Protein Alignment Ca-alpha1D and cacna1g

DIOPT Version :9

• Sequence 1: NP_723952.2
• Gene: Ca-alpha1D / 34950
• FlyBaseID: FBgn0001991
• Length: 2705
• Species: Drosophila melanogaster
• Sequence 2: XP_031750725.1
• Gene: cacna1g / 100497283
• XenbaseID: XB-GENE-993391
• Length: 2361
• Species: Xenopus tropicalis
• Alignment Length: 1919
• Identity: 470/1919 - (24%)
• Similarity: 767/1919 - (39%)
• Gaps: 647/1919 - (33%)

  Fly   729 GQKRQQRRGKPQPDRPQRALFCLSVKNPLRALCIRIV--EWKPFEFLILLTIFANCIALAVYTPY 791
            |....:..|.|.|.......|.|:.::..|:.|:::|  .|  ||...:|.|..||:.|.::  :
 Frog    14 GDPGSELEGLPYPTLAPVVFFFLTQESRPRSWCLKMVCNPW--FERFSMLVILLNCVTLGMF--H 74

  Fly   792 PGSDSNVTNQTLEKV----EYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAI 852
            |..|....:|..:.:    :::| ..|..|.::|:||.| :.....||.:.||.||..|||.|.:
 Frog    75 PCEDIACDSQRCKILQGFDDFIF-AFFAVEMIIKMLALG-IFGKQCYLGDTWNCLDLVIVVAGML 137

  Fly   853 STALSQLMKDAFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAI 917
            ..:| .|....|  .|:|..|||||||.::.|||:::::..:|..:..|.::.||..||..|:.|
 Frog   138 EYSL-DLQNVTF--SAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGI 199

  Fly   918 IGLELFSGKLHKAC----------------------RDE---ITGEYEEN-IRPC-------GVG 949
            :|::|::|.|...|                      .||   |..:..|| :|.|       ..|
 Frog   200 VGVQLWAGLLRNRCFLPENFSLPVSLELERYYQTENEDENPFICSQARENGMRYCRNVPAMREDG 264

  Fly   950 YQCPPGY-------------------KCYGGWDGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVL 995
            .:|...:                   .|..|...|..|..||||.|.|.:.:||.:|||||.|::
 Frog   265 LECTLDHYFYNNTSNTSCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITLEGWVDIM 329

  Fly   996 YSIQDAMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERNKAKNRGDFQKLR--------- 1051
            |.:.|| .|.:.::|||.::|:|:||::||.|.|::.:||:.:.:.......|::|
 Frog   330 YFVMDA-HSFYNFIYFILLIIIGSFFMINLCLVVIATQFSETKQRESQLMKEQRVRFLSNASTLA 393

  Fly  1052 ---EKQQIEEDLRGYLDWIT--------------------------------------------- 1068
               |.....::|..||.:||
 Frog   394 SFSEPGSCYDELLKYLVYITRKGSKRLVQFYRAAAFKAGLSARPVVKNSAEKPNRKHRRRRSSVH 458

  Fly  1069 ---------------------------QAEDIE-------------------------------- 1074
                                       :..::|
 Frog   459 HLIHHHHHHHHHYHLGNGSLRAPQASPELSEVETSSPHNTSRLMVPFAGSPIASATNTQSIHSIY 523

  Fly  1075 ------------------------PDAVGGLISDGKG------------------KQPNEMDSTE 1097
                                    |:.:...|:.||.                  .:|:|:.|..
 Frog   524 HADCHLEPVHCVQTFAHPGSSSENPEVLPRSITGGKNYPTLHPSASPDIQVDAEPVEPSEITSDA 588

  Fly  1098 NL----------------------------------------GE-------------EMPE---- 1105
            |:                                        ||             |.||
 Frog   589 NIHPLPVFNSMNRLLETQSTGIGRGVCKISGQTANLESGSCDGEKCSHCKETELRDTEGPESDSD 653

  Fly  1106 --------------VQMTESRWRKMKKDF-DRVNRRMRRAC---RKAVKSQAFYWLIIVLVFLNT 1152
                          .|.||::..|.:... .::.:..:..|   ||.|.|:.|...|::.:.:||
 Frog   654 GCYEFTQDPQGSEQQQQTEAKRAKSRSQIPSKLQQLWKMVCETFRKIVDSKYFGRGIMIAILINT 718

  Fly  1153 GVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRFDCFVVIGSITET 1217
            ..:..|::.|.:.|.|..|.:|:.|..||..|||||:...|..||..:.:|.||..:|:.|:.|.
 Frog   719 LSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIKNPYNIFDGIIVVISVWEI 783

  Fly  1218 LLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLLLLFLFIVIFALL 1282
            :....|     |:||||..||:||.|:.::..:|...:..|:.::.::|:..:||.|||.||::|
 Frog   784 IGQQGG-----GLSVLRTFRLMRVLKLVRFMPALQRQLVVLMKTMDNVATFCMLLMLFIFIFSIL 843

  Fly  1283 GMQVFGGKF--NFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYGGVSSYGALAC 1345
            ||.:||.||  ..||.....|.|||....|.:|||||:|.||||.|:      |.|::|..:.|.
 Frog   844 GMHLFGCKFASEKDGDTLPDRKNFDSLLWATVTVFQILTQEDWNKVL------YNGMASTSSWAA 902

  Fly  1346 IYFIILFICGNYILLNVFLAIAVDNLADADSLSEVEKEEE----------PHD------------ 1388
            :|||.|...|||:|.|:.:||.|:..    ...||.|.|:          |.|
 Frog   903 LYFIALMTFGNYVLFNLLVAILVEGF----QTEEVSKREDMSAHLSCIQLPVDSIGQGEGSQSGS 963

  Fly  1389 ESAQKKSH--------SPTPTIDGMDDHLSI-----------------------DIDMEQQELDD 1422
            |||.:..|        |.|| :.|..|..|:                       ||.|..:...:
 Frog   964 ESAHEDCHIRKGLSNASFTP-LHGYPDGKSMLQPPLIIHTAATPMPMPKCALFGDIPMAGESRRE 1027

  Fly  1423 ---------------------------------------------------EDKMDHETL----- 1431
                                                               |...:|::|
 Frog  1028 SNVSGGPHACEIRSMSSSRNSPHSSWGAVCSWNSRRSSWNSIGRASSLKRHEQSGEHKSLLSADG 1092

  Fly  1432 --------SDEEV----------------REMCE------------------------------- 1441
                    |||||                ||..:
 Frog  1093 KESSEGDTSDEEVSSRTGSSLNRMDLVGKREAYDMHDTLHVPYSYGMQSRHSLPGEYQDCNGKTS 1157

  Fly  1442 --------EEEEVD-----EEGMITARPRRMSEVNTATKILPIPPGT------SFFLFSQTNRFR 1487
                    ||.:||     ::.:..:|..|:.    |..|..:|...      |.:||...::||
 Frog  1158 PVFPPLHVEESKVDYSNNIDDDVNMSRGERLK----AWIISHLPAWCKERETWSLYLFPPYSKFR 1218

  Fly  1488 VFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDDLNKV-LNKFDYFFTAVFTIELILKLIS 1551
            :.|:.:..|..|.:::|..|..:...:|.|.|........:: |...:|.||.:|..|:.:|:::
 Frog  1219 LMCNKIITHRMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLTLSNYIFTLIFLAEMTVKVVA 1283

  Fly  1552 YGFVLHDGAFCRSAFNLLDLLVVCVS----LISLVSSSNA--ISVVKILRVLRVLRPLRAINRAK 1610
            ..|.....|:.||::|:||.::|.:|    |:|:||.|..  :.::::||:||.|||||.|:||:
 Frog  1284 MNFCFGGKAYLRSSWNVLDGMLVLISVIDILVSMVSDSGTKILGMLRVLRLLRTLRPLRVISRAQ 1348

  Fly  1611 GLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFM 1675
            |||.||:.::.::|.|||||::.|    .|.:|
 Frog  1349 GLKLVVETLMSSLKPIGNIVVICC----AFFII-------------------------------- 1377

  Fly  1676 FAVIGVQLFKGKFFKC--TDGSKMT-QDECYGTYLVYDDGDVHKPRLREREWSNNRFHFDDVAKG 1737
            |.::|||||||||:.|  .|...:| :.:|..               .:.:|:.::::||::.:.
 Frog  1378 FGILGVQLFKGKFYYCQGEDTRNITNKSDCLE---------------NKYKWARHKYNFDNLGQA 1427

  Fly  1738 MLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTF 1802
            :::||.:::.:||..::|..:|:...:..|:.|:.|.:..|:|.:::|:|||::|:|||.|:..|
 Frog  1428 LMSLFVLASKDGWVDIMYDGLDAVGVDQQPVMNYNPWMLLYFISFLLIVAFFVLNMFVGVVVENF 1492

  Fly  1803 ----QNEGEQEYKNCD------LDKNQRN-------------CIEFALKAKPVRRYIPKHGIQYK 1844
                |::.|:|.|..:      ::|.:|:             .:|.:  |.||:.      .|.|
 Frog  1493 HKCRQHQEEEEAKRREEKRLRRMEKKRRSKERELADLMLDDVILEHS--ASPVKE------AQCK 1549

  Fly  1845 VWW------------FVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALNMIFTAVFAL 1897
            .::            ..||...:..|..:|.:|.:|:||:.|.||....|.|...|.|||.:|.|
 Frog  1550 PYYSEYSHPRLLIHQMCTSHYLDLFITGVIGLNVITMAMEHYQQPKVLDEALKICNYIFTLIFVL 1614

  Fly  1898 EFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGCKSTKKSAGS 1962
            |...|:.||.|:.:|.|.||..|..|||.|.:.|...||:                  ...|...
 Frog  1615 ESGCKMVAFGFRRFFKDRWNQLDLAIVLLSIMGITLEEIE------------------VNASLPI 1661

  Fly  1963 NLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYV---ALLIVLLFFIYAVVGMQVF 2024
            |...|...|:.|:.|::|||....|:|.||.|.:   ||||.|   .||.:|||||:|.:|:::|
 Frog  1662 NPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVL---QALPQVGNLGLLFMLLFFIFAALGVELF 1723

  Fly  2025 GKIALDGGN---AITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDMNSDTPGEPC 2086
            |.:.....:   .:..:..|:.|..|.|.|||.:||:.|..||      .|...|.|.|:   .|
 Frog  1724 GDLECTDSHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIM------KDTLRDCNEDS---TC 1779

  Fly  2087 GSSIAYP-YFISFYVLCSFLIINLFVAVIMDNFD 2119
            .:::..| ||:||.:...|:::|:.:||:|.:.:
 Frog  1780 YNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLE 1813

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ca-alpha1D	NP_723952.2	Ion_trans	767..1042	CDD:395416	100/330 (30%)
		Ion_trans	1137..1379	CDD:395416	90/243 (37%)
		Ion_trans	1496..1809	CDD:395416	94/326 (29%)
		Ion_trans	1851..2126	CDD:395416	92/276 (33%)
		GPHH	2135..2188	CDD:407139
		Ca_chan_IQ	2199..2271	CDD:400901
cacna1g	XP_031750725.1	Ion_trans	52..375	CDD:395416	100/332 (30%)
		Ion_trans	703..932	CDD:395416	90/243 (37%)
		Ion_trans	1227..1499	CDD:395416	93/322 (29%)
		Ion_trans	1568..1809	CDD:395416	91/270 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010