DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ca-alpha1D and Cacna1d

DIOPT Version :9

Sequence 1:	NP_723952.2	Gene:	Ca-alpha1D / 34950	FlyBaseID:	FBgn0001991	Length:	2705	Species:	Drosophila melanogaster
Sequence 2:	XP_006518538.1	Gene:	Cacna1d / 12289	MGIID:	88293	Length:	2207	Species:	Mus musculus

Alignment Length:	2225	Identity:	1136/2225 - (51%)
Similarity:	1367/2225 - (61%)	Gaps:	403/2225 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   680 SGEGDLGGGNNI--------MGIDSMGIANIPETMNGTTIGPSGAGGQKGGAAAGAAGQKRQQ-- 734
            ||||.....|:.        ..||:...|...:||:.:...|.|:..|:          ||||
Mouse    35 SGEGPTSQPNSSKQTVLSWQAAIDAARQAKAAQTMSTSAPPPVGSLSQR----------KRQQYA 89

  Fly   735 ---RRGKPQPDRPQRALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDS 796
               ::|.....||.|||||||:.||:|..||.|||||||:..|||.|||||:|||:|.|:|..||
Mouse    90 KSKKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDS 154

  Fly   797 NVTNQTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMK 861
            |.||..||||||.||:|||.|..:||:|||.:||..||:|||||||||.||::|..|..|.||.|
Mouse   155 NSTNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTK 219

  Fly   862 D------------AFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIII 914
            :            .|||||||||||||||||||||||||||||||:||||||.||||||||||||
Mouse   220 ETEGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIII 284

  Fly   915 YAIIGLELFSGKLHKAC---RDEITGEYEENIRPC---GVGYQCPP-GYKCYGGWDGPNDGITNF 972
            |||||||||.||:||.|   ..:|..  ||:..||   |.|.||.. |.:|..||.|||.|||||
Mouse   285 YAIIGLELFIGKMHKTCFFADSDIVA--EEDPAPCAFSGNGRQCTANGTECRSGWVGPNGGITNF 347

  Fly   973 DNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKE 1037
            |||..||||||||:|:||||||||.:.||:|.:|.|:||:|::|||:|||:||:|||||||||||
Mouse   348 DNFAFAMLTVFQCITMEGWTDVLYWVNDAIGWEWPWVYFVSLIILGSFFVLNLVLGVLSGEFSKE 412

  Fly  1038 RNKAKNRGDFQKLREKQQIEEDLRGYLDWITQAEDIEP--DAVGGLISDGKGK-----QPNEMDS 1095
            |.|||.||||||||||||:||||:||||||||||||:|  :..||  .:||..     ...|..:
Mouse   413 REKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGG--EEGKRNTSMPTSETESVN 475

  Fly  1096 TENLGEEMPEVQMTESRW-------------------------RKMKKDFDRVNRRMRRACRKAV 1135
            |||:..|........:.|                         .|:.:.:.|.||..||.||.||
Mouse   476 TENVSGEGETQGCCGTLWCWWKRRGAAKTGPSGCRRWGQAISKSKLSRRWRRWNRFNRRRCRAAV 540

  Fly  1136 KSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVS 1200
            ||..||||:||||||||..:::|||.|.|||...|:..|...:.|||||||:||||||.|.||||
Mouse   541 KSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCEMLVKMYSLGLQAYFVS 605

  Fly  1201 LFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSI 1265
            ||||||||||.|.||||:|....:|.||||||.|||||||:||||::|.||||||||||||::||
Mouse   606 LFNRFDCFVVCGGITETILVELELMSPLGVSVFRCVRLLRIFKVTRHWTSLSNLVASLLNSMKSI 670

  Fly  1266 ASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVG 1330
            |||||||||||:||:|||||:||||||||..:.| |..||.|.|||||||||:||||||||||.|
Mouse   671 ASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTK-RSTFDNFPQALLTVFQILTGEDWNAVMYDG 734

  Fly  1331 INAYGGVSSYGALACIYFIILFICGNYILLNVFLAIAVDNLADADSLSEVEKEEEPHDESAQ--- 1392
            |.||||.||.|.:.||||||||||||||||||||||||||||||:||:..:|||....|..:
Mouse   735 IMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTAQKEEAEEKERKKIAR 799

  Fly  1393 ------KKSHSP-TPTIDGMDDHLSIDIDMEQQELDDEDKMDHETLSDEEVREMCEEEEEVDEEG 1450
                  ||::.| ...|...|:.::||   :.|| |.||| |.....|..|.|..|||||.:.|.
Mouse   800 KESLENKKNNKPEVNQIANSDNKVTID---DYQE-DAEDK-DPYPPCDVPVGEEEEEEEEDEPEV 859

  Fly  1451 MITARPRRMSEVNTATKILPIPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLA 1515
            ....||||:||:|...||.|||.|::||:.|:||..||.||.|.||..|.|:||..||.|||.||
Mouse   860 PAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLILVFIMLSSAALA 924

  Fly  1516 AENPLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLIS 1580
            ||:|:|::...|.:|..|||.|||:||:|::||:.::|..||.|||||:.|||||:|||.|||:|
Mouse   925 AEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLLDMLVVGVSLVS 989

  Fly  1581 LVSSSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGV 1645
            ....|:|||||||||||||||||||||||||||||||||.
Mouse   990 FGIQSSAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVF------------------------- 1029

  Fly  1646 QLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYD 1710
                       |||:||||||:||.|||||||.||||||||||::|||.:|...:||.|.:::|.
Mouse  1030 -----------VAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYK 1083

  Fly  1711 DGDVHKPRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIV 1775
            ||||..|.:|||.|.|:.|:||:|...|:.|||||||||||.|||.:||||.||.||::|:|..:
Mouse  1084 DGDVDSPVVRERIWQNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENVGPVYNYRVEI 1148

  Fly  1776 AAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQEYKNCDLDKNQRNCIEFALKAKPVRRYIPKHG 1840
            :.::||||||:||||:||||||||||||.:||:|||||:||||||.|:|:||||:|:||||||:.
Mouse  1149 SIFFIIYIIIVAFFMMNIFVGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPKNP 1213

  Fly  1841 IQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAA 1905
            .|||.|:.|.||.|||.:|:|||:||:.|||:.|.|...:.:.:|.|||:||.||.:|.|.|:.|
Mouse  1214 YQYKFWYVVNSSPFEYMMFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIA 1278

  Fly  1906 FRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDT------------SQIAECDIVEGCKSTKK 1958
            |:.|.||.||||.||.:||:||.||:..||.....|            ..:.:..|.|...|..:
Mouse  1279 FKPKGYFSDAWNTFDSLIVIGSIIDVALSEADHYFTDAWNTFDALIVVGSVVDIAITEVNPSESE 1343

  Fly  1959 -----------SAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLL 2012
                       |..||.|||.|||||||||||||||:|||||||||||||||||||||||||.:|
Mouse  1344 TIPLPTATPGNSEESNRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAML 1408

  Fly  2013 FFIYAVVGMQVFGKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDM 2077
            ||||||:|||:|||:|:...|.|..|||||||.||||:|||.||||||||||::|  .|...||.
Mouse  1409 FFIYAVIGMQMFGKVAMRDNNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLAC--LPGKLCDP 1471

  Fly  2078 NSD-TPGE--PCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRL 2139
            :|| .|||  .|||:.|..||||||:||:|||||||||||||||||||||||||||||||||.|:
Mouse  1472 DSDYNPGEEYTCGSNFAIVYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRI 1536

  Fly  2140 WSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNATLFAV 2204
            ||||||:|||||||||||||||:|.||||||||||||:||||||:|||||||||||:|||||||:
Mouse  1537 WSEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFAL 1601

  Fly  2205 VRTSLSIKTDGNIDDANSELRATIKQIWKRTNPKLLDQVVPPPGNDDEVTVGKFYATYLIQDYFR 2269
            |||:|.|||:||::.||.||||.||:|||:|:.|||||||||.| ||||||||||||:|||||||
Mouse  1602 VRTALKIKTEGNLEQANEELRAVIKKIWKKTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQDYFR 1665

  Fly  2270 RFKKRKEQEGKEGHPDSN-TVTLQAGLRTLHEVSPALKRAISGNLDELDQEPEPMHRRHHTLF-- 2331
            :|||||||.....:|..| |:.|||||||||::.|.::||||.:|.  |.|||........:|
Mouse  1666 KFKKRKEQGLVGKYPAKNTTIALQAGLRTLHDIGPEIRRAISCDLQ--DDEPEDSKPEEEDVFKR 1728

  Fly  2332 -GSVWSSIRRHGNGTFRRSAKATASQSNGALAIGGSASAALGVGGSSLVLGSS------DPAGGD 2389
             |::..:...|.|...|.|.:.|           .:....|.|...|:...|.      .|||..
Mouse  1729 NGALLGNHVNHVNSDRRDSLQQT-----------NTTHRPLHVQRPSMPPASDTEKPLFPPAGNS 1782

  Fly  2390 -----YLYDTLNRSVADGVNNITRNIMQARLA-----AAGKLQD-------------ELQGAGS- 2430
                 :.::::.:......|....|...::.|     :.|.|:.             |||...|
Mouse  1783 GCHNHHNHNSIGKQAPTSTNANLNNANMSKAAHGKPPSIGNLEHVSENGHYSCKHDRELQRRSSI 1847

  Fly  2431 ------------------------------G--------GELRTF-------------------- 2437
                                          |        ||...|
Mouse  1848 KRTRYYETYIRSESGDEQFPTICREDPEIHGYFRDPRCLGEQEYFSSEECCEDDSSPTWSRQNYN 1912

  Fly  2438 ------GESISM-RPLAKNGGGAATVAGTLPPEANAINYDNR----------------------- 2472
                  |.|:.. ||     .|.....|.|..:.:...||:|
Mouse  1913 YYNRYPGSSMDFERP-----RGYHHPQGFLEDDDSPTGYDSRRSPRRRLLPPTPPSHRRSSFNFE 1972

  Fly  2473 ------------------NRGIL-LH------------------------------------PYN 2482
                              :|..| ||                                    ||.
Mouse  1973 CLRRQSSQDDVLPSPALPHRAALPLHLMQQQIMAVAGLDSSKAQKYSPSHSTRSWATPPATPPYR 2037

  Fly  2483 N---VYAP-------------NGALPGHERMI-----------QSTPASPYDQRRLPTS-----S 2515
            :   .|.|             ||:||...|..           ..||||    ..:|:|     |
Mouse  2038 DWSPCYTPLIQVDRSESMDQVNGSLPSLHRSSWYTDEPDISYRTFTPAS----LTVPSSFRNKNS 2098

  Fly  2516 DMNGLAESLIGGVLAAEGLGKYC-DSEFVGTAAREMREALDMTPEEMNLAAHQILSNEHSLSLIG 2579
            |....|:||:..||.:||||:|. |.:||.....|:.:|.|:|.:||..||..:|
Mouse  2099 DKQRSADSLVEAVLISEGLGRYARDPKFVSATKHEIADACDLTIDEMESAASTLL---------- 2153

  Fly  2580 SSNGSIFGGSAGGLG 2594
              |||:...:.|.:|
Mouse  2154 --NGSVCPRANGDMG 2166

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1D	NP_723952.2	Ion_trans	767..1042	CDD:395416	194/293 (66%)
		Ion_trans	1137..1379	CDD:395416	180/241 (75%)
		Ion_trans	1496..1809	CDD:395416	182/312 (58%)
		Ion_trans	1851..2126	CDD:395416	178/300 (59%)
		GPHH	2135..2188	CDD:407139	45/52 (87%)
		Ca_chan_IQ	2199..2271	CDD:400901	55/71 (77%)
Cacna1d	XP_006518538.1	Ion_trans	125..417	CDD:366146	194/293 (66%)
		Ion_trans	545..780	CDD:366146	177/235 (75%)
		Ion_trans	905..1182	CDD:366146	182/312 (58%)
		Ion_trans	1224..1523	CDD:366146	178/300 (59%)
		GPHH	1532..1585	CDD:374878	45/52 (87%)
		Ca_chan_IQ	1596..1667	CDD:370105	55/71 (77%)
		CAC1F_C	1690..2206	CDD:374867	102/511 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	383	1.000	Domainoid score	I823
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H578
Inparanoid	1	1.050	2021	1.000	Inparanoid score	I52
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48156
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	1	1.000	-	-		FOG0000179
OrthoInspector	1	1.000	-	-		otm43218
orthoMCL	1	0.900	-	-		OOG6_100303
Panther	1	1.100	-	-	LDO	PTHR45628
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R175
SonicParanoid	1	1.000	-	-		X533
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	13.010