLREKQQIEEDLRGYLDWITQAEDI----------EPDAV---GGL 1081
            |||||:|||.:.:||.:|.|||.:||||.:|.|||:||..||::          |..|:   ...
 Worm   530 LSGEFAKERERVENRREFLKLRRQQQIERELNGYLEWILTAEEVILKEDRTTEEEKAAIMEARRR 594

  Fly  1082 ISDGKGKQPNEMDSTENLGE-EMPEVQMTESRWRKMKKDFDRVNRRMRRAC-------------- 1131
            .::.|.||.::..|||...: |..|.:|.|....:.....|....|.:|.|              
 Worm   595 AANKKLKQASKQQSTETEEDFEEDEDEMEEEYVDEGGTVEDEFAERKKRGCCHSVGKFIKQLRIQ 659

  Fly  1132 -RKAVKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQ 1195
             |..||:|.|||.:|.||||||..:|:|||||..|..:|.:|....|:|:|..|||||::::|.:
 Worm   660 IRIMVKTQIFYWSVITLVFLNTCCVASEHYGQPQWFTDFLKYAEFVFLGIFVVEMLLKLFAMGSR 724

  Fly  1196 GYFVSLFNRFDCFVVIGSITETLLTNT--GMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASL 1258
            .||.|.||||||.|::||..|.:....  |   ..|:||:|.:||||:||:|.||.||.|||.||
 Worm   725 TYFASKFNRFDCVVIVGSAAEVIWAEVYGG---SFGISVMRALRLLRIFKLTSYWVSLRNLVRSL 786

  Fly  1259 LNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEKYRMNFDCFWQALLTVFQIMTGEDW 1323
            :||::||.|||.||||||:||||||||:|||:|||.....  ..:||.|..||:|||||:|||||
 Worm   787 MNSMRSIISLLFLLFLFILIFALLGMQLFGGRFNFPTMHP--YTHFDTFPVALITVFQILTGEDW 849

  Fly  1324 NAVMYVGINAYGGVSSYGALACIYFIILFICGNYILLNVFLAIAVDNLADADSL----------S 1378
            |.|||:.|.:.||:.|.|....||||:|.:.|||.||||||||||||||:|..|          :
 Worm   850 NEVMYLAIESQGGIYSGGWPYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEADEKAN 914

  Fly  1379 EVEKEEEPHDESAQKKSHSPTPTIDGMDDHLSIDIDMEQQELDDEDKMDHETLSDEEVREMCEEE 1443
            |:|:|.|..||..|:..|.   ||| |:...:.|:....:.:||.|             |.||||
 Worm   915 EIEEESEELDEQYQEGDHC---TID-MEGKTAGDMCAVARAMDDLD-------------EECEEE 962

  Fly  1444 EEVDEEGMITARPRRMSEVNTATKILPIPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIM 1508
            |..      ...|:            |:.|.:|.|..|.||.|||..|.:.....|..:::..|.
 Worm   963 ESP------FGGPK------------PMVPYSSMFFLSPTNPFRVLIHSIVCTKYFEMMVMTVIC 1009

  Fly  1509 FSSAMLAAENPLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLV 1573
            .||..||||:|:...:..||||...||.||.||..|::||||..|.:||.|::||..:|:||.:|
 Worm  1010 LSSVSLAAEDPVDEENPRNKVLQYMDYCFTGVFACEMLLKLIDQGILLHPGSYCRDFWNILDGIV 1074

  Fly  1574 VCVSLISL------VSSSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLV 1632
            |..:|.:.      .|:...::.:|.||||||||||:.|.|...||.|..               
 Worm  1075 VTCALFAFGFAGTEGSAGKNLNTIKSLRVLRVLRPLKTIKRIPKLKAVFD--------------- 1124

  Fly  1633 TCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTDGSKM 1697
                                 |||.::|.:.||::|.:|.||:||||.||||.||||.|||.::.
 Worm  1125 ---------------------CVVNSLKNVFNILIVYFLFQFIFAVIAVQLFNGKFFFCTDKNRK 1168

  Fly  1698 TQDECYGTYLVYDDGDVHKPRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNK 1762
            ..:.|:|.:.|||:.: ..||:.:|||....|::|:....|||||.|:|.|||||:...|:|:..
 Worm  1169 FANTCHGQFFVYDNQN-DPPRVEQREWRLRPFNYDNTINAMLTLFVVTTGEGWPGIRQNSMDTTF 1232

  Fly  1763 ENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQEYKNCDLDKNQRNCIEFAL 1827
            |:.||...||..||.:|:::.|:..||.|||||..:|:|||.:||.|....||||||:.||:|||
 Worm  1233 EDQGPSPFFRVEVALFYVMFFIVFPFFFVNIFVALIIITFQEQGEAELSEGDLDKNQKQCIDFAL 1297

  Fly  1828 KAKPVRRYIP--KHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMI 1890
            .|:|...::|  |:..:|::|..|||..|||.|..:|..||:.|.||:||.||:|.|:|...|..
 Worm  1298 NARPRSLFMPEDKNSTKYRIWRLVTSPPFEYFIMTMICCNTLILMMKYYNNPLFYEEILRLFNTA 1362

  Fly  1891 FTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKS 1955
            .||||.:|.:.|:.||..:|||.|.||.|||:.|:||..|.:.:|.                   
 Worm  1363 LTAVFTVESILKILAFGVRNYFRDGWNRFDFVTVVGSITDALVTEF------------------- 1408

  Fly  1956 TKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVG 2020
                 |.:.:|:.|.||||..||::||.:|..||.|||||::||:|||||.|||.:||||||:||
 Worm  1409 -----GGHFVSLGFLRLFRAARLIRLLQQGYTIRILLWTFVQSFKALPYVCLLIGMLFFIYAIVG 1468

  Fly  2021 MQVFGKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDV----KCDMNSDT 2081
            |||||.|.|:....|..:||||:|..||::|||.||||.||:|||:.....|.    ..::|.: 
 Worm  1469 MQVFGNIWLNAATEINRHNNFQSFFNAVILLFRCATGEGWQDIMMAAVQGKDCARAGSAEINFE- 1532

  Fly  2082 PGEPCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPD 2146
            .|:.|||:::|.||.||..|.|||::|||||||||||||||||.|||||||||||||:|::|||.
 Worm  1533 KGQTCGSNVSYAYFTSFVFLSSFLMLNLFVAVIMDNFDYLTRDSSILGPHHLDEFIRVWADYDPA 1597

  Fly  2147 AKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSI 2211
            |.|||.:.::..:||.::||:||||.||:|:|.|.|:.||||:..||||.|..||||::|.||||
 Worm  1598 ATGRIHYSEMYEMLRIMAPPVGFGKKCPYRLAYKHLIRMNMPVAEDGTVHFTTTLFALIRESLSI 1662

  Fly  2212 KTD--GNIDDANSELRATIKQIWK-RTNPKLLDQVVPPPGNDD----EVTVGKFYATYLIQDYFR 2269
            |..  ..:|:|:.|||.|:|:||. :....::|.||||  |.:    ::||||.||..||.:.:|
 Worm  1663 KMRPVEEMDEADEELRLTLKKIWPLKAKKNMVDLVVPP--NHELCFQKLTVGKIYAGLLILENYR 1725

  Fly  2270 RFKKRKEQEGKEGHPDSNTVTLQAGLRTLHEVSPALKRAISGNLDELDQEPEPMHRRHHTLFGSV 2334
            . :|...:.|.:|       ....|||:|...:.|.:...|.:..:..:|..|:..:|...|.:.
 Worm  1726 A-RKSGTEVGGQG-------LFGGGLRSLVAAAKAAESQHSSHTPQPPEETTPIIPQHAQQFSAA 1782

  Fly  2335 WSSIRRHGNGTFRRSAKATASQSNGALAIGGSASAALGVGGSSLV----LGSSDPAGGDYLYDTL 2395
            .:           .||:.:..|..|..:.||....:|   .:|.|    .|..|....|..|.::
 Worm  1783 PT-----------MSAQGSLQQMQGTSSGGGQRPYSL---FNSFVDTIKSGKQDGDVTDVQYQSV 1833

  Fly  2396 N----------RSVADGVNNITR------NIMQARLAAAGKLQDELQGAGSGGELRTFGESISMR 2444
            :          |.::|..:.|.|      |..|.....|   ||  ..:.|....|:...:....
 Worm  1834 DQQHEKMNSTGRRLSDMFSKIRRGTSADHNPHQTEHLLA---QD--NRSPSSPRYRSMARASPPS 1893

  Fly  2445 PLAKNGGGAATVAGTLPPEANAINYD--------NRNRGILLHPYNNVYAPNGALPGHERMIQST 2501
            | |:..|.........||.:.: .|.        .|||      ||.:.....:........|..
 Worm  1894 P-AERYGHPPRYRTESPPSSRS-EYQMSIRDPIIRRNR------YNTMEHSRSSHDPQYHQDQQQ 1950

  Fly  2502 PASPYDQR--------------------RLPTSSDMNGLAESLIGGVLAAEGLGKYCDS------ 2540
            ...|:.|:                    |.|..||.:.:|||    ........:|.||      
 Worm  1951 QQQPHHQQHSQHLQHSHHKTYQNHNQYSRSPIYSDDSSVAES----YRREREFRRYQDSTPQDVS 2011

  Fly  2541 ---EFVGTAAREMREALDMTPEEMNLAAHQILS-NEHSLSLIGSSNGSIFGGSAGGLGGAGSGGV 2601
               :.:.||.|..|..|..|......:|:|..| |:|       .|.|.         |.|:|..
 Worm  2012 EDDDPMPTAVRARRLPLISTMPTHYESAYQPSSYNQH-------LNDSY---------GLGTGYQ 2060

  Fly  2602 GGLGGSSSIRNAFGGSGSGPSSLSPQHQPYSGTLNSPPI 2640
            .....|.|       ....|:|...||||...|  ||.|
 Worm  2061 RDYHTSHS-------HSHHPTSQQQQHQPMYST--SPLI 2090

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 153/292 (52%)
Ion_trans 1137..1379 CDD:395416 138/253 (55%)
Ion_trans 1496..1809 CDD:395416 126/318 (40%)
Ion_trans 1851..2126 CDD:395416 137/278 (49%)
GPHH 2135..2188 CDD:407139 28/52 (54%)
Ca_chan_IQ 2199..2271 CDD:400901 34/78 (44%)
unc-2NP_001355464.1 Ion_trans 254..536 CDD:366146 148/283 (52%)
Ion_trans 667..904 CDD:366146 137/241 (57%)
Ion_trans 998..1279 CDD:366146 126/317 (40%)
Ion_trans 1323..1577 CDD:366146 137/278 (49%)
GPHH 1586..1639 CDD:374878 28/52 (54%)
Ca_chan_IQ 1650..1726 CDD:370105 33/77 (43%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100303
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
54.850

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