DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and Cacna1e

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:XP_011246211.1 Gene:Cacna1e / 12290 MGIID:106217 Length:2466 Species:Mus musculus


Alignment Length:2602 Identity:872/2602 - (33%)
Similarity:1188/2602 - (45%) Gaps:747/2602 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   587 DEQEQQHDQGDSAEEEDDDE-------------DVDEYFEEEEDDTQAF----------SPFYSS 628
            ||:..:..|....|....||             ..|.:|..:|.:...:          |||...
Mouse    43 DEEAWRPQQCALLEANASDEVGMLPASPRSAVAGFDNFFPVQEGEGPGWEGSTTLDAGSSPFLPV 107

  Fly   629 SAELIDNFGGGAGKFFNIM-----------------DFERGASGEGGFSPNGNGGPGSGDVSRTA 676
            |.|::....||..:..:|:                 ::|....||....    |.|||||     
Mouse   108 SPEVMKRRRGGLIEQRDIIKAHEAHKMQSTPQARRKEWEMARFGEAVVV----GRPGSGD----- 163

  Fly   677 RYDSGEGDLGGGNNIMGIDSMGIANIPETMNGTTIGPSGAGGQKGGAAAGAAGQKRQQRRG---- 737
                  ||.....|               ..||.:..||        .|.|..|.:.||..    
Mouse   164 ------GDSDQSRN---------------RQGTPVPASG--------PAAAYKQSKAQRARTMAL 199

  Fly   738 -KPQPDRP-----QRALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDS 796
             .|.|.|.     .|:||.....|.:|....::::|.|||::||.||.||||.||:....|..|.
Mouse   200 YNPIPVRQNCFTVNRSLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDK 264

  Fly   797 NVTNQTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMK 861
            ...::.|||.|..|:.||..|..:||:|.||:.|.|:|||||||::||.:|:.|.::||.:. ..
Mouse   265 TPMSRRLEKTEPYFIGIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTH-FN 328

  Fly   862 DAFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGK 926
            ...|::.|||.||||||:||||:||||:||.||:||||||..|.||:.|.|:::||||||.:|||
Mouse   329 THVDLRTLRAVRVLRPLKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGK 393

  Fly   927 LHKACRDEITGEYE--ENIRPCGVGYQCPPGYKCYGGWDGPNDGITNFDNFGLAMLTVFQCVTLE 989
            ||:||....:|..|  :...|||| ..||.||:| ..|.|||||||.|||...|:||||||:|:|
Mouse   394 LHRACFMNNSGILEGFDPPHPCGV-QGCPAGYEC-KDWIGPNDGITQFDNILFAVLTVFQCITME 456

  Fly   990 GWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERNKAKNRGDFQKLREKQ 1054
            |||.|||:..||:|:.|.|:|||.::|:|:|||:||:||||||||:|||.:.:||..|.|||.:|
Mouse   457 GWTTVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLRRQQ 521

  Fly  1055 QIEEDLRGYLDWITQAEDIEPDAVGGLISDGKGKQPNEMDSTENLGEEMPEVQMTESRWRKMKKD 1119
            |||.:|.||..||.:||::       :::     :.|:...|..| |.:....:..||...|.:|
Mouse   522 QIERELNGYRAWIDKAEEV-------MLA-----EENKNSGTSAL-EVLRRATIKRSRTEAMTRD 573

  Fly  1120 -------------------------------FDRVNRRMRRACRKAVKSQAFYWLIIVLVFLNTG 1153
                                           |....|.:|.:.|..||||.|||:::.:|.|||.
Mouse   574 SSDEHCVDISSVGTPLARASIKSTKVDGASYFRHKERLLRISIRHMVKSQVFYWIVLSVVALNTA 638

  Fly  1154 VLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETL 1218
            .:|..|:.|..||.:...|....|:|||..||.||||.:|.:.||.|.||.||..|.:|||.|.:
Mouse   639 CVAIVHHNQPQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVV 703

  Fly  1219 LTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLG 1283
            ..........|:||||.:||||:||:||||.||.|||.||::|::||.|||.|||||||:|||||
Mouse   704 WAIFRPGTSFGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLG 768

  Fly  1284 MQVFGGKFNF-DGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIY 1347
            ||:|||:||| ||...   .|||.|..|::|||||:||||||.|||.||.:.||||| |..:.||
Mouse   769 MQLFGGRFNFNDGTPS---ANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSS-GMWSAIY 829

  Fly  1348 FIILFICGNYILLNVFLAIAVDNLADADSLSEVEKEEE-----------------------PHDE 1389
            ||:|.:.|||.||||||||||||||:|..|::.|:|||                       |..|
Mouse   830 FIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEEEAFNQKHALQKAKEVSPMSAPNMPSIE 894

  Fly  1390 SAQKKSH---------------------------------------------------------- 1396
            ..:::.|                                                          
Mouse   895 RDRRRRHHMSMWEPRSSHLRERRRRHHMSVWEQRTSQLRRHMQMSSQEALNKEEAPPMNPLNPLN 959

  Fly  1397 --SP-----------------------------------------------TPTIDGMDDHLSI- 1411
              ||                                               |..:|.....||: 
Mouse   960 PLSPLNPLNAHPSLYRRPRPIEGLALGLGLEKCEEERISRGGSLKGDIGGLTSALDNQRSPLSLG 1024

  Fly  1412 -------------DIDMEQQE-------------------------------------------- 1419
                         :.|..|||                                            
Mouse  1025 KREPPWLPRSCHGNCDPIQQEAGGGETVVTFEDRARHRQSQRRSRHRRVRTEGKDSASASRSRSA 1089

  Fly  1420 -----LDD----EDKMDHETLSDEEVREMCEEEEE----------------------VDE----- 1448
                 ||:    |.:.:||..|....:|....|||                      :||     
Mouse  1090 SQERSLDEGVSVEGEKEHEPHSSHRSKEPTIHEEERTQDLRRTNSLMVPRGSGLVGALDEAETPL 1154

  Fly  1449 -------------------------------------EGMITARP----------RRMSEVNTAT 1466
                                                 .|:..:.|          :..:|..:.|
Mouse  1155 VQPQPELEVGKDAALTEQEAEGSSEQALLGDVQLDVGRGISQSEPDLSCMTANMDKATTESTSVT 1219

  Fly  1467 KILP----------------------------------------------------IPPGTSFFL 1479
            ..:|                                                    :.|.:|.|:
Mouse  1220 VAIPDVDPLVDSTVVNISNKTDGEASPLKEAETKEEEEEVEKKKKQKKEKRETGKAMVPHSSMFI 1284

  Fly  1480 FSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDDLNKVLNKFDYFFTAVFTIE 1544
            ||.||..|..||::.|...|...||..|..||..||||:|:..|.:.||||..|||.||.|||.|
Mouse  1285 FSTTNPIRRACHYIVNLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFE 1349

  Fly  1545 LILKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISLVSSSNA--------ISVVKILRVLRVLR 1601
            :::|:|..|.:|.||::.|..:|:||.:||..:|::. :.:||        |..:|.||||||||
Mouse  1350 MVIKMIDQGLILQDGSYFRDLWNILDFVVVVGALVAF-ALANALGTNKGRDIKTIKSLRVLRVLR 1413

  Fly  1602 PLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIM 1666
            ||:.|.|...||.|..                                    |||.::|.:.||:
Mouse  1414 PLKTIKRLPKLKAVFD------------------------------------CVVTSLKNVFNIL 1442

  Fly  1667 LVTYLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDDGDVHKPRLREREWSNNRFHF 1731
            :|..|..|:||||.|||||||||.|||.||.|:.||.|.|:   |.:.:|..::.|||..:.||:
Mouse  1443 IVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEKECIGNYV---DHEKNKMEVKGREWKRHEFHY 1504

  Fly  1732 DDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVG 1796
            |::...:||||||||.||||.:|..|:|..:|:.||..:.|..::.:|::|.::..||.|||||.
Mouse  1505 DNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFVVFPFFFVNIFVA 1569

  Fly  1797 FVIVTFQNEGEQEYKNCDLDKNQRNCIEFALKAKPVRRYIP--KHGIQYKVWWFVTSSSFEYTIF 1859
            .:|:|||.:|::..:.|.|:||:|.||:||:.|||:.||:|  :|..||:||.||.|.||||||.
Mouse  1570 LIIITFQEQGDKMMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIM 1634

  Fly  1860 ILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIV 1924
            .:|.:|||.|.||:|:.|..|...|..||:.||.||:||.|.|:.||.|.|||.|.||:||||.|
Mouse  1635 AMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYFRDTWNIFDFITV 1699

  Fly  1925 LGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIR 1989
            :||..:|:.::.|..:||                  |.|:   :|.:|||..||:|||.:|..||
Mouse  1700 IGSITEIILTDSKLVNTS------------------GFNM---SFLKLFRAARLIKLLRQGYTIR 1743

  Fly  1990 TLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIALDGGNAITANNNFQTFQQAVLVLFRS 2054
            .|||||::||:|||||.|||.:||||||::||||||.|.||..:.|..:|||::|..::::||||
Mouse  1744 ILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDEESHINRHNNFRSFFGSLMLLFRS 1808

  Fly  2055 ATGEAWQEIMMSCSAQPDVKCDMNSDTP-----GEPCGSSIAYPYFISFYVLCSFLIINLFVAVI 2114
            ||||||||||:||..:..  |:.::..|     .|.||:.:||.||:||...||||::|||||||
Mouse  1809 ATGEAWQEIMLSCLGEKG--CEPDTTAPSGQNESERCGTDLAYVYFVSFIFFCSFLMLNLFVAVI 1871

  Fly  2115 MDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMAC 2179
            ||||:|||||.|||||||||||:|:|:|||..|.|||.:.::..:|..:|||||.||.||.::|.
Mouse  1872 MDNFEYLTRDSSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAY 1936

  Fly  2180 KRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIK-TDGNID--DANSELRATIKQIWKRTNPKLLD 2241
            ||||.||||:..|.||.|.:||.|::||:|.|| ..|..|  ..:|||:.....||...:.|:||
Mouse  1937 KRLVLMNMPVAEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLD 2001

  Fly  2242 QVVPPPGNDDEVTVGKFYATYLIQDYFRRFKKRKEQEGKEG----------HPDS-------NTV 2289
            .:||.|...| :||||.||..:|.||:::.|.:|:::..|.          .|.|       |..
Mouse  2002 LLVPMPKASD-LTVGKIYAAMMIMDYYKQSKVKKQRQQLEEQKNAPMFQRMEPSSLPQEIIANAK 2065

  Fly  2290 TL-------------QAGLRTLHEVSP-------ALKRAISGNLDELD-----QEPEPMHRRHHT 2329
            .|             ::|..::..:||       .:..|..|...|..     ||||....:   
Mouse  2066 ALPYLQQDPVSGLSGRSGYPSMSPLSPQEIFQLACMDPADDGQFQEQQSLVNAQEPEVSELK--- 2127

  Fly  2330 LFGSVWSSIRRHG----------NGTFRRSAKATASQSNGALAIGGSASAALGV-----GGSSLV 2379
               ||.||  .||          .|:.|.|:....:.....:....|...:...     ..||.:
Mouse  2128 ---SVQSS--NHGIYLPPDTQEHAGSGRASSMPRLTMDPQVVTDPSSMRRSFSTIRDKRSNSSWL 2187

  Fly  2380 LGSSDPAGGDYLYDTLNRSVADGVNNITRNIMQARLAA------AGKLQDELQGAGSGGELRTFG 2438
            ...|.....:..|.:..||....:          ||:|      :|...|..:   |||..|  |
Mouse  2188 EEFSMERSSENTYKSRRRSYHSSL----------RLSAHRLNSDSGHKSDTHR---SGGRER--G 2237

  Fly  2439 ESISMRPLAKNGGGAATVAGTLPPEANAINYDNRNRGILLHPYNNVYAPNGALPGHERMIQSTPA 2503
            .|...:.|             |.|:.:..|.:.|                |.....|...:....
Mouse  2238 RSKERKHL-------------LSPDVSRCNSEER----------------GTQADWESPERRQSR 2273

  Fly  2504 SPYDQR-RLPTSSDMNGLAESLIGGVLAAEGLGKYCDSEFVGTAAREMREALDMTPEEMNLAAHQ 2567
            ||.:.| :.|.......|:||.|..:            ....|..|..|:...:.|:...|.::.
Mouse  2274 SPSEGRSQTPNRQGTGSLSESSIPSI------------SDTSTPRRSRRQLPPVPPKPRPLLSYS 2326

  Fly  2568 ILSNEHSLSLIGSSNGSIFGGSAGGLGGAGSGGVGG-------LGGSSSIRNAFGGS-----GSG 2620
            .|...                 .||:.....|..||       |..:|:.......|     |..
Mouse  2327 SLMRH-----------------TGGISPPPDGSEGGSPLASQALESNSACLTESSNSLHPQQGQH 2374

  Fly  2621 PSSLSPQH---QPY------------------------------SGTLNSPP-------IPDNRL 2645
            |   ||||   :||                              |.|:.|.|       :|:...
Mouse  2375 P---SPQHYISEPYLALHEDSHASDCGEEETLTFEAAVATSLGRSNTIGSAPPLRHSWQMPNGHY 2436

  Fly  2646 RR 2647
            ||
Mouse  2437 RR 2438

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 153/276 (55%)
Ion_trans 1137..1379 CDD:395416 139/242 (57%)
Ion_trans 1496..1809 CDD:395416 130/320 (41%)
Ion_trans 1851..2126 CDD:395416 144/279 (52%)
GPHH 2135..2188 CDD:407139 28/52 (54%)
Ca_chan_IQ 2199..2271 CDD:400901 31/74 (42%)
Cacna1eXP_011246211.1 Ion_trans 235..509 CDD:366146 153/276 (55%)
Ion_trans 622..861 CDD:366146 139/242 (57%)
Ion_trans 1302..1536 CDD:366146 112/273 (41%)
Ion_trans 1626..1883 CDD:366146 144/279 (52%)
GPHH 1892..1945 CDD:374878 28/52 (54%)
Ca_chan_IQ 1956..2029 CDD:370105 31/73 (42%)
SR-25 2168..>2243 CDD:371095 18/89 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100303
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.810

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