DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and cacna1h

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:XP_031748783.1 Gene:cacna1h / 100494894 XenbaseID:XB-GENE-6042121 Length:2460 Species:Xenopus tropicalis


Alignment Length:2552 Identity:594/2552 - (23%)
Similarity:947/2552 - (37%) Gaps:892/2552 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   667 PGSGDVSRTARYDSGEGDLGGGNNIMGIDSMGIANIPETMNGTTIGPSGAGGQKG-GAAAGAAGQ 730
            |.:||.|.       |.|.|....                  :.:|..|:||..| |...|...:
 Frog    26 PQAGDPSE-------EEDAGNAEK------------------SALGSLGSGGSSGRGREQGMGSE 65

  Fly   731 KRQQRRGKPQPDRPQRALFCLSVKNPLRALCIRIV--EWKPFEFLILLTIFANCIALAVYTPYPG 793
            :.:|   .|.|.......||||.....|..|:|:|  .|  ||.:.:|.|..||:.|.::.|.  
 Frog    66 EGEQ---VPYPALAPTVFFCLSQTTRPRNWCLRLVCNPW--FEHVSMLVILLNCVTLGMFQPC-- 123

  Fly   794 SDSNVTNQ---TLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIGAISTA 855
            .|:|..::   .||..:......|..|.|:|::|.| :.....||.:.||.|||.||:.|.:..:
 Frog   124 EDTNCMSERCNILEAFDGFIFAFFAVEMVIKMVALG-IFGQKCYLGDTWNWLDFFIVMAGMLEYS 187

  Fly   856 LSQLMKDAFDV--KALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHIALLVLFVIIIYAII 918
            |     |..:|  .|:|..|||||||.::.|||:::::..:|..:..|.::.||..||..|:.|:
 Frog   188 L-----DGHNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIV 247

  Fly   919 GLELFSGKLHKACRDEITGEYEENIRPCGVGYQ---------------------C---PPGYKC- 958
            |::|::|.|...|..:.......|..|....||                     |   ||...| 
 Frog   248 GVQLWAGLLRNRCFMDTNFVMSYNFTPLRPYYQVDDAEDNPYICSSNRDNGMLKCQDIPPKMDCS 312

  Fly   959 -------------------YG----GWDGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQD 1000
                               |.    |...|:.|..||||.|.|.:.:||.:|||||.|::|.:.|
 Frog   313 HVYYSDFPSRNSCVNINQYYNVCKPGEFNPHKGAINFDNIGYAWIAIFQVITLEGWVDIMYYVMD 377

  Fly  1001 AMGSDWQWMYFISMVILGAFFVMNLILGVLSGEFSKERNKAKNRGDFQKLREKQQIEED------ 1059
            | .|.:.::|||.::|:|:||::||.|.|::.:||:           .|.||.|.::|.      
 Frog   378 A-HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSE-----------TKQRENQLMQEQRARYLS 430

  Fly  1060 ---------------------------------LRGYLDW------------------------- 1066
                                             ||.|.:|                         
 Frog   431 NDSTIASFSEPGSCYEELLKYICHIFRKVKRRTLRLYNNWQNKRRKKVQPNSNTNSQGRHRKCKR 495

  Fly  1067 -ITQAE-------------------------------DIE------------PDAVGGLISDGKG 1087
             ||...                               |:|            |.|...|.|....
 Frog   496 RITSIHHLIHHHHHHHHHHYHISNGSPRGPRSSPEICDVEMKIMKPKNQLRLPPASPSLQSMSPN 560

  Fly  1088 KQ------------------------------------------PNEMDSTEN------------ 1098
            .:                                          |..|.|..|            
 Frog   561 SEAVHSIYHADCHLEAPQRKSSKSSNASSNIKLNAGLNHSNMNYPTIMPSQANKTSPATLPKGKR 625

  Fly  1099 --------------------------LGE------------------------------------ 1101
                                      :||                                    
 Frog   626 NGSNAVSLLSSPVSMKADSFGKTNHLVGEHGLCRSSSKLSGLSVPCSLPSPQPSPLLCEIQNCPY 690

  Fly  1102 -----EMPEVQMTES---------------------------RWRKMKKDFDRVNR--------- 1125
                 |.|::::::|                           :.||:|......|:         
 Frog   691 CANLLENPDLELSDSESCESDSNGVYEFTQDLRRGDQRDQVQKGRKLKTKPKEANKVYLLWEEFT 755

  Fly  1126 -RMRRACRKAVKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKM 1189
             |::|    .|.|:.|...|::.:.:||..:..|::.|.:.|.|..|.:|:.|..:|..|||||:
 Frog   756 VRLKR----IVDSKYFNRGIMIAILINTLSMGIEYHEQPEELTNALEISNIVFTSMFALEMLLKL 816

  Fly  1190 YSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNL 1254
            .:.|...|..:.:|.||..:|:.|:.|.:..:.|     |:||||..|||||.|:.::..:|...
 Frog   817 LAFGIFQYIKNPYNIFDGIIVVISVWEIIGQSDG-----GLSVLRTFRLLRVLKLVRFMPALRRQ 876

  Fly  1255 VASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNF---DGKEEKYRMNFDCFWQALLTVFQ 1316
            :..|:.::.::|:..:||.|||.||::|||.:||.||.:   .|:..|.|.|||....|::||||
 Frog   877 LVVLVKTMDNVATFCMLLMLFIFIFSILGMHLFGCKFTWTADTGETVKDRKNFDSLLWAIVTVFQ 941

  Fly  1317 IMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYILLNVFLAIAVDNL-ADAD---SL 1377
            |:|.||||.|:      |.|::|..:.|.:||:.|...|||:|.|:.:||.|:.. |:.|   |.
 Frog   942 ILTQEDWNMVL------YNGMASTSSWAALYFVALMTFGNYVLFNLLVAILVEGFQAEGDATRSD 1000

  Fly  1378 SEVEKEEEPHDESAQK------------------------KSHSPTPTI--------------DG 1404
            :|.:|.....||..:|                        :|..|.|.|              ..
 Frog  1001 TEEDKASGNFDEDLEKLKELRAAELKMYSLAVTPNGHLDPRSSMPPPIIMRTAATPMPTPKSSPC 1065

  Fly  1405 MDD---------HLSIDID---MEQQEL------------------------------------- 1420
            ||.         ..|:.||   ::|:.|                                     
 Frog  1066 MDSSHPFGDSRRESSVSIDPSIVDQKSLASLRSTPCTPWGTYSNWGSRRSSWNSLGRAPSIKKKS 1130

  Fly  1421 ------------------DDED------------------------------------------- 1424
                              ||.|                                           
 Frog  1131 QSGERESLLSGEGKGSTDDDSDDCKSSPAARVSLHRRAGSLDTRGSLDIPDFLQVPTLRHSLSVS 1195

  Fly  1425 --------------KMDHETLSDEEVREMCEEEE----EVDEEGMITARPRRMSEVNTATKILPI 1471
                          ||.| ..||..||.....|:    |.|.|.....|.|:|.|        |.
 Frog  1196 PLAMVPSDYQDCNGKMMH-VPSDLFVRVEKHREDPLEYEDDIEDSYCFRIRKMLE--------PY 1251

  Fly  1472 PP-------GTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCIMFSSAMLAAENPLRANDDLNKV 1529
            .|       ..|.::||..|:||:.|..:..|..|.:::|..|..:...:|.|.|....:.|.::
 Frog  1252 KPTWCKTHEDWSLYMFSPQNQFRMMCQKVIAHKMFDHVVLVFIFLNCITIALERPDIDPNSLERI 1316

  Fly  1530 -LNKFDYFFTAVFTIELILKLISYGFVLHDGAFCRSAFNLLDLLVVCVSLISLVSS------SNA 1587
             |:..:|.|||:|.:|:.:|:::.|||..:..:.:|::|:||.::|.||:|.:|.|      :..
 Frog  1317 FLSVSNYIFTAIFVLEMAIKVVALGFVSGENTYLQSSWNVLDGILVFVSIIDIVVSLASAGGAKI 1381

  Fly  1588 ISVVKILRVLRVLRPLRAINRAKGLKHVVQCVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVV 1652
            :.|:::||:||.|||||.|:||.|||.||:.:|.:::.||||||:.|    .|.:|         
 Frog  1382 LGVLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLRPIGNIVLICC----AFFII--------- 1433

  Fly  1653 KCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFKGKFFKCTDGSK----MTQDECYGTYLVYDDGD 1713
                                   |.::|||||||||:.| :|.:    ..:.||           
 Frog  1434 -----------------------FGILGVQLFKGKFYYC-EGLETRNITNRSEC----------- 1463

  Fly  1714 VHKPRLRER-EWSNNRFHFDDVAKGMLTLFTVSTFEGWPGLLYVSIDSNKENGGPIHNFRPIVAA 1777
                 .|.| :|...:::||::.:.:::||.:|:.:||..::|..:|:...:..|:.|..|.:..
 Frog  1464 -----TRARYKWVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVATDVQPVKNHNPWMLL 1523

  Fly  1778 YYIIYIIIIAFFMVNIFVGFVIVTF----QNEGEQEYKNCD------LDKNQRNCIEFALKAK-- 1830
            |:|.:::|::||::|:|||.|:..|    |::..:|.:..:      |:|.:|:...:..:|:  
 Frog  1524 YFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLEKKRRSKALYMSEAQRR 1588

  Fly  1831 -------PVRRYIPKHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPLWYTELLDALN 1888
                   |.|.||  |.:       .||...:..|..:|.||.:|::|:.||||....|.|...|
 Frog  1589 PYYAEYSPARLYI--HTM-------CTSHYLDLFITCIICINVITMSMEHYNQPKSLDEALKYCN 1644

  Fly  1889 MIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQIAECDIVEGC 1953
            .:||.||..|.:|||.||.|:.:|.|.||..|..|||.|.:.|...||:...:..|         
 Frog  1645 YVFTIVFVFEALFKLVAFGFRRFFKDRWNQLDLAIVLLSIMGITLEEIEINASLPI--------- 1700

  Fly  1954 KSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYV---ALLIVLLFFI 2015
                     |...|...|:.|:.|::|||....|:|.||.|.:   ||||.|   .||.:|||||
 Frog  1701 ---------NPTIIRIMRVLRIARVLKLLKMATGMRALLDTVV---QALPQVGNLGLLFMLLFFI 1753

  Fly  2016 YAVVGMQVFGKIALDGGN---AITANNNFQTFQQAVLVLFRSATGEAWQEIMMSCSAQPDVKCDM 2077
            ||.:|:::|||:..:..|   .::.:..|:.|..|.|.|||.:||:.|..||      .|...:.
 Frog  1754 YAALGVELFGKLVCNEENPCEGLSRHATFENFGMAFLTLFRVSTGDNWNGIM------KDTLREC 1812

  Fly  2078 NSDTPGEPCGSSIAYP-YFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFIRLWS 2141
            |||.........:..| ||::|.::..|:::|:.|||:|               .||:|..:...
 Frog  1813 NSDDKNCLTYLPVISPVYFVTFVLIAQFVLVNVVVAVLM---------------KHLEESNKEAK 1862

  Fly  2142 EYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNATLFAVVR 2206
            | |.:....|:    :.:.|.::|                 :|......|||.            
 Frog  1863 E-DAEMDAEIE----MEMSRALTP-----------------ISGGCTPASDGK------------ 1893

  Fly  2207 TSLSIKTDGNIDDANSELRATIKQIWKRTNPKLLDQVVPPPGNDDEVTVGKFYATYLIQDYFRRF 2271
                 .|:|..|....||   :||:......:.:..|:|                          
 Frog  1894 -----GTEGGQDPLKGEL---LKQVGGAVCQENVTLVIP-------------------------- 1924

  Fly  2272 KKRKEQEGKEGHPDSNTVTLQAGLRTLHEVSPALKRAISGNLDELDQEPEPMHRRHHTLFGSVWS 2336
                  |..||          |.|  |::..||.      ::.:....|.|:.           .
 Frog  1925 ------ESMEG----------AAL--LNDAVPAC------SIYQQQALPLPLQ-----------P 1954

  Fly  2337 SIRRHGNGTFRRSAKATASQSNGALAIGG-SASAALGVGGSSLVLGSSDPAGGDYLYDTLNRSVA 2400
            .:..|.:|.|:|   ...|.|...||:.. |.|..|.:...|.:.....||...|          
 Frog  1955 CVLGHEDGDFQR---RDGSGSRNLLAVKKISVSRMLSLPNDSYMFRPVLPAKSSY---------- 2006

  Fly  2401 DGVNNITRNIMQARLAAAGKLQDELQGAGSGGELRTFGESISMRPLAKNGGGAATVAGTLPPEAN 2465
                                   .||...:..:....|.:.|:.....:......:.....|:|:
 Frog  2007 -----------------------PLQEVETTEDNSPHGSTASLHSQPGDNNSLLNIPVECQPQAS 2048

  Fly  2466 AINY-DNRNRGILLHPYNNVYAP--NGALPGHERMIQSTPASPYDQRRLPTSSDMNGLAESLIGG 2527
            ..|: |:.:...:..|:.:..:|  |.:|...|.:...:.....|.:.|...|     .|||..|
 Frog  2049 VSNHQDSADLPKIPPPHTSSRSPSLNRSLRRQEAIRMDSVDQGGDSKDLNVES-----TESLHLG 2108

  Fly  2528 VLAAEGL--GKYC--DSEFVGTAAREMREALDMTPEEMNLAAHQILSNEHSL----SLIGSSNG- 2583
            ..:...|  ...|  :....||.....|  |...|...::..|..:.::||:    |.:.|.|. 
 Frog  2109 APSVTTLVPNLLCTLNVSLQGTPQSSPR--LSPQPRHSSVLTHNHVYSQHSIPSRPSSVSSGNSN 2171

  Fly  2584 ---SIFGGSAGGLGGAGSGGVGGLGGSSSIRNAFGGSGSGPSSLSPQHQPYSGTLNSPPIPDNRL 2645
               |:|..|     ......|..:  :||.::..|.|.:...|:|    |:....:|||.....|
 Frog  2172 PEESMFESS-----DLADEEVSHI--NSSAKDWRGSSNNRSHSVS----PFISQSSSPPPLSPSL 2225

  Fly  2646 RRV-ATVTTTNNNNKSQ 2661
            :.. :||:...::.|.:
 Frog  2226 KNCNSTVSLAGSSGKDK 2242

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 100/327 (31%)
Ion_trans 1137..1379 CDD:395416 91/248 (37%)
Ion_trans 1496..1809 CDD:395416 98/328 (30%)
Ion_trans 1851..2126 CDD:395416 96/281 (34%)
GPHH 2135..2188 CDD:407139 7/52 (13%)
Ca_chan_IQ 2199..2271 CDD:400901 9/71 (13%)
cacna1hXP_031748783.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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