Protein Alignment Ca-alpha1D and Cacna1b

DIOPT Version :10

• Sequence 1: NP_723952.2
• Gene: Ca-alpha1D / 34950
• FlyBaseID: FBgn0001991
• Length: 2705
• Species: Drosophila melanogaster
• Sequence 2: XP_006497689.1
• Gene: Cacna1b / 12287
• MGIID: 88296
• Length: 2351
• Species: Mus musculus
• Alignment Length: 2521
• Identity: 871/2521 - (34%)
• Similarity: 1156/2521 - (45%)
• Gaps: 700/2521 - (27%)

  Fly   631 ELIDNFGGGAGKFFNIMDFERGASGEGGFSPNGNGGPGSGDVSRTARYDSGEGDLGGGNNIMGID 695
            ||...:||..|.       ||...|..|    |.|||             |:|.|..|..::...
Mouse     7 ELGGRYGGTGGG-------ERARGGGAG----GAGGP-------------GQGGLPPGQRVLYKQ 47

  Fly   696 S-------MGIAN-IPETMNGTTIGPSGAGGQKGGAAAGAAGQKRQQRRGKPQPDRPQRALFCLS 752
            |       |.:.| ||...|..|:                                 .|:||..|
Mouse    48 SIAQRARTMALYNPIPVKQNCFTV---------------------------------NRSLFVFS 79

  Fly   753 VKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVIFTAE 817
            ..|.:|....||.||.|||::||.||.||||.||:....|..|....::.|:..|..|:.||..|
Mouse    80 EDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFIGIFCFE 144

  Fly   818 CVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAFRVLRPLRLVS 882
            ..:||:|.|||.|.|:|||||||::||.:|:.|.::||.:.     ||::.|||.||||||:|||
Mouse   145 AGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILATAGTD-----FDLRTLRAVRVLRPLKLVS 204

  Fly   883 GVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDEITGEYEENIRPCG 947
            |:|||||||.||:||||||..|.||:.|.|:::||||||.:.||.||||....|........|||
Mouse   205 GIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACFPNSTDTEPVGDFPCG 269

  Fly   948 VGYQCPPGYKCYGG------WDGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDW 1006
               :.||..:|.|.      |.|||.|||||||...|:||||||:|:|||||:||:..||.|:.|
Mouse   270 ---KDPPARQCDGDTECREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGNTW 331

  Fly  1007 QWMYFISMVILGAFFVMNLILGVLSGEFSKERNKAKNRGDFQKLREKQQIEEDLRGYLDWITQAE 1071
            .|:|||.::|:|:||::||:||||||||:|||.:.:||..|.|||.:||||.:|.|||:||.:||
Mouse   332 NWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERELNGYLEWIFKAE 396

  Fly  1072 DI------------EP-DAVGGLISDGKGKQPNEMDSTEN----------LGEEMPEVQM----T 1109
            ::            .| |||  |......|..|::...|.          :|.......:    |
Mouse   397 EVMLAEEDKNAEEKSPLDAV--LKRAATKKSRNDLIHAEEGEDRFVDLCAVGSPFARASLKSGKT 459

  Fly  1110 ESRWRKMKKDFDRVNRRMRRACRKAVKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQEYTN 1174
            ||     ...|.|..:..|...|:.||:|:|||:::.:|.|||..:|..||.|...|.....:..
Mouse   460 ES-----SSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYNQPQRLTTALYFAE 519

  Fly  1175 VFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLL 1239
            ..|:|||..||.||||.||.:.||.|.||.||..|::|||.|.:..........|:||||.:|||
Mouse   520 FVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSIFEVVWAAIKPGTSFGISVLRALRLL 584

  Fly  1240 RVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEKYRMNF 1304
            |:|||||||.||.|||.|||||::||.|||.|||||||:|||||||:|||:|||  ::|....||
Mouse   585 RIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNF--QDETPTTNF 647

  Fly  1305 DCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYILLNVFLAIAVD 1369
            |.|..|:||||||:||||||||||.||.:.||||. |..:..|||:|.:.|||.|||||||||||
Mouse   648 DTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSK-GMFSSFYFIVLTLFGNYTLLNVFLAIAVD 711

  Fly  1370 NLADADSLSEVEKEEE------------------------------------------------- 1385
            |||:|..|::.|:|.|
Mouse   712 NLANAQELTKDEEEMEEAANQKLALQKAKEVAEVSPMSAANISIAAFVKQTRGTVSRSSSVSSVN 776

  Fly  1386 -PHDESAQK----------------------------------------------KSHSPTPTI- 1402
             |..:::.|                                              |:|...|.:
Mouse   777 SPRQQNSAKARSVWEQRASQLRLQNLRASCEALYSEMDPEERLRYASTRHVRPDMKTHMDRPLVV 841

  Fly  1403 -----------------DGMDDHLSIDIDMEQQELDDEDKMD----------------------- 1427
                             :|.:...|.|:........|.||..
Mouse   842 EPGRDGLRGPVGSKSKPEGTEATESADLPRRHHRHRDRDKTSATAPAGGEQDRTESTETGAREER 906

  Fly  1428 --------------------------HETLSDEEV------------------------------ 1436
                                      |...|.||.
Mouse   907 ARPRRSHSKETPGADTQVRCERSRRHHRRGSPEEATEREPRRHRAHRHAQDSSKEGTAPVLVPKG 971

  Fly  1437 ----------------------------------------REMCEEE------------------ 1443
                                                    ||..|:|
Mouse   972 ERRARHRGPRTGPREAENNEEPTRRHRARHKVPPTLQPPEREAAEKESNAVEGDKETRNHQPKEP 1036

  Fly  1444 ------------------------------EEVDEEGMITARPRRMSEVNTATKI---------- 1468
                                          |:.|.:..:|....:.|:.:|...:
Mouse  1037 HCDLEAIAVTGVGPLHMLPSTCLQKVDEQPEDADNQRNVTRMGSQPSDPSTTVHVPVTLTGPPGE 1101

  Fly  1469 -------------------------------LPIPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNI 1502
                                           .||.|.:|.|..|.||..|.|||::.....|..:
Mouse  1102 TPVVPSGNMNLEGQAEGKKEAEADDVLRRGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFEMV 1166

  Fly  1503 ILCCIMFSSAMLAAENPLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFN 1567
            ||..|..||..||||:|:|.:...|..|...||.||.|||.|:::|:|..|.:||.||:.|..:|
Mouse  1167 ILVVIALSSIALAAEDPVRTDSFRNNALKYMDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDLWN 1231

  Fly  1568 LLDLLVVCVSLISLVSSS-------NAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKT 1625
            :||.:||..:|::...||       ..|:.:|.||||||||||:.|.|...||.|..
Mouse  1232 ILDFIVVSGALVAFAFSSFMGGSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFD-------- 1288

  Fly  1626 IGNIVLVTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFK 1690
                                        |||.::|.:.||::|..|..|:||||.|||||||||.
Mouse  1289 ----------------------------CVVNSLKNVLNILIVYMLFMFIFAVIAVQLFKGKFFY 1325

  Fly  1691 CTDGSKMTQDECYGTYLVYDDGDVHKPRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLY 1755
            |||.||..:.:|.|.||.|:..:|   ..:.|:|....||:|:|...:||||||||.||||.:|.
Mouse  1326 CTDESKELERDCRGQYLDYEKEEV---EAQPRQWKKYDFHYDNVLWALLTLFTVSTGEGWPMVLK 1387

  Fly  1756 VSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQEYKNCDLDKNQR 1820
            .|:|:..|..||...||..::.:|::|.::..||.|||||..:|:|||.:|::....|.|:||:|
Mouse  1388 HSVDATYEEQGPSPGFRMELSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKVMSECSLEKNER 1452

  Fly  1821 NCIEFALKAKPVRRYIP--KHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTEL 1883
            .||:||:.|||:.||:|  |...|||.|.||.|..|||.|..:|.:|||.|.||||:.|..|..:
Mouse  1453 ACIDFAISAKPLTRYMPQNKQSFQYKTWTFVVSPPFEYFIMAMIALNTVVLMMKFYDAPYEYELM 1517

  Fly  1884 LDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECD 1948
            |..||::||::|::|.:.|:.||...|||.||||||||:.||||..||:.:|        |||.
Mouse  1518 LKCLNIVFTSMFSMECILKIIAFGVLNYFRDAWNVFDFVTVLGSITDILVTE--------IAET- 1573

  Fly  1949 IVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLF 2013
                         :|.|:::|.||||..||:|||.:|..||.|||||::||:|||||.|||.:||
Mouse  1574 -------------NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLF 1625

  Fly  2014 FIYAVVGMQVFGKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMN 2078
            ||||::||||||.||||...:|..:|||:||.||:::||||||||||.|||:||..  :..||.:
Mouse  1626 FIYAIIGMQVFGNIALDDDTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLG--NRACDPH 1688

  Fly  2079 SDTPGEPCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEY 2143
            ::  ...|||..||.||:||..|||||::|||||||||||:|||||.|||||||||||||:|:||
Mouse  1689 AN--ASECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFIRVWAEY 1751

  Fly  2144 DPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPL-NSDGTVLFNATLFAVVRT 2207
            ||.|.|||.:.|:..:|:.:|||||.||.||.|:|.||||.||||: |.|.||.|.:||.|::||
Mouse  1752 DPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTSTLMALIRT 1816

  Fly  2208 SLSIK-----TDGNIDDANSELRATIKQIWKRTNPKLLDQVVPPPGNDDEVTVGKFYATYLIQDY 2267
            :|.||     |..:..||  |||..|..:|.....|.||.:| ||...||:||||.||..:|.|:
Mouse  1817 ALEIKLAPAGTKQHQCDA--ELRKEISSVWANLPQKTLDLLV-PPHKPDEMTVGKVYAALMIFDF 1878

  Fly  2268 FRRFKKRKEQ--EGKEGHPDSNTVTLQAGLR-TLHEVSPALKRAISGNLDELDQEPEPMHRRHHT 2329
            :::.|..::|  :...|......|:|...|: ||.:..||:.|
Mouse  1879 YKQNKTTRDQTHQAPGGLSQMGPVSLFHPLKATLEQTQPAVLR---------------------- 1921

  Fly  2330 LFGSVWSSIRRHGNGTFRRSAKATASQSNGALAIGGS-------------------ASAALGVGG 2375
                        |...|.|...||:..:.||:....|                   |.|.|..|.
Mouse  1922 ------------GARVFLRQKSATSLSNGGAIQTQESGIKESLSWGTQRTQDALYEARAPLERGH 1974

  Fly  2376 SS-LVLGSSDPAGGDYLYDTLNRSVADGVNNITRNIMQARLAAAGKLQDELQGAGSGGELRTFGE 2439
            |: :.:|.|.....|.....:.....||....... .|.|.|:..:|..|.|.|.:...::....
Mouse  1975 SAEIPVGQSGTLAVDVQMQNMTLRGPDGEPQPGLE-SQGRAASMPRLAAETQPAPNASPMKRSIS 2038

  Fly  2440 SISMRPLAKNGGGAATVAGTLPPEANAINY---------DNRNRGILLHPYNNVYAPNGALPGHE 2495
            :::.||   :|....:.....||.:.|.::         |.:.|.:...|..:| .|.||
Mouse  2039 TLAPRP---HGTQLCSTVLDRPPPSQASHHHHHRCHRRRDKKQRSLEKGPSLSV-DPEGA----- 2094

  Fly  2496 RMIQSTPASP---------------------YDQRRLPTSSDMNGLAESLIGGVLAAEGLGKYCD 2539
               .||.|.|                     ..:||.|:||              ::|....|..
Mouse  2095 ---PSTAAGPGLPHGEGSTACRRDRKQERGRSQERRQPSSS--------------SSEKQRFYSC 2142

  Fly  2540 SEFVGTAAREMREALDMTPEE----MNLAAHQILSNEHSLSLIGSSNGSIFGGSAGGLGGAGSGG 2600
            ..|......::..:|...|..    :..|.|.            ..:||:.|.......||.:.|
Mouse  2143 DRFGSREPPQLMPSLSSHPTSPTAALEPAPHP------------QGSGSVNGSPLMSTSGASTPG 2195

  Fly  2601 VGG------------------LGGSSSIRNAFGGSG---SGPSSLS-------------PQHQPY 2631
            .||                  ...||.:..|.|.||   ..|..||             |..||.
Mouse  2196 RGGRRQLPQTPLTPRPSITYKTANSSPVHFAEGQSGLPAFSPGRLSRGLSEHNALLQKEPLSQPL 2260

  Fly  2632 S--GTLNSPPIPDNRLRRVATVTT-------------TNNNNKSQVSQNNS 2667
            :  ..:.|.|....||...|:..|             ||:...|:.|..:|
Mouse  2261 APGSRIGSDPYLGQRLDSEASAHTLPEDTLTFEEAVATNSGRSSRTSYVSS 2311

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1D	NP_723952.2	Ion_trans	767..1042	CDD:459842	149/280 (53%)
		Ion_trans	1137..1379	CDD:459842	140/241 (58%)
		Ion_trans	1496..1809	CDD:459842	128/319 (40%)
		Ion_trans	1851..2126	CDD:459842	148/274 (54%)
		GPHH	2135..2188	CDD:465306	32/52 (62%)
		Ca_chan_IQ	2198..2273	CDD:462591	32/79 (41%)
Cacna1b	XP_006497689.1	Ion_trans	94..367	CDD:459842	149/280 (53%)
		Ion_trans	482..721	CDD:459842	140/241 (58%)
		Granin	<936..>1041	CDD:279595	7/104 (7%)
		Ion_trans	1161..1395	CDD:459842	109/272 (40%)
		Ion_trans	1485..1734	CDD:459842	148/274 (54%)
		GPHH	1743..1796	CDD:465306	32/52 (62%)
		Ca_chan_IQ	1807..1884	CDD:462591	32/79 (41%)
		PHA03307	1959..>2326	CDD:223039	77/392 (20%)