DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and Cacna1h

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:XP_008765754.2 Gene:Cacna1h / 114862 RGDID:68943 Length:2370 Species:Rattus norvegicus


Alignment Length:2424 Identity:550/2424 - (22%)
Similarity:891/2424 - (36%) Gaps:824/2424 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   660 SPNGNGGPGSGDVSRTARYDSGEGDLGGGNNIMGIDSMGIANIPETMNGTTIGPSGAGGQKGGAA 724
            ||...|.||        |.:.|    |.|:.::.         ||           :.|.:.||.
  Rat    29 SPASPGAPG--------REEQG----GSGSGVLA---------PE-----------SPGTECGAD 61

  Fly   725 AGAAGQKRQQRRGKPQPDRPQRALFCLSVKNPLRALCIRIV--EWKPFEFLILLTIFANCIALAV 787
            .||     .:.:..|.|.......|||......|:.|:|:|  .|  ||.:.:|.|..||:.|.:
  Rat    62 LGA-----DEEQPVPYPALAATVFFCLGQTTRPRSWCLRLVCNPW--FEHISMLVIMLNCVTLGM 119

  Fly   788 YTPYPGSDSNVTN-QTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGA 851
            :.|....:..... ..||..:......|..|.|:|::|.| :.....||.:.||.|||.||:.|.
  Rat   120 FRPCEDVECRSERCSILEAFDDFIFAFFAVEMVIKMVALG-LFGQKCYLGDTWNRLDFFIVMAGM 183

  Fly   852 ISTALSQLMKDAFDV--KALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIII 914
            :..:|     |..:|  .|:|..|||||||.::.|||:::::..:|..:..|.::.||..||..|
  Rat   184 MEYSL-----DGHNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFI 243

  Fly   915 YAIIGLELFSGKLHKAC-------RDE---------ITGEYEEN-----------IRPCG----- 947
            :.|:|::|::|.|...|       |:.         .|.|.|||           ::.|.     
  Rat   244 FGIVGVQLWAGLLRNRCFLDSAFVRNNNLTFLRPYYQTEEGEENPFICSSRRDNGMQKCSHIPSR 308

  Fly   948 --VGYQCPPGYKCYG---------------GWD-----------GPNDGITNFDNFGLAMLTVFQ 984
              :..||..|::.||               .|:           .|::|..||||.|.|.:.:||
  Rat   309 RELRVQCTLGWEAYGQPQAEDGGAGRNACINWNQYYNVCRSGEFNPHNGAINFDNIGYAWIAIFQ 373

  Fly   985 CVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERNKAKNRGDFQK 1049
            .:|||||.|::|.:.|| .|.:.::|||.::|:|:||::||.|.|::.:||:.:.:     :.|.
  Rat   374 VITLEGWVDIMYYVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQR-----ENQL 432

  Fly  1050 LREKQQ------------------IEE---------------DLRGYLDWITQ-AEDIEPDAV-- 1078
            :||::.                  .||               .||.|..|.:: .:.::|.:.  
  Rat   433 MREQRARYLSNDSTLASFSEPGSCYEELLKYVGHIFRKVKRRSLRLYARWQSRWRKKVDPSSTVH 497

  Fly  1079 ----------------------------------------------------------------- 1078
                                                                             
  Rat   498 GQGPGRRPRRAGRRTASVHHLVYHHHHHHHHHYHFSHGGPRRPSPEPGAGDNRLVRACAPPSPPS 562

  Fly  1079 ---------------------------------------------------------------GG 1080
                                                                           ||
  Rat   563 PGHGPPDSESVHSIYHADCHVEGPQERARVAHSIATAASLKLASGLGTMNYPTILPSGTVNSKGG 627

  Fly  1081 LISDGKGKQ-----------------PNEMDSTEN-LGE-------------------------- 1101
            ..|..||.:                 |...:..:: :||                          
  Rat   628 TSSRPKGLRGAGAPGAAVHSPLSLGSPRPYEKIQHVVGEQGLGRASSHLSGLSVPCPLPSPQAGT 692

  Fly  1102 ---------------EMPEVQMTESRWRKMKKDFD------------------------------ 1121
                           |.||.:.:.|.    ..|.|                              
  Rat   693 LTCELKSCPYCASALEDPEFEFSGSE----SGDSDAHGVYEFTQDVRHGDCRDPVQQPHEVGTPG 753

  Fly  1122 RVNRRMRRACRKA--------------------VKSQAFYWLIIVLVFLNTGVLATEHYGQLDWL 1166
            ..|.|.|...|||                    |.|:.|...|:..:.:||..:..|::.|.:.|
  Rat   754 HSNERRRTPLRKASQPGGIGHLWASFSGKLRRIVDSKYFNRGIMAAILVNTLSMGVEYHEQPEEL 818

  Fly  1167 DNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVS 1231
            .|..|.:|:.|..:|..|||||:.:.|..||..:.:|.||..||:.|:.|.:....|     |:|
  Rat   819 TNALEISNIVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIVVVISVWEIVGQADG-----GLS 878

  Fly  1232 VLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNF--- 1293
            |||..|||||.|:.::..:|...:..|:.::.::|:..:||.|||.||::|||.:||.||:.   
  Rat   879 VLRTFRLLRVLKLVRFLPALRRQLVVLMRTMDNVATFCMLLMLFIFIFSILGMHLFGCKFSLKTD 943

  Fly  1294 DGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYI 1358
            .|.....|.|||....|::|||||:|.||||.|:      |.|::|..:.|.:||:.|...|||:
  Rat   944 SGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVL------YNGMASTSSWAALYFVALMTFGNYV 1002

  Fly  1359 LLNVFLAIAVDNL-ADADSLSEVEKEEEPHDE------------SAQKKSHSPTPTIDGMDDHL- 1409
            |.|:.:||.|:.. |:.|:......|::...:            :.:.|.:|...|.:|   || 
  Rat  1003 LFNLLVAILVEGFQAEGDATRSDTDEDKTSTQLEGDFDKLRDLRATEMKMYSLAVTPNG---HLE 1064

  Fly  1410 -----------------------SIDIDMEQQELD---------DEDKMDHETLS---------- 1432
                                   |.::|:....||         |....|.::|:          
  Rat  1065 GRGSLPPPLITHTAATPMPTPKSSPNLDVAHALLDSRRSSSGSVDPQLGDQKSLASLRSSPCTPW 1129

  Fly  1433 --------------------DEEVREMCEEEEEV---------DEEGMITARP------------ 1456
                                ..:.|..|.|.|.:         |:|.. .:||            
  Rat  1130 GPNSAGSSRRSSWNSLGRAPSLKRRSQCGERESLLSGEGKGSTDDEAE-DSRPSTGTHPGASPGP 1193

  Fly  1457 -----RRMSEVNTATKILPIPP------GTSF--------------------------------- 1477
                 ||...::..:.:...||      .|.|                                 
  Rat  1194 RATPLRRAESLDHRSTLDLCPPRPAALLPTKFHDCNGQMVALPSEFFLRIDSHKEDAAEFDDDIE 1258

  Fly  1478 ---------------------------FLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLA 1515
                                       :||...||.||.|..:..|..|.:::|..|..:...:|
  Rat  1259 DSCCFRLHKVLEPYAPQWCRSRESWALYLFPPQNRLRVSCQKVIAHKMFDHVVLVFIFLNCITIA 1323

  Fly  1516 AENP-LRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLI 1579
            .|.| :.........|:..:|.|||:|.:|:::|:::.|.:..:.|:.:|::|:||.|:|.|||:
  Rat  1324 LERPDIDPGSTERAFLSVSNYIFTAIFVVEMMVKVVALGLLWGEHAYLQSSWNVLDGLLVLVSLV 1388

  Fly  1580 SLV------SSSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQF 1638
            .::      ..:..:.|:::||:||.|||||.|:||.|||.||:.:|.:::.||||||:.|    
  Rat  1389 DIIVAMASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICC---- 1449

  Fly  1639 MFAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKC--TDGSKM-TQD 1700
            .|.:|                                |.::|||||||||:.|  ||...: |:.
  Rat  1450 AFFII--------------------------------FGILGVQLFKGKFYYCEGTDTRNITTKA 1482

  Fly  1701 ECYGTYLVYDDGDVHKPRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENG 1765
            ||:..:.               .|...:::||::.:.:::||.:|:.:||..::|..:|:...:.
  Rat  1483 ECHAAHY---------------RWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGIDQ 1532

  Fly  1766 GPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTF----QNEGEQEYKNCD------LDKNQR 1820
            .|:.|..|.:..|:|.:::|::||::|:|||.|:..|    |::..:|.:..:      |::.:|
  Rat  1533 QPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERRRR 1597

  Fly  1821 NCIEFALKAKPVRR--YIPKHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTEL 1883
            :...   ..:..||  |......:..:....||...:..|..:|.:|.:|::|:.||||....|.
  Rat  1598 STFP---NPEAQRRPYYADYSHTRRSIHSLCTSHYLDLFITFIICLNVITMSMEHYNQPKSLDEA 1659

  Fly  1884 LDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECD 1948
            |...|.:||.||..|...||.||.|:.:|.|.||..|..|||.|.:.|...||:......|    
  Rat  1660 LKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSIMGIALEEIEMNAALPI---- 1720

  Fly  1949 IVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYV---ALLIV 2010
                          |...|...|:.|:.|::|||....|:|.||.|.:   ||||.|   .||.:
  Rat  1721 --------------NPTIIRIMRVLRIARVLKLLKMATGMRALLDTVV---QALPQVGNLGLLFM 1768

  Fly  2011 LLFFIYAVVGMQVFGKIALDGGN---AITANNNFQTFQQAVLVLFRSATGEAWQEIM----MSCS 2068
            |||||||.:|:::||::.....|   .::.:..|..|..|.|.|||.:||:.|..||    ..|:
  Rat  1769 LLFFIYAALGVELFGRLECSEDNPCEGLSRHATFTNFGMAFLTLFRVSTGDNWNGIMKDTLRECT 1833

  Fly  2069 AQPDVKCDMNSDTPGEPCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHL 2133
            .: |..|  .|..|      :::..||::|.::..|:::|:.|||:|               .||
  Rat  1834 RE-DKHC--LSYLP------ALSPVYFVTFVLVAQFVLVNVVVAVLM---------------KHL 1874

  Fly  2134 DEF---IRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTV 2195
            :|.   .|..:|.|.:.:..:.............||                    .|..|.||.
  Rat  1875 EESNKEAREDAEMDAEIELEMAQGSTAQPPPTAQPP--------------------SPQESQGTQ 1919

  Fly  2196 LFNATLFAVVRTS----LSIKTD---------------------------GNIDDANS---ELRA 2226
            .....|..|.:.|    ||:..|                           |.:..|:|   |.||
  Rat  1920 PDTPNLLVVRKVSVSRMLSLPNDSYMFRPVAPAAAPHSHPLQEVEMETYTGPVTSAHSPPLEPRA 1984

  Fly  2227 TIKQIWKRTNPKLLDQ---VVPPPGNDDEVTVGKFYATY------------------LIQDYFRR 2270
            :.:.....::|..:..   .:.|.|....:::.:.....                  .|.||...
  Rat  1985 SFQVPSAASSPARVSDPLCALSPRGTPRSLSLSRILCRQEAMHSESLEGKVDDVGGDSIPDYTEP 2049

  Fly  2271 FKKRKEQEGKEGHPDS----------NTVTLQAGLRTLHEVSPALKRAISGNLDELDQEPEPMHR 2325
            .:.....:...|.|.|          .|.....|.|.:....|.|....:...|..|:|..    
  Rat  2050 AENMSTSQASTGAPRSPPCSPRPASVRTRKHTFGQRCISSRPPTLGGDEAEAADPADEEVS---- 2110

  Fly  2326 RHHTLFGSVWSSIRRHGNGTFRRSAKATASQSNGALAIGGSASAALGVGGSSLVLGSSDPAGGDY 2390
             |.|.....|.:...|.     ..|..|||...|.:..|........|...|.:    |..|...
  Rat  2111 -HITSSAHPWPATEPHS-----PEASPTASPVKGTMGSGRDPRRFCSVDAQSFL----DKPGRPD 2165

  Fly  2391 LYDTLNRSVADGVNNITRNIMQARLAAAGKLQDELQGAGSGGELRTFGESISMRPLAKNGGGAAT 2455
            .....:..:.:|.:::....::.|   |.:|:..|   ||..:.:.....||:.|..::.|.:. 
  Rat  2166 AQRWSSVELDNGESHLESGEVRGR---ASELEPAL---GSRRKKKMSPPCISIEPPTEDEGSSR- 2223

  Fly  2456 VAGTLPPEANAINYDNRNR 2474
                 ||.|...|...|.|
  Rat  2224 -----PPAAEGGNTTLRRR 2237

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 101/337 (30%)
Ion_trans 1137..1379 CDD:395416 91/245 (37%)
Ion_trans 1496..1809 CDD:395416 95/326 (29%)
Ion_trans 1851..2126 CDD:395416 93/284 (33%)
GPHH 2135..2188 CDD:407139 6/55 (11%)
Ca_chan_IQ 2199..2271 CDD:400901 18/126 (14%)
Cacna1hXP_008765754.2 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.920

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