Protein Alignment Ca-alpha1D and Cacna1e

DIOPT Version :10

• Sequence 1: NP_723952.2
• Gene: Ca-alpha1D / 34950
• FlyBaseID: FBgn0001991
• Length: 2705
• Species: Drosophila melanogaster
• Sequence 2: XP_011246211.1
• Gene: Cacna1e / 12290
• MGIID: 106217
• Length: 2466
• Species: Mus musculus
• Alignment Length: 2602
• Identity: 872/2602 - (33%)
• Similarity: 1188/2602 - (45%)
• Gaps: 747/2602 - (28%)

  Fly   587 DEQEQQHDQGDSAEEEDDDE-------------DVDEYFEEEEDDTQAF----------SPFYSS 628
            ||:..:..|....|....||             ..|.:|..:|.:...:          |||...
Mouse    43 DEEAWRPQQCALLEANASDEVGMLPASPRSAVAGFDNFFPVQEGEGPGWEGSTTLDAGSSPFLPV 107

  Fly   629 SAELIDNFGGGAGKFFNIM-----------------DFERGASGEGGFSPNGNGGPGSGDVSRTA 676
            |.|::....||..:..:|:                 ::|....||....    |.|||||
Mouse   108 SPEVMKRRRGGLIEQRDIIKAHEAHKMQSTPQARRKEWEMARFGEAVVV----GRPGSGD----- 163

  Fly   677 RYDSGEGDLGGGNNIMGIDSMGIANIPETMNGTTIGPSGAGGQKGGAAAGAAGQKRQQRRG---- 737
                  ||.....|               ..||.:..||        .|.|..|.:.||..
Mouse   164 ------GDSDQSRN---------------RQGTPVPASG--------PAAAYKQSKAQRARTMAL 199

  Fly   738 -KPQPDRP-----QRALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDS 796
             .|.|.|.     .|:||.....|.:|....::::|.|||::||.||.||||.||:....|..|.
Mouse   200 YNPIPVRQNCFTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDK 264

  Fly   797 NVTNQTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMK 861
            ...::.|||.|..|:.||..|..:||:|.||:.|.|:|||||||::||.:|:.|.::||.:. ..
Mouse   265 TPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTH-FN 328

  Fly   862 DAFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGK 926
            ...|::.|||.||||||:||||:||||:||.||:||||||..|.||:.|.|:::||||||.:|||
Mouse   329 THVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGK 393

  Fly   927 LHKACRDEITGEYE--ENIRPCGVGYQCPPGYKCYGGWDGPNDGITNFDNFGLAMLTVFQCVTLE 989
            ||:||....:|..|  :...|||| ..||.||:| ..|.|||||||.|||...|:||||||:|:|
Mouse   394 LHRACFMNNSGILEGFDPPHPCGV-QGCPAGYEC-KDWIGPNDGITQFDNILFAVLTVFQCITME 456

  Fly   990 GWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERNKAKNRGDFQKLREKQ 1054
            |||.|||:..||:|:.|.|:|||.::|:|:|||:||:||||||||:|||.:.:||..|.|||.:|
Mouse   457 GWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLRRQQ 521

  Fly  1055 QIEEDLRGYLDWITQAEDIEPDAVGGLISDGKGKQPNEMDSTENLGEEMPEVQMTESRWRKMKKD 1119
            |||.:|.||..||.:||::       :::     :.|:...|..| |.:....:..||...|.:|
Mouse   522 QIERELNGYRAWIDKAEEV-------MLA-----EENKNSGTSAL-EVLRRATIKRSRTEAMTRD 573

  Fly  1120 -------------------------------FDRVNRRMRRACRKAVKSQAFYWLIIVLVFLNTG 1153
                                           |....|.:|.:.|..||||.|||:::.:|.|||.
Mouse   574 SSDEHCVDISSVGTPLARASIKSTKVDGASYFRHKERLLRISIRHMVKSQVFYWIVLSVVALNTA 638

  Fly  1154 VLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETL 1218
            .:|..|:.|..||.:...|....|:|||..||.||||.:|.:.||.|.||.||..|.:|||.|.:
Mouse   639 CVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVV 703

  Fly  1219 LTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLG 1283
            ..........|:||||.:||||:||:||||.||.|||.||::|::||.|||.|||||||:|||||
Mouse   704 WAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLG 768

  Fly  1284 MQVFGGKFNF-DGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIY 1347
            ||:|||:||| ||...   .|||.|..|::|||||:||||||.|||.||.:.||||| |..:.||
Mouse   769 MQLFGGRFNFNDGTPS---ANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSS-GMWSAIY 829

  Fly  1348 FIILFICGNYILLNVFLAIAVDNLADADSLSEVEKEEE-----------------------PHDE 1389
            ||:|.:.|||.||||||||||||||:|..|::.|:|||                       |..|
Mouse   830 FIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQKHALQKAKEVSPMSAPNMPSIE 894

  Fly  1390 SAQKKSH---------------------------------------------------------- 1396
            ..:::.|
Mouse   895 RDRRRRHHMSMWEPRSSHLRERRRRHHMSVWEQRTSQLRRHMQMSSQEALNKEEAPPMNPLNPLN 959

  Fly  1397 --SP-----------------------------------------------TPTIDGMDDHLSI- 1411
              ||                                               |..:|.....||:
Mouse   960 PLSPLNPLNAHPSLYRRPRPIEGLALGLGLEKCEEERISRGGSLKGDIGGLTSALDNQRSPLSLG 1024

  Fly  1412 -------------DIDMEQQE-------------------------------------------- 1419
                         :.|..|||
Mouse  1025 KREPPWLPRSCHGNCDPIQQEAGGGETVVTFEDRARHRQSQRRSRHRRVRTEGKDSASASRSRSA 1089

  Fly  1420 -----LDD----EDKMDHETLSDEEVREMCEEEEE----------------------VDE----- 1448
                 ||:    |.:.:||..|....:|....|||                      :||
Mouse  1090 SQERSLDEGVSVEGEKEHEPHSSHRSKEPTIHEEERTQDLRRTNSLMVPRGSGLVGALDEAETPL 1154

  Fly  1449 -------------------------------------EGMITARP----------RRMSEVNTAT 1466
                                                 .|:..:.|          :..:|..:.|
Mouse  1155 VQPQPELEVGKDAALTEQEAEGSSEQALLGDVQLDVGRGISQSEPDLSCMTANMDKATTESTSVT 1219

  Fly  1467 KILP----------------------------------------------------IPPGTSFFL 1479
            ..:|                                                    :.|.:|.|:
Mouse  1220 VAIPDVDPLVDSTVVNISNKTDGEASPLKEAETKEEEEEVEKKKKQKKEKRETGKAMVPHSSMFI 1284

  Fly  1480 FSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDDLNKVLNKFDYFFTAVFTIE 1544
            ||.||..|..||::.|...|...||..|..||..||||:|:..|.:.||||..|||.||.|||.|
Mouse  1285 FSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFE 1349

  Fly  1545 LILKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISLVSSSNA--------ISVVKILRVLRVLR 1601
            :::|:|..|.:|.||::.|..:|:||.:||..:|::. :.:||        |..:|.||||||||
Mouse  1350 MVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAF-ALANALGTNKGRDIKTIKSLRVLRVLR 1413

  Fly  1602 PLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIM 1666
            ||:.|.|...||.|..                                    |||.::|.:.||:
Mouse  1414 PLKTIKRLPKLKAVFD------------------------------------CVVTSLKNVFNIL 1442

  Fly  1667 LVTYLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDDGDVHKPRLREREWSNNRFHF 1731
            :|..|..|:||||.|||||||||.|||.||.|:.||.|.|:   |.:.:|..::.|||..:.||:
Mouse  1443 IVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEKECIGNYV---DHEKNKMEVKGREWKRHEFHY 1504

  Fly  1732 DDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVG 1796
            |::...:||||||||.||||.:|..|:|..:|:.||..:.|..::.:|::|.::..||.|||||.
Mouse  1505 DNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVA 1569

  Fly  1797 FVIVTFQNEGEQEYKNCDLDKNQRNCIEFALKAKPVRRYIP--KHGIQYKVWWFVTSSSFEYTIF 1859
            .:|:|||.:|::..:.|.|:||:|.||:||:.|||:.||:|  :|..||:||.||.|.||||||.
Mouse  1570 LIIITFQEQGDKMMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIM 1634

  Fly  1860 ILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIV 1924
            .:|.:|||.|.||:|:.|..|...|..||:.||.||:||.|.|:.||.|.|||.|.||:||||.|
Mouse  1635 AMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITV 1699

  Fly  1925 LGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIR 1989
            :||..:|:.::.|..:||                  |.|:   :|.:|||..||:|||.:|..||
Mouse  1700 IGSITEIILTDSKLVNTS------------------GFNM---SFLKLFRAARLIKLLRQGYTIR 1743

  Fly  1990 TLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIALDGGNAITANNNFQTFQQAVLVLFRS 2054
            .|||||::||:|||||.|||.:||||||::||||||.|.||..:.|..:|||::|..::::||||
Mouse  1744 ILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRS 1808

  Fly  2055 ATGEAWQEIMMSCSAQPDVKCDMNSDTP-----GEPCGSSIAYPYFISFYVLCSFLIINLFVAVI 2114
            ||||||||||:||..:..  |:.::..|     .|.||:.:||.||:||...||||::|||||||
Mouse  1809 ATGEAWQEIMLSCLGEKG--CEPDTTAPSGQNESERCGTDLAYVYFVSFIFFCSFLMLNLFVAVI 1871

  Fly  2115 MDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMAC 2179
            ||||:|||||.|||||||||||:|:|:|||..|.|||.:.::..:|..:|||||.||.||.::|.
Mouse  1872 MDNFEYLTRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAY 1936

  Fly  2180 KRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIK-TDGNID--DANSELRATIKQIWKRTNPKLLD 2241
            ||||.||||:..|.||.|.:||.|::||:|.|| ..|..|  ..:|||:.....||...:.|:||
Mouse  1937 KRLVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLD 2001

  Fly  2242 QVVPPPGNDDEVTVGKFYATYLIQDYFRRFKKRKEQEGKEG----------HPDS-------NTV 2289
            .:||.|...| :||||.||..:|.||:::.|.:|:::..|.          .|.|       |..
Mouse  2002 LLVPMPKASD-LTVGKIYAAMMIMDYYKQSKVKKQRQQLEEQKNAPMFQRMEPSSLPQEIIANAK 2065

  Fly  2290 TL-------------QAGLRTLHEVSP-------ALKRAISGNLDELD-----QEPEPMHRRHHT 2329
            .|             ::|..::..:||       .:..|..|...|..     ||||....:
Mouse  2066 ALPYLQQDPVSGLSGRSGYPSMSPLSPQEIFQLACMDPADDGQFQEQQSLVNAQEPEVSELK--- 2127

  Fly  2330 LFGSVWSSIRRHG----------NGTFRRSAKATASQSNGALAIGGSASAALGV-----GGSSLV 2379
               ||.||  .||          .|:.|.|:....:.....:....|...:...     ..||.:
Mouse  2128 ---SVQSS--NHGIYLPPDTQEHAGSGRASSMPRLTMDPQVVTDPSSMRRSFSTIRDKRSNSSWL 2187

  Fly  2380 LGSSDPAGGDYLYDTLNRSVADGVNNITRNIMQARLAA------AGKLQDELQGAGSGGELRTFG 2438
            ...|.....:..|.:..||....:          ||:|      :|...|..:   |||..|  |
Mouse  2188 EEFSMERSSENTYKSRRRSYHSSL----------RLSAHRLNSDSGHKSDTHR---SGGRER--G 2237

  Fly  2439 ESISMRPLAKNGGGAATVAGTLPPEANAINYDNRNRGILLHPYNNVYAPNGALPGHERMIQSTPA 2503
            .|...:.|             |.|:.:..|.:.|                |.....|...:....
Mouse  2238 RSKERKHL-------------LSPDVSRCNSEER----------------GTQADWESPERRQSR 2273

  Fly  2504 SPYDQR-RLPTSSDMNGLAESLIGGVLAAEGLGKYCDSEFVGTAAREMREALDMTPEEMNLAAHQ 2567
            ||.:.| :.|.......|:||.|..:            ....|..|..|:...:.|:...|.::.
Mouse  2274 SPSEGRSQTPNRQGTGSLSESSIPSI------------SDTSTPRRSRRQLPPVPPKPRPLLSYS 2326

  Fly  2568 ILSNEHSLSLIGSSNGSIFGGSAGGLGGAGSGGVGG-------LGGSSSIRNAFGGS-----GSG 2620
            .|...                 .||:.....|..||       |..:|:.......|     |..
Mouse  2327 SLMRH-----------------TGGISPPPDGSEGGSPLASQALESNSACLTESSNSLHPQQGQH 2374

  Fly  2621 PSSLSPQH---QPY------------------------------SGTLNSPP-------IPDNRL 2645
            |   ||||   :||                              |.|:.|.|       :|:...
Mouse  2375 P---SPQHYISEPYLALHEDSHASDCGEEETLTFEAAVATSLGRSNTIGSAPPLRHSWQMPNGHY 2436

  Fly  2646 RR 2647
            ||
Mouse  2437 RR 2438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1D	NP_723952.2	Ion_trans	767..1042	CDD:459842	153/276 (55%)
		Ion_trans	1137..1379	CDD:459842	139/242 (57%)
		Ion_trans	1496..1809	CDD:459842	130/320 (41%)
		Ion_trans	1851..2126	CDD:459842	144/279 (52%)
		GPHH	2135..2188	CDD:465306	28/52 (54%)
		Ca_chan_IQ	2198..2273	CDD:462591	31/77 (40%)
Cacna1e	XP_011246211.1	Ion_trans	235..509	CDD:459842	153/276 (55%)
		Ion_trans	622..861	CDD:459842	139/242 (57%)
		Ion_trans	1302..1536	CDD:459842	112/273 (41%)
		Ion_trans	1626..1883	CDD:459842	144/279 (52%)
		GPHH	1892..1945	CDD:465306	28/52 (54%)
		Ca_chan_IQ	1955..2031	CDD:462591	31/76 (41%)