DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ca-alpha1D and Cacna1f

DIOPT Version :9

Sequence 1:	NP_723952.2	Gene:	Ca-alpha1D / 34950	FlyBaseID:	FBgn0001991	Length:	2705	Species:	Drosophila melanogaster
Sequence 2:	NP_446153.2	Gene:	Cacna1f / 114493	RGDID:	621535	Length:	1980	Species:	Rattus norvegicus

Alignment Length:	2065	Identity:	1062/2065 - (51%)
Similarity:	1307/2065 - (63%)	Gaps:	309/2065 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   703 PETMNGTTIGP---------------SGAGGQKGGAAAGAAGQKRQQRRGK----PQPDRPQRAL 748
            |...|||..||               |||.|      .|...::.|..:.|    ....|..|||
  Rat    14 PSPANGTGPGPEWGLCPGPPTVGTDTSGASG------LGTPRRRTQHNKHKTVVVASAQRSPRAL 72

  Fly   749 FCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVI 813
            |||::.||:|..||.|||||||:.||||||||||:||.||.|:|..|||..|..||:||||||||
  Rat    73 FCLTLTNPIRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYVFLVI 137

  Fly   814 FTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQ---LMKDA---------FDV 866
            ||.|.|:||:|||.|||..||:|||||||||.|||:|..|..|.|   ...||         |||
  Rat   138 FTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPGGFDV 202

  Fly   867 KALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKAC 931
            |||||||||||||||||||||.:|||||:||:|||.|||||||||||||||||||||.|::||.|
  Rat   203 KALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRMHKTC 267

  Fly   932 RDEITG---EYEENIRPC---GVGYQCPPGY-KCYGGWDGPNDGITNFDNFGLAMLTVFQCVTLE 989
              ...|   |.||:..||   |.|..|.... :|.|.|.|||.||||||||..||||||||:|:|
  Rat   268 --YFLGSDMEAEEDPSPCASSGSGRSCTLNQTECRGRWPGPNGGITNFDNFFFAMLTVFQCITME 330

  Fly   990 GWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERNKAKNRGDFQKLREKQ 1054
            |||||||.:|||||.:..|:||:|:||.|:|||:||:||||||||||||.|||.|||||||||||
  Rat   331 GWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFSKEREKAKARGDFQKLREKQ 395

  Fly  1055 QIEEDLRGYLDWITQAEDI---EPDAVGGLIS---DGK-GKQP--NEMDS--------------- 1095
            |:|||||||||||||||::   :|...|.|.|   :|: |.:|  :|:.:
  Rat   396 QMEEDLRGYLDWITQAEELDLHDPSVDGNLASLAEEGRAGHRPQLSELTNRRRGRLRWFSHSTRS 460

  Fly  1096 ------------------TENLGEE------MPEVQMTESRWRKMK--KDFDRVNRRMRRACRKA 1134
                              |:..|:|      |....:..::..|.|  :.|.|.||.:|..||:|
  Rat   461 THSTSSHASLPASDTGSITDTPGDEDEEEGTMASCTLCLNKIMKTKVCRHFRRANRGLRARCRRA 525

  Fly  1135 VKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFV 1199
            |||.|.||.:::||||||..:|:||:||..||...|||.|...:.|||.|||||:|.||...|..
  Rat   526 VKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQTQEYANKVLLCLFTVEMLLKLYGLGPSVYVA 590

  Fly  1200 SLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQS 1264
            |.|||||||||.|.|.||.|...|.|.|||:||||||||||:||||::|.||||||||||||::|
  Rat   591 SFFNRFDCFVVCGGILETTLVEVGAMQPLGISVLRCVRLLRIFKVTRHWASLSNLVASLLNSMKS 655

  Fly  1265 IASLLLLLFLFIVIFALLGMQVFGGKFNFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYV 1329
            ||||||||||||:||:|||||:||||||||....| |..||.|.|||||||||:||||||.|||.
  Rat   656 IASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTK-RSTFDTFPQALLTVFQILTGEDWNVVMYD 719

  Fly  1330 GINAYGGVSSYGALACIYFIILFICGNYILLNVFLAIAVDNLADADSLSEVEKEEEPHDESAQKK 1394
            ||.||||....|.|.|:||||||||||||||||||||||||||..|:.:..:|..|        |
  Rat   720 GIMAYGGPFFPGMLVCVYFIILFICGNYILLNVFLAIAVDNLASGDAGAAKDKGRE--------K 776

  Fly  1395 SHSPTPTIDGMDDHLSIDIDMEQQELDDEDKMDHETLSDEEVREMCEEEEEVDEEGMITARPRRM 1459
            |....|..:.     .:.:...:.|..:..|.:......||..|  |||||.:|.|  ......:
  Rat   777 SSEGNPPQEN-----KVLVPGGENEDTEGTKSEGAAPGMEEEEE--EEEEEEEENG--AGHVELL 832

  Fly  1460 SEVNTATKILPIPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRAND 1524
            .||....|::|||.|::||..||||..|..||.|.:|..|.::||..|:.||..||||:|:||:.
  Rat   833 QEVVPKEKVVPIPEGSAFFCLSQTNPLRKACHTLIHHHVFTSLILVFIILSSVSLAAEDPIRAHS 897

  Fly  1525 DLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISLVSSSNAIS 1589
            ..|.:|..|||.||::||:|::||:..:|..||.|:||||.|||||||||.|||||....|:|||
  Rat   898 FRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHQGSFCRSWFNLLDLLVVSVSLISFGIHSSAIS 962

  Fly  1590 VVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKC 1654
            ||||||||||||||||||||||||||||||.
  Rat   963 VVKILRVLRVLRPLRAINRAKGLKHVVQCVF---------------------------------- 993

  Fly  1655 VVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTDGSKMTQDECYGTYLVYDDGDVHKPRL 1719
              |||:||||||:||.|||||||.||||||||||:.|||.:|.|..||.|::|:|.||||.:|.:
  Rat   994 --VAIRTIGNIMIVTTLLQFMFACIGVQLFKGKFYSCTDEAKHTLKECKGSFLIYPDGDVSRPLV 1056

  Fly  1720 REREWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYII 1784
            |||.|.|:.|:||:|...|:.|||||||||||.|||.:||::.|:.|||:|:...::.::|:|||
  Rat  1057 RERLWVNSDFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAHAEDEGPIYNYHVEISVFFIVYII 1121

  Fly  1785 IIAFFMVNIFVGFVIVTFQNEGEQEYKNCDLDKNQRNCIEFALKAKPVRRYIPKHGIQYKVWWFV 1849
            ||||||:||||||||:||:.:|||||:||:||||||.|:|:||||:|:||||||:..||:||..|
  Rat  1122 IIAFFMMNIFVGFVIITFRAQGEQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPHQYRVWATV 1186

  Fly  1850 TSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGD 1914
            .|::|||.:|:||::|||.|||:.|.|...:...:|.|||:||.:|.:|.|.|:.||:.|:||.|
  Rat  1187 NSAAFEYLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTVEMVLKIIAFKPKHYFAD 1251

  Fly  1915 AWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLV 1979
            |||.||.:||:||.:||..:|:.:             |....:.|..|:.|||.|||||||||||
  Rat  1252 AWNTFDALIVVGSVVDIAVTEVNN-------------GGHLGESSEDSSRISITFFRLFRVMRLV 1303

  Fly  1980 KLLSKGEGIRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIALDGGNAITANNNFQTF 2044
            ||||||||||||||||||||||||||||||.::||||||:|||:|||:||..|..|..|||||||
  Rat  1304 KLLSKGEGIRTLLWTFIKSFQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGTQINRNNNFQTF 1368

  Fly  2045 QQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSD-TPGE--PCGSSIAYPYFISFYVLCSFLI 2106
            .||||:|||.||||||||||:  ::.|..:||..|| .|||  .|||:.|..|||||::||:|||
  Rat  1369 PQAVLLLFRCATGEAWQEIML--ASLPGNRCDPESDFGPGEEFTCGSNFAIVYFISFFMLCAFLI 1431

  Fly  2107 INLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGK 2171
            ||||||||||||||||||||||||||||||.|:||||||.|||||||||||.|||:|.|||||||
  Rat  1432 INLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGK 1496

  Fly  2172 LCPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIKTDGNIDDANSELRATIKQIWKRTN 2236
            |||||:||||||:||:||||||||.|||||||:|||||.|||:||:|.||.|||..||:||||..
  Rat  1497 LCPHRVACKRLVAMNVPLNSDGTVTFNATLFALVRTSLRIKTEGNLDQANQELRMVIKKIWKRIK 1561

  Fly  2237 PKLLDQVVPPPGNDDEVTVGKFYATYLIQDYFRRFKKRKEQEGKEG--HPDSNTVTLQAGLRTLH 2299
            .||||:|:||| :::||||||||||:|||||||:|::||| :|..|  .|.|.:..||||||:|.
  Rat  1562 QKLLDEVIPPP-DEEEVTVGKFYATFLIQDYFRKFRRRKE-KGLLGADAPTSTSSVLQAGLRSLQ 1624

  Fly  2300 EVSPALKRAISGNLDELDQ---------EPEPMHRRHHTLFGSVWSSIRRHGNGTFRRSAKATAS 2355
            ::.|.:::|::.:.:|.::         |.|.......|...|:.|..:...|           |
  Rat  1625 DLGPEIRQALTYDTEEEEEEEEAAGQEAEEEEAENNPETYKDSIDSQPQAQWN-----------S 1678

  Fly  2356 QSNGALAIGGSASAALGVGGS---SLVLGSSDPAG------------GDYLY------------- 2392
            :.:.:|.:......:|..|.|   .:...|..|:|            |.:::
  Rat  1679 RISVSLPVKEKLPDSLSTGPSDDDGVAPNSRQPSGLQAGSQPHRRSSGVFMFTIPEEGSTQLKGV 1743

  Fly  2393 ---DTLN--RSVADGVNNIT-----------------------RNIMQARL---AAAGKLQDE-- 2424
               |..|  :.|.|...|:.                       .::.:.||   ..||:....
  Rat  1744 QGQDNQNEEQEVPDWTPNLDEQAGMPSNPVLLPPHWSQQHVNGHHVPRRRLLPPTPAGRKPSFTI 1808

  Fly  2425 --LQGAGSGGELRTFGESISMRPLAKNGGGAATVAGTLPPEANAINYDNRNRGILLHPYNNVYAP 2487
              ||..||..:|...|.....|   .:|.|.|..:...||:          :|.||      |||
  Rat  1809 QCLQRQGSCEDLPIPGTYHRGR---TSGPGRAQGSWAAPPQ----------KGRLL------YAP 1854

  Fly  2488 -------------NGALPGHER-----MIQSTPASPYDQRRLPTSSDMNGLAESLIGGVLAAEGL 2534
                         .|.|.|..|     .:...|:.|..::|        |.|:||:..||.:|||
  Rat  1855 LLLVEESTVGEGYLGKLGGPLRTFTCLQVPGAPSDPSHRKR--------GSADSLVEAVLISEGL 1911

  Fly  2535 GKYC-DSEFVGTAAREMREALDMTPEEMNLAAHQIL--------SNEHSL 2575
            |.:. |..||..|.:|:.:|..:|.:||:.||..:|        |:|.|:
  Rat  1912 GLFAQDPRFVALAKQEIADACHLTLDEMDSAASDLLAQRTTSLYSDEESI 1961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1D	NP_723952.2	Ion_trans	767..1042	CDD:395416	195/293 (67%)
		Ion_trans	1137..1379	CDD:395416	167/241 (69%)
		Ion_trans	1496..1809	CDD:395416	178/312 (57%)
		Ion_trans	1851..2126	CDD:395416	170/277 (61%)
		GPHH	2135..2188	CDD:407139	44/52 (85%)
		Ca_chan_IQ	2199..2271	CDD:400901	52/71 (73%)
Cacna1f	NP_446153.2	Ion_trans	91..383	CDD:395416	195/293 (67%)
		Ion_trans	532..763	CDD:395416	163/231 (71%)
		Ion_trans	869..1106	CDD:395416	154/272 (57%)
		Ion_trans	1188..1451	CDD:395416	170/277 (61%)
		GPHH	1460..1513	CDD:407139	44/52 (85%)
		Ca_chan_IQ	1524..1595	CDD:400901	52/71 (73%)
		CAC1F_C	1618..1977	CDD:407123	82/382 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	383	1.000	Domainoid score	I788
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	2028	1.000	Inparanoid score	I47
OMA	1	1.010	-	-		QHG48156
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	1	1.000	-	-		FOG0000179
OrthoInspector	1	1.000	-	-		otm45290
orthoMCL	1	0.900	-	-		OOG6_100303
Panther	1	1.100	-	-	O	PTHR45628
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X533
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.980