DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ca-alpha1D and SCN11A

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:XP_016861136.1 Gene:SCN11A / 11280 HGNCID:10583 Length:1916 Species:Homo sapiens


Alignment Length:1811 Identity:455/1811 - (25%)
Similarity:783/1811 - (43%) Gaps:401/1811 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   745 QRALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYV 809
            :.|||.....|.:|:|.||:.....|...|:.|:..||:.:|.   .|..:||..|..:  .|.|
Human   231 KHALFIFGPFNSIRSLAIRVSVHSLFSMFIIGTVIINCVFMAT---GPAKNSNSNNTDI--AECV 290

  Fly   810 FLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAFRV 874
            |..|:..|.::||||.||:|...::||:.||.||..::.|..:|......:|    :..||.|||
Human   291 FTGIYIFEALIKILARGFILDEFSFLRDPWNWLDSIVIGIAIVSYIPGITIK----LLPLRTFRV 351

  Fly   875 LRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKAC--RD--EI 935
            .|.|:.:|.|..|:|::.::|:::..|.::.:|..|.:.|:|::|.:||.|.|:..|  ||  .|
Human   352 FRALKAISVVSRLKVIVGALLRSVKKLVNVIILTFFCLSIFALVGQQLFMGSLNLKCISRDCKNI 416

  Fly   936 TG--------EYEEN---IRPCGV---GYQCPPGYKCYGGWDGPNDGITNFDNFGLAMLTVFQCV 986
            :.        |.:||   .:.||:   ...|...|:|......|:...|||||||.:.|.:|:.:
Human   417 SNPEAYDHCFEKKENSPEFKMCGIWMGNSACSIQYECKHTKINPDYNYTNFDNFGWSFLAMFRLM 481

  Fly   987 TLEGW---------TDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERNK-- 1040
            |.:.|         |..|||:          .:||.::.||:|:::||.|.|::..: :|:||  
Human   482 TQDSWEKLYQQTLRTTGLYSV----------FFFIVVIFLGSFYLINLTLAVVTMAY-EEQNKNV 535

  Fly  1041 -AKNRGDFQKLREKQQIEEDLRGYLDWITQAEDIEPDAVGGL----------------------I 1082
             |:.....:..:|.||:.::.:..|    .|..|:..::..|                      :
Human   536 AAEIEAKEKMFQEAQQLLKEEKEAL----VAMGIDRSSLTSLETSYFTPKKRKLFGNKKRKSFFL 596

  Fly  1083 SDGKGKQPNEMDSTENLGEEMPEVQMTESRWRKMKKD-FDRVNRRMRR----------------- 1129
            .:....||...||.|:..::...::.|:...:.:..| ||.....::|                 
Human   597 RESGKDQPPGSDSDEDCQKKPQLLEQTKRLSQNLSLDHFDEHGDPLQRQRALSAVSILTITMKEQ 661

  Fly  1130 --------ACRKAVKSQAFYW------------------------LIIVLVFLNTGVLATEHYGQ 1162
                    .|.:.:.|:...|                        .|.:.:.:||..||.||:..
Human   662 EKSQEPCLPCGENLASKYLVWNCCPQWLCVKKVLRTVMTDPFTELAITICIIINTVFLAMEHHKM 726

  Fly  1163 LDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPP 1227
            ....:......|:.|..:|..||.||:.:|....||...:|.||..|.:.|..:.:   ..::..
Human   727 EASFEKMLNIGNLVFTSIFIAEMCLKIIALDPYHYFRRGWNIFDSIVALLSFADVM---NCVLQK 788

  Fly  1228 LGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFN 1292
            .....||..|:|||||:.|.|.:|:.|:..:.||:.::.||.::|.:.|.||:::|||:||..||
Human   789 RSWPFLRSFRVLRVFKLAKSWPTLNTLIKIIGNSVGALGSLTVVLVIVIFIFSVVGMQLFGRSFN 853

  Fly  1293 FDGKEEKY------------RMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALAC 1345
             ..|..|.            ..:...||.:.|.||:|:.|| |...|:..:......||   |..
Human   854 -SQKSPKLCNPTGPTVSCLRHWHMGDFWHSFLVVFRILCGE-WIENMWECMQEANASSS---LCV 913

  Fly  1346 IYFIILFICGNYILLNVFLAIAVDNLADADSLSEVE----------------------------- 1381
            |.||::.:.|..::||:|:|:.:::.::.:....:|                             
Human   914 IVFILITVIGKLVVLNLFIALLLNSFSNEERNGNLEGEARKTKVQLALDRFRRAFCFVRHTLEHF 978

  Fly  1382 ------KEEEPHDE------SAQKKSHSP----------------------------------TP 1400
                  |:..|..:      :||.|...|                                  .|
Human   979 CHKWCRKQNLPQQKEVAGGCAAQSKDIIPLVMEMKRGSETQEELGILTSVPKTLGVRHDWTWLAP 1043

  Fly  1401 TIDGMDDHLSIDIDMEQQELDDEDKMDHETLSDEEVREMCEEEEEV-------DEEGMITARPRR 1458
            ..:..||......|..|:....|.:.....|..|..:...:..:.|       ||..:....||:
Human  1044 LAEEEDDVEFSGEDNAQRITQPEPEQQAYELHQENKKPTSQRVQSVEIDMFSEDEPHLTIQDPRK 1108

  Fly  1459 MSEVNT-------------------------ATKILPIPPGTSFFLFSQTNR---------FRVF 1489
            .|:|.:                         ..:.||...|..|...|...|         .|..
Human  1109 KSDVTSILSECSTIDLQDGFGWLPEMVPKKQPERCLPKGFGCCFPCCSVDKRKPPWVIWWNLRKT 1173

  Fly  1490 CHWLCNHSNFGNIILCCIMFSSAMLAAEN-PLRANDDLNKVLNKFDYFFTAVFTIELILKLISYG 1553
            |:.:..||.|.:.|:..|:.||..|..|: .|.....:.::||..|..||.:|.:|::||.:::|
Human  1174 CYQIVKHSWFESFIIFVILLSSGALIFEDVHLENQPKIQELLNCTDIIFTHIFILEMVLKWVAFG 1238

  Fly  1554 FVLHDGAFCRSAFNLLDLLVVCVSLISLVSSSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQC 1618
            |    |.:..||:..||.::|.||:.:|::    :..:|..|.||.||||||:::.:|:|.||..
Human  1239 F----GKYFTSAWCCLDFIIVIVSVTTLIN----LMELKSFRTLRALRPLRALSQFEGMKVVVNA 1295

  Fly  1619 VIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQL 1683
            :|.|:..|.|::|| ||:.::                                   :|.::||..
Human  1296 LIGAIPAILNVLLV-CLIFWL-----------------------------------VFCILGVYF 1324

  Fly  1684 FKGKFFKCTDGSK--------MTQDECYGTYLVYDDGDVHKPRLREREWSNNRFHFDDVAKGMLT 1740
            |.|||.||.:|:.        ..:.:|       :.|:.        .|.|.:.:||:|....|.
Human  1325 FSGKFGKCINGTDSVINYTIITNKSQC-------ESGNF--------SWINQKVNFDNVGNAYLA 1374

  Fly  1741 LFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNE 1805
            |..|:||:||..::|.::||.::...|......:...|::::||..:||.:|:|:|.:|..|..:
Human  1375 LLQVATFKGWMDIIYAAVDSTEKEQQPEFESNSLGYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQ 1439

  Fly  1806 ----GEQEYKNCDLDKNQRNCIEFALKAKPVRRYIPK--HGIQYKVWWFVTSSSFEYTIFILIMI 1864
                |.|:....:..|...|.:: .|.:|..::.||:  :..|..|:..|||..|:..|..||::
Human  1440 QKKLGGQDIFMTEEQKKYYNAMK-KLGSKKPQKPIPRPLNKCQGLVFDIVTSQIFDIIIISLIIL 1503

  Fly  1865 NTVTLAMKFYNQPLWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFI 1929
            |.:::..:.||||.....:||.||.:|..:|.||.:.|:.|.| :.||.:.||:||.::||.|.:
Human  1504 NMISMMAESYNQPKAMKSILDHLNWVFVVIFTLECLIKIFALR-QYYFTNGWNLFDCVVVLLSIV 1567

  Fly  1930 DIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWT 1994
            ..:.|.:::::.....                ..|..|  .||.|:.|:::|:....||||||:.
Human  1568 STMISTLENQEHIPFP----------------PTLFRI--VRLARIGRILRLVRAARGIRTLLFA 1614

  Fly  1995 FIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIALDGGNAITANNNFQTFQQAVLVLFRSATGEA 2059
            .:.|..:|..:.||:.|:.||||::||..|.|:..:.|  |....||:||..::|.||:.:|...
Human  1615 LMMSLPSLFNIGLLLFLIMFIYAILGMNWFSKVNPESG--IDDIFNFKTFASSMLCLFQISTSAG 1677

  Fly  2060 WQEIMM-------SCSAQPDVKCDMNSDTPGEPCGSSIAYPYFISFYVLCSFLIINLFVAVIMDN 2117
            |..::.       ||::..:     |...||      ||..||:|:.::...:::|:::|||::|
Human  1678 WDSLLSPMLRSKESCNSSSE-----NCHLPG------IATSYFVSYIIISFLIVVNMYIAVILEN 1731

  Fly  2118 FDYLTRD-WSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKR 2181
            |:..|.: ...||....|.|..:|.::||:|...||:..:......:..||...|  |::.   :
Human  1732 FNTATEESEDPLGEDDFDIFYEVWEKFDPEATQFIKYSALSDFADALPEPLRVAK--PNKY---Q 1791

  Fly  2182 LVSMNMPLNSDGTVLFNATLFAVVRTSLSIKTDGNIDDANSELRATIKQIWKRTNP--KLLDQVV 2244
            .:.|::|:.|:..:.....|||.....|     |..|..:| ::|.:::.:...||  ||.:.:|
Human  1792 FLVMDLPMVSEDRLHCMDILFAFTARVL-----GGSDGLDS-MKAMMEEKFMEANPLKKLYEPIV 1850

  Fly  2245 PPPGNDDEVTVGKFYATYLIQDYFRRF--KKRKEQEGK----EGHPDSNTVTLQAG 2294
            ......:|..     ...:||..||::  |..|..:|.    |..|.|...||..|
Human  1851 TTTKRKEEER-----GAAIIQKAFRKYMMKVTKGDQGDQNDLENGPHSPLQTLCNG 1901

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 93/304 (31%)
Ion_trans 1137..1379 CDD:395416 74/277 (27%)
Ion_trans 1496..1809 CDD:395416 91/325 (28%)
Ion_trans 1851..2126 CDD:395416 85/282 (30%)
GPHH 2135..2188 CDD:407139 12/52 (23%)
Ca_chan_IQ 2199..2271 CDD:400901 18/73 (25%)
SCN11AXP_016861136.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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