DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ca-alpha1D and Cacna1c

DIOPT Version :9

Sequence 1:	NP_723952.2	Gene:	Ca-alpha1D / 34950	FlyBaseID:	FBgn0001991	Length:	2705	Species:	Drosophila melanogaster
Sequence 2:	XP_036021662.1	Gene:	Cacna1c / 12288	MGIID:	103013	Length:	2245	Species:	Mus musculus

Alignment Length:	2291	Identity:	1133/2291 - (49%)
Similarity:	1393/2291 - (60%)	Gaps:	423/2291 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   606 EDVDEYFEEEEDDTQAFSPFYSSSAELIDNFGGGAGKFFNIMDFERGASGEGGFSPNGNGGPGSG 670
            |:.:..|:.:.......:.||.|...  .|:|.......|:     .|:...|.:|.....||:.
Mouse    22 EETERKFKGKVVHEAQLNCFYISPGG--SNYGSPRPAHANM-----NANAAAGLAPEHIPTPGAA 79

  Fly   671 -------DVSRTARYDSGEGDLGGGNNIMGIDSMGIANIPETMNGTTIGPSGAGGQKGGAAAGAA 728
                   |.:|.|:             :||  |.|.|.| .|::.|
Mouse    80 LSWQAAIDAARQAK-------------LMG--SAGNATI-STVSST------------------- 109

  Fly   729 GQKRQQRRGKPQPD------RPQRALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAV 787
             |:::|:.|||:..      ||.|||.||::|||:|..||.||||||||.:|||||||||:|||:
Mouse   110 -QRKRQQYGKPKKQGGTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAI 173

  Fly   788 YTPYPGSDSNVTNQTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAI 852
            |.|:|..|||.||..||:|||:||:|||.|..:|::|||.:.|..||||||||||||.|||:|..
Mouse   174 YIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLF 238

  Fly   853 STALSQLMK-----------DAFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIAL 906
            |..|.|..|           ..|||||||||||||||||||||||||||||||:||||||.||||
Mouse   239 SAILEQATKADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIAL 303

  Fly   907 LVLFVIIIYAIIGLELFSGKLHKACRDE---ITGEYEENIRPC----GVGYQCPPGYKCYGGWDG 964
            |||||||||||||||||.||:||.|.::   |....||:..||    |.|.||..|..|..||||
Mouse   304 LVLFVIIIYAIIGLELFMGKMHKTCYNQEGIIDVPAEEDPSPCALETGHGRQCQNGTVCKPGWDG 368

  Fly   965 PNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGV 1029
            |..||||||||..||||||||:|:||||||||.:|||||.:..|:||:|:||.|:|||:||:|||
Mouse   369 PKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGV 433

  Fly  1030 LSGEFSKERNKAKNRGDFQKLREKQQIEEDLRGYLDWITQAEDIEPD---------------AVG 1079
            |||||||||.|||.||||||||||||:||||:||||||||||||:|:               |..
Mouse   434 LSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEGMDEDKPRNRGAPA 498

  Fly  1080 GLISDGKGK--------------QPNEMDST------------ENLGEEMPEVQMTESR----WR 1114
            ||....|||              ..:|.:|.            ||.|..:.. ::::|:    ||
Mouse   499 GLHDQKKGKFAWFSHSTETHVSMPTSETESVNTENVAGGDIEGENCGARLAH-RISKSKFSRYWR 562

  Fly  1115 KMKKDFDRVNRRMRRACRKAVKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIG 1179
                   |.||..||.||.||||..||||:|.||||||..:|:|||.|..||...|:..|...:.
Mouse   563 -------RWNRFCRRKCRAAVKSNVFYWLVIFLVFLNTLTIASEHYNQPHWLTEVQDTANKALLA 620

  Fly  1180 LFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKV 1244
            |||.||||||||||.|.||||||||||||:|.|.|.||:|..|.:|.|||:||||||||||:||:
Mouse   621 LFTAEMLLKMYSLGLQAYFVSLFNRFDCFIVCGGILETILVETKIMSPLGISVLRCVRLLRIFKI 685

  Fly  1245 TKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEKYRMNFDCFWQ 1309
            |:||.||||||||||||::|||||||||||||:||:|||||:||||||||..:.: |..||.|.|
Mouse   686 TRYWNSLSNLVASLLNSVRSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDEMQTR-RSTFDNFPQ 749

  Fly  1310 ALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYILLNVFLAIAVDNLADA 1374
            :|||||||:||||||:|||.||.||||.|..|.|.||||||||||||||||||||||||||||||
Mouse   750 SLLTVFQILTGEDWNSVMYDGIMAYGGPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADA 814

  Fly  1375 DSLSEVEKEEEPH---------------------------DESAQKKSHSPTPTIDGMDDHLSID 1412
            :||:..:||||..                           :||.::|....:.|.|| :...:..
Mouse   815 ESLTSAQKEEEEEKERKKLARPARTASPEKKQEVMEKPAVEESKEEKIELKSITADG-ESPPTTK 878

  Fly  1413 IDMEQ-QELDDEDKMDHETLSDEEVREMCEEEEEVDEEGMITARPRRMSEVNTATKILPIPPGTS 1476
            |:|:. |..::|||..|..      .:...||:|.:.|..:..|||.:||::...|.:|:|..::
Mouse   879 INMDDLQPSENEDKSPHSN------PDTAGEEDEEEPEMPVGPRPRPLSELHLKEKAVPMPEASA 937

  Fly  1477 FFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDDLN-------------- 1527
            ||:||..||||:.||.:.|.:.|.|:||..|:.||..||||:|::.....|
Mouse   938 FFIFSPNNRFRLQCHRIVNDTIFTNLILFFILLSSISLAAEDPVQHTSFRNHILFYFDIVFTTIF 1002

  Fly  1528 ------KVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISLVSSSN 1586
                  |:|...||.||::||:|:|||:.:||..||.|:|||:.||:||||||.|||||....|:
Mouse  1003 TIEIALKILGNADYVFTSIFTLEIILKMTAYGAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSS 1067

  Fly  1587 AISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYV 1651
            ||:||||||||||||||||||||||||||||||.||::||||||:||.|||||||
Mouse  1068 AINVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTTLLQFMFA---------- 1122

  Fly  1652 VKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDDGDVHK 1716
              |                        |||||||||.:.|:|.||.|:.||.|.|:.|.||:|..
Mouse  1123 --C------------------------IGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDH 1161

  Fly  1717 PRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYII 1781
            |.::.|.|.|::|.||:|...|:.|||||||||||.|||.||||:.|:.|||:|:|..::.::||
Mouse  1162 PIIQPRSWENSKFDFDNVLAAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFII 1226

  Fly  1782 YIIIIAFFMVNIFVGFVIVTFQNEGEQEYKNCDLDKNQRNCIEFALKAKPVRRYIPKHGIQYKVW 1846
            |||||||||:||||||||||||.:||||||||:||||||.|:|:||||:|:||||||:..|||||
Mouse  1227 YIIIIAFFMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQHQYKVW 1291

  Fly  1847 WFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNY 1911
            :.|.|:.|||.:|:||::||:.|||:.|.|...:...::.|||:||.:|.:|.:.||.||:.|.|
Mouse  1292 YVVNSTYFEYLMFVLILLNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGY 1356

  Fly  1912 FGDAWNVFDFIIVLGSFIDIVYSEIKSK--DTSQIAECDIVEG-----------------CKSTK 1957
            |.|.||||||:||:||.||::.||....  |.....:..||.|                 |..:.
Mouse  1357 FSDPWNVFDFLIVIGSIIDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVHPAEHTQCSPSM 1421

  Fly  1958 KSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQ 2022
            .:..::.|||.|||||||||||||||:||||||||||||||||||||||||||:|||||||:|||
Mouse  1422 SAEENSRISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQ 1486

  Fly  2023 VFGKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKC----DMNSDTPG 2083
            |||||||:....|..|||||||.||||:|||.|||||||:||::|  .|..||    :.::.|.|
Mouse  1487 VFGKIALNDTTEINRNNNFQTFPQAVLLLFRCATGEAWQDIMLAC--MPGKKCAPESEPSNSTEG 1549

  Fly  2084 E-PCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDA 2147
            | |||||.|..||||||:||:|||||||||||||||||||||||||||||||||.|:|:||||:|
Mouse  1550 ETPCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEA 1614

  Fly  2148 KGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIK 2212
            ||||||||||||||:|.||||||||||||:||||||||||||||||||:|||||||:|||:|.||
Mouse  1615 KGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIK 1679

  Fly  2213 TDGNIDDANSELRATIKQIWKRTNPKLLDQVVPPPGNDDEVTVGKFYATYLIQDYFRRFKKRKEQ 2277
            |:||::.||.||||.||:|||||:.|||||||||.| ||||||||||||:|||:|||:|||||||
Mouse  1680 TEGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAG-DDEVTVGKFYATFLIQEYFRKFKKRKEQ 1743

  Fly  2278 EGKEGHPDS-NTVTLQAGLRTLHEVSPALKRAISGNL---DELDQ---------EPEPMHRRHHT 2329
             |..|.|.. |.::|||||||||::.|.::|||||:|   :|||:         ..:.:.||...
Mouse  1744 -GLVGKPSQRNALSLQAGLRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVSAASEDDIFRRAGG 1807

  Fly  2330 LFG---SVWSS-----------------IRRHGN---------------GTFRRSA-KATASQSN 2358
            |||   :.:.|                 |.:.||               .||..|: .:|.|.:|
Mouse  1808 LFGNHVTYYQSDSRGNFPQTFATQRPLHINKTGNNQADTESPSHEKLVDSTFTPSSYSSTGSNAN 1872

  Fly  2359 GALAIGGSASAALG-----VGGSSLV----------------------LGSSDPAGGDYLYDTLN 2396
                |..:.:.|||     .|.||.|                      |.|......:....|:|
Mouse  1873 ----INNANNTALGRFPHPAGYSSTVSTVEGHGPPLSPAVRVQEAAWKLSSKRCHSRESQGATVN 1933

  Fly  2397 RSVADGVNNITRNIMQARLAAAGKL---------QDELQGAGSGGE---------LRTFGESISM 2443
            :.:........|...:|...:...|         :||.:......|         .|:|..|.|:
Mouse  1934 QEIFPDETRSVRMSEEAEYCSEPSLLSTDMFSYQEDEHRQLTCPEEDKREIQPSPKRSFLRSASL 1998

  Fly  2444 RPLA----------KNGGG----------------AATVAG------------TLPPEANAINYD 2470
            ...|          |:.||                |..|||            |.|.........
Mouse  1999 GRRASFHLECLKRQKDQGGDISQKTALPLHLVHHQALAVAGLSPLLQRSHSPTTFPRPCPTPPVT 2063

  Fly  2471 NRNRGILLHPYNNVYAPNGALPG---HERMIQSTP----------------ASPYDQRRLPTS-- 2514
            ..:||..|.|     .|...|.|   .|::..|.|                :|...:|..|.|
Mouse  2064 PGSRGRPLRP-----IPTLRLEGAESSEKLNSSFPSIHCSSWSEETTACSGSSSMARRARPVSLT 2123

  Fly  2515 ---------SDMNGLAESLIGGVLAAEGLGKYC-DSEFVGTAAREMREALDMTPEEMNLAAHQIL 2569
                     ...:|.|.||:..||.:||||::. |.:|:....:|:.:|.|||.|||..||..||
Mouse  2124 VPSQAGAPGRQFHGSASSLVEAVLISEGLGQFAQDPKFIEVTTQELADACDMTIEEMENAADNIL 2188

  Fly  2570 SNEHSLSLIGSSNGSI 2585
            |.    ....|.||::
Mouse  2189 SG----GAQQSPNGTL 2200

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1D	NP_723952.2	Ion_trans	767..1042	CDD:395416	195/292 (67%)
		Ion_trans	1137..1379	CDD:395416	175/241 (73%)
		Ion_trans	1496..1809	CDD:395416	177/332 (53%)
		Ion_trans	1851..2126	CDD:395416	175/298 (59%)
		GPHH	2135..2188	CDD:407139	45/52 (87%)
		Ca_chan_IQ	2199..2271	CDD:400901	55/71 (77%)
Cacna1c	XP_036021662.1	Ion_trans	153..446	CDD:395416	195/292 (67%)
		Ion_trans	578..819	CDD:395416	175/241 (73%)
		Ion_trans	957..1254	CDD:395416	177/332 (53%)
		Ion_trans	1296..1593	CDD:395416	175/298 (59%)
		GPHH	1602..1655	CDD:407139	45/52 (87%)
		Ca_chan_IQ	1666..1737	CDD:400901	55/71 (77%)
		CAC1F_C	1759..2194	CDD:407123	103/447 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	383	1.000	Domainoid score	I823
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2021	1.000	Inparanoid score	I52
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48156
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	1	1.000	-	-		FOG0000179
OrthoInspector	1	1.000	-	-		otm43218
orthoMCL	1	0.900	-	-		OOG6_100303
Panther	1	1.100	-	-	O	PTHR45628
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R175
SonicParanoid	1	1.000	-	-		X533
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.010