DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and Cacna1a

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:XP_006530650.1 Gene:Cacna1a / 12286 MGIID:109482 Length:2464 Species:Mus musculus


Alignment Length:2419 Identity:856/2419 - (35%)
Similarity:1159/2419 - (47%) Gaps:669/2419 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   663 GNGGPGSGDVSRTARYDSGEGDLGGGNNIMGIDSMGIANIPETMNGTTIGPSGAGGQKGGAAAGA 727
            |:..||        ||.:|.|..|....::    :|.|           |..||||.:.|...||
Mouse    94 GDEMPG--------RYGAGGGGSGPAAGVV----VGAA-----------GGRGAGGSRQGGQPGA 135

  Fly   728 AGQKRQQ--RRGK------PQPDRP-----QRALFCLSVKNPLRALCIRIVEWKPFEFLILLTIF 779
            ....:|.  :|.:      |.|.|.     .|:||..|..|.:|....:|.||.|||::||.||.
Mouse   136 QRMYKQSMAQRARTMALYNPIPVRQNCLTVNRSLFLFSEDNVVRKYAKKITEWPPFEYMILATII 200

  Fly   780 ANCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDF 844
            ||||.||:....|..|....::.|:..|..|:.||..|..:||:|.||..|.|:|||||||::||
Mouse   201 ANCIVLALEQHLPDDDKTPMSERLDDTEPYFIGIFCFEAGIKIVALGFAFHKGSYLRNGWNVMDF 265

  Fly   845 TIVVIGAISTALSQLMKDAFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVL 909
            .:|:.|.::|..::     ||::.|||.||||||:||||:|||||||.||:|||:||..|.||:.
Mouse   266 VVVLTGILATVGTE-----FDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMIPLLQIGLLLF 325

  Fly   910 FVIIIYAIIGLELFSGKLHKACRDEITGEYE-ENIRPCGV---GYQCPPGYKCYGGWDGPNDGIT 970
            |.|:|:||||||.:.||.|..|.:|.|.:.: |:..|||.   ...||.|.||...|:|||:|||
Mouse   326 FAILIFAIIGLEFYMGKFHTTCFEEGTDDIQGESPAPCGTEEPARTCPNGTKCQPYWEGPNNGIT 390

  Fly   971 NFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFS 1035
            .|||...|:||||||:|:|||||:||:..||.|:.|.|:|||.::|:|:||::||:||||||||:
Mouse   391 QFDNILFAVLTVFQCITMEGWTDLLYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFA 455

  Fly  1036 KERNKAKNRGDFQKLREKQQIEEDLRGYLDWITQAEDI------------EPDAVGGLISDGKGK 1088
            |||.:.:||..|.|||.:||||.:|.||::||::||::            .|..||.|......|
Mouse   456 KERERVENRRAFLKLRRQQQIERELNGYMEWISKAEEVILAEDETDVEQRHPFDVGALRRATLKK 520

  Fly  1089 QPNEMDSTENLGEEMPEVQMTES-------RWRKMKKD--FDRVNRRMRRACRKAVKSQAFYWLI 1144
            ...::.:.|...:::.::....|       :..|::..  |.:..||||...|:.||:|||||.:
Mouse   521 SKTDLLNPEEAEDQLADIASVGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTV 585

  Fly  1145 IVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFV 1209
            :.||.|||..:|..||.|.:||.:|..|....|:|||..||.:|||.||.:.||.|.||.|||.|
Mouse   586 LSLVALNTLCVAIVHYNQPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGV 650

  Fly  1210 VIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFL 1274
            :||||.|.:..........|:||||.:||||:|||||||.||.|||.|||||::||.|||.||||
Mouse   651 IIGSIFEVIWAVIKPGTSFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFL 715

  Fly  1275 FIVIFALLGMQVFGGKFNFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSS 1339
            |||:|||||||:|||:||||  |.....|||.|..|::|||||:||||||.|||.||.:.|||..
Mouse   716 FIVVFALLGMQLFGGQFNFD--EGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQG 778

  Fly  1340 YGALACIYFIILFICGNYILLNVFLAIAVDNLADADSLSEVEKEEEPHDESA------------- 1391
             |.:..||||:|.:.|||.||||||||||||||:|..|::.|:|||   |:|             
Mouse   779 -GMVFSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKDEQEEE---EAANQKLALQKAKEVA 839

  Fly  1392 ----------------QKKSHSPT-------------------------------PT-------- 1401
                            |:|:..||                               ||        
Mouse   840 EVSPLSAANMSIAVKEQQKNQKPTKSVWEQRTSEMRKQNLLASREALYGDAAERWPTPYARPLRP 904

  Fly  1402 -----------IDGMD------------------------------------------------- 1406
                       :|..:                                                 
Mouse   905 DVKTHLDRPLVVDPQENRNNNTNKSRAPEALRPTARPRESARDPDARRAWPGSPERAPGREGPYG 969

  Fly  1407 --------------DHLSIDIDMEQ------------------------------QELDD----- 1422
                          :|...|.|.|:                              .|.||     
Mouse   970 RESEPQQREHAPPREHAPWDADTERAKAGDAPRRHTHRPVAEGEPRRHRARRRPGDEPDDRPERR 1034

  Fly  1423 --------------------EDKMDHE----TLSDEEVREMCEEE-------------------- 1443
                                |.|..|.    ...|.|.|....:|                    
Mouse  1035 PRPRDATRPARAADGEGDDGERKRRHRHGPPAHDDRERRHRRRKENQGSGVPVSGPNLSTTRPIQ 1099

  Fly  1444 -----------EEVD-------------------------------------------------- 1447
                       |::|                                                  
Mouse  1100 QDLGRQDLPLAEDLDNMKNNKLATGEPASPHDSLGHSGLPPSPAKIGNSTNPGPALATNPQNAAS 1164

  Fly  1448 -------------------EEGMI-------------TAR-PRRMS-EVNTATKIL--------- 1469
                               |..:|             ||| |..|: |:..|...|         
Mouse  1165 RRTPNNPGNPSNPGPPKTPENSLIVTNPSSTQPNSAKTARKPEHMAVEIPPACPPLNHTVVQVNK 1229

  Fly  1470 ----------------------------PIPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCC 1506
                                        |:||.:|.|:.|.||..|..||::.|...|...||..
Mouse  1230 NANPDPLPKKEEEKKEEEEADPGEDGPKPMPPYSSMFILSTTNPLRRLCHYILNLRYFEMCILMV 1294

  Fly  1507 IMFSSAMLAAENPLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDL 1571
            |..||..||||:|::.|...|.||..|||.||.|||.|:::|:|..|.|||.||:.|..:|:||.
Mouse  1295 IAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGVFTFEMVIKMIDLGLVLHQGAYFRDLWNILDF 1359

  Fly  1572 LVVCVSLISLVSSSNA--------ISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGN 1628
            :||..:|::...:|:.        |:.:|.||||||||||:.|.|...||.|..           
Mouse  1360 IVVSGALVAFAFTSSTRGNSKGKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFD----------- 1413

  Fly  1629 IVLVTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTD 1693
                                     |||.::|.:.||::|..|..|:|||:.|||||||||.|||
Mouse  1414 -------------------------CVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTD 1453

  Fly  1694 GSKMTQDECYGTYLVYDDGDVHKPRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSI 1758
            .||..:.:|.|.||:|:..:|   :.|:|||....||:|:|...:||||||||.||||.:|..|:
Mouse  1454 ESKEFERDCRGKYLLYEKNEV---KARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSV 1515

  Fly  1759 DSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQEYKNCDLDKNQRNCI 1823
            |:..||.||...:|..::.:|::|.::..||.|||||..:|:|||.:|::..:...|:||:|.||
Mouse  1516 DATFENQGPSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACI 1580

  Fly  1824 EFALKAKPVRRYIP--KHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDA 1886
            :||:.|||:.|::|  |...||::|.||.|..|||||..:|.:||:.|.||||...:.|...|..
Mouse  1581 DFAISAKPLTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRV 1645

  Fly  1887 LNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVE 1951
            .|::||::|:||.|.|:.||...|||.||||:|||:.||||..||:.:|..:.            
Mouse  1646 FNIVFTSLFSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNP------------ 1698

  Fly  1952 GCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIY 2016
                      :|.|:::|.||||..||:|||.:|..||.|||||::||:|||||.|||.:|||||
Mouse  1699 ----------NNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIY 1753

  Fly  2017 AVVGMQVFGKIALDGGN--------AITANNNFQTFQQAVLVLFRSATGEAWQEIMMSC-SAQPD 2072
            |::||||||.|.:||.:        .||.:|||:||.||:::||||||||||..||:|| |.:| 
Mouse  1754 AIIGMQVFGNIGIDGEDEDSDEDEFQITEHNNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKP- 1817

  Fly  2073 VKCDMNSDTPGEPCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFI 2137
              ||.||......||:..||.||:||..|||||::|||||||||||:|||||.||||||||||::
Mouse  1818 --CDKNSGILTADCGNEFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYV 1880

  Fly  2138 RLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNATLF 2202
            |:|:||||.|.|||.:.|:.:|||.||||||.||.||||:|||||:.|::|:..|.||.||:||.
Mouse  1881 RVWAEYDPAACGRIHYKDMYSLLRVISPPLGLGKKCPHRVACKRLLRMDLPVADDNTVHFNSTLM 1945

  Fly  2203 AVVRTSLSIK-TDGNID--DANSELRATIKQIWKRTNPKLLDQVVPPPGNDDEVTVGKFYATYLI 2264
            |::||:|.|| ..|..|  ..::|||..:..||...:.|.||.:|.|..:.| :||||.||..:|
Mouse  1946 ALIRTALDIKIAKGGADKQQMDAELRKEMMAIWPNLSQKTLDLLVTPHKSTD-LTVGKIYAAMMI 2009

  Fly  2265 QDYFRRFKKRKEQEGKEGHPDSNTVTLQAGLRTLHEVSPALKRAISGN------LDE-------- 2315
            .:|:|:.|.:|.|..:|   :.|...|.  .:.:...||..:...|.|      ||.        
Mouse  2010 MEYYRQSKAKKLQAMRE---EQNRTPLM--FQRMEPPSPTQEGGPSQNALPSTQLDPGGGLMAHE 2069

  Fly  2316 --LDQEPEPMHRRHHTLF--GSVWSSIRRHGNGTFRRSAKATASQSNGALAIGGSASAALGVGGS 2376
              :.:.|..:.:|...:|  ...||..|                                   |.
Mouse  2070 GGMKESPSWVTQRAQEMFQKTGTWSPER-----------------------------------GP 2099

  Fly  2377 SLVLGSSDP---------AGGDYLYDTLNRSVADGVNNITRNIMQARLAAAGKLQDELQ---GAG 2429
            .:.:.:|.|         .|.|...|:.:....:|         |.|.|:..:|..|.|   |..
Mouse  2100 PIDMPNSQPNSQSVEMREMGTDGYSDSEHYLPMEG---------QTRAASMPRLPAENQRRRGRP 2155

  Fly  2430 SGGELRTFGESISMRPLAKNGGGAATVAG------------TLPPEAN-AINYDNRNRG-----I 2476
            .|.:|.|..::..|:       .:|:|.|            .:|||.| ..:...|:||     .
Mouse  2156 RGNDLSTISDTSPMK-------RSASVLGPKARRLDDYSLERVPPEENQRYHQRRRDRGHRTSER 2213

  Fly  2477 LLHPYNNV----------YAPNGALPGHERMIQSTPASPYDQRRL-----------PTSSDMNGL 2520
            .|..|.:|          ...:|.||..:|  ......|.|::..           |.:.|.:..
Mouse  2214 SLGRYTDVDTGLGTDLSMTTQSGDLPSKDR--DQDRGRPKDRKHRPHHHHHHHHHHPPAPDRDRY 2276

  Fly  2521 AESLIGGVLAAEGLGKYCDSEFVGTA-AREMREALDMTPEEMNLAAHQILSNEHSLSLIGSSNGS 2584
            |:                :....|.| |||.|  ...:|.|         ..||:....|||  |
Mouse  2277 AQ----------------ERPDTGRARAREQR--WSRSPSE---------GREHTTHRQGSS--S 2312

  Fly  2585 IFGGSAGGLGGAGS 2598
            :.|..|....|..:
Mouse  2313 VSGSPAPSTSGTST 2326

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 147/278 (53%)
Ion_trans 1137..1379 CDD:395416 145/241 (60%)
Ion_trans 1496..1809 CDD:395416 131/320 (41%)
Ion_trans 1851..2126 CDD:395416 146/283 (52%)
GPHH 2135..2188 CDD:407139 33/52 (63%)
Ca_chan_IQ 2199..2271 CDD:400901 30/74 (41%)
Cacna1aXP_006530650.1 Ion_trans 188..462 CDD:366146 147/278 (53%)
Ion_trans 579..817 CDD:366146 145/240 (60%)
PHA03247 <895..1277 CDD:223021 38/381 (10%)
Ion_trans 1285..1520 CDD:366146 112/273 (41%)
Ion_trans 1610..1869 CDD:366146 146/283 (52%)
GPHH 1878..1931 CDD:374878 33/52 (63%)
Ca_chan_IQ 1942..2015 CDD:370105 29/73 (40%)
PHA03307 2046..>2460 CDD:223039 67/363 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100303
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.850

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