DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and cacna1e

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:XP_017949086.2 Gene:cacna1e / 100488514 XenbaseID:XB-GENE-1012852 Length:2393 Species:Xenopus tropicalis


Alignment Length:2346 Identity:849/2346 - (36%)
Similarity:1147/2346 - (48%) Gaps:566/2346 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   704 ETMNGTTIGPSGAGGQKGGAAAGAAGQKRQQRRG-----KPQPDRP-----QRALFCLSVKNPLR 758
            :|:.|:...|.|        ...|..|.:.||..     .|.|.|.     .|:||.....|.:|
 Frog   179 KTLQGSPAAPVG--------TQAAFKQSKAQRARTMALYNPIPVRQNCFTVNRSLFIFGEDNIIR 235

  Fly   759 ALCIRIVEWKPFEFLILLTIFANCIALAVYTPYPGSDSNVTNQTLEKVEYVFLVIFTAECVMKIL 823
            ....::::|.|||::||.||.||||.||:....||.|....::.|||.|..|:.||..|..:||:
 Frog   236 KYAKKLIDWPPFEYMILATIIANCIVLALEQHLPGDDKTPMSRRLEKTEPYFIGIFCFEAGIKIV 300

  Fly   824 AYGFVLHNGAYLRNGWNLLDFTIVVIGAISTALSQLMKDAFDVKALRAFRVLRPLRLVSGVPSLQ 888
            |.|.|.|.|:|||||||::||.:|:.|.::||.:. .....|::.|||.||||||:||||:||||
 Frog   301 ALGLVFHKGSYLRNGWNVMDFIVVLSGILATAGTH-FNTHVDLRTLRAVRVLRPLKLVSGIPSLQ 364

  Fly   889 VVLNSILKAMVPLFHIALLVLFVIIIYAIIGLELFSGKLHKACRDEITGEYEENI---------- 943
            :||.||:||||||..|.||:.|.|:::||||||.:||||||||       |..|.          
 Frog   365 IVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHKAC-------YRNNSGMELDPMDPP 422

  Fly   944 RPCGVGYQCPPGYKCYGGWDGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQW 1008
            .||||. :||.||:| ..|.|||||||.|||...|:||||||:|:||||.|||:..||:|:.|.|
 Frog   423 HPCGVP-RCPAGYEC-KEWIGPNDGITQFDNILFAVLTVFQCITMEGWTTVLYNTNDALGATWNW 485

  Fly  1009 MYFISMVILGAFFVMNLILGVLSGEFSKERNKAKNRGDFQKLREKQQIEEDLRGYLDWITQAEDI 1073
            :|||.::|:|:|||:||:||||||||:|||.:.:||..|.|||.:||||.:|.||..||.:||::
 Frog   486 LYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLRRQQQIERELNGYRAWIDKAEEV 550

  Fly  1074 ---EPDAVGG----------LISDGKGKQPNEMDSTENLGEEMPEV--QMTESRWRKMKKD---- 1119
               |.:...|          .|...:.:..|. ||||:...::..|  .:..:..:..|.|    
 Frog   551 MLAEENKNSGTSALEVLRRATIKRSRTEAMNR-DSTEDHCVDISSVGTPLARASIKSTKMDGASY 614

  Fly  1120 FDRVNRRMRRACRKAVKSQAFYWLIIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCE 1184
            |....:.:|.:.|..:|||.|||:::.:|.|||..:|..|:.|..||.|...|....|:|||..|
 Frog   615 FRHKEKLLRVSVRHMIKSQVFYWMVLGVVALNTFCVAIVHHNQTLWLSNVLYYAEFLFLGLFLVE 679

  Fly  1185 MLLKMYSLGFQGYFVSLFNRFDCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWR 1249
            |..|||.:|.:.||.|.||.|||.|.||||.|.|..........|:||||.:||||:||:||||.
 Frog   680 MAFKMYGMGPRLYFHSSFNCFDCGVTIGSIFEVLWAIFRPGTSFGISVLRALRLLRIFKITKYWA 744

  Fly  1250 SLSNLVASLLNSIQSIASLLLLLFLFIVIFALLGMQVFGGKFNF-DGKEEKYRMNFDCFWQALLT 1313
            ||.|||.||:||::||.|||.|||||||:|||||||::||:||| ||...   .|||.|..|::|
 Frog   745 SLRNLVVSLMNSMKSIISLLFLLFLFIVVFALLGMQLYGGRFNFNDGTPS---ANFDTFPAAIMT 806

  Fly  1314 VFQIMTGEDWNAVMYVGINAYGGVSSYGALACIYFIILFICGNYILLNVFLAIAVDNLADADSLS 1378
            ||||:||||||.|||.||.:.|||.| |..:.||||:|.:.|||.||||||||||||||:|..|:
 Frog   807 VFQILTGEDWNEVMYNGIRSQGGVRS-GMWSSIYFIVLTLFGNYTLLNVFLAIAVDNLANAQELT 870

  Fly  1379 EVEKEEE---------------------------------------------------------- 1385
            :.|:|||                                                          
 Frog   871 KDEQEEEEAFNQKHALQKAKEVSPMSAPNASCIEKERRKRHTLSIWEQRTSQLRRHIQMSSQEAL 935

  Fly  1386 ---------PHD-------ESA------------------------------------------- 1391
                     ||.       |:|                                           
 Frog   936 QSEELAALNPHSSIYRKTKEAAEQNTEKEEVHQDAKLAIDPVEGPPEGEGSPSNRNLRENWRQKS 1000

  Fly  1392 ----------------------------------------------------------------- 1391
                                                                             
 Frog  1001 RHGNSENTEPNGTTPEEAMRRRQSQRRSRHRRVRTEGREQCSNPNSTSASREGGLDKVSAEDGRT 1065

  Fly  1392 --QKKSHSPTPTIDGMDDH-LSIDI--------------------------DMEQQELD----DE 1423
              ::||:.....:.|:||. |.|.|                          |:..||.|    |.
 Frog  1066 IPEEKSNGEAKEVKGVDDEPLKICISSRNCEDRNIRTLGCEGIALNDTPLQDVNSQEKDSSPPDL 1130

  Fly  1424 DKMDHETL---------------------SDEEVREM-------------C-------------- 1440
            |..:...|                     |.|.|.|.             |              
 Frog  1131 DCSEQALLGSIQSQESPNPTSCSLPDVSSSTERVTESTVITLPDTGMPTDCTVVQMSEGRDGEVN 1195

  Fly  1441 --------EEEEEVDEEGMITARPRRMSEVNTATKILPIPPGTSFFLFSQTNRFRVFCHWLCNHS 1497
                    ||||..|.|.....|..::.|...|     |.|.:|..:||.||..|..||::.|..
 Frog  1196 FGSSQQEKEEEEAEDGEERTIKRKEKLLESPKA-----IVPYSSMLIFSSTNPIRKVCHYIVNLR 1255

  Fly  1498 NFGNIILCCIMFSSAMLAAENPLRANDDLNKVLNKFDYFFTAVFTIELILKLISYGFVLHDGAFC 1562
            .|...||..|..||..||||:|:..|.|.||||..|||.||.|||.|:|:|:|..|.:||:|::.
 Frog  1256 YFEMSILLVIAASSIALAAEDPVLTNSDRNKVLRYFDYVFTGVFTFEMIIKMIDQGLILHEGSYF 1320

  Fly  1563 RSAFNLLDLLVVCVSLISL-------VSSSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQCVI 1620
            |..:|:||.:||..:||:.       .:....|..:|.||||||||||:.|.|...||.|..   
 Frog  1321 RDLWNILDFVVVVGALIAFALANVLGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFD--- 1382

  Fly  1621 VAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQLFK 1685
                                             |||.::|.:.||::|..|..|:||||.|||||
 Frog  1383 ---------------------------------CVVNSLKNVFNILIVYKLFMFIFAVIAVQLFK 1414

  Fly  1686 GKFFKCTDGSKMTQDECYGTYLVYDDGDVHKPRLREREWSNNRFHFDDVAKGMLTLFTVSTFEGW 1750
            ||||.|||.||.|:.||.|:|:   |.:.:|..::.|||..:.||:|::...:||||||||.|||
 Frog  1415 GKFFYCTDSSKETEKECIGSYI---DHEKNKMEVKRREWKRHDFHYDNIIWALLTLFTVSTGEGW 1476

  Fly  1751 PGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQEYKNCDL 1815
            |.:|..|:|..:|:.||..:.|..::.:|:||.::..||.|||||..:|:|||.:|::..:.|.|
 Frog  1477 PQVLQHSVDITEEDRGPSRSNRMEMSIFYVIYFVVFPFFFVNIFVALIIITFQEQGDKMMEECSL 1541

  Fly  1816 DKNQRNCIEFALKAKPVRRYIP--KHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQPL 1878
            :||:|.||:||:.|||:.||:|  :|..||:||.||.|.||||||..:|.:|||.|.||:|:.|.
 Frog  1542 EKNERACIDFAISAKPLTRYMPQNRHTFQYRVWHFVVSPSFEYTIMAMIALNTVVLMMKYYSAPY 1606

  Fly  1879 WYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSKDTSQ 1943
            .|...|..||:.||.:|:||.:.|:.||.|.|||.|.||:||||.|:||..:|:.::.|..:||.
 Frog  1607 TYELALKYLNIAFTMLFSLECILKIIAFGFLNYFRDTWNIFDFITVIGSITEIILTDSKLVNTSS 1671

  Fly  1944 IAECDIVEGCKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGIRTLLWTFIKSFQALPYVALL 2008
                                 .:::|.:|||..||:|||.:|..||.|||||::||:|||||.||
 Frog  1672 ---------------------FNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLL 1715

  Fly  2009 IVLLFFIYAVVGMQVFGKIALDGGNAITANNNFQTFQQAVLVLFRSATGEAWQEIMMSC----SA 2069
            |.:||||||::||||||.|.|:..:.|..:|||::|..::::||||||||||||||:||    ..
 Frog  1716 IAMLFFIYAIIGMQVFGNIRLEEDSHINRHNNFRSFFSSLMLLFRSATGEAWQEIMLSCLSDKGC 1780

  Fly  2070 QPDVKCDMNSDTPGEPCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNFDYLTRDWSILGPHHLD 2134
            :||... .:.....|.||:.:||.||:||...||||::|||||||||||:|||||.|||||||||
 Frog  1781 EPDTSA-ASGHNENERCGTELAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLD 1844

  Fly  2135 EFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLVSMNMPLNSDGTVLFNA 2199
            ||:|:|:|||..|.|||.:.|:..|:|.||||||.|:.||:|:||||||.||||::.|.||.|.:
 Frog  1845 EFVRIWAEYDRAACGRIPYKDMYKLVRVISPPLGLGENCPYRVACKRLVLMNMPVSEDMTVHFTS 1909

  Fly  2200 TLFAVVRTSLSIK-TDGNID--DANSELRATIKQIWKRTNPKLLDQVVPPPGNDDEVTVGKFYAT 2261
            ||.|::||:|.|| ..|..|  ..:|||:..|..||...:.|::|.:||.|...| :||||.||.
 Frog  1910 TLMALIRTALDIKIAKGGADRQQLDSELQKDILAIWPNLSQKMIDLLVPMPRASD-LTVGKIYAA 1973

  Fly  2262 YLIQDYFRRFKKRKEQEGKEGHPDS---------------------------NTVTLQAGLRTLH 2299
            .:|.||:::.|.:|:::..|...::                           :|::...|..:|.
 Frog  1974 MMIMDYYKQSKAKKQRQQLEEQKNAPMFQRMEASALPEEILSNAKALPYLQQDTLSGLGGFPSLS 2038

  Fly  2300 EVSPA---LKRAISGNLDE-----LDQEPEPMHRRHHTL--FGSVWSSIRRHGNGTFRRSAKATA 2354
            .:||.   ....:.|..:|     |..|||....|...|  .||...........:.|.|:....
 Frog  2039 PLSPEEVFQPPCLDGEEEEDFEEQLSLEPEVREFRREQLPNRGSYIPVEMLERPASVRASSMPRL 2103

  Fly  2355 SQSNGALAIGGSASAALGVGGSSLVLGSSDPAGGDYLYD-TLNRSVADGVNNITRNIMQA--RLA 2416
            :::...|:...|...:........|..|       :|.: |::||..|......|....|  ||:
 Frog  2104 AENPQVLSDVSSMRRSFSTTAEKRVRSS-------WLDEFTMDRSSTDCAYRYQRRSYHASLRLS 2161

  Fly  2417 A------AGKLQDELQGAGSGGELRTFGESISMRPLAKNGGGAATVAGTLPPEANAINYDNRNRG 2475
            |      .|...|..:   |||..|  |.|...:.|             |.|:.:..|.:.|   
 Frog  2162 AHRLNTDTGHWSDNHR---SGGRER--GRSKERKHL-------------LSPDPSRCNSEER--- 2205

  Fly  2476 ILLHPYNNVYAPNGAL--------PGHERMIQSTPASPYDQRRLPTSSDMNGLAESLIGGVLAAE 2532
                      :|..|.        |||      ||:|                       |...:
 Frog  2206 ----------SPQAACEHRDHQLSPGH------TPSS-----------------------VQILD 2231

  Fly  2533 GLGKYCDSEFVGTAAREMRE--ALDMTPEEMNLAAHQILSNEHSLSLIGSSNGSIFGGSAGGLGG 2595
            .|.:.|......|..|..|:  ::..||..:...:..|...:|| ....:.|.:|.....|....
 Frog  2232 SLSESCTPSDTSTPRRGRRQLPSVPPTPRPLISFSSLIRRQKHS-PPPQNKNDTILPSEPGLTES 2295

  Fly  2596 AGSGGVGGLGGSSSIRNAFGGSGSGPSSLSPQH---QPYSG-----TLNSPPIPDNRLRRVATVT 2652
            :.|     |||..|            |..:|||   :||..     ..:..|..|.....||..|
 Frog  2296 SCS-----LGGHQS------------SQSTPQHYISEPYLALHEEMQSSDCPAEDTLTFEVAVAT 2343

  Fly  2653 TTNNNN 2658
            :...:|
 Frog  2344 SLGRSN 2349

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 155/284 (55%)
Ion_trans 1137..1379 CDD:395416 141/242 (58%)
Ion_trans 1496..1809 CDD:395416 132/319 (41%)
Ion_trans 1851..2126 CDD:395416 139/278 (50%)
GPHH 2135..2188 CDD:407139 32/52 (62%)
Ca_chan_IQ 2199..2271 CDD:400901 31/74 (42%)
cacna1eXP_017949086.2 Ion_trans 244..519 CDD:395416 155/284 (55%)
Ion_trans 632..871 CDD:395416 141/242 (58%)
Ion_trans 1255..1485 CDD:395416 112/268 (42%)
Ion_trans 1579..1836 CDD:395416 139/278 (50%)
GPHH 1845..1898 CDD:407139 32/52 (62%)
Ca_chan_IQ 1909..1982 CDD:400901 31/73 (42%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.920

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