DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ca-alpha1D and unc-77

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:NP_001293824.1 Gene:unc-77 / 177379 WormBaseID:WBGene00006809 Length:1867 Species:Caenorhabditis elegans


Alignment Length:1899 Identity:405/1899 - (21%)
Similarity:719/1899 - (37%) Gaps:520/1899 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   754 KNPLRALCIRI--VEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVIFTA 816
            |.|:|:..:..  |||   ...|..||  :.|.:.::||.........|..:...:::.:.||..
 Worm    73 KKPVRSSYVESDRVEW---ALKIACTI--SMITVCIHTPRTIELFQPLNYIILAADFISVSIFML 132

  Fly   817 ECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALS--QLMKDAFDVKALR------AFR 873
            :.|::|...|....:.:||.|.|:.....|.:|..:|..|.  ||:.:.|....|.      |.|
 Worm   133 DSVLRIHYEGIFRCDSSYLSNRWSQFSVFISIIHLLSFLLHCYQLIDNFFPFLHLNYRAWYGAIR 197

  Fly   874 VLRP---LRLVSGVPSLQVVLNSI----LKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKAC 931
            .:||   :||:..|...::..|.|    .::...:.::.|..:|.:.:|||.|::|| |::...|
 Worm   198 SIRPFIIIRLIPLVVKFKLPKNRIEQLLKRSSQQVKNVTLFFVFFMTLYAIFGIQLF-GRMDYHC 261

  Fly   932 RDEITGEYEENI----------RPCGV-GYQCPPGYKC------------YGGWDGPNDGITNFD 973
            ....|......|          .|.|: ||:||....|            ||          .|:
 Worm   262 VQPKTDPNNVTIMDLAIPDTMCAPEGIGGYECPAPMVCMQLNLNAKGEGFYG----------MFN 316

  Fly   974 NFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKER 1038
            :||.::.||:...:.|||..|||...|::.|...::||.:::...|:.|.|:.:.|::..|    
 Worm   317 DFGASVFTVYLAASEEGWVYVLYDCMDSLPSYLAFLYFCTLIFFLAWLVKNVFIAVITETF---- 377

  Fly  1039 NKAKNRGDFQKLREKQQIEEDLRGYLDWITQAEDIEPDAVGGLISDGKGKQPNEMDSTENLGEEM 1103
              |:.|..|.::.:|:::..|                        :|..|               
 Worm   378 --AEIRVQFSEMWQKKEVTLD------------------------EGFRK--------------- 401

  Fly  1104 PEVQMTESRWRKMKKDFDRVNRRMRRACRKAVKSQAFYWLIIVLVFLN---TGVLATEHYGQLDW 1165
             :::.|:..||.::.|.:......::..:..::|..|...:|:.|.:|   ..:....|    |.
 Worm   402 -KLEKTDDGWRLIRLDGEVEPEGPKQKLQWMLRSMYFQCFVIIFVVINAIGNAMFVYRH----DE 461

  Fly  1166 LDNFQEYT----NVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMP 1226
            .|..::|.    .|.|..||..|.::|:...||:.:......:|:..:.:|              
 Worm   462 TDKPRKYNFYLFEVGFTILFNVECIIKILCYGFRNFIRRGIFKFELILCLG-------------- 512

  Fly  1227 PLGVSVLRCV---------------RLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFI 1276
                |.|.||               ||||:.|.:..   |.:.|..:.:..:.:..|::....||
 Worm   513 ----SSLNCVKFFYERNYFTYFQTFRLLRLIKASPI---LEDFVWKIFSPGKKLGGLVIFTIAFI 570

  Fly  1277 VIFALLGMQVFGGKFNFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYG 1341
            ..::.:.:|:|....|..        :|..|.||.:::|||:|.|.|...:...:.|..  .:..
 Worm   571 CCYSAISLQLFYSVPNLH--------HFRTFPQAFMSMFQIITQEGWTDFVVEVLRATD--DNLV 625

  Fly  1342 ALACIYFIILFICGNYILLNVFLAIAVDNLADADSLSEV-----------------------EKE 1383
            .|..:||:...:....|:|::|:|:.:|||...:.|.:|                       ||.
 Worm   626 PLVALYFVAYHLFVTLIVLSLFVAVILDNLEMDEELKKVKQLRAREATTSMRSTLPWRLRVFEKF 690

  Fly  1384 EEPHDESAQKKSHS--PTPTIDGMDDH-LSIDIDMEQQELDDED--------------KMDHETL 1431
            ......:|.:|:.|  |.|.:.|...| .::|..:|..::.:.|              |:....|
 Worm   691 PTRPQMAAMRKADSDFPMPKVRGSFTHQFAVDHSLETTDVIESDFEFPKRIMKSAGKRKISKSGL 755

  Fly  1432 SDEEV------------REMCEEEEE--------------------------------------- 1445
            :..::            .||.:...:                                       
 Worm   756 TFRQIGSTSLRCSLNNLLEMSDRTRQSLSNSLSFLPHFTRSSGSLYPRKDALPKSRSMTGKFLQT 820

  Fly  1446 ---------VDEEGMITARP----------------------RRMSEVNTATKI----------- 1468
                     ..|.|.: :||                      |:::|: |..:|           
 Worm   821 AVRNKQFNMYSENGDL-SRPSDSAPKKNAKQGEIDIRALQQKRQLAEI-TRNRIEEDMRENHPFF 883

  Fly  1469 -LPIPPGTSFFLFSQTNRFRVFCHWLCNHSNFGN------------------------------- 1501
             .|:      ||..:.::.|.||..:. ||.:.:                               
 Worm   884 DRPL------FLVGRASQLREFCKKMV-HSKYDSQDDGTNGGAKTKKRFKEIRALIGIMPYIDWA 941

  Fly  1502 ----IILCCI--MFSSAMLAAENPLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGA 1560
                .|:.||  :|.|........|..|   |..|...||||....|.||.:|:|:.|......|
 Worm   942 MATVTIVSCISMLFESPWPTTGENLVMN---NGYLQISDYFFVLSMTFELCVKIIANGLFFTPKA 1003

  Fly  1561 FCRSAFNLLDLLVVCVSLISLVSSSNAI---SVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVA 1622
            ..|....:::|.:...|:|.|......:   |:.:.|.:.|.:||||....   :.|:.:.|:..
 Worm  1004 VVRDVGGVMNLFIYFTSVIFLAWMPKHVEINSLAQFLMICRAMRPLRIYTL---VPHIRRVVLEF 1065

  Fly  1623 VKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGK 1687
            .:....|:|||.|:                  :||               .|:||..|||:..||
 Worm  1066 FRGFKEILLVTILM------------------IVV---------------MFIFASFGVQIVGGK 1097

  Fly  1688 FFKCTDGSKMTQDECYGTYL---------VY--DDGDVHKPRLREREWSNNR-FHFDDVAKGMLT 1740
            ...|.|.:..:::.|.|.:.         ||  |...:|...:..|.|:|.| |:||.|...||.
 Worm  1098 LAACNDPTVSSRENCTGVFWQKLFVTRLEVYGKDTEAMHPKIMVPRVWTNPRNFNFDHVGNAMLA 1162

  Fly  1741 LFTVSTFEGWPGLLYVSIDSNKENGGP-----IHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIV 1800
            ||...:|:||    .|..|......||     ||           ||:.|.....:.:|||.||.
 Worm  1163 LFETLSFKGW----NVIRDILWSRHGPWAVVFIH-----------IYVFIGCMIGLTLFVGVVIA 1212

  Fly  1801 TF-QNEGEQEYKNCDLDKNQRNCIEFALK-AKPVRRYIP-----KHGIQYKVWWFVTSSSFEYTI 1858
            .: ||.|.   ....:|:.:.:.::..|| |:|:  ::|     ...::.|::....|..|....
 Worm  1213 NYTQNRGT---ALLTVDQRRWHDLKARLKMAQPL--HVPPKPSESARLRTKLYDLTMSRWFNQAF 1272

  Fly  1859 FILIMINTVTLAMKF----YNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVF 1919
            .:|:::|:.||.:.:    ..|...|...:.||......:|.:|.:.|:.|:.|..::....|..
 Worm  1273 ALLVVLNSFTLVIPWNVEEEEQRATYVFTVTALAAFMNMLFVIEIILKVIAYTFSGFWQSRRNRV 1337

  Fly  1920 DFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSK 1984
            |.:|.:...|.|......:..:|:| :.|:....|....:.|..::.:.||.:......:|:|  
 Worm  1338 DLLITVFGVIWIFLHFFVALPSSKI-DVDVQVELKKFTYTFGYLVVILRFFTIASRNSTLKML-- 1399

  Fly  1985 GEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIALDGGNAITANNNFQTFQQAVL 2049
               :.|::.:..:||    ::...:.||...||..|:.:|..:..  |.|::.:.||:|..:|::
 Worm  1400 ---MLTVIMSMFRSF----FIITALFLLVLFYAYTGVILFPMVKY--GMAVSKHVNFRTASEALV 1455

  Fly  2050 VLFRSATGEAWQEIMMSCSAQPDVKCDMNS-----DTPGEPCGSSI-AYPYFISFYVLCSFLIIN 2108
            ||||..|||.|.:||..|...... |..|.     :|   .||:.. |..||.|||::.::::.|
 Worm  1456 VLFRCLTGEDWNDIMHDCMRSAPF-CYWNEGMNYWET---DCGNFYGAIIYFCSFYLIITYIVRN 1516

  Fly  2109 LFVAVIMDNFD--YLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGK 2171
            |.|||||:||.  |.:.:.::|....:..|..:|:..|.:.|..|....|..|||.:...|   :
 Worm  1517 LLVAVIMENFSLFYSSEEDALLSYADIRNFQYVWNMVDQEQKRTIPVERVKFLLRLLKGRL---E 1578

  Fly  2172 LCPH--RMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIKTDGNIDD--ANSELRATI-KQI 2231
            :.|.  |:..|.:......|::...|.|:..|:.:...|:.|:....:::  ...||...| :::
 Worm  1579 VDPEKDRILFKHMCYEMERLHNGEEVSFHDVLYMLSYRSVDIRKSLQLEELLQREELEFIIEEEV 1643

  Fly  2232 WKRTNPKLLDQVVPPPGNDDEVTVGKFYATYLIQDYFRRFK--KRKEQEG----KEGHPDSNTVT 2290
            .|:|                       ..|:| :...|:.:  .:|:.||    ..|||    |.
 Worm  1644 AKQT-----------------------IRTWL-EGCLRKMRNPSQKDAEGVLPFGGGHP----VI 1680

  Fly  2291 LQAGLRTLHEVSPALKRAISGNL--DELDQE---------PEPM-------HRRHHTLFGSVWSS 2337
            ..:|..::.......:|....|:  |.:|.|         |.|:       :||     ||:...
 Worm  1681 HSSGHSSISHEETVAQRLRFENIRGDSVDTEETESSEEETPPPIRKKAAVKNRR-----GSIPDV 1740

  Fly  2338 IRRHGNGTFRRSAK 2351
            :.|  .|.|:.:|:
 Worm  1741 LSR--TGLFQEAAR 1752

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 75/312 (24%)
Ion_trans 1137..1379 CDD:395416 58/263 (22%)
Ion_trans 1496..1809 CDD:395416 91/370 (25%)
Ion_trans 1851..2126 CDD:395416 76/286 (27%)
GPHH 2135..2188 CDD:407139 13/54 (24%)
Ca_chan_IQ 2199..2271 CDD:400901 11/74 (15%)
unc-77NP_001293824.1 Ion_trans 107..383 CDD:278921 70/292 (24%)
Ion_trans 455..660 CDD:278921 52/239 (22%)
Ion_trans 973..1214 CDD:278921 78/291 (27%)
Ion_trans 1310..1534 CDD:278921 66/239 (28%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.950

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