Protein Alignment Ca-alpha1D and SCN11A

DIOPT Version :10

• Sequence 1: NP_723952.2
• Gene: Ca-alpha1D / 34950
• FlyBaseID: FBgn0001991
• Length: 2705
• Species: Drosophila melanogaster
• Sequence 2: XP_047303334.1
• Gene: SCN11A / 11280
• HGNCID: 10583
• Length: 1916
• Species: Homo sapiens
• Alignment Length: 1818
• Identity: 455/1818 - (25%)
• Similarity: 783/1818 - (43%)
• Gaps: 415/1818 - (22%)

  Fly   745 QRALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYV 809
            :.|||.....|.:|:|.||:.....|...|:.|:..||:.:|.   .|..:||..|..:  .|.|
Human   231 KHALFIFGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMAT---GPAKNSNSNNTDI--AECV 290

  Fly   810 FLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAFRV 874
            |..|:..|.::||||.||:|...::||:.||.||..::.|..:|......:|    :..||.|||
Human   291 FTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK----LLPLRTFRV 351

  Fly   875 LRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKAC--RD--EI 935
            .|.|:.:|.|..|:|::.::|:::..|.::.:|..|.:.|:|::|.:||.|.|:..|  ||  .|
Human   352 FRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNI 416

  Fly   936 TG--------EYEEN---IRPCGV---GYQCPPGYKCYGGWDGPNDGITNFDNFGLAMLTVFQCV 986
            :.        |.:||   .:.||:   ...|...|:|......|:...|||||||.:.|.:|:.:
Human   417 SNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLM 481

  Fly   987 TLEGW---------TDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERNK-- 1040
            |.:.|         |..|||:          .:||.::.||:|:::||.|.|::..: :|:||
Human   482 TQDSWEKLYQQTLRTTGLYSV----------FFFIVVIFLGSFYLINLTLAVVTMAY-EEQNKNV 535

  Fly  1041 -AKNRGDFQKLREKQQIEEDLRGYLDWITQAEDIEPDAVGGL----------------------I 1082
             |:.....:..:|.||:.::.:..|    .|..|:..::..|                      :
Human   536 AAEIEAKEKMFQEAQQLLKEEKEAL----VAMGIDRSSLTSLETSYFTPKKRKLFGNKKRKSFFL 596

  Fly  1083 SDGKGKQPNEMDSTENLGEEMPEVQMTESRWRKMKKD-FDRVNRRMRR----------------- 1129
            .:....||...||.|:..::...::.|:...:.:..| ||.....::|
Human   597 RESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRALSAVSILTITMKEQ 661

  Fly  1130 --------ACRKAVKSQAFYW------------------------LIIVLVFLNTGVLATEHYGQ 1162
                    .|.:.:.|:...|                        .|.:.:.:||..||.||:..
Human   662 EKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKM 726

  Fly  1163 LDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPP 1227
            ....:......|:.|..:|..||.||:.:|....||...:|.||..|.:.|..:.:   ..::..
Human   727 EASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSFADVM---NCVLQK 788

  Fly  1228 LGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFN 1292
            .....||..|:|||||:.|.|.:|:.|:..:.||:.::.||.::|.:.|.||:::|||:||..||
Human   789 RSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFN 853

  Fly  1293 FDGKEEKY------------RMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALAC 1345
             ..|..|.            ..:...||.:.|.||:|:.|| |...|:..:......||   |..
Human   854 -SQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGE-WIENMWECMQEANASSS---LCV 913

  Fly  1346 IYFIILFICGNYILLNVFLAIAVDNLADADSLSEVE----------------------------- 1381
            |.||::.:.|..::||:|:|:.:::.::.:....:|
Human   914 IVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEARKTKVQLALDRFRRAFCFVRHTLEHF 978

  Fly  1382 ------KEEEPHDE------SAQKKSHSP----------------------------------TP 1400
                  |:..|..:      :||.|...|                                  .|
Human   979 CHKWCRKQNLPQQKEVAGGCAAQSKDIIPLVMEMKRGSETQEELGILTSVPKTLGVRHDWTWLAP 1043

  Fly  1401 TIDGMDDHLSIDIDMEQQELDDEDKMDHETLSDEEVREMCEEEEEV-------DEEGMITARPRR 1458
            ..:..||......|..|:....|.:.....|..|..:...:..:.|       ||..:....||:
Human  1044 LAEEEDDVEFSGEDNAQRITQPEPEQQAYELHQENKKPTSQRVQSVEIDMFSEDEPHLTIQDPRK 1108

  Fly  1459 MSEVNT-------------------------ATKILPIPPGTSFFLFSQTNR---------FRVF 1489
            .|:|.:                         ..:.||...|..|...|...|         .|..
Human  1109 KSDVTSILSECSTIDLQDGFGWLPEMVPKKQPERCLPKGFGCCFPCCSVDKRKPPWVIWWNLRKT 1173

  Fly  1490 CHWLCNHSNFGNIILCCIMFSSAMLAAEN-PLRANDDLNKVLNKFDYFFTAVFTIELILKLISYG 1553
            |:.:..||.|.:.|:..|:.||..|..|: .|.....:.::||..|..||.:|.:|::||.:::|
Human  1174 CYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEMVLKWVAFG 1238

  Fly  1554 FVLHDGAFCRSAFNLLDLLVVCVSLISLVSSSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQC 1618
            |    |.:..||:..||.::|.||:.:|::    :..:|..|.||.||||||:::.:|:|.||..
Human  1239 F----GKYFTSAWCCLDFIIVIVSVTTLIN----LMELKSFRTLRALRPLRALSQFEGMKVVVNA 1295

  Fly  1619 VIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQL 1683
            :|.|:..|.|::|| ||:.::                                   :|.::||..
Human  1296 LIGAIPAILNVLLV-CLIFWL-----------------------------------VFCILGVYF 1324

  Fly  1684 FKGKFFKCTDGSK--------MTQDECYGTYLVYDDGDVHKPRLREREWSNNRFHFDDVAKGMLT 1740
            |.|||.||.:|:.        ..:.:|       :.|:.        .|.|.:.:||:|....|.
Human  1325 FSGKFGKCINGTDSVINYTIITNKSQC-------ESGNF--------SWINQKVNFDNVGNAYLA 1374

  Fly  1741 LFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNE 1805
            |..|:||:||..::|.::||.::...|......:...|::::||..:||.:|:|:|.:|..|..:
Human  1375 LLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQ 1439

  Fly  1806 ----GEQEYKNCDLDKNQRNCIEFALKAKPVRRYIPK--HGIQYKVWWFVTSSSFEYTIFILIMI 1864
                |.|:....:..|...|.:: .|.:|..::.||:  :..|..|:..|||..|:..|..||::
Human  1440 QKKLGGQDIFMTEEQKKYYNAMK-KLGSKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIIL 1503

  Fly  1865 NTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFI 1929
            |.:::..:.||||.....:||.||.:|..:|.||.:.|:.|.| :.||.:.||:||.::||.|.:
Human  1504 NMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALR-QYYFTNGWNLFDCVVVLLSIV 1567

  Fly  1930 DIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINF-------FRLFRVMRLVKLLSKGEG 1987
            ..:.|.:::::                         .|.|       .||.|:.|:::|:....|
Human  1568 STMISTLENQE-------------------------HIPFPPTLFRIVRLARIGRILRLVRAARG 1607

  Fly  1988 IRTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIALDGGNAITANNNFQTFQQAVLVLF 2052
            |||||:..:.|..:|..:.||:.|:.||||::||..|.|:..:.|  |....||:||..::|.||
Human  1608 IRTLLFALMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNPESG--IDDIFNFKTFASSMLCLF 1670

  Fly  2053 RSATGEAWQEIMM-------SCSAQPDVKCDMNSDTPGEPCGSSIAYPYFISFYVLCSFLIINLF 2110
            :.:|...|..::.       ||::..:     |...||      ||..||:|:.::...:::|::
Human  1671 QISTSAGWDSLLSPMLRSKESCNSSSE-----NCHLPG------IATSYFVSYIIISFLIVVNMY 1724

  Fly  2111 VAVIMDNFDYLTRD-WSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCP 2174
            :|||::||:..|.: ...||....|.|..:|.::||:|...||:..:......:..||...|  |
Human  1725 IAVILENFNTATEESEDPLGEDDFDIFYEVWEKFDPEATQFIKYSALSDFADALPEPLRVAK--P 1787

  Fly  2175 HRMACKRLVSMNMPLNSDGTVLFNATLFAVVRTSLSIKTDGNIDDANSELRATIKQIWKRTNP-- 2237
            ::.   :.:.|::|:.|:..:.....|||.....|     |..|..:| ::|.:::.:...||
Human  1788 NKY---QFLVMDLPMVSEDRLHCMDILFAFTARVL-----GGSDGLDS-MKAMMEEKFMEANPLK 1843

  Fly  2238 KLLDQVVPPPGNDDEVTVGKFYATYLIQDYFRRF--KKRKEQEGK----EGHPDSNTVTLQAG 2294
            ||.:.:|......:|..     ...:||..||::  |..|..:|.    |..|.|...||..|
Human  1844 KLYEPIVTTTKRKEEER-----GAAIIQKAFRKYMMKVTKGDQGDQNDLENGPHSPLQTLCNG 1901

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1D	NP_723952.2	Ion_trans	767..1042	CDD:459842	93/304 (31%)
		Ion_trans	1137..1379	CDD:459842	74/277 (27%)
		Ion_trans	1496..1809	CDD:459842	91/325 (28%)
		Ion_trans	1851..2126	CDD:459842	85/289 (29%)
		GPHH	2135..2188	CDD:465306	12/52 (23%)
		Ca_chan_IQ	2198..2273	CDD:462591	18/78 (23%)
SCN11A	XP_047303334.1	Ion_trans	253..534	CDD:459842	92/300 (31%)
		Ion_trans	701..945	CDD:459842	72/251 (29%)
		Na_trans_assoc	951..1176	CDD:461936	29/224 (13%)
		Ion_trans	1180..1442	CDD:459842	90/320 (28%)
		Na_channel_gate	1434..1486	CDD:240441	11/52 (21%)
		Ion_trans	1507..1740	CDD:459842	79/271 (29%)