DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and Cacna1b

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:XP_006497689.1 Gene:Cacna1b / 12287 MGIID:88296 Length:2351 Species:Mus musculus


Alignment Length:2521 Identity:871/2521 - (34%)
Similarity:1156/2521 - (45%) Gaps:700/2521 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   631 ELIDNFGGGAGKFFNIMDFERGASGEGGFSPNGNGGPGSGDVSRTARYDSGEGDLGGGNNIMGID 695
            ||...:||..|.       ||...|..|    |.|||             |:|.|..|..::...
Mouse     7 ELGGRYGGTGGG-------ERARGGGAG----GAGGP-------------GQGGLPPGQRVLYKQ 47

  Fly   696 S-------MGIAN-IPETMNGTTIGPSGAGGQKGGAAAGAAGQKRQQRRGKPQPDRPQRALFCLS 752
            |       |.:.| ||...|..|:                                 .|:||..|
Mouse    48 SIAQRARTMALYNPIPVKQNCFTV---------------------------------NRSLFVFS 79

  Fly   753 VKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVIFTAE 817
            ..|.:|....||.||.|||::||.||.||||.||:....|..|....::.|:..|..|:.||..|
Mouse    80 EDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFE 144

  Fly   818 CVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAFRVLRPLRLVS 882
            ..:||:|.|||.|.|:|||||||::||.:|:.|.::||.:.     ||::.|||.||||||:|||
Mouse   145 AGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTD-----FDLRTLRAVRVLRPLKLVS 204

  Fly   883 GVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDEITGEYEENIRPCG 947
            |:|||||||.||:||||||..|.||:.|.|:::||||||.:.||.||||....|........|||
Mouse   205 GIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDTEPVGDFPCG 269

  Fly   948 VGYQCPPGYKCYGG------WDGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDW 1006
               :.||..:|.|.      |.|||.|||||||...|:||||||:|:|||||:||:..||.|:.|
Mouse   270 ---KDPPARQCDGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTW 331

  Fly  1007 QWMYFISMVILGAFFVMNLILGVLSGEFSKERNKAKNRGDFQKLREKQQIEEDLRGYLDWITQAE 1071
            .|:|||.::|:|:||::||:||||||||:|||.:.:||..|.|||.:||||.:|.|||:||.:||
Mouse   332 NWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAE 396

  Fly  1072 DI------------EP-DAVGGLISDGKGKQPNEMDSTEN----------LGEEMPEVQM----T 1109
            ::            .| |||  |......|..|::...|.          :|.......:    |
Mouse   397 EVMLAEEDKNAEEKSPLDAV--LKRAATKKSRNDLIHAEEGEDRFVDLCAVGSPFARASLKSGKT 459

  Fly  1110 ESRWRKMKKDFDRVNRRMRRACRKAVKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQEYTN 1174
            ||     ...|.|..:..|...|:.||:|:|||:::.:|.|||..:|..||.|...|.....:..
Mouse   460 ES-----SSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPQRLTTALYFAE 519

  Fly  1175 VFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLL 1239
            ..|:|||..||.||||.||.:.||.|.||.||..|::|||.|.:..........|:||||.:|||
Mouse   520 FVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSIFEVVWAAIKPGTSFGISVLRALRLL 584

  Fly  1240 RVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEKYRMNF 1304
            |:|||||||.||.|||.|||||::||.|||.|||||||:|||||||:|||:|||  ::|....||
Mouse   585 RIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF--QDETPTTNF 647

  Fly  1305 DCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYILLNVFLAIAVD 1369
            |.|..|:||||||:||||||||||.||.:.||||. |..:..|||:|.:.|||.|||||||||||
Mouse   648 DTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSK-GMFSSFYFIVLTLFGNYTLLNVFLAIAVD 711

  Fly  1370 NLADADSLSEVEKEEE------------------------------------------------- 1385
            |||:|..|::.|:|.|                                                 
Mouse   712 NLANAQELTKDEEEMEEAANQKLALQKAKEVAEVSPMSAANISIAAFVKQTRGTVSRSSSVSSVN 776

  Fly  1386 -PHDESAQK----------------------------------------------KSHSPTPTI- 1402
             |..:::.|                                              |:|...|.: 
Mouse   777 SPRQQNSAKARSVWEQRASQLRLQNLRASCEALYSEMDPEERLRYASTRHVRPDMKTHMDRPLVV 841

  Fly  1403 -----------------DGMDDHLSIDIDMEQQELDDEDKMD----------------------- 1427
                             :|.:...|.|:........|.||..                       
Mouse   842 EPGRDGLRGPVGSKSKPEGTEATESADLPRRHHRHRDRDKTSATAPAGGEQDRTESTETGAREER 906

  Fly  1428 --------------------------HETLSDEEV------------------------------ 1436
                                      |...|.||.                              
Mouse   907 ARPRRSHSKETPGADTQVRCERSRRHHRRGSPEEATEREPRRHRAHRHAQDSSKEGTAPVLVPKG 971

  Fly  1437 ----------------------------------------REMCEEE------------------ 1443
                                                    ||..|:|                  
Mouse   972 ERRARHRGPRTGPREAENNEEPTRRHRARHKVPPTLQPPEREAAEKESNAVEGDKETRNHQPKEP 1036

  Fly  1444 ------------------------------EEVDEEGMITARPRRMSEVNTATKI---------- 1468
                                          |:.|.:..:|....:.|:.:|...:          
Mouse  1037 HCDLEAIAVTGVGPLHMLPSTCLQKVDEQPEDADNQRNVTRMGSQPSDPSTTVHVPVTLTGPPGE 1101

  Fly  1469 -------------------------------LPIPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNI 1502
                                           .||.|.:|.|..|.||..|.|||::.....|..:
Mouse  1102 TPVVPSGNMNLEGQAEGKKEAEADDVLRRGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEMV 1166

  Fly  1503 ILCCIMFSSAMLAAENPLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFN 1567
            ||..|..||..||||:|:|.:...|..|...||.||.|||.|:::|:|..|.:||.||:.|..:|
Mouse  1167 ILVVIALSSIALAAEDPVRTDSFRNNALKYMDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWN 1231

  Fly  1568 LLDLLVVCVSLISLVSSS-------NAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKT 1625
            :||.:||..:|::...||       ..|:.:|.||||||||||:.|.|...||.|..        
Mouse  1232 ILDFIVVSGALVAFAFSSFMGGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFD-------- 1288

  Fly  1626 IGNIVLVTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFK 1690
                                        |||.::|.:.||::|..|..|:||||.|||||||||.
Mouse  1289 ----------------------------CVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFY 1325

  Fly  1691 CTDGSKMTQDECYGTYLVYDDGDVHKPRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLY 1755
            |||.||..:.:|.|.||.|:..:|   ..:.|:|....||:|:|...:||||||||.||||.:|.
Mouse  1326 CTDESKELERDCRGQYLDYEKEEV---EAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLK 1387

  Fly  1756 VSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQEYKNCDLDKNQR 1820
            .|:|:..|..||...||..::.:|::|.::..||.|||||..:|:|||.:|::....|.|:||:|
Mouse  1388 HSVDATYEEQGPSPGFRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNER 1452

  Fly  1821 NCIEFALKAKPVRRYIP--KHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTEL 1883
            .||:||:.|||:.||:|  |...|||.|.||.|..|||.|..:|.:|||.|.||||:.|..|..:
Mouse  1453 ACIDFAISAKPLTRYMPQNKQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELM 1517

  Fly  1884 LDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECD 1948
            |..||::||::|::|.:.|:.||...|||.||||||||:.||||..||:.:|        |||. 
Mouse  1518 LKCLNIVFTSMFSMECILKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTE--------IAET- 1573

  Fly  1949 IVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLF 2013
                         :|.|:::|.||||..||:|||.:|..||.|||||::||:|||||.|||.:||
Mouse  1574 -------------NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLF 1625

  Fly  2014 FIYAVVGMQVFGKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMN 2078
            ||||::||||||.||||...:|..:|||:||.||:::||||||||||.|||:||..  :..||.:
Mouse  1626 FIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLG--NRACDPH 1688

  Fly  2079 SDTPGEPCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEY 2143
            ::  ...|||..||.||:||..|||||::|||||||||||:|||||.|||||||||||||:|:||
Mouse  1689 AN--ASECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEY 1751

  Fly  2144 DPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPL-NSDGTVLFNATLFAVVRT 2207
            ||.|.|||.:.|:..:|:.:|||||.||.||.|:|.||||.||||: |.|.||.|.:||.|::||
Mouse  1752 DPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRT 1816

  Fly  2208 SLSIK-----TDGNIDDANSELRATIKQIWKRTNPKLLDQVVPPPGNDDEVTVGKFYATYLIQDY 2267
            :|.||     |..:..||  |||..|..:|.....|.||.:| ||...||:||||.||..:|.|:
Mouse  1817 ALEIKLAPAGTKQHQCDA--ELRKEISSVWANLPQKTLDLLV-PPHKPDEMTVGKVYAALMIFDF 1878

  Fly  2268 FRRFKKRKEQ--EGKEGHPDSNTVTLQAGLR-TLHEVSPALKRAISGNLDELDQEPEPMHRRHHT 2329
            :::.|..::|  :...|......|:|...|: ||.:..||:.|                      
Mouse  1879 YKQNKTTRDQTHQAPGGLSQMGPVSLFHPLKATLEQTQPAVLR---------------------- 1921

  Fly  2330 LFGSVWSSIRRHGNGTFRRSAKATASQSNGALAIGGS-------------------ASAALGVGG 2375
                        |...|.|...||:..:.||:....|                   |.|.|..|.
Mouse  1922 ------------GARVFLRQKSATSLSNGGAIQTQESGIKESLSWGTQRTQDALYEARAPLERGH 1974

  Fly  2376 SS-LVLGSSDPAGGDYLYDTLNRSVADGVNNITRNIMQARLAAAGKLQDELQGAGSGGELRTFGE 2439
            |: :.:|.|.....|.....:.....||....... .|.|.|:..:|..|.|.|.:...::....
Mouse  1975 SAEIPVGQSGTLAVDVQMQNMTLRGPDGEPQPGLE-SQGRAASMPRLAAETQPAPNASPMKRSIS 2038

  Fly  2440 SISMRPLAKNGGGAATVAGTLPPEANAINY---------DNRNRGILLHPYNNVYAPNGALPGHE 2495
            :::.||   :|....:.....||.:.|.::         |.:.|.:...|..:| .|.||     
Mouse  2039 TLAPRP---HGTQLCSTVLDRPPPSQASHHHHHRCHRRRDKKQRSLEKGPSLSV-DPEGA----- 2094

  Fly  2496 RMIQSTPASP---------------------YDQRRLPTSSDMNGLAESLIGGVLAAEGLGKYCD 2539
               .||.|.|                     ..:||.|:||              ::|....|..
Mouse  2095 ---PSTAAGPGLPHGEGSTACRRDRKQERGRSQERRQPSSS--------------SSEKQRFYSC 2142

  Fly  2540 SEFVGTAAREMREALDMTPEE----MNLAAHQILSNEHSLSLIGSSNGSIFGGSAGGLGGAGSGG 2600
            ..|......::..:|...|..    :..|.|.            ..:||:.|.......||.:.|
Mouse  2143 DRFGSREPPQLMPSLSSHPTSPTAALEPAPHP------------QGSGSVNGSPLMSTSGASTPG 2195

  Fly  2601 VGG------------------LGGSSSIRNAFGGSG---SGPSSLS-------------PQHQPY 2631
            .||                  ...||.:..|.|.||   ..|..||             |..||.
Mouse  2196 RGGRRQLPQTPLTPRPSITYKTANSSPVHFAEGQSGLPAFSPGRLSRGLSEHNALLQKEPLSQPL 2260

  Fly  2632 S--GTLNSPPIPDNRLRRVATVTT-------------TNNNNKSQVSQNNS 2667
            :  ..:.|.|....||...|:..|             ||:...|:.|..:|
Mouse  2261 APGSRIGSDPYLGQRLDSEASAHTLPEDTLTFEEAVATNSGRSSRTSYVSS 2311

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 149/280 (53%)
Ion_trans 1137..1379 CDD:395416 140/241 (58%)
Ion_trans 1496..1809 CDD:395416 128/319 (40%)
Ion_trans 1851..2126 CDD:395416 148/274 (54%)
GPHH 2135..2188 CDD:407139 32/52 (62%)
Ca_chan_IQ 2199..2271 CDD:400901 32/76 (42%)
Cacna1bXP_006497689.1 Ion_trans 94..367 CDD:366146 149/280 (53%)
Ion_trans 482..721 CDD:366146 140/241 (58%)
Granin <936..>1041 CDD:279595 7/104 (7%)
Ion_trans 1161..1395 CDD:366146 109/272 (40%)
Ion_trans 1485..1734 CDD:366146 148/274 (54%)
GPHH 1743..1796 CDD:374878 32/52 (62%)
Ca_chan_IQ 1808..1882 CDD:370105 32/76 (42%)
PHA03307 1959..>2326 CDD:223039 77/392 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100303
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.820

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