DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Ca-alpha1D and cacna1c

DIOPT Version :9

Sequence 1:NP_723952.2 Gene:Ca-alpha1D / 34950 FlyBaseID:FBgn0001991 Length:2705 Species:Drosophila melanogaster
Sequence 2:XP_012814814.1 Gene:cacna1c / 100488055 XenbaseID:XB-GENE-991126 Length:2196 Species:Xenopus tropicalis


Alignment Length:2225 Identity:1121/2225 - (50%)
Similarity:1359/2225 - (61%) Gaps:370/2225 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly   686 GGGNNIMGIDSMGIANIPETMNGTT------IGPSGAG------------GQKGGAAAGA----- 727
            ||.|....:.::|      |||.|.      |...||.            .:..||||.|     
 Frog    46 GGSNYTNPLPALG------TMNSTPGLATEHIASPGAALSWQAAIDAARQAKLMGAAANATISTV 104

  Fly   728 --AGQKRQQ-----RRGKPQPDRPQRALFCLSVKNPLRALCIRIVEWKPFEFLILLTIFANCIAL 785
              ..:||||     ::|.....||.|||.||::|||:|..||.||||||||.:|||||||||:||
 Frog   105 SSTQRKRQQYSKQKKQGTTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVAL 169

  Fly   786 AVYTPYPGSDSNVTNQTLEKVEYVFLVIFTAECVMKILAYGFVLHNGAYLRNGWNLLDFTIVVIG 850
            |||.|:|..|||.||..||:|||:||:|||.|..:|::|||.:.|..||||||||||||.|||:|
 Frog   170 AVYIPFPEDDSNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVG 234

  Fly   851 AISTALSQLMK-----------DAFDVKALRAFRVLRPLRLVSGVPSLQVVLNSILKAMVPLFHI 904
            ..|..|.|..|           ..|||||||||||||||||||||||||||||||:||||||.||
 Frog   235 LFSAILEQATKADGGSAIGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHI 299

  Fly   905 ALLVLFVIIIYAIIGLELFSGKLHKACRDEITGEY-----EENIRPCGV----GYQCPPGYKCYG 960
            |||||||||||||||||||.||:||.|. .:|..|     ||...||.:    |..||.|..|..
 Frog   300 ALLVLFVIIIYAIIGLELFMGKMHKTCY-YLTNGYPDVLTEEEPSPCALESNNGRHCPNGTLCRS 363

  Fly   961 GWDGPNDGITNFDNFGLAMLTVFQCVTLEGWTDVLYSIQDAMGSDWQWMYFISMVILGAFFVMNL 1025
            ||.||..||||||||..||||||||:|:||||||||.:|||||.:...:||:|:||.|:|||:||
 Frog   364 GWVGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPCVYFVSLVIFGSFFVLNL 428

  Fly  1026 ILGVLSGEFSKERNKAKNRGDFQKLREKQQIEEDLRGYLDWITQAEDIEPDAVGGLISDGKGK-- 1088
            :||||||||||||.|||.||||||||||||:||||:||||||||||||:|:.....|.:.|.:  
 Frog   429 VLGVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEDEDIDEEKPRNM 493

  Fly  1089 ----QPNEMDSTENLG-----EEMPEVQMTESRWRKMKKDFDRV----NRRMRRACRKAVKSQAF 1140
                ...|..:|:|:|     ||...|::..   |..|..|.|.    ||..||.||.||||..|
 Frog   494 SMPTSETESVNTDNVGSGDVEEESCGVRLAH---RISKSKFSRYWRRWNRFCRRKCRAAVKSNVF 555

  Fly  1141 YWLIIVLVFLNTGVLATEHYGQLDWLDNFQEYTNVFFIGLFTCEMLLKMYSLGFQGYFVSLFNRF 1205
            |||:|.||||||..:|:|||.|.|||...|:..|...:.|||.||||||||||.|.|||||||||
 Frog   556 YWLVIFLVFLNTLTIASEHYNQPDWLTEVQDTANKVLLALFTAEMLLKMYSLGLQAYFVSLFNRF 620

  Fly  1206 DCFVVIGSITETLLTNTGMMPPLGVSVLRCVRLLRVFKVTKYWRSLSNLVASLLNSIQSIASLLL 1270
            |||:|.|.|.||:|..|.:|.|||:||||||||||:||:|:||.||||||||||||::|||||||
 Frog   621 DCFIVCGGILETILVETRIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLL 685

  Fly  1271 LLFLFIVIFALLGMQVFGGKFNFDGKEEKYRMNFDCFWQALLTVFQIMTGEDWNAVMYVGINAYG 1335
            ||||||:||:|||||:||||||||....: |..||.|.|||||||||:||||||:|||.||.|||
 Frog   686 LLFLFIIIFSLLGMQLFGGKFNFDEMLTR-RSTFDNFPQALLTVFQILTGEDWNSVMYDGIMAYG 749

  Fly  1336 GVSSYGALACIYFIILFICGNYILLNVFLAIAVDNLADADSLSEVEKEEEPHDE--------SAQ 1392
            |.|..|.|.||||||||||||||||||||||||||||||:||:..:||||...|        |.:
 Frog   750 GPSFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPE 814

  Fly  1393 KKSH------SPTPTIDGMDDHLSIDIDMEQQELDDEDKMDHETLSDEEVREMCE---------E 1442
            ||..      ||.|.::...:.:.:.......|.....|:..|..|..|..|...         |
 Frog   815 KKQENESLGKSPVPAVEENKEKIELKAITADGESPPNTKISVEEFSTNENEEKTPYPSSNETPGE 879

  Fly  1443 EEEVDEEGMITARPRRMSEVNTATKILPIPPGTSFFLFSQTNRFRVFCHWLCNHSNFGNIILCCI 1507
            |||.:.|..:..|||.:||::...|..|:|..::||:|...|||||.||.:.|::.|.|:||..|
 Frog   880 EEEEEPEMPVGPRPRPLSELHIKEKAAPMPEASAFFVFRSDNRFRVHCHRIVNNNIFTNLILFFI 944

  Fly  1508 MFSSAMLAAENPLRANDDLN--------------------KVLNKFDYFFTAVFTIELILKLISY 1552
            :.||..||||:|:|.|...|                    |:|...||.||::||:|:|||:.:|
 Frog   945 LLSSISLAAEDPVRHNSFRNQVLFYFDIVFTAIFTVEIVLKILGNADYVFTSIFTLEIILKMTAY 1009

  Fly  1553 GFVLHDGAFCRSAFNLLDLLVVCVSLISLVSSSNAISVVKILRVLRVLRPLRAINRAKGLKHVVQ 1617
            |..||.|:|||:.||:||||||.|||||....|:||:||||||||||||||||||||||||||||
 Frog  1010 GAFLHKGSFCRNYFNILDLLVVSVSLISFGIQSSAINVVKILRVLRVLRPLRAINRAKGLKHVVQ 1074

  Fly  1618 CVIVAVKTIGNIVLVTCLLQFMFAVIGVQLFKYVVKCVVVAIKTIGNIMLVTYLLQFMFAVIGVQ 1682
            ||.||::||||||:||.|||||||            |                        ||||
 Frog  1075 CVFVAIRTIGNIVIVTTLLQFMFA------------C------------------------IGVQ 1103

  Fly  1683 LFKGKFFKCTDGSKMTQDECYGTYLVYDDGDVHKPRLREREWSNNRFHFDDVAKGMLTLFTVSTF 1747
            |||||.:.|||.||:|:.||.|.|:.|.||||.:|.:.:|.|.|::|.||:|...|:.|||||||
 Frog  1104 LFKGKLYSCTDSSKITEAECKGKYITYKDGDVSQPMIVDRSWENSKFDFDNVLSAMMALFTVSTF 1168

  Fly  1748 EGWPGLLYVSIDSNKENGGPIHNFRPIVAAYYIIYIIIIAFFMVNIFVGFVIVTFQNEGEQEYKN 1812
            ||||.|||.:|||:.|:.|||:|.|..::.::|||||||||||:||||||||||||.:|||||||
 Frog  1169 EGWPELLYRAIDSHTEDVGPIYNHRVEISIFFIIYIIIIAFFMMNIFVGFVIVTFQEQGEQEYKN 1233

  Fly  1813 CDLDKNQRNCIEFALKAKPVRRYIPKHGIQYKVWWFVTSSSFEYTIFILIMINTVTLAMKFYNQP 1877
            |:||||||.|:|:||||:|:||||||:..|||||:.|.|:.|||.:|:||::||:.|||:.|.|.
 Frog  1234 CELDKNQRQCVEYALKARPLRRYIPKNQYQYKVWYVVNSTYFEYLMFVLILLNTICLAMQHYGQS 1298

  Fly  1878 LWYTELLDALNMIFTAVFALEFVFKLAAFRFKNYFGDAWNVFDFIIVLGSFIDIVYSEIKSK--D 1940
            ..:.|.::.|||:||.:|.:|.:.||.||:.|.||.|.||||||:||:||.:|::.||....  |
 Frog  1299 CSFKEAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSVVDVILSETNHYFCD 1363

  Fly  1941 TSQIAECDIVEG-----------------CKSTKKSAGSNLISINFFRLFRVMRLVKLLSKGEGI 1988
            .....:..||.|                 |.|:.....::.|||.|||||||||||||||:||||
 Frog  1364 AWNTFDALIVVGSIVDIAITELNPGEHAQCSSSMNVEENSRISITFFRLFRVMRLVKLLSRGEGI 1428

  Fly  1989 RTLLWTFIKSFQALPYVALLIVLLFFIYAVVGMQVFGKIALDGGNAITANNNFQTFQQAVLVLFR 2053
            ||||||||||||||||||||||:|||||||:||||||||||:....|..|||||||.||||:|||
 Frog  1429 RTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTEINRNNNFQTFPQAVLLLFR 1493

  Fly  2054 SATGEAWQEIMMSCSAQPDVKCDMNSDTPGEPCGSSIAYPYFISFYVLCSFLIINLFVAVIMDNF 2118
            .||||||||||::|  .|...|...|:|..|.||||.|..||||||:||:|||||||||||||||
 Frog  1494 CATGEAWQEIMLAC--LPSKPCAPESETSEEKCGSSFAVFYFISFYMLCAFLIINLFVAVIMDNF 1556

  Fly  2119 DYLTRDWSILGPHHLDEFIRLWSEYDPDAKGRIKHLDVVTLLRKISPPLGFGKLCPHRMACKRLV 2183
            ||||||||||||||||||.|:|:||||:|||||||||||||||:|.||||||||||||:||||||
 Frog  1557 DYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKLCPHRVACKRLV 1621

  Fly  2184 SMNMPLNSDGTVLFNATLFAVVRTSLSIKTDGNIDDANSELRATIKQIWKRTNPKLLDQVVPPPG 2248
            :|||||||||||:|||||||:|||||.||||||::.||.||||.||:|||||:.|||||||||.|
 Frog  1622 AMNMPLNSDGTVMFNATLFALVRTSLCIKTDGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPAG 1686

  Fly  2249 NDDEVTVGKFYATYLIQDYFRRFKKRKEQEGKEGHPDS-NTVTLQAGLRTLHEVSPALKRAISGN 2312
             ||||||||||||:|||:|||:||||||| |..|.|.. |.::|||||||||::.|.::|||||:
 Frog  1687 -DDEVTVGKFYATFLIQEYFRKFKKRKEQ-GLVGKPSQRNALSLQAGLRTLHDIGPEIRRAISGD 1749

  Fly  2313 L---DELDQ---------EPEPMHRRHHTLFGS----VWSSIR---------------------- 2339
            |   :|||:         ..:.:.||...|||:    ..|.:|                      
 Frog  1750 LTAEEELDKAMKEAVSAASEDDIFRRAGGLFGNHVGYYQSEVRSAFPQTFTTQRPLHINKTSGGP 1814

  Fly  2340 ------------------------------RHGNGT-------FRRSAKATASQ-----SNGALA 2362
                                          .:.|.|       :|.:......|     |.|:..
 Frog  1815 GDLDSPSHEKLVDSTFTPSSYSSSGSNANINNANNTALVRLPCYRSTVSTVEGQSRPVTSRGSWK 1879

  Fly  2363 IGGSASAALGVGGSSLVLGSSDPAGGDYLYDTL-----------------------NRSVADGVN 2404
            :|..:|.:   ..|.|.:...:.|..|..||..                       :|.:.....
 Frog  1880 LGSKSSVS---RDSRLPIICREEASQDETYDASEEVEYSSEPSLLCSEMFSDRDEESRQLTPSEG 1941

  Fly  2405 NITRNIMQA------RLAAAGKL--------------------------------QDELQGAGSG 2431
            .:.|.:..:      |.|:.|:.                                ...|..||..
 Frog  1942 EVERGLCPSPKKGFLRSASLGRRASFHLECLRRYRHQGAEMSSPKAVLPQLHLVHHQALAVAGLS 2006

  Fly  2432 GELR------TFGESISMRPL--AKNGGGAATVAGTLPPEANAINYDNRNRGILLHPYNNVYAPN 2488
            ..||      .|....|..|.  ...||.......||.......:.:|.|..     :.:::..:
 Frog  2007 PLLRRSHSPTAFSRLCSTPPATPCPRGGWMQQTVPTLRLHGEPGSRENLNSS-----FPSIHCSD 2066

  Fly  2489 GALPGHERMIQSTPASPYDQRRLPTSSDMNGLAESLIGGVLAAEGLGKYC-DSEFVGTAAREMRE 2552
            .::..:.....:.|..|.:|.|     ..:|.|.||:..||.:|||.::. |..|:..|..|:.:
 Frog  2067 CSIGRNRPSSLTVPCHPREQGR-----QHHGSASSLVEAVLISEGLAQFAQDPRFLQVATHELAD 2126

  Fly  2553 ALDMTPEEMNLAAHQILSNEHSLSLIGSSNGSIFGGS---AGGLGGAGSGGVGGLGGSSSIRNAF 2614
            |.|||.|||..||...|:.:      .|.||.:...|   ..||..|                  
 Frog  2127 ACDMTIEEMETAADSFLNGK------ASPNGKLSPFSHRRDQGLDCA------------------ 2167

  Fly  2615 GGSGSGPSSLSPQHQ 2629
             |.||..:.|||:.|
 Frog  2168 -GGGSEETGLSPECQ 2181

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Ca-alpha1DNP_723952.2 Ion_trans 767..1042 CDD:395416 194/294 (66%)
Ion_trans 1137..1379 CDD:395416 177/241 (73%)
Ion_trans 1496..1809 CDD:395416 180/332 (54%)
Ion_trans 1851..2126 CDD:395416 175/293 (60%)
GPHH 2135..2188 CDD:407139 44/52 (85%)
Ca_chan_IQ 2199..2271 CDD:400901 57/71 (80%)
cacna1cXP_012814814.1 Ion_trans 169..445 CDD:278921 179/276 (65%)
Ion_trans 570..793 CDD:278921 165/223 (74%)
Ion_trans 985..1230 CDD:278921 165/280 (59%)
Ion_trans 1290..1564 CDD:278921 166/275 (60%)
GPHH 1572..1635 CDD:293510 54/62 (87%)
Ca_chan_IQ 1637..1708 CDD:285917 57/71 (80%)
CAC1F_C 1731..2149 CDD:293490 83/436 (19%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 377 1.000 Domainoid score I851
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1988 1.000 Inparanoid score I55
OMA 1 1.010 - - QHG48156
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 1 1.000 - - otm48359
Panther 1 1.100 - - O PTHR45628
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X533
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1111.080

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